Article
Clinical Neurology
Joseph Therriault, Stijn Servaes, Cecile Tissot, Nesrine Rahmouni, Nicholas J. Ashton, Andrea Lessa Benedet, Thomas K. Karikari, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Yi-Ting Wang, Jaime Fernandez-Arias, Alyssa Stevenson, Kely Quispialaya Socualaya, Arlette Haeger, Tahnia Nazneen, Etienne Aumont, Ali Hosseini, Soham Rej, Paolo Vitali, Gallen Triana-Baltzer, Hartmuth C. Kolb, Jean-Paul Soucy, Tharick A. Pascoal, Serge Gauthier, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Summary: This study evaluated the performance of plasma and cerebrospinal fluid (CSF) p-tau(181), p-tau(217), and p-tau(231) in Alzheimer's disease (AD) diagnosis and found that plasma p-tau(217) had diagnostic performance equivalent to CSF, suggesting that it may help reduce the need for invasive lumbar punctures without compromising accuracy in AD identification.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Jianping Jia, Tingting Li, Jianwei Yang, Baian Chen, Wei Qin, Cuibai Wei, Yang Song, Qigeng Wang, Yan Li, Longfei Jia
Summary: This study evaluates the diagnostic value of plasma beta-amyloid (A beta) seeding activity in distinguishing Alzheimer's disease (AD) from other forms of dementia. The results show that plasma A beta seeding activity accurately identifies AD patients and is strongly associated with cognitive performance and conventional biomarkers.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Genetics & Heredity
Yuxin Deng, Hui Song, Yan Xiao, Yi Zhao, Liangzao Chu, Jiuyang Ding, Xiangchun Shen, Xiaolan Qi
Summary: This study explores the effects of A beta and senescence on astrocytes at the transcriptome level and identifies core genes associated with extracellular matrix and focal adhesion. In addition, competing endogenous RNA networks are constructed to uncover the regulatory mechanism of A beta and senescence on astrocytes. This work provides new insights and research perspectives into the pathogenesis of AD.
FRONTIERS IN GENETICS
(2022)
Review
Clinical Neurology
Lizhen Cheng, Wei Li, Yixin Chen, Yijia Lin, Beiyun Wang, Qihao Guo, Ya Miao
Summary: Plasma A beta 42 values and plasma A beta 42/A beta 40 ratio could serve as independent biomarkers for predicting A beta-PET status, while plasma A beta 40 values may not distinguish between PET (+) and PET (-) individuals.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto
Summary: This study aimed to evaluate the effect of removing Aβ from blood plasma on the accumulation of amyloid plaques in the brain. The results showed a reduction in Aβ levels in the plasma and insoluble brain fractions, as well as a decrease in amyloid plaque burden and changes in plaque size distribution in the cortex and hippocampus. These findings support the importance of targeting Aβ in the periphery and suggest plasma exchange as a potential non-pharmacological strategy for slowing down AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Stephen Zicha, Randall J. Bateman, Leslie M. Shaw, Henrik Zetterberg, Anthony W. Bannon, Wesley A. Horton, Mike Baratta, Hartmuth C. Kolb, Iwona Dobler, Yulia Mordashova, Ziad S. Saad, David L. Raunig, Emmanouil (Manos) Spanakis, Yan Li, Suzanne E. Schindler, Kyle Ferber, Carrie E. Rubel, Robert L. Martone, Christopher J. Weber, Rebecca M. Edelmayer, Emily A. Meyers, James G. Bollinger, Erin G. Rosenbaugh, William Z. Potter
Summary: This study evaluated the performance of six plasma A beta assays in predicting amyloid positivity compared to age and APOE genotype. The results showed that three of the assays significantly improved the prediction accuracy, and plasma A beta 42/40 predicted amyloid PET status better than A beta 42 or A beta 40 alone.
ALZHEIMERS & DEMENTIA
(2023)
Article
Chemistry, Analytical
Danhua Wang, Yibei Dai, Xuchu Wang, Pan Yu, Shufang Qu, Zhenping Liu, Ying Cao, Lingyu Zhang, Ying Ping, Weiwei Liu, Zhihua Tao
Summary: The RCA-CLIA method enables accurate quantitation of plasma A beta, showing higher sensitivity and specificity than conventional CLIA. The A beta 42/A beta 40 ratio in plasma serves as an accurate indicator for AD diagnosis, indicating great potential for noninvasive diagnosis and progressive assessment of AD.
Article
Clinical Neurology
Christina Rabe, Tobias Bittner, Alexander Jethwa, Ivonne Suridjan, Ekaterina Manuilova, Michel Friesenhahn, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Summary: This study evaluated the clinical performance and robustness of plasma Aβ(42)/Aβ(40) as a prescreening tool for Alzheimer's disease. It found that there were misclassifications caused by measurement errors and pre-analytical errors, and suggested that other blood biomarkers may be easier to implement as robust prescreening tools.
ALZHEIMERS & DEMENTIA
(2023)
Review
Neurosciences
Shen Ning, Mehdi Jorfi, Shaun R. Patel, Doo Yeon Kim, Rudolph E. Tanzi
Summary: This article reviews the current state of AD therapeutics and recent advancements in both invasive and non-invasive neurotechnologies that can be used to ameliorate AD pathology, including optogenetics, photobiomodulation, electrical stimulation, ultrasound stimulation, and magnetic neurostimulation, as well as nanotechnologies employing nanovectors, magnetic nanoparticles, and quantum dots.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Clifford R. Jack Jr, Heather J. Wiste, Alicia Algeciras-Schimnich, Dan J. Figdore, Christopher G. Schwarz, Val J. Lowe, Vijay K. Ramanan, Prashanthi Vemuri, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Bradley F. Boeve, Kejal Kantarci, Petrice M. Cogswell, Matthew L. Senjem, Jeffrey L. Gunter, Terry M. Therneau, Ronald C. Petersen
Summary: Staging the severity of Alzheimer's disease pathology is important for therapeutic trials and clinical prognosis. Biomarkers such as amyloid and tau PET can be used for disease staging, but plasma biomarkers would be more practical.
Article
Clinical Neurology
Lei Liu, Hyunchang Kwak, Trebor L. Lawton, Shan-Xue Jin, Angela L. Meunier, Yifan Dang, Beth Ostaszewski, Alison C. Pietras, Andrew M. Stern, Dennis J. Selkoe
Summary: The study developed a new method for detecting and quantifying soluble oligomers of amyloid beta protein in human plasma. The method is highly sensitive, cost-effective, and suitable for high throughput analysis.
ALZHEIMERS & DEMENTIA
(2022)
Review
Clinical Neurology
Joyce R. Chong, Nicholas J. Ashton, Thomas K. Karikari, Tomotaka Tanaka, Michael Scholl, Henrik Zetterberg, Kaj Blennow, Christopher P. Chen, Mitchell K. P. Lai
Summary: Recent research efforts have focused on discovering and developing clinically useful biomarkers for AD and related dementias. While advancements in blood-based biomarkers hold promise for diagnosis, prognosis, and clinical trial outcome assessments, further studies are needed to establish A beta and P-tau as blood-based biomarkers for AD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Neurosciences
Cristiano D'Andrea, Federico Angelo Cazzaniga, Edoardo Bistaffa, Andrea Barucci, Marella de Angelis, Martina Banchelli, Edoardo Farnesi, Panagis Polykretis, Chiara Marzi, Antonio Indaco, Pietro Tiraboschi, Giorgio Giaccone, Paolo Matteini, Fabio Moda
Summary: This article describes a new diagnostic approach for Alzheimer's disease (AD) which combines seed amplification assay (SAA) with surface-enhanced Raman spectroscopy (SERS). The method efficiently identified pathological A beta oligomers in the cerebrospinal fluid of patients with a clinical diagnosis of AD or mild cognitive impairment due to AD. This approach can aid in early recognition of disease features, enabling early stratification and selection of patients, which is crucial in clinical treatments and pharmacological trials.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Clinical Neurology
Kate E. Foley, Zachary Winder, Tiffany L. Sudduth, Barbara J. Martin, Peter T. Nelson, Gregory A. Jicha, Jordan P. Harp, Erica M. Weekman, Donna M. Wilcock
Summary: Protein-based plasma assays show promise in improving accessibility and specificity of molecular diagnostics for dementia. The study found significant associations between Alzheimer's disease and inflammatory biomarkers, suggesting peripheral inflammation plays a role in AD pathology. The strength of biomarker correlations varied across different clinical diagnoses, reflecting changes in cognitive continuum.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Lorena Garcia-Valles, Carmen Pena-Bautista, Lourdes Alvarez-Sanchez, Ines Ferrer-Cairols, Miguel Baquero, Consuelo Chafer-Pericas
Summary: This study aims to analyze the characteristics of cases showing discrepancies between methods for detecting amyloid pathology. The results show that discrepancies between CSF biomarkers and amyloid PET are more common than expected in clinical practice. Episodic memory tests remain an important support method for Alzheimer's disease diagnosis in cases with discrepant results between amyloid PET and CSF biomarkers.
Article
Clinical Neurology
Frank Jessen, Steffen Wolfsgruber, Luca Kleineindam, Annika Spottke, Slawek Altenstein, Claudia Bartels, Moritz Berger, Frederic Brosseron, Marcel Daamen, Martin Dichgans, Laura Dobisch, Michael Ewers, Friederike Fenski, Klaus Fliessbach, Silka D. Freiesleben, Wenzel Glanz, Doreen Goerss, Selim Guersel, Daniel Janowitz, Ingo Kilimann, Xenia Kobeleva, Andrea Lohse, Franziska Maier, Coraline Metzger, Matthias Munk, Lukas Preis, Carolin Sanzenbacher, Eike Spruth, Boris Rauchmann, Ruth Vukovich, Renat Yakupov, Anne-Sophie Weyrauch, Gabriel Ziegler, Matthias Schmid, Christoph Laske, Robert Perneczky, Anja Schneider, Jens Wiltfang, Stefan Teipel, Katharina Buerger, Josef Priller, Oliver Peters, Alfredo Ramirez, Henning Boecker, Michael T. Heneka, Michael Wagner, Emrah Duezel
Summary: Research finds that subjective cognitive decline (SCD) in individuals who seek medical help may serve as an initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum. The SCD group shows slightly worse cognition, as well as more subtle functional and behavioral symptoms compared to the control group (CO). It is also discovered that SCD-A+ cases (39.3% of all SCD) exhibit greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Luca Kleineidam, Michael Wagner, Jannis Guski, Steffen Wolfsgruber, Lisa Miebach, Horst Bickel, Hans-Helmut Koenig, Siegfried Weyerer, Dagmar Luehmann, Hanna Kaduszkiewicz, Melanie Luppa, Susanne Rohr, Michael Pentzek, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Johannes Kornhuber, Oliver Peters, Lutz Frolich, Jens Wiltfang, Piotr Lewczuk, Michael Huell, Alfredo Ramirez, Frank Jessen, Steffi G. Riedel-Heller, Kathrin Heser
Summary: This study found that subjective cognitive decline (SCD) typically precedes depressive symptoms (DS), and individuals with SCD and high DS are at an increased risk for cognitive decline and dementia progression. Additionally, levels of CSF Ass42 can predict increasing DS.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Marie-Theres Huemer, Alexander Kluttig, Beate Fischer, Wolfgang Ahrens, Stefanie Castell, Nina Ebert, Sylvia Gastell, Karl-Heinz Joeckel, Rudolf Kaaks, Andre Karch, Thomas Keil, Yvonne Kemmling, Lilian Krist, Michael Leitzmann, Wolfgang Lieb, Claudia Meinke-Franze, Karin B. Michels, Rafael Mikolajczyk, Ilais Moreno Velasquez, Tobias Pischon, Sabine Schipf, Boerge Schmidt, Ben Schoettker, Matthias B. Schulze, Hannah Stocker, Henning Teismann, Kerstin Wirkner, Michael Drey, Annette Peters, Barbara Thorand
Summary: This study compared the cut-off points for low grip strength in assessing sarcopenia between the European Working Group on Sarcopenia in Older People (EWGSOP) and a large German sample. The results showed that the German sample had cut-off points that were 2 kg higher than the EWGSOP2 cut-off points. Using higher cut-off points increased the sensitivity, suggesting intervention for more patients at risk, but also potentially leading to unnecessary diagnostics/treatment for others without immediate need.
Letter
Clinical Neurology
Ilais Moreno Velasquez, Tobias Pischon
CLINICAL AUTONOMIC RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sergios Gatidis, Turkay Kart, Marc Fischer, Stefan Winzeck, Ben Glocker, Wenjia Bai, Robin Buelow, Carina Emmel, Lena Friedrich, Hans-Ulrich Kauczor, Thomas Keil, Thomas Kroencke, Philipp Mayer, Thoralf Niendorf, Annette Peters, Tobias Pischon, Benedikt M. Schaarschmidt, Boerge Schmidt, Matthias B. Schulze, Lale Umutle, Henry Voelzke, Thomas Kuestner, Fabian Bamberg, Bernhard Schoelkopf, Daniel Rueckert
Summary: This study demonstrates how MRI data from the UK Biobank (UKBB) and German National Cohort (NAKO) can be jointly analyzed to derive comprehensive quantitative image-based phenotypes across the general adult population. The researchers extracted image-derived features of abdominal organs from T1-weighted Dixon MRI data and used causal discovery and batch effect correction methods to harmonize data from UKBB and NAKO. They performed quantile regression on the harmonized data, providing quantitative models for the variation of image-derived features stratified by sex and dependent on age, height, and weight.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Clinical Neurology
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Hasler, Roisin McManus, Christina Ising, Sandra Roske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Gorss, Christoph Laske, Matthias H. Munk, Emrah Duzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka
Summary: This study investigated the potential use of experimental inflammation markers in serum for Alzheimer's disease (AD) research. The findings suggest that serum soluble AXL, IL-6, and YKL-40 are associated with AD pathology features, indicating that peripheral blood markers may correspond to specific stages of the disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Sibille Merz, Philipp Jaehn, Tobias Pischon, Beate Fischer, Kerstin Wirkner, Stefan Rach, Kathrin Guenther, Nadia Obi, Christine Holmberg, AdvanceGender Study Grp
Summary: This study uses an intersectionality-informed approach to explore the reasons why people participate in health research and how intersecting social structures and experiences impact their attitudes. The findings show that attitudes towards study participation can be categorized into four themes: making a contribution, seeking personalized health information, excitement and feeling chosen, and seeking social recognition. Social experiences, cultural value systems, and care responsibilities also influenced the decision to participate.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2023)
Article
Clinical Neurology
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Goeerss, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Duezel, Gabriel Ziegler
Summary: This study used voxel-based morphometry to validate the classification system of Alzheimer's disease biomarkers. The results showed that early amyloid conversion is associated with brain volume loss, supporting the monotonic progression model of the amyloid-tau-neurodegeneration (ATN) system.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Zerrin Yildirim, Firuze Delen, David Berron, Hannah Baumeister, Gabriel Ziegler, Hartmut Schuetze, Wenzel Glanz, Laura Dobisch, Oliver Peters, Silka Dawn Freiesleben, Luisa-Sophie Schneider, Josef Priller, Eike Jakob Spruth, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern-Hendrik Schott, Dix Meiberth, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael Heneka, Frederic Brosseron, Michael Wagner, Sandra Roeske, Alfredo Ramirez, Michael Ewers, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Luca Kleineidam, Steffen Wolfsgruber, Renat Yakupov, Matthias Schmid, Moritz Berger, Hakan Gurvit, Frank Jessen, Emrah Duzel
Summary: In preclinical Alzheimer's disease, individuals in stage 1 with amyloid pathology have larger brain volumes in memory-related regions compared to asymptomatic amyloid-negative older adults. In stage 2, individuals with subjective cognitive decline (SCD) have smaller brain volumes. This suggests the presence of a brain reserve mechanism that allows individuals with amyloid pathology to remain cognitively normal in stage 1.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Jose Bernal, Stefanie Schreiber, Inga Menze, Anna Ostendorf, Malte Pfister, Jonas Geisendoerfer, Aditya Nemali, Anne Maass, Renat Yakupov, Oliver Peters, Lukas Preis, Luisa Schneider, Ana Lucia Herrera, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern H. Schott, Ayda Rostamzadeh, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Frank Jessen, Miranka Wirth, Emrah Duezel, Gabriel Ziegler
Summary: Hypertension and A-beta positivity are associated with larger volumes of white matter hyperintensities (WMH), which in turn negatively impact cognition. Both hypertension and A-beta positivity are related to worse cognitive performance, and the relationship is partially mediated by WMH in specific brain regions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Medicine, General & Internal
Jiao Luo, Jesper Qvist Thomassen, Celine Bellenguez, Benjamin Grenier-Boley, Itziar de Rojas, Atahualpa Castillo, Kayenat Parveen, Fahri Kuecuekali, Aude Nicolas, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Deckert Juergen, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina Porcel, Emrah Duezel, Timo Grimmer, Jens Wiltfang, Stefanie Heilmann-Heimbach, Susanne Moebus, Thomas Tegos, Nikolaos Scarmeas, Jordi Clarimon, Fermin Moreno, Jordi Perez-Tur, Maria J. Bullido, Pau Pastor, Raquel Sanchez-Valle, Victoria Alvarez, Merce Boada, Pablo Garcia-Gonzalez, Raquel Puerta, Pablo Mir, Luis M. Real, Gerard Pinol-Ripoll, Jose Maria Garcia-Alberca, Jose Luis Royo, Eloy Rodriguez-Rodriguez, Hilkka Soininen, Teemu Kuulasmaa, Alexandre de Mendonca, Shima Mehrabian, Jakub Hort, Martin Vyhnalek, Sven van der Lee, Caroline Graff, Goran Papenberg, Vilmantas Giedraitis, Anne Boland, Delphine Bacq-Daian, Jean-Francois Deleuze, Gael Nicolas, Carole Dufouil, Florence Pasquier, Olivier Hanon, Stephanie Debette, Edna Gruenblatt, Julius Popp, Luisa Benussi, Daniela Galimberti, Beatrice Arosio, Patrizia Mecocci, Vincenzo Solfrizzi, Lucilla Parnetti, Alessio Squassina, Lucio Tremolizzo, Barbara Borroni, Benedetta Nacmias, Sandro Sorbi, Paolo Caffarra, Davide Seripa, Innocenzo Rainero, Antonio Daniele, Carlo Masullo, Gianfranco Spalletta, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick Kehoe, Tsolaki Magda, Giacomina Rossi, Pascual Sanchez-Juan, Kristel Sleegers, Martin Ingelsson, Ole A. Andreassen, Mikko Hiltunen, Cornelia Van Duijn, Rebecca Sims, Wiesje van der Flier, Agustin Ruiz, Alfredo Ramirez, Jean-Charles Lambert, Ruth Frikke-Schmidt
Summary: This genetic association study identifies novel genetic associations between high HDL cholesterol concentrations and high systolic blood pressure with increased risk of AD, potentially inspiring new drug targeting and improved prevention implementation.
Article
Medicine, General & Internal
Katharina Nimptsch, Krasimira Aleksandrova, Thu Thi Pham, Nikos Papadimitriou, Juergen Janke, Sofia Christakoudi, Alicia Heath, Anja Olsen, Anne Tjonneland, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Bethany van Guelpen, Justin Harbs, Domenico Palli, Alessandra Macciotta, Fabrizio Pasanisi, Sandra Milena Colorado Yohar, Marcela Guevara, Pilar Amiano, Sara Grioni, Paula Gabriela Jakszyn, Jane C. Figueiredo, N. Jewel Samadder, Christopher I. Li, Victor Moreno, John D. Potter, Robert E. Schoen, Caroline Y. Um, Elisabete Weiderpass, Mazda Jenab, Marc J. Gunter, Tobias Pischon
Summary: The study suggests that circulating FABP-4 may not have a causal role in the development of colorectal cancer (CRC), although a positive association was observed in women through a cis-MR approach.
Article
Psychiatry
Forugh S. Dafsari, Bettina Bewernick, Sabine Boehringer, Katharina Domschke, Moritz Elsaesser, Margrit Loebner, Melanie Luppa, Lukas Preis, Julia Puesken, Sandra Schmitt, Andreea-Johanna Szekely, Martin Hellmich, Wiebke Mueller, Michael Wagner, Oliver Peters, Lutz Froelich, Steffi Riedel-Heller, Elisabeth Schramm, Martin Hautzinger, Frank Jessen
Summary: A study in Germany evaluated the efficacy of cognitive behavioral therapy (LLD-CBT) and a supportive unspecific intervention (SUI) in the treatment of late-life depression. The results showed that both LLD-CBT and SUI provided clinical benefit without evidence for the superiority of LLD-CBT.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Medicine, General & Internal
O. Peters, S. Nitschmann
Article
Nutrition & Dietetics
Rebecca Klapp, Katharina Nimptsch, Tobias Pischon, Lynne R. Wilkens, Unhee Lim, Cherie Guillermo, V. Wendy Setiawan, John A. Shepherd, Loic Le Marchand, Gertraud Maskarinec
Summary: This study explores the relationship between the Lifestyle Risk Factor Index (LSRI) and Type 2 diabetes (T2D) as well as body fat distribution. The findings suggest that a healthy lifestyle, especially in terms of diet, plays a significant role in preventing T2D with variations observed among different ethnicities.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
