Modification of a PE/PPE substrate pair reroutes an Esx substrate pair from the mycobacterial ESX-1 type VII secretion system to the ESX-5 system

Species‐specific secretion of ESX‐5 type VII substrates is determined by the linker 2 of EccC 5

(2020) Catalin M. Bunduc et al.   MOLECULAR MICROBIOLOGY

Structural insights into substrate recognition by the type VII secretion system

(2019) Shuhui Wang et al.   Protein & Cell

Esx Paralogs Are Functionally Equivalent to ESX-1 Proteins but Are Dispensable for Virulence in Mycobacterium marinum

(2018) Rachel E. Bosserman et al.   JOURNAL OF BACTERIOLOGY

EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF

(2018) Trang H. Phan et al.   PLoS Pathogens

Structural basis of the PE–PPE protein interaction inMycobacterium tuberculosis

(2017) Xin Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Enigmatic Esx Proteins: Looking Beyond Mycobacteria

(2017) Meera Unnikrishnan et al.   TRENDS IN MICROBIOLOGY

Structure of the mycobacterial ESX-5 type VII secretion system membrane complex by single-particle analysis

(2017) Katherine S. H. Beckham et al.   Nature Microbiology

Identification of a substrate domain that determines system specificity in mycobacterial type VII secretion systems

(2017) Trang H. Phan et al.   Scientific Reports

Role of Metal-Dependent Regulation of ESX-3 Secretion in Intracellular Survival of Mycobacterium tuberculosis

(2016) Emir Tinaztepe et al.   INFECTION AND IMMUNITY

ESX secretion systems: mycobacterial evolution to counter host immunity

(2016) Matthias I. Gröschel et al.   NATURE REVIEWS MICROBIOLOGY

Separable roles forMycobacterium tuberculosisESX-3 effectors in iron acquisition and virulence

(2016) JoAnn M. Tufariello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III Secretion: Building and Operating a Remarkable Nanomachine

(2016) Athina G. Portaliou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion

(2015) Oren S. Rosenberg et al.   CELL

Structure of EspB, a secreted substrate of the ESX-1 secretion system of Mycobacterium tuberculosis

(2015) Natalia Korotkova et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure of EspB from the ESX-1 Type VII Secretion System and Insights into its Export Mechanism

(2015) Matthew Solomonson et al.   STRUCTURE

Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria

(2015) Louis S. Ates et al.   PLoS Genetics

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

(2015) Roxane Simeone et al.   PLoS Pathogens

The ESX-5 Secretion System of Mycobacterium marinum Modulates the Macrophage Response

(2014) A. M. Abdallah et al.   JOURNAL OF IMMUNOLOGY

Structure of theMycobacterium tuberculosistype VII secretion system chaperone EspG5in complex with PE25-PPE41 dimer

(2014) Natalia Korotkova et al.   MOLECULAR MICROBIOLOGY

WXG100 Protein Superfamily Consists of Three Subfamilies and Exhibits an α-Helical C-Terminal Conserved Residue Pattern

(2014) Christian Poulsen et al.   PLoS One

Structure of a PE-PPE-EspG complex from Mycobacterium tuberculosis reveals molecular specificity of ESX protein secretion

(2014) D. C. Ekiert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Take five — Type VII secretion systems of Mycobacteria

(2013) Edith N.G. Houben et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mycobacterium tuberculosis EspB binds phospholipids and mediates EsxA-independent virulence

(2013) Jeffrey M. Chen et al.   MOLECULAR MICROBIOLOGY

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

(2012) Diane Houben et al.   CELLULAR MICROBIOLOGY

ESX-5-deficient Mycobacterium marinum is hypervirulent in adult zebrafish

(2012) Eveline M. Weerdenburg et al.   CELLULAR MICROBIOLOGY

Specific Chaperones for the Type VII Protein Secretion Pathway

(2012) Maria H. Daleke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Composition of the type VII secretion system membrane complex

(2012) Edith N. G. Houben et al.   MOLECULAR MICROBIOLOGY

General secretion signal for the mycobacterial type VII secretion pathway

(2012) M. H. Daleke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

(2012) Roxane Simeone et al.   PLoS Pathogens

Solution Structure of theMycobacterium tuberculosisEsxG·EsxH Complex

(2011) Dariush Ilghari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EspA Acts as a Critical Mediator of ESX1-Dependent Virulence in Mycobacterium tuberculosis by Affecting Bacterial Cell Wall Integrity

(2010) Alejandra Garces et al.   PLoS Pathogens

ESX-1 secreted virulence factors are recognized by multiple cytosolic AAA ATPases in pathogenic mycobacteria

(2009) Patricia A. DiGiuseppe Champion et al.   MOLECULAR MICROBIOLOGY

PPE and PE_PGRS proteins ofMycobacterium marinumare transported via the type VII secretion system ESX-5

(2009) Abdallah M. Abdallah et al.   MOLECULAR MICROBIOLOGY

Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition

(2009) M. S. Siegrist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Genetic Nomenclature for Type VII Secretion Systems

(2009) Wilbert Bitter et al.   PLoS Pathogens

Evidence for Pore Formation in Host Cell Membranes by ESX-1-Secreted ESAT-6 and Its Role in Mycobacterium marinum Escape from the Vacuole

(2008) J. Smith et al.   INFECTION AND IMMUNITY