An Activator of an Adenylation Domain Revealed by Activity but Not Sequence Homology

Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases

(2016) Tiia Kittilä et al.   CHEMBIOCHEM

New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C–C Bond?

(2016) Petra Jiraskova et al.   Frontiers in Microbiology

Identification of the dioxygenase-generated intermediate formed during biosynthesis of the dihydropyrrole moiety common to anthramycin and sibiromycin

(2015) Shalini Saha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activity of α-Aminoadipate Reductase Depends on the N-Terminally Extending Domain

(2015) Daniel Kalb et al.   CHEMBIOCHEM

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

(2015) Tilmann Weber et al.   NUCLEIC ACIDS RESEARCH

Adenylation and S-Methylation of Cysteine by the Bifunctional Enzyme TioN in Thiocoraline Biosynthesis

(2014) Ahmad H. Al-Mestarihi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Production of mycobacterial cell wall glycopeptidolipids requires a member of the MbtH-like protein family

(2013) Elizabeth Tatham et al.   BMC MICROBIOLOGY

Core Assembly Mechanism of Quinocarcin/SF-1739: Bimodular Complex Nonribosomal Peptide Synthetases for Sequential Mannich-type Reactions

(2013) Tomoshige Hiratsuka et al.   CHEMISTRY & BIOLOGY

KtzJ-dependent serine activation and O-methylation by KtzH for kutznerides biosynthesis

(2013) Olga E Zolova et al.   JOURNAL OF ANTIBIOTICS

MbtH homology codes to identify gifted microbes for genome mining

(2013) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Structural Characterization of the Heterobactin Siderophores from Rhodococcus erythropolis PR4 and Elucidation of Their Biosynthetic Machinery

(2013) Mattia Bosello et al.   JOURNAL OF NATURAL PRODUCTS

Non-ribosomal Propeptide Precursor in Nocardicin A Biosynthesis Predicted from Adenylation Domain Specificity Dependent on the MbtH Family Protein NocI

(2013) Jeanne M. Davidsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Characterization of Echinomycin Biosynthesis: Formation and Hydroxylation of L-Tryptophanyl-S-Enzyme and Oxidation of (2S,3S) β-Hydroxytryptophan

(2013) Chen Zhang et al.   PLoS One

Mutasynthesis of a Potent Anticancer Sibiromycin Analogue

(2012) Isaac T. Yonemoto et al.   ACS Chemical Biology

A Domain of RubC1 of Rubradirin Biosynthesis Can Functionally Replace MbtH-Like Proteins in Tyrosine Adenylation

(2012) Björn Boll et al.   CHEMBIOCHEM

Analyses of MbtB, MbtE, and MbtF Suggest Revisions to the Mycobactin Biosynthesis Pathway in Mycobacterium tuberculosis

(2012) M. D. McMahon et al.   JOURNAL OF BACTERIOLOGY

Structural Basis of the Interaction of MbtH-like Proteins, Putative Regulators of Nonribosomal Peptide Biosynthesis, with Adenylating Enzymes

(2012) Dominik A. Herbst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains

(2012) Max Crüsemann et al.   Chemical Science

Importance of the MbtH-like protein TioT for production and activation of the thiocoraline adenylation domain of TioK

(2012) Olga E. Zolova et al.   MedChemComm

A Four-Enzyme Pathway for 3,5-Dihydroxy-4-methylanthranilic Acid Formation and Incorporation into the Antitumor Antibiotic Sibiromycin

(2011) Tobias W. Giessen et al.   BIOCHEMISTRY

Insights into the Biosynthesis of Hormaomycin, An Exceptionally Complex Bacterial Signaling Metabolite

(2011) Ivonne Höfer et al.   CHEMISTRY & BIOLOGY

Role of MbtH-like Proteins in the Adenylation of Tyrosine during Aminocoumarin and Vancomycin Biosynthesis

(2011) Björn Boll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Activation of the Pacidamycin PacL Adenylation Domain by MbtH-like Proteins

(2010) Wenjun Zhang et al.   BIOCHEMISTRY

MbtH-Like Proteins as Integral Components of Bacterial Nonribosomal Peptide Synthetases

(2010) Elizabeth A. Felnagle et al.   BIOCHEMISTRY

N-Acylation during Glidobactin Biosynthesis by the Tridomain Nonribosomal Peptide Synthetase Module GlbF

(2010) Heidi J. Imker et al.   CHEMISTRY & BIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

(2010) Barbara Gerratana   MEDICINAL RESEARCH REVIEWS

Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic

(2009) W. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE