Article
Endocrinology & Metabolism
Melissa S. A. M. Bevers, Frans L. Heyer, Caroline E. Wyers, Bert van Rietbergen, Piet P. M. M. Geusens, Heinrich M. J. Janzing, Okke Lambers Heerspink, Martijn Poeze, Joop P. van den Bergh
Summary: This study investigates the contribution of lower-mineralized tissue to the stiffness of fractured distal radii during healing. The results suggest that the contribution of lower-mineralized tissue is minor but changes significantly around the time of cast removal. This finding has clinical relevance and provides a more complete understanding of strength recovery post-fracture.
Article
Endocrinology & Metabolism
Nicholas Ohs, Caitlyn J. Collins, Duncan C. Tourolle, Penny R. Atkins, Bryant J. Schroeder, Michael Blauth, Patrik Christen, Ralph Mueller
Summary: Radius fractures are common and the standard of care is debated, with HR-pQCT being a key tool in understanding fracture healing. A new method based on 3D-GAC for automatically contouring images of fractured distal radii was presented, showing accurate and robust results while reducing the need for time-consuming hand-contouring.
Article
Endocrinology & Metabolism
Julian Stuerznickel, Felix N. Schmidt, Hannah S. Schaefer, Frank Timo Beil, Karl-Heinz Frosch, Carsten Schlickewei, Michael Amling, Alexej Barg, Tim Rolvien
Summary: This study demonstrates that age, female sex, and osteoporosis have severe negative effects on distal fibula bone mineralization and microarchitecture, with cortical microarchitecture declining with age in both sexes. There are moderate positive associations between distal tibial and fibular microarchitecture.
Article
Orthopedics
Constantin Schmidt, Christoph Riedel, Julian Stuerznickel, Herbert Mushumba, Maximilian M. Delsmann, Christian Ries, Sebastian Kleiss, Peter Bannas, Frank Timo Beil, Michael Amling, Klaus Pueschel, Tim Rolvien, Jan Hubert
Summary: This study investigates the association between demographic characteristics and microarchitectural parameters in distal femur fractures. The findings suggest that female sex, advanced age, and low bone mineral density (BMD) are major risk factors for impaired microarchitecture and fracture in this skeletal site.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Tiev Miller, Michael T. C. Ying, Vivian W. Y. Hung, Charlotte S. L. Tsang, Huixi Ouyang, Raymond C. K. Chung, Ling Qin, Marco Y. C. Pang
Summary: The study used High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) to investigate bone properties at the distal radius in people with chronic stroke, revealing compromised bone microstructure and lower estimated failure load in the paretic side. Motor impairment was identified as a significant determinant of estimated bone strength at the distal radius, suggesting it may be a potential target for improving bone health post-stroke.
Article
Endocrinology & Metabolism
Kazuteru Shiraishi, Andrew J. Burghardt, Makoto Osaki, Sundeep Khosla, Julio Carballido-Gamio
Summary: This study investigated the interrelationships of bone parameters derived from HR-pQCT and their spatial distribution, comparing postmenopausal women with and without a recent Colles' fracture. The results showed significant differences in the correlations of bone parameters between controls and fracture cases, indicating heterogeneous spatial distribution of bone parameter interrelationships. This information may provide valuable insights into understanding different mechanisms of bone fracture.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
J. P. van den Bergh, P. Szulc, A. M. Cheung, M. Bouxsein, K. Engelke, R. Chapurlat
Summary: HR-pQCT has been developed for imaging bone microarchitecture in peripheral skeletal sites, with increasing clinical research focusing on understanding skeletal fragility and improving fracture prediction. Differentiation and reference data for HR-pQCT variables by age, sex, and race/ethnicity have been provided, along with discussions on fracture risk prediction, monitoring response to anti-osteoporosis therapy, and novel applications in patients with metabolic bone disorders and secondary osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
M. Revel, F. Bermond, F. Duboeuf, D. Mitton, H. Follet
Summary: Although HR-pQCT allows for assessment of bone microstructure and strength to evaluate fracture risk, it does not show clear improvement in accuracy compared to DXA measurements. Changes in loading conditions do not enhance the prediction of radius fracture risk based on ex vivo experiments, as demonstrated by similar ROC curves and accuracies with different loading conditions.
Article
Endocrinology & Metabolism
M. S. A. M. Bevers, A. M. Daniels, B. van Rietbergen, P. P. M. M. Geusens, S. M. J. van Kuijk, S. Sassen, S. Kaarsemaker, P. F. W. Hannemann, M. Poeze, H. M. J. Janzing, J. P. van den Bergh, C. E. Wyers
Summary: By utilizing high-resolution peripheral quantitative computed tomography, this study examined changes in bone density, microstructure, and strength during the healing of conservatively-treated scaphoid fractures. The findings indicated a substantial decrease in bone density, trabecular thickness, and failure load during the initial 6 weeks of healing, followed by stabilization or increase in these parameters. However, at 26 weeks, these parameters had not returned to baseline levels.
Article
Endocrinology & Metabolism
Shingo Ota, Ko Chiba, Narihiro Okazaki, Akihiko Yonekura, Masato Tomita, Makoto Osaki
Summary: An advanced method using HR-pQCT was developed to analyze the cortical bone microarchitecture of the distal radius. The study found that cortical bone density and thickness decreased while cortical porosity increased with age. The thinning of cortical bone was particularly pronounced in the dorsal and palmar regions.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Rheumatology
Scott Cameron Brunet, Stephanie Finzel, Klaus Engelke, Steven Kyle Boyd, Cheryl Barnabe, Sarah Lynn Manske
Summary: HR-pQCT is sensitive in detecting bone surface changes in early inflammatory arthritis (EIA) patients. Gradual degradation of joint space width proportional to symptom duration was observed in the study. Patients with EIA need close monitoring for exacerbation of arthritis and progression of periarticular bone damage.
Article
Endocrinology & Metabolism
Kara B. Anderson, Monica C. Tembo, Sophia X. Sui, Natalie K. Hyde, Julie A. Pasco, Mark A. Kotowicz, Kara L. Holloway-Kew
Summary: Peripheral quantitative computed tomography (pQCT) provides information about bone structure and density, which can help in predicting fracture risk. This study found that key pQCT parameters at both the radius and tibia were associated with prior fractures in men, highlighting their potential use in fracture risk prediction.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Computer Science, Interdisciplinary Applications
Xuanchi Liu, Saeed Miramini, Minoo Patel, Peter Ebeling, Jinjing Liao, Lihai Zhang
Summary: This study aimed to develop optimal machine learning algorithms for designing effective physiotherapy programs for distal radius fractures at different healing stages. A three-dimensional computational model was developed, which integrated mechano-regulated cell differentiation, tissue formation, and angiogenesis. The model could predict healing outcomes based on physiologically relevant conditions. The results showed that different machine learning algorithms performed best at different healing stages.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Rheumatology
Rasmus Klose-Jensen, Josephine Therkildsen, Anne-Birgitte Garm Blavnsfeldt, Bente L. Langdahl, Anna Zejden, Jesper Thygesen, Kresten Krarup Keller, Ellen-Margrethe Hauge
Summary: This study compares the accuracy of HR-pQCT and CR in classifying patients as having erosive RA, and the results show that these two methods are comparable.
Article
Orthopedics
Carsten Schlickewei, Conradin Schweizer, Klaus Pueschel, Benjamin Ondruschka, Holger Kleinertz, Alexej Barg, Tim Rolvien, Julian Stuerznickel
Summary: This study examines the effects of age, sex, and subregion on the bone microarchitecture and strength of the distal fibula. Results show that cortical parameters increase and trabecular parameters decrease from distal to proximal. Age is primarily associated with a cortical decrease in all subregions for women, while men also exhibit age-associated decreases in certain parameters. The stiffness and failure load are highest in the type C subregion for both genders. A critical age-related decline in bone strength parameters is observed in the type B subregion for women, providing an explanation for the increased incidence of low-traumatic type B fractures in the elderly.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Shuta Yamada, Ko Chiba, Narihiro Okazaki, Makoto Era, Yuichiro Nishino, Kazuaki Yokota, Akihiko Yonekura, Masato Tomita, Toshiyuki Tsurumoto, Makoto Osaki
Article
Endocrinology & Metabolism
Makoto Era, Ko Chiba, Yuichiro Nishino, Narihiro Okazaki, Takashi Miyamoto, Akihiko Yonekura, Masato Tomita, Toshiyuki Tsurumoto, Makoto Osaki
Article
Endocrinology & Metabolism
Kazuaki Yokota, Ko Chiba, Narihiro Okazaki, Choko Kondo, Mitsuru Doi, Shuta Yamada, Makoto Era, Yuichiro Nishino, Akihiko Yonekura, Masato Tomita, Makoto Osaki
JOURNAL OF BONE AND MINERAL METABOLISM
(2020)
Article
Orthopedics
Makoto Era, Junichiro Maeda, Tadashi Tomonaga
Summary: The study found that using a navigation system can improve the accuracy of lag screw placement by less experienced surgeons without increasing operative time. In terms of TAD and operative time, the Navigation-Young surgeon group showed better results.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2021)
Article
Endocrinology & Metabolism
Ko Chiba, Shuta Yamada, Itaru Yoda, Makoto Era, Kazuaki Yokota, Narihiro Okazaki, Shingo Ota, Yusaku Isobe, Satsuki Miyazaki, Shigeki Tashiro, Sawako Nakashima, Shimpei Morimoto, Shuntaro Sato, Tomoo Tsukazaki, Tsuyoshi Watanabe, Hiroshi Enomoto, Yoshihiro Yabe, Akihiko Yonekura, Masato Tomita, Masako Ito, Makoto Osaki
Summary: Sequential therapy with monthly intravenous ibandronate can decrease bone resorption and increase bone mineral density, particularly showing good improvement in lumbar spine density. Additionally, it significantly improves cortical bone microstructure, enhancing cortical thickness and stability of the tibia.
Article
Endocrinology & Metabolism
Ko Chiba, Narihiro Okazaki, Ayako Kurogi, Tsuyoshi Watanabe, Ai Mori, Nobuhiko Suzuki, Koichi Adachi, Makoto Era, Kazuaki Yokota, Takuma Inoue, Yoshihiro Yabe, Keizo Furukawa, Choko Kondo, Keiichi Tsuda, Shingo Ota, Yusaku Isobe, Satsuki Miyazaki, Shimpei Morimoto, Shuntaro Sato, Sawako Nakashima, Shigeki Tashiro, Akihiko Yonekura, Masato Tomita, Makoto Osaki
Summary: The effects of daily and weekly high-dose teriparatide, as well as bisphosphonates, were investigated in postmenopausal osteoporosis patients. The study found that both daily and weekly teriparatide increased cortical thickness, had a strong effect on trabecular bone, and increased total bone strength. The bisphosphonates also had positive effects on bone density and strength.
