Tenuifolin Attenuates Amyloid-β42-Induced Neuroinflammation in Microglia Through the NF-κB Signaling Pathway

Protective effect of Tenuifolin against Alzheimer’s disease

(2019) Lin Wang et al.   NEUROSCIENCE LETTERS

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB)- a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease

(2018) Gurdeep Marwarha et al.   CNS & Neurological Disorders-Drug Targets

Genetic diversity and population structure of a protected species: Polygala tenuifolia Willd

(2018) Yan Qun Peng et al.   COMPTES RENDUS BIOLOGIES

Integrated communications between cyclooxygenase-2 and Alzheimer’s disease

(2018) Pei-Pei Guan et al.   FASEB JOURNAL

IL-1β, IL-6, TNF- α and CRP in Elderly Patients with Depression or Alzheimer’s disease: Systematic Review and Meta-Analysis

(2018) Ada Ng et al.   Scientific Reports

Functions and dysfunctions of nitric oxide in brain

(2018) Pol Picón-Pagès et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

New data in causes of autoinflammatory diseases

(2018) Isabelle Kone-Paut et al.   JOINT BONE SPINE

Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation by downregulating galectin-3 via the NF-κB and AMPK signaling pathways

(2018) ChongZhe Pei et al.   PHYTOTHERAPY RESEARCH

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment

(2017) Jiansong Fang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease

(2016) Shi Shi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Upstream regulators and downstream effectors of NF-κB in Alzheimer's disease

(2016) Zhe-Min Shi et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

(2016) Pan Xu et al.   Journal of Zhejiang University-SCIENCE B

Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice

(2016) Qing Cao et al.   PHYTOMEDICINE

Inflammatory Cytokines and Alzheimer’s Disease: A Review from the Perspective of Genetic Polymorphisms

(2016) Fan Su et al.   Neuroscience Bulletin

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Tenuifolin, a secondary saponin from hydrolysates of polygalasaponins, counteracts the neurotoxicity induced by Aβ25–35 peptides in vitro and in vivo

(2015) Ya-min Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches

(2013) Almudena Fuster-Matanzo et al.   MEDIATORS OF INFLAMMATION

Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations

(2012) Linda Chami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Tenuifolin, an extract derived fromtenuigenin, inhibits amyloid-β secretionin vitro

(2009) J. Lv et al.   Acta Physiologica

iNOS gene deficiency modifies amyloid β deposition, cognitive performance and hippocampal long-term potentiation in an APP transgenic mouse model

(2009) Markus P. Kummer et al.   Alzheimers & Dementia

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration

(2008) Edward L Tobinick et al.   Journal of Neuroinflammation

Effects of tenuifolin extracted from radix polygalae on learning and memory: A behavioral and biochemical study on aged and amnesic mice

(2008) Hong Zhang et al.   PHYTOMEDICINE