Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 64, Issue 7, Pages 1062-1066Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c16-00086
Keywords
Curcuma phaeocaulis; Zingiberaceae; sesquiterpenoid; Toll-like receptor 4 (TLR4); lipopolysaccharide (LPS)
Funding
- Ministry of Oceans and Fisheries
- KRIBB Research Initiative Program, Republic of Korea [KGM2221622]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [201304252] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Council of Science & Technology (NST), Republic of Korea [KGM2221622] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation.
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