Journal
JOURNAL OF BIOPHOTONICS
Volume 13, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.202000040
Keywords
allergic contact dermatitis; hyperspectral imaging; optical imaging; SWIR; tissue optics
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Funding
- National Institutes of Health [1S10RR03162, R01 CA208623]
- National Science Foundation [IIA-1355406, PFITT 1827656]
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Short-wave infrared hyperspectral imaging is applied to diagnose and monitor a case of allergic contact dermatitis (ACD) due to poison ivy exposure in one subject. This approach directly demonstrates increased tissue fluid content in ACD lesional skin with a spectral signature that matches the spectral signature of intradermally injected normal saline. The best contrast between the affected and unaffected skin is achieved through a selection of specific wavelengths at 1070, 1340 and 1605 nm and combining them in a pseudo-red-green-blue color space. An image derived from these wavelengths normalized to unaffected skin defines a tissue fluid index that may aid in the quantitative diagnosis and monitoring of ACD. Further clinical testing of this promising approach towards disease detection and monitoring with tissue fluid content quantification is warranted.
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