Article
Engineering, Environmental
Yulu Yang, Ju Liu, Maowen Chen, Pengfei Gao, Yi Gong, Rui Chen, Yu Tang, Weihu Yang, Kaiyong Cai
Summary: This study developed a novel strategy for Ti implants based on photolithography, achieving near-infrared light-controlled loading, releasing, and clearing of antimicrobial agents. In vitro antibacterial evaluation and cell experiments demonstrated that the modified Ti substrate exhibited excellent antibacterial and osteoinductive abilities. This work may provide a promising strategy for dynamic orthopedic applications.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Romina Alarcon, Mariana Walter, Maritza Paez, Manuel Ignacio Azocar
Summary: In this study, the stability and antibacterial activity of silver nanoparticles (AgNPs) coated with different stabilizers were investigated. The AgNPs showed differences in stability and size change depending on the coating agent used. The stabilizer may function as a growth controller of the nanoparticles, affecting their biological properties. The protective or stabilizing agents also played a role in the antibacterial capacity and stability of AgNPs over time.
Article
Materials Science, Ceramics
M. Nadimi, C. Dehghanian
Summary: The study found that incorporating ZnO-ZrO2 nanoparticles into TiO2 ceramic coating on Ti6-Al-4V can significantly improve corrosion resistance and wettability of the coating, while greatly enhancing antibacterial properties.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Environmental
Thuy Thi Thanh Nguyen, Y. Ngoc Nhu Nguyen, Xuan Thanh Tran, Tam Thi Thanh Nguyen, Thuan Van Tran
Summary: Plant extract-mediated synthesis of CuONPs, ZnONPs, and CuO/ZnONPs using Annona glabra L. leaf extract can provide environmentally friendly and cost-effective nano-particles with good photocatalytic, antibacterial, and antioxidant activities.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Biophysics
Yunhui Si, Huanyao Liu, Hongying Yu, Xuzhou Jiang, Dongbai Sun
Summary: In this study, a metal-organic framework derived CuO@ZnO composite was coated onto polydopamine modified titanium alloy, which exhibits antibacterial properties by inhibiting bacterial biofilm formation and sterilizing Staphylococcus aureus. Moreover, it promotes the adhesion and proliferation of human bone marrow mesenchymal stem cells and stimulates angiogenesis by up-regulating the expression of vascular endothelial growth factor.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Multidisciplinary Sciences
Jin Liu, Lu Shi, Xinxin Ma, Sijin Jiang, Xinyao Hou, Pu Li, Yue Cheng, Jia Lv, Shaoru Li, Tianyou Ma, Bei Han
Summary: A patented strain of Bacillus amyloliquefaciens C-1 in our laboratory has been found to produce functional sodium selenite under optimized fermentation conditions. This strain, known as C-1, has the ability to synthesize selenium nanoparticles and has shown potential as selenium-enriched postbiotics. The synthesized selenium nanoparticles exhibited antioxidant activity and C-1 cells enriched with selenium demonstrated anti-inflammatory effects. Transcriptome data analysis revealed differential gene expression in C-1 with and without selenium-enrichment, suggesting the involvement of various genes related to ABC transporter proteins and selenium metabolism. This study provides valuable insights for the development of nano-selenium biomaterials and selenium-enriched postbiotics.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Ankush Agrawal, Ruhani Sharma, Ankita Sharma, Kailash Chand Gurjar, Sanjay Kumar, Samit Chatterjee, Harsh Pandey, Kamlendra Awasthi, Anjali Awasthi
Summary: In this study, green synthesized zinc oxide nanoparticles (ZnO NPs) were found to exhibit excellent antibacterial and antibiofilm activity against biofilm-producing Bacillus subtilis bacteria. The nanoparticles were shown to inhibit biofilm formation and damage bacterial cell membranes, indicating their potential as an alternative treatment for biofilms and drug-resistant bacteria.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Physical
K. Chandramouli, B. Suryanarayana, T. Anil Babu, Vemuri Raghavendra, D. Parajuli, N. Murali, Venkaiah Malapati, Tulu Wegayehu Mammo, P. S. Shanmukhi, Umesh Reddy Gudla
Summary: The structure, particle size, and antibiotic nature of synthesized ZnO nanoparticles were studied using XRD, TEM, and FTIR, revealing spherical particles with a single wurtzite hexagonal crystal structure. The correlation between defect and antibiotic properties of ZnO was identified.
SURFACES AND INTERFACES
(2021)
Article
Engineering, Environmental
Bindia Junejo, Mujde Eryilmaz, Suna Sibel Rizvanoglu, Ismail Murat Palabiyik, Tania Ghumro, Arfana Mallah, Amber R. R. Solangi, Syed Iqleem Hyder, Hassan Karimi Maleh, Elena Niculina Dragoi
Summary: The resistance to antibiotics has led to an increase in disease-causing infections, especially those caused by pathogens. However, nanotechnology offers a new avenue for creating effective antimicrobial agents. Metal-based nanoparticles have been proven to have strong antibacterial activities, but a comprehensive analysis is still lacking. This study synthesized Co3O4, CuO, NiO, and ZnO nanoparticles and tested their antibacterial activities against different bacteria. ZnO nanoparticles showed the best inhibitory concentration against Staphylococcus epidermidis ATCC12228. The study also examined the biofilm inhibition and antiquorum sensing activities of nanoparticles, demonstrating their potential for bacteria removal from water and wastewater.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Swathi Ippili, Venkatraju Jella, Jeong Min Lee, Jang-Su Jung, Dong-Hyun Lee, Tae-Youl Yang, Soon-Gil Yoon
Summary: In this study, anti-reflective, hydrophobic, antimicrobial zinc oxide-polytetrafluoroethylene (ZnO-PTFE) composite thin films with sensorial capabilities were developed, and an antimicrobial self-powered touch sensor based on these composite films was demonstrated. These films exhibited low refractive index, high transmittance, excellent antibacterial properties, and water stability. The potential applications of these coatings in interactive devices for a safer experience were highlighted.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Physical
Han Liang, Huiyan Wang, Xuemei Sun, Wang Xu, Na Meng, Ninglin Zhou
Summary: Nanocomposites of zinc oxide nano-particles and silver nanoparticles loaded on polydopamine-modified montmorillonite demonstrated potent antibacterial ability. The synergistic effect between the two types of nanoparticles resulted in higher antimicrobial activity compared to other materials tested. The biocompatibility of the nanocomposites was also confirmed, making them promising for antibacterial applications.
APPLIED CLAY SCIENCE
(2023)
Article
Materials Science, Ceramics
Junwei Cui, Dapeng Wu, Zhenyun Li, Guoan Zhao, Jinshui Wang, Le Wang, Bingxuan Niu
Summary: The Ag/ZnO hybrid cages, prepared through in situ pyrolysis with well-preserved polyhedron shape and rich mesoporous structures, exhibit enhanced photocatalytic and antibacterial performances by improving light absorption and promoting charge separation. The cages demonstrate significant degradation of various organic dyes and inhibition against bacteria, with detailed mechanism studies conducted through optical/electrochemical dynamic tests and Ag+ and Zn2+ release measurements.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Kaouther. Khlifi, Mohamed Salah. Atallah, Ichraf. Cherif, Ines Karkouch, Najoua. Barhoumi, Sameh. Attia-Essaies
Summary: The present study synthesized a PMMA/ZnO-NPs composite by incorporating different concentrations of ZnO nanoparticles into PMMA for improved mechanical properties and demonstrated excellent antibacterial activity.
SURFACES AND INTERFACES
(2023)
Article
Agricultural Engineering
Liqiang Xiao, Zheng Yao, Yongbin He, Zeyu Han, Xujing Zhang, Chengcheng Li, Pengwu Xu, Weijun Yang, Piming Ma
Summary: The lignin-zinc oxide hybrid particles were successfully synthesized using a hydrothermal method, and their addition to PBAT resulted in improved mechanical properties. The PBAT/LZn composite films exhibited UV shielding, antioxidant, and antibacterial activities, making them suitable for active food packaging.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Materials Science, Paper & Wood
Sepideh Hamedi, Seyed Abbas Shojaosadati
Summary: Nanocomposite hydrogel plays a crucial role in wound healing, with the addition of ZnO nanoparticles and functionalization of bacterial cellulose enhancing its properties and antibacterial effects. It can also stimulate the proliferation of human fibroblast cells.
Article
Chemistry, Physical
Yulu Yang, Rui Chen, Ke Li, Pengfei Gao, Yi Gong, Weihu Yang, Kaiyong Cai
Summary: The study demonstrates the effectiveness of ferroptosis in treating refractory DLBCL and identifies two subtypes of DLBCL with different clinical characteristics. Researchers developed a novel ferroptosis nanocarrier PBPMn@PEG, which can induce ferroptosis and apoptosis in lymphoma cells and exhibit better anti-tumor effects in animal experiments.
Article
Engineering, Biomedical
Wenbo Geng, Xuezhe Liu, Bailong Tao, Ye He, Ke Li, Pengfei Gao, Qian Feng, Peng Zhao, Zhong Luo, Kaiyong Cai
Summary: This study reports a new block polymer that can scavenge NO and release H2S for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrate that the polymer can suppress reactive oxygen species and pro-inflammatory cytokines, regulate macrophage phenotype, and mitigate synovial inflammation. This work provides new insight into the synergistic treatment of rheumatoid arthritis and other endogenous gas-related diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shi Mo, Kaiwei Tang, Qing Liao, Lingxia Xie, Yuzheng Wu, Guomin Wang, Qingdong Ruan, Ang Gao, Yuanliang Lv, Kaiyong Cai, Liping Tong, Zhengwei Wu, Paul K. Chu, Huaiyu Wang
Summary: Bacteria killing behavior based on physical effects is preferred for biomedical implants due to minimal side effects. However, the understanding of antibacterial activity of nanostructures is limited, and nanoarchitectures on orthopedics should also promote bone formation. This study fabricated tilted and vertical nanolamellar structures on polyether-ether-ketone (PEEK) and found that both types physically kill bacteria, but through different mechanisms. Tilted nanostructures are more desirable for peri-implant bone regeneration. This research provides insights into the arrangement of nanostructures in orthopedic applications and different mechanisms of physical antibacterial activity.
MATERIALS HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Dan Li, Danyang Wang, Yulu Yang, Pengfei Gao, Wuzhe Fan, Xianhui Zhang, Yu Tang, Weihu Yang, Kaiyong Cai
Summary: In this study, the genomic characteristics of osteonecrosis of the femoral head (ONFH) were analyzed, and differentially expressed genes (DEGs) related to autophagy were identified. A modified titanium substrate was designed to upregulate HIF-1 alpha expression in mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) through receptors of TGF-beta and TNFR. The upregulated HIF-1 alpha in MSCs promoted autophagy and regulated MSCs proliferation and osteogenic differentiation, while in HUVECs, it accelerated angiogenesis by increasing VEGF expression. The modified titanium substrate enhanced the integration effect of the implant and reta\rded the deterioration of ONFH.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuai Wang, Jixi Huang, Hanyin Zhu, Jing Zhu, Zhenqiang Wang, Yuxin Xing, Xiyue Xie, Kaiyong Cai, Jixi Zhang
Summary: A 2D allomelanin nanomodulator was prepared by DNA guidance to scavenge reactive oxygen species (ROS) for inflammation and prognosis control following photothermal therapy (PTT). Compared with conventional photothermal agents, the nanodisks greatly reduce ROS accumulation during PTT, downregulate proinflammatory factors, and effectively prevent burn wound progression and promote tissue repair. The study provides useful inspiration for rationally modulating redox active nanostructures to address prognosis issues following PTT.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biophysics
Yuhua Chen, Yuxin Xing, Zhenqiang Wang, Lin Li, Hailing Wang, Shuqi Tang, Kaiyong Cai, Jixi Zhang
Summary: A dual-factor coactivation strategy was developed to enhance tumor imaging by increasing the accessibility of cytosolic biomarkers. Application of a lysosomotropic agent facilitated the release of nanosensors, leading to a significant increase in intracellular fluorescence in vitro. The coactivation strategy also improved the cancer-to-normal cell signal ratio and resulted in high tumor-to-normal tissue ratio values in the in vivo imaging results. This strategy establishes a new paradigm for selective and specific tumor imaging using fluorescent nanosensors.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Multidisciplinary
Jinxiu Yu, Pengfei Gao, Yulu Yang, Dan Peng, Xianhui Zhang, Danyang Wang, Weihu Yang, Yu Tang, Kaiyong Cai
Summary: In this study, a functionalized titanium implant was developed by incorporating H2S donors into Ti nanotubes and coating with chitosan/gelatin multilayers to enhance osteointegration. By optimizing the polarization regulation of M1 to M2 macrophages, the phagocytosis and neovascularization functions of M1 macrophages can be maintained, while the anti-inflammatory response can be improved by M2 macrophages polarization. The immunomodulation of macrophages leads to efficient osteogenic differentiation of MSCs, promoting neovascularization and osteogenesis around the implants.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Ke Li, Kun Xu, Shaopeng Liu, Ye He, Meijun Tan, Yulan Mao, Yulu Yang, Jing Wu, Qian Feng, Zhong Luo, Kaiyong Cai
Summary: Researchers have developed an engineered multifunctional nanoplatform that combines low-temperature photothermal therapy (PTT) with ferroptosis and chemotherapy to effectively induce tumor cell death and eradicate tumor cells in vivo, prolonging the survival time of mice.
Article
Engineering, Biomedical
Jiawu Yu, Yuchen Zhang, Liqi Li, Yang Xiang, Xuemei Yao, Youbo Zhao, Kaiyong Cai, Menghuan Li, Zhongjun Li, Zhong Luo
Summary: By constructing a cooperative radio-ferroptosis-stimulatory nanomedicine, breast cancer cells can be selectively targeted and their sensitivity to radiotherapy can be enhanced.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Kangkang Zha, Wenqian Zhang, Weixian Hu, Meijun Tan, Shengming Zhang, Yongsheng Yu, Shuangquan Gou, Pengzhen Bu, Bikun Zhou, Yanan Zou, Yuan Xiong, Bobin Mi, Guohui Liu, Qian Feng, Kaiyong Cai
Summary: A bilayered gelatin/acryloyl & beta;-cyclodextrin hydrogel loaded with humic acids and astragaloside IV in the lower layer and verteporfin in the upper layer was developed to treat bacteria-infected cutaneous wounds. The hydrogel alleviates oxidative stress, promotes M2 macrophage polarization and angiogenesis during the inflammation and early proliferation phases, and inhibits excessive vessel growth during the late proliferation and remodeling phases.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shuangquan Gou, Gangyang Wang, Yanan Zou, Wenbo Geng, Tingting He, Zizhen Qin, Lingbin Che, Qian Feng, Kaiyong Cai
Summary: A self-assembled gelatin/silk fibroin composite (GSC) particle based drug delivery system with universal drug loading capacity for cancer treatment is developed. It shows efficient drug loading, protects loaded drugs, and has adjustable particle sizes. The GSC system has potential applications in lung cancer treatment.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Meng Li, Jing Wu, Wenbo Geng, Yulu Yang, Xuan Li, Kun Xu, Ke Li, Yan Li, Qiaojian Duan, Pengfei Gao, Kaiyong Cai
Summary: Localized corrosion of 316L stainless steel reduces the viability, adhesion, proliferation, and osteogenic differentiation abilities of BMSCs. It causes cytotoxicity through the release of metallic ions and generates reactive oxygen species (ROS) around the corrosion pits, leading to oxidative stress and cell membrane depolarization. This study provides insights into corrosion-mediated degradation of cell function and material-cell interactions.
Article
Chemistry, Physical
Jingpi Gao, Gaofeng Liang, Xiaoran Liu, Kaiyong Cai, Jinghua Li
Summary: The study develops a photothermal-driven Cu2O-SnO2-Polydopamine (PDA) triple cubic heterostructures Fenton catalyst system, which exhibits strong photothermal capabilities in the NIR region and achieves higher degradation efficiency. The system significantly improves the energy conversion efficiency of Cu2O and exhibits excellent catalytic activity over a wide pH range using Rhodamine B (RhB) as the model dye. This study offers a novel approach for environmental remediation through the synergistic effect of photocatalysis and photothermal processes.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Physical
Genhua Liu, Ruichen Ma, Peng Liu, Kui Wang, Kaiyong Cai
Summary: This study developed a multifunctional nanocomposite hydrogel system that can prevent tumor recurrence, limit bacterial infections, and promote wound healing. The system demonstrated superior photothermal effects and antioxidant properties, resulting in synergistic therapeutic effects against bacteria and tumor cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)