Mycosporine-like amino acids stimulate hyaluronan secretion by up-regulating hyaluronan synthase 2 via activation of the p38/MSK1/CREB/c-Fos/AP-1 axis

The stem cell factor-stimulated melanogenesis in human melanocytes can be abrogated by interrupting the phosphorylation of MSK1: evidence for involvement of the p38/MSK1/CREB/MITF axis

(2018) Takao Niwano et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Extracellular ATP activates hyaluronan synthase 2 ( HAS2 ) in epidermal keratinocytes via P2Y 2 , Ca 2+ signaling, and MAPK pathways

(2018) Leena Rauhala et al.   BIOCHEMICAL JOURNAL

Molecular photoprotection of human keratinocytes in vitro by the naturally occurring mycosporine-like amino acid palythine

(2018) K.P. Lawrence et al.   BRITISH JOURNAL OF DERMATOLOGY

Reduction of hyaluronan and increased expression of HYBID (alias CEMIP and KIAA1199) correlate with clinical symptoms in photoaged skin

(2018) H. Yoshida et al.   BRITISH JOURNAL OF DERMATOLOGY

Signaling Cascades Activated by UVB in Human Melanocytes Lead to the Increased Expression of Melanocyte Receptors, Endothelin B Receptor and c-KIT

(2018) Shuko Terazawa et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Relationship of hyaluronan and HYBID (KIAA1199) expression with roughness parameters of photoaged skin in Caucasian women

(2018) H. Yoshida et al.   SKIN RESEARCH AND TECHNOLOGY

Epithelial-mesenchymal interaction mechanisms leading to the over-expression of neprilysin are involved in the UVB-induced formation of wrinkles in the skin

(2016) Genji Imokawa   EXPERIMENTAL DERMATOLOGY

20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginsenoside Rb1, enhances the production of hyaluronic acid through the activation of ERK and Akt mediated by Src tyrosin kinase in human keratinocytes

(2015) TAE-GYU LIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging I: Reduced Skin Elasticity, Highly Associated with Enhanced Dermal Elastase Activity, Triggers Wrinkling and Sagging

(2015) Genji Imokawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role

(2015) Genji Imokawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts

(2015) Aya Nagaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UVB Stimulates the Expression of Endothelin B Receptor in Human Melanocytes via a Sequential Activation of the p38/MSK1/CREB/MITF Pathway Which Can Be Interrupted by a French Maritime Pine Bark Extract through a Direct Inactivation of MSK1

(2015) Hideki Tagashira et al.   PLoS One

The UVB-Stimulated Expression of Transglutaminase 1 Is Mediated Predominantly via the NFκB Signaling Pathway: New Evidence of Its Significant Attenuation through the Specific Interruption of the p38/MSK1/NFκBp65 Ser276 Axis

(2015) Shuko Terazawa et al.   PLoS One

Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human melanocytes

(2014) Shuko Terazawa et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Extracellular UDP-Glucose Activates P2Y14Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705Phosphorylation and Binding to Hyaluronan Synthase 2 (HAS2) Promoter, Stimulating Hyaluronan Synthesis of Keratinocytes

(2014) Tiina A. Jokela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of viability and apoptosis of UVB-exposed human keratinocyte HaCaT cells by aqueous methanol extract of laver (Porphyra yezoensis)

(2014) Saerong Kim et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan SynthasesHas1–3Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling

(2013) Leena Rauhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

(2013) H. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial–mesenchymal interaction during UVB-induced up-regulation of neutral endopeptidase

(2012) Hiroaki Nakajima et al.   BIOCHEMICAL JOURNAL

Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner

(2012) Shuko Terazawa et al.   EXPERIMENTAL DERMATOLOGY

Neutral Sphingomyelinase 2 Deficiency Increases Hyaluronan Synthesis by Up-regulation of Hyaluronan Synthase 2 through Decreased Ceramide Production and Activation of Akt

(2012) Jingdong Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methyl-β-cyclodextrin Suppresses Hyaluronan Synthesis by Down-regulation of Hyaluronan Synthase 2 through Inhibition of Akt

(2010) Anne Kultti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neprilysin Is Identical to Skin Fibroblast Elastase

(2010) Naoko Morisaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single UVB exposure increases the expression of functional KIT in human melanocytes by up-regulating MITF expression through the phosphorylation of p38/CREB

(2009) Yuki Mizutani et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Regulation of the Hyaluronan Synthase 2 Gene by Convergence in Cyclic AMP Response Element-binding Protein and Retinoid Acid Receptor Signaling

(2009) Katri M. Makkonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ser276 Phosphorylation of NF-kB p65 by MSK1 Controls SCF Expression in Inflammation

(2009) Laurent Reber et al.   PLoS One

Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin

(2008) Gary J. Fisher et al.   AMERICAN JOURNAL OF PATHOLOGY