Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Review
Engineering, Biomedical
Duoyi Zhao, Tongtong Zhu, Jie Li, Liguo Cui, Zhiyu Zhang, Xiuli Zhuang, Jianxun Ding
Summary: This article comprehensively reviews the research and applications of artificial bone-substitute materials based on PLGA and its composites, discussing their potential and challenges in bone regeneration.
BIOACTIVE MATERIALS
(2021)
Article
Polymer Science
Alastair Little, Alan M. Wemyss, David M. Haddleton, Bowen Tan, Zhaoyang Sun, Yang Ji, Chaoying Wan
Summary: The study investigates the effects of various reaction conditions on the synthesis of PLGA25, showing how factors such as reaction temperature, initiator concentration, and catalyst concentration impact the molecular weight, monomer conversion, and thermal properties.
Article
Materials Science, Multidisciplinary
Eva M. M. Eger, Seema Agarwal
Summary: This study focuses on the characterization and reprocessing ability of PLGA in the form of dynamic covalent networks. The synthesized networks with dynamic bonding and debonding have enhanced thermomechanical properties and maintain the potential for thermal reprocessing and recycling like thermoplastics.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Biophysics
Orkun Uyanik, Kubra Cigdem Pekkoc-Uyanik, Siddika Findik, Ahmet Avci, Zeynep Altuntas
Summary: In a study on rat Achilles tendon injury models, the application of poly (lactic acid-co-glycolic acid) significantly reduces peritendinous adhesions, promotes tendon healing, and demonstrates good biocompatibility in histopathological examination.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Pharmacology & Pharmacy
Kostas Tsachouridis, Evi Christodoulou, Alexandra Zamboulis, Anna Michopoulou, Panagiotis Barmpalexis, Dimitrios N. Bikiaris
Summary: The present study evaluates the use of novel copolymers for the preparation of paclitaxel loaded nanoparticles. The copolymers showed good enzymatic hydrolysis and low cytotoxicity, making them suitable drug matrix/carriers. The prepared nanoparticles exhibited small size, good drug loading and encapsulation efficiency. In vitro dissolution analysis showed biphasic drug dissolution profiles.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Pharmacology & Pharmacy
Wan-Yi Liu, Yun-Shan Hsieh, Yu-Tse Wu
Summary: This study aimed to develop a nanoparticle formulation for the oral delivery of beta-carotene. The results showed that the formulation significantly enhanced the release and intestinal permeability of the drug, suggesting its potential for oral administration.
Article
Biochemistry & Molecular Biology
Seounghun Lee, Hyo-Jung Shin, Chan Noh, Song- Kim, Young-Kwon Ko, Sun-Yeul Lee, Chaeseong Lim, Boohwi Hong, Sin-Young Yang, Dong-Woon Kim, Won-Hyung Lee, Yoon-Hee Kim
Summary: The activation of NF-kappa B in microglia is crucial for the development of neuropathic pain. Inhibitor of I kappa B (I kappa B) blocks NF-kappa B activation, and IKBKB is responsible for breaking down I kappa B to inhibit NF-kappa B activity. Delivering IKBKB siRNA via PLGA nanoparticles effectively reduces pain response and inflammatory mediators in SNL rats, suggesting its potential as a treatment for neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Ying Mao, Robert Guidoin, Yan Li, Gaetan Brochu, Ze Zhang, Lu Wang
Summary: Blending L-alpha-phosphatidylcholine (PC) with PLGA to yield hybrid scaffolds alters the physical properties and wettability, affecting biodegradability and biocompatibility. The addition of PC decreases fiber diameter and increases porosity and hydrophilicity, although it also reduces mechanical strength of the scaffolds.
MATERIALS & DESIGN
(2021)
Article
Polymer Science
Hong Wang, Yanwei Zhang, Yaru Liu, Yi Ren, Jianhong Wang, Baolong Niu, Wenfeng Li
Summary: This paper focuses on the development of targeted drug delivery systems for cancer therapy. HA-SS-PLGA copolymer was used to form reduction-sensitive amphiphilic micelles, which actively targeted tumor cells and inhibited cancer cell proliferation. This research provides a promising drug carrier for cancer therapy.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Dongxue Han, Reem Ghubayra, Rhett Dacy Carpenter-Thompson, Tifeng Jiao, Bingbing Li
Summary: The crystallization behavior of electrospun PCL/PLGA blend fibers was studied, and it was found that the choice of solvent and the PCL concentration significantly affected the crystallization mechanism and morphology. Thicker fibers showed microscopic phase separation while thinner fibers exhibited failure and fracture after solvent wash. Solvent vapor annealing experiments revealed the PCL lamellar network in thicker fibers and the PCL shish-kebab in thinner fibers.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Pharmacology & Pharmacy
Yabing Hua, Yuhuai Su, Hui Zhang, Nan Liu, Zengming Wang, Xiang Gao, Jing Gao, Aiping Zheng
Summary: PLGA is a candidate drug delivery polymer with excellent properties for sustained drug release, and its different characteristics can benefit therapeutic effects. Various factors such as organic phase, continuous phase, emulsifying stage, and solidification process must be considered during manufacturing. Continuous production may be a potential solution for achieving consistency in batches.
Article
Polymer Science
Fahad Pervaiz, Wajeeha Tanveer, Hina Shoukat, Sadia Rehman
Summary: The present study developed a polyethylene glycol and xanthan-gum based interpenetrating network for controlled drug release. The network, synthesized via copolymerization of natural and synthetic polymers, showed potential for drug release control according to various characterization and analysis techniques.
Article
Polymer Science
Huma Butt, Muhammad Usman Minhas, Kifayat Ullah Khan, Muhammad Sohail, Ikrima Khalid, Sehrish Rehmani, Muhammad Suhail
Summary: In this study, beta-cyclodextrin-based pH-responsive hydrogels were prepared by grafting 2-acrylamido-2-methylpropane sulphonic acid (AMPS) and methacrylic acid (MAA) using the free radical polymerization technique. Captopril was loaded as a model drug. The properties of the hydrogels were influenced by the acrylamide sulphonate and methacrylate-modified beta-cyclodextrin. The swelling dynamics and drug release of the hydrogels were pH-responsive, with the highest swelling and drug release observed at pH 7.4. The addition of beta-cyclodextrin, AMPS, and MAA increased the gel fraction of the hydrogels.
Review
Rehabilitation
Manthar Ali Mallah, Tahmina Soomro, Sobia Noreen, Mukhtiar Ali, Akriti Kafle, Nafeesa Khatoon, Muhammad Naveed
Summary: Obesity is a severe health concern that is associated with heart failure and cardiovascular disease. It is caused by a metabolic imbalance where more calories are consumed than burnt. Obesity has adverse impacts on the cardiovascular system, including inflammation, atherosclerosis, and high blood pressure. It is also a known risk factor for various diseases.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2023)
Article
Medicine, General & Internal
Zhikal O. Khudhur, Goran Othman, Galawezh O. Othman, Aziz M. Jafaar, Mahdi Kh. Qadir, Harem Kh. Awla, Sara Sh. Qasim, Shayma M. Hadi, Samiha S. Khan, Sobia Noreen, Shukur W. Smail
Summary: The study investigated the association between the eNOS rs1800779 (A/G) polymorphism and the progress of myocardial infarction (MI). The results showed no association between the rs1800779 genotype and allele distribution and susceptibility to MI.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Rubina Qaiser, Fahad Pervaiz, Hina Shoukat, Haya Yasin, Hanasul Hanan, Ghulam Murtaza
Summary: By utilizing chitosan as a mucoadhesive and pH-sensitive polymer, a novel CS/PVP-co-poly (AMPS) network-based hydrogel was fabricated. Captopril was successfully loaded into the hydrogel network using a diffusion-aided-swelling technique. The physicochemical properties and morphology of the hydrogel were characterized, showing the entrapment of captopril at a molecular level and the dissolution profile of the hydrogel system. The developed hydrogel system demonstrated mucoadhesive properties and biocompatibility, making it suitable for sustained release of captopril and improved drug absorption in the stomach.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
E. A. Dawi, E. Mustafa, M. Padervand, A. Ashames, S. Hajiahmadi, L. Saleem, M. Baghernejad, O. Nur, M. Willander
Summary: Environmental contaminants have adverse effects on drinking water quality, which is a major concern for human beings. Ag@AgCl nanoparticles loaded onto tantalum pentoxide were used as a plasmonic photocatalyst to remove Congo Red dye. The photocatalyst degraded 96% of the dye within 20 minutes with a rate constant of 0.14 min(-1). The potential cytotoxicity activity of the nanomaterials against human brain glioblastoma tumor cells was also investigated.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Fahad Pervaiz, Ayesha Saba, Haya Yasin, Manal Buabeid, Sobia Noreen, Abida Kalsoom Khan, Ghulam Murtaza
Summary: This study aimed to enhance drug absorption and bioavailability of paroxetine by preparing novel paroxetine-loaded solid lipid nanoparticles (SLNs) based sustained-release transdermal patches. The SLNs showed a particle size range of 113-230 nm and an entrapment efficiency of 85.14%. Paroxetine was evenly distributed in an amorphous form in SLNs, as demonstrated by DSC and PXRD analysis. SLNs formulated patches showed higher drug permeation through the skin and sustained release behavior. Draize patch test revealed no sign of erythema after applying paroxetine-loaded SLN patches.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gul Rehman Elmi, Kamil Anum, Kalsoom Saleem, Rameesha Fareed, Sobia Noreen, Haiyan Wei, Yongxing Chen, Avirup Chakraborty, Masood Ur Rehman, Shi Liyuan, Muhammad Abbas, Yongtao Duan
Summary: Diabetes mellitus (DM) is a global metabolic disorder that causes 6.7 million deaths annually. Current treatments have common side effects, making ethnomedicine an attractive option. Ethnomedicine works by inhibiting glucose absorption and production while promoting uptake and insulin secretion. Despite numerous plant-based clinical trials, few have been approved for use. This study evaluates these trials, highlighting major limitations.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Shazia Akram Ghumman, Amna Ijaz, Sobia Noreen, Afeefa Aslam, Rizwana Kausar, Ali Irfan, Sumera Latif, Gamal A. Shazly, Pervaiz Akhtar Shah, Maria Rana, Asma Aslam, Momina Altaf, Katarzyna Kotwica-Mojzych, Yousef A. Bin Jardan
Summary: Curcumin has potential applications in treating various diseases, but its limited bioavailability poses a challenge. In this study, curcumin niosomes were developed and optimized. The optimized curcumin niosomes showed small particle size, high entrapment efficiency, and significant antioxidant potential, and exhibited increased cytotoxicity against ovarian cancer cells.
Article
Polymer Science
Hina Shoukat, Fahad Pervaiz, Sadia Rehman, Faizan Akram, Sobia Noreen, Kifayat Ullah Khan, Abdul Basit, Muhammad Azeem Ashraf
Summary: This study successfully synthesized and characterized interpenetrating polymer network (IPN) nanogels using a combination of natural and synthetic polymers. The nanogels exhibited high entrapment efficiency, significantly improved drug solubility and release rate, and potential pharmacodynamic improvements for treating hyperlipidemia.
POLYMER-PLASTICS TECHNOLOGY AND MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Moyad Shahwan, Nageeb Hassan, Akram Ashames, Mohammed Alrouji, Fahad Alhumaydhi, Waleed Al Abdulmonem, Abdullatif Bin Muhsinah, Mohammad Furkan, Rizwan Hasan Khan, Anas Shamsi, Akhtar Atiya
Summary: This study aimed to find a potential SphK1 inhibitor through virtual screening and identified a compound with high potential. The stability of the compound and its binding with SphK1 were evaluated through various molecular dynamics and analysis methods. The results provide a platform for the discovery and development of new anticancer therapeutics targeting SphK1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Physics, Multidisciplinary
Samer H. Zyoud, Bayan M. Al Radi, Bashayer M. Al Maamari, Mohamed Nasor, H. Y. Zahran, I. S. Yahia, Taimoor Ahmad, Sohaib N. Khan, Ahed H. Zyoud, Moyad Shahwan, Nageeb Hassan, Akram Ashames, Malek G. Daher, Ghaseb N. Makhadmeh, Naser Qamhieh, Ammar Abdulrahman Jairoun, Mohamed Sh. Abdel-wahab
Summary: This study synthesized pure and Al-doped ZnO nanostructures using laser-assisted chemical bath synthesis (LACBS), a catalyst-free hydrothermal approach. The photocatalytic degradation of methylene blue was studied under the influence of a blue laser. Using a continuous blue laser, numerous doping concentrations were produced for the first time. X-ray diffraction, scanning electron microscopy, and UV-vis spectrophotometry were used to verify the structural and optical properties. The photocatalytic activity was significantly enhanced for Al-doped ZnO nanosheets, leading to improved methylene blue degradation efficiency.
INDIAN JOURNAL OF PHYSICS
(2023)
Article
Biotechnology & Applied Microbiology
Jada Naga Lakshmi, Ankem Narendra Babu, S. S. Mani Kiran, Lakshmi Prasanthi Nori, Nageeb Hassan, Akram Ashames, Richie R. Bhandare, Afzal B. Shaik
Summary: This review discusses the role of different herbs in the treatment of polycystic ovarian syndrome (PCOS) by conducting a thorough literature search and data mining. The results show that herbal remedies have significant therapeutic efficacy in treating PCOS, and the specific chemical composition, mechanism of action, and application areas are also discussed. This review will serve as an excellent resource for researchers working on understanding the role of herbal medicine in PCOS.
Review
Environmental Sciences
Karim Kakaei, Mohsen Padervand, Yuksel Akinay, Elmuez Dawi, Akram Ashames, Lama Saleem, Chuanyi Wang
Summary: COVID-19 pandemic has caused significant impacts on society, economy, psychology, and public health. It spreads mainly through physical contact and airborne transmission. Disinfection measures, mask-wearing, social distancing, and ventilation are recommended for prevention. However, ozone, commonly used for air purification, is not effective against SARS-CoV-2 at nonharmful concentrations and can pose health risks at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Chemistry, Analytical
Muhammad Sohail, Zunaira Urooj, Xinlan Bian, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Jannat BiBi, Xing Zhang, Bingzhi Li, He Huang
Summary: This article reviews the potential applications of molybdenum disulfide in analytical sciences, focusing on its unique electronic structure, low toxicity, and advantages over other dichalcogenides, as well as the future direction of integration with emerging technologies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
