Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 22, Pages 6142-6153Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c01778
Keywords
tangeretin; antiobesity; cholesterol-lowering; lipidomics; diacyglycerols
Funding
- National Key R&D Program of China-Technological innovation of artificial forest nonwood forest resources high-quality utilization [2016YFD0600806]
- Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods [2018B030322010]
- Program for Guangdong Introducing Innovative and Entrepreneurial Teams [2019ZT08N291]
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Tangeretin (TAN) exhibited antilipogenic, antidiabetic, and lipid-lowering effects. However, the lipid biomarkers and the underlying mechanisms for antiobesity and cholesterol-lowering effects of TAN have not been sufficiently investigated. Herein, we integrated biochemical analysis with lipidomics to elucidate its efficacy and mechanisms in high-fat diet-fed rats. TAN at supplementation levels of 0.04 and 0.08% not only significantly decreased body weight gain, serum total cholesterol, and low-density lipoprotein cholesterol levels but also ameliorated hepatic steatosis. These beneficial effects were associated with the declining levels of fatty acids, diacylglycerols (DGs), triacylglycerols, ceramides, and cholesteryl esters by hepatic lipidomics analysis, which were attributed to downregulating lipogenesis-related genes and upregulating lipid oxidation- and bile acid biosynthesis-related genes. Additionally, 21 lipids were identified as potential lipid biomarkers, such as DGs and phosphatidylethanolamines. These findings indicated that the modulation of lipid homeostasis might be the key pathways for the mechanisms of TAN in the antiobesity and cholesterol-lowering effects.
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