Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 14, Pages 4196-4204Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b07876
Keywords
Ficus hirta; phenolic glycosides; neuroinflammatory; NF-kappa B/MAPK/AKT signaling pathways
Funding
- Natural Science Foundation of China (NSFC) [81773806, 81771377, U1705285]
- National Key Research and Development Program of China [2016YFC1305903, 2018YFC2000400]
- Fundamental Research Funds for the Central Universities [20720190079]
- Natural Science Foundation of Fujian Province of China [2019J007]
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Ficus hirta Vahl. (Wuzhimaotao) is an edible functional food used for the soup cooking and health products. Seven undescribed phenolic glycosides (1-7), along with 20 analogues, were isolated from the roots of Ficus hirta. Their structures were determined by comprehensive spectroscopic methods (UV, IR, HRESIMS, and NMR), while the absolute configuration of 1 was established by comparison of the experimental and calculated ECD data. The antineuroinflammatory effects of all the compounds were examined by Western blot. Compounds 1 and 11 attenuated the phosphorylation of AKT, JNK, and ERK1/2. In addition, compound 11 inhibited the NF-kappa B p65 phosphorylation. Our results indicated that compounds 1 and 11 decreased the occurrence of neuroinflammation in BV2 microglia cells, which might be regulated by inhibiting the activity of proteins in NF-kappa B, MAPK (JNK and ERK1/2), or AKT signaling pathways. Thus, 1 and 11 might exhibit antineuroinflammatory activities and show promise in treating neurodegenerative diseases.
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