Expanding Substrate Promiscuity by Engineering a Novel Adenylating-Methylating NRPS Bifunctional Enzyme

Enzymatic Evidence for a Revised Congocidine Biosynthetic Pathway

(2015) Ahmad H. Al-Mestarihi et al.   CHEMBIOCHEM

Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis

(2015) Kristin J. Labby et al.   NATURAL PRODUCT REPORTS

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution

(2015) Oleg V. Tsodikov et al.   BMC STRUCTURAL BIOLOGY

Adenylation and S-Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis

(2014) Ahmad H. Al-Mestarihi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

KtzJ-dependent serine activation and O-methylation by KtzH for kutznerides biosynthesis

(2013) Olga E Zolova et al.   JOURNAL OF ANTIBIOTICS

Non-ribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on the MbtH Family Protein NocI

(2013) Jeanne M. Davidsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Characterization of Echinomycin Biosynthesis: Formation and Hydroxylation of L-Tryptophanyl-S-Enzyme and Oxidation of (2S,3S) β-Hydroxytryptophan

(2013) Chen Zhang et al.   PLoS One

The A9 Core Sequence from NRPS Adenylation Domain Is Relevant for Thioester Formation

(2012) Viljemka Bučević-Popović et al.   CHEMBIOCHEM

Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis

(2012) M. D. McMahon et al.   JOURNAL OF BACTERIOLOGY

Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes

(2012) Dominik A. Herbst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of the MbtH-like protein TioT for production and activation of the thiocoraline adenylation domain of TioK

(2012) Olga E. Zolova et al.   MedChemComm

Role of MbtH-like Proteins in the Adenylation of Tyrosine during Aminocoumarin and Vancomycin Biosynthesis

(2011) Björn Boll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster

(2011) Ahmed S. A. Mady et al.   Molecular BioSystems

Activation of the Pacidamycin PacL Adenylation Domain by MbtH-like Proteins

(2010) Wenjun Zhang et al.   BIOCHEMISTRY

MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases

(2010) Elizabeth A. Felnagle et al.   BIOCHEMISTRY

Recent developments in bisintercalator natural products

(2010) Olga E. Zolova et al.   BIOPOLYMERS

N-Acylation during Glidobactin Biosynthesis by the Tridomain Nonribosomal Peptide Synthetase Module GlbF

(2010) Heidi J. Imker et al.   CHEMISTRY & BIOLOGY

A New Scaffold of an Old Protein Fold Ensures Binding to the Bisintercalator Thiocoraline

(2010) Tapan Biswas et al.   JOURNAL OF MOLECULAR BIOLOGY

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis

(2008) Thomas J. McQuade et al.   ANALYTICAL BIOCHEMISTRY

Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis

(2008) Anita Sheoran et al.   Molecular BioSystems