Article
Psychiatry
Manish Dama, Michelle Wu, Vanessa K. Tassone, Ilya Demchenko, Benicio N. Frey, Roumen Milev, Arun Ravindran, Sagar Parikh, Susan Rotzinger, Wendy Lou, Raymond W. Lam, Sidney H. Kennedy, Venkat Bhat
Summary: This study examined the changes in insomnia symptoms during the acute treatment of major depressive disorder with antidepressant medication. The results showed that monitoring subjective sleep-onset and mid-nocturnal insomnia throughout the treatment can predict acute remission of depression.
PSYCHIATRY RESEARCH
(2023)
Article
Clinical Neurology
Valentina Kieseppa, Niina Markkula, Heidi Taipale, Minna Holm, Markus Jokela, Jaana Suvisaari, Antti Tanskanen, Mika Gissler, Venla Lehti
Summary: Immigrants in Finland are more likely to initiate antidepressant use compared to Finnish-born population, but they also discontinue them earlier. Immigrants from Sub Saharan Africa, the Middle East and Northern Africa are most likely to discontinue antidepressants earlier. More severe depression and longer length of residence in Finland are associated with decreased risk of discontinuation.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Neslihan Altunsoy, Didem Suculluoglu Dikici, Fikret Poyraz Cokmus, Huseyin Murat Ozkan, Kadir Ascibasi, Deniz Alci, Erkan Kuru, Serra Yuzeren, Omer Aydemir
Summary: This study aimed to evaluate the outcome of acute term treatment for major depressive disorder in terms of psychosocial functioning. Results showed significant improvements in symptoms and disabilities for patients with MDD, but they still did not reach the normative level. Different antidepressant options may have varied effects on treatment outcomes, with SNRI users scoring higher in pain and physical functioning, and SSRI users showing better outcomes in mental health and vitality.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Antony Loebel, Kenneth S. Koblan, Joyce Tsai, Ling Deng, Maurizio Fava, Justine Kent, Seth C. Hopkins
Summary: The study evaluated the efficacy and safety of non-racemic amisulpride (SEP-4199) for bipolar depression treatment. Results showed improvements in depressive symptoms with SEP-4199 and minimal impact on weight and lipids.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Neurosciences
Alessandro Serretti
Summary: Major depressive disorders have a significant impact on health and biomarkers have the potential to improve clinical care. However, the field of psychiatry lacks valid biomarkers. This paper critically reviews the field and discusses the potential application of DNA analysis-derived biomarkers. Other potential biomarkers include circulating transcription products, proteins, and inflammatory markers. DNA polygenic risk scores have shown promise in other medical fields and preliminary results suggest they could be useful in depression as well.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Article
Clinical Neurology
Rogerio Hoefler, Gustavo Magno Baldin Tiguman, Tais Freire Galvao, Ines Ribeiro-Vaz, Marcus Tolentino Silva
Summary: This study investigated the trends in antidepressant sales in Brazil from 2014 to 2020. The results showed a significant increase in antidepressant sales, mainly driven by higher prescriptions of serotonin reuptake inhibitors and other antidepressant classes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Xue, Junneng Shao, Huan Wang, Xinyi Wang, Rongxin Zhu, Zhijian Yao, Qing Lu
Summary: This study used DTI data and LDA model to determine the clinical homogeneous and heterogeneous sets among depressive patients. The results showed that patients targeted by different types of antidepressant drugs have unique imaging characteristics that are related to different symptoms.
EUROPEAN RADIOLOGY
(2023)
Article
Neurosciences
Aida Khadivi, Parnian Shobeiri, Sara Momtazmaneh, Farhaneh-Sadat Samsami, Mohammadreza Shalbafan, Elham Shirazi, Shahin Akhondzadeh
Summary: This study investigated the safety and efficacy of combining phosphodiesterase-3 inhibitor cilostazol with sertraline in the treatment of major depressive disorder (MDD). The results showed that patients in the cilostazol group had lower depression severity scores, higher remission rate, and faster response time compared to the placebo group. No serious adverse effects were observed.
PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elisabeth Jufresa-Blanch, Neus Carrilero, Anna Garcia-Altes
Summary: This retrospective cohort study aims to determine the influence of general practitioner (GP) and patient sex on the treatment of major depression. It found that female patients were more likely to be prescribed an antidepressant at the time of diagnosis, regardless of the GP's sex. Furthermore, both male and female GPs were influenced by biases and stereotypes that led to differential antidepressant-prescribing behaviors based on the patient's sex and characteristics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Isaac Lage, Melanie F. Pradier, Thomas H. McCoy, Roy H. Perlis, Finale Doshi-Velez
Summary: This study investigated the application of heuristics in antidepressant prescribing by analyzing clinical features. The results showed that certain clinical features, such as overweight, underweight, and sexual dysfunction, had a significant impact on prescribing choices. These heuristics were applied consistently across different hospital systems and providers.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
M. P. Schuster, J. Borkent, M. Chrispijn, M. Ioannou, B. Doornbos, H. Burger, B. C. M. Haarman
Summary: This study found a higher prevalence of MetS in Dutch BD subjects compared to the control group, with factors such as smoking, body mass index, and antidepressant drug use being associated with MetS. BD subjects showed undertreatment for hypertension, hyperglycemia, and lipid disorders in this study.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Pharmacology & Pharmacy
Dorota Danielak
Summary: Depressive disorders are common in older patients with a prevalence rate of up to 17.1%. Treatment for elderly patients should consider medication preference, safety, and tolerability. Vortioxetine, a multimodal antidepressant, has shown effectiveness in treating major depressive disorders in elderly patients and may have unique properties compared to commonly used antidepressants.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Daoyun Lei, Jie Sun, Jiangyan Xia
Summary: This study found activated immune responses and dysregulated cuproptosis-related genes in individuals with MDD compared to healthy controls. The researchers developed a prediction model to assess the risk of MDD and explored the potential connection between cuproptosis and MDD.
Article
Clinical Neurology
Nikita van der Vinne, Madelon A. Vollebregt, A. John Rush, Michiel Eebes, Michel J. A. M. van Putten, Martijn Arns
Summary: The feasibility of using EEG variables to guide antidepressant prescription was confirmed in this study, with majority of clinicians and patients being satisfied with the protocol, indicating a potential improvement in antidepressant treatment efficacy.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Lauro Estivalete Marchionatti, Paula Blaya-Rocha, Pedro V. S. Magalhaes
Summary: This article discusses the definition and meaning of the term mood stabilizer, proposes a theoretical model for a mood stabilizer, and validates this model through clinical evidence. The prophylactic effects are considered the core aspect of a mood stabilizer.
Article
Neurosciences
Junko Ishida, Toshiya Murai, Keita Ueda, Toshiaki A. Furukawa, Rumi Tanemura
Summary: This study examined the effectiveness of an ICT tool in improving memory function in individuals with brain injuries. The results showed that the ICT tool did not significantly improve memory difficulties in everyday life, but it did lead to higher scores on tests related to memory function and self-efficacy.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Psychology, Developmental
Sayuri Nakane, Sachiko Tanaka-Mizuno, Chika Nishiyama, Kenji Kochi, Madoka Yamamoto-Sasaki, Masato Takeuchi, Yusuke Ogawa, Yuko Doi, Masaru Arai, Yosuke Fujii, Toshiyuki Matsunaga, Toshiaki A. Furukawa, Koji Kawakami
Summary: Little is known about the prescription patterns of antipsychotic drugs among children and adolescents in Japan, particularly in outpatient settings. This study investigated the prevalence and trends of antipsychotic prescription among outpatients aged <= 17 years from 2006 to 2012. The results showed that the most common prescription pattern was second-generation antipsychotic monotherapy, with risperidone being the most frequently prescribed drug.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Letter
Psychology, Clinical
Yan Luo, Toshi A. Furukawa
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yusuke Tsutsumi, Yasushi Tsujimoto, Aran Tajika, Kenji Omae, Tomoko Fujii, Akira Onishi, Yuki Kataoka, Morihiro Katsura, Hisashi Noma, Ethan Sahker, Edoardo Giuseppe Ostinelli, Toshi A. Furukawa
Summary: The study examines the magnitude and variability of contextual effects (PCE) in placebo-controlled trials across various interventions. The results show that subjective outcomes are influenced more by specific intervention effects compared to objective or semiobjective outcomes. The study highlights the importance of considering each PCE individually in different clinical settings.
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Oncology
Tatsuo Akechi, Takuhiro Yamaguchi, Megumi Uchida, Fuminobu Imai, Kanae Momino, Fujika Katsuki, Naomi Sakurai, Tempei Miyaji, Tomoe Mashiko, Masaru Horikoshi, Toshi A. Furukawa, Akiyo Yoshimura, Shinji Ohno, Natsue Uehiro, Kenji Higaki, Yoshie Hasegawa, Kazuhisa Akahane, Yosuke Uchitomi, Hiroji Iwata
Summary: This study investigated the effectiveness of smartphone problem-solving therapy and behavioral activation applications in breast cancer survivors. The results showed that smartphone psychotherapy offers a promising way to reduce fear of cancer recurrence in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Ulrich Mansmann, Clara Locher, Fabian Prasser, Tracey Weissgerber, Ulrich Sax, Martin Posch, Evelyne Decullier, Ioana A. A. Cristea, Thomas P. A. Debray, Leonhard Held, David Moher, John P. A. Ioannidis, Joseph S. S. Ross, Christian Ohmann, Florian Naudet
Summary: Data sharing improves the value of medical research and promotes trust in clinical trials, but more biomedical researchers need training in approaches such as meta-research, data science, and ethical, legal, and social issues.
Article
Mathematical & Computational Biology
Orestis Efthimiou, Jeroen Hoogland, Thomas P. A. Debray, Michael Seo, Toshiaki A. Furukawa, Matthias Egger, Ian R. White
Summary: When individual patient data from a randomized trial are available, statistical and machine learning methods can be used to develop models for predicting treatment effects and guide personalized treatment choices. This article proposes measures to evaluate personalized treatment effect predictions, including discrimination and calibration. The methods are applicable to different outcome types and prediction models.
STATISTICS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Tasnim Hamza, Konstantina Chalkou, Fabio Pellegrini, Jens Kuhle, Pascal Benkert, Johannes Lorscheider, Chiara Zecca, Cynthia P. Iglesias-Urrutia, Andrea Manca, Toshi A. Furukawa, Andrea Cipriani, Georgia Salanti
Summary: In network meta-analysis (NMA), all relevant evidence about health outcomes with competing treatments is synthesized. The evidence can come from randomized clinical trials (RCT) or non-randomized studies (NRS) as individual participant data (IPD) or aggregate data (AD). A suite of Bayesian NMA and network meta-regression (NMR) models are introduced to allow for cross-design and cross-format synthesis. The models integrate a three-level hierarchical model for synthesizing IPD and AD into four approaches, accounting for differences in design and risk of bias (RoB) in the evidence.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Medicine, General & Internal
Thomas P. A. Debray, Gary S. Collins, Richard Riley, Kym I. E. Snell, Ben Van Calster, Johannes B. Reitsma, Karel G. M. Moons
Summary: The TRIPOD-Cluster statement is a checklist consisting of 19 items, aiming to improve reporting of studies on prediction models in clustered data. This document provides explanations for each item, clarifies their meaning, and emphasizes the importance of transparent reporting to assess bias risk and clinical usefulness of the model. Authors are advised to include a completed checklist in their submission.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Kym I. E. Snell, Brooke Levis, Johanna A. A. Damen, Paula Dhiman, Thomas P. A. Debray, Lotty Hooft, Johannes B. Reitsma, Karel G. M. Moons, Gary S. Collins, Richard Riley
Summary: Most clinical fields have numerous studies developing or validating prediction models for diagnosis or prognosis. Systematic reviews and meta-analyses are necessary to evaluate and summarize the evidence on the predictive performance of existing models. This article introduces a new reporting guideline to ensure complete, transparent, and accurate reporting of such reviews.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Thomas P. A. Debray, Gary S. Collins, Richard Riley, Kym I. E. Snell, Ben Van Calster, Johannes B. Reitsma, Karel G. M. Moons
Summary: The increasing availability of big data presents new opportunities and challenges for researchers developing and validating prediction models. Accounting for clustering in these datasets is important to avoid misleading conclusions and tailor prediction models to different clusters. Therefore, prediction model studies based on clustered data need to be reported differently to enhance their use and implementation.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Mathematical & Computational Biology
Hisashi Noma, Yasuyuki Hamura, Masahiko Gosho, Toshi A. Furukawa
Summary: Network meta-analysis is an important methodology for comparative effectiveness research. This article proposes improved inference methods using higher-order asymptotic approximations based on the Kenward and Roger approach. The proposed methods show accurate coverage properties in simulation studies and real applications.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Mathematical & Computational Biology
Hisashi Noma, Yasuyuki Hamura, Shonosuke Sugasawa, Toshi A. Furukawa
Summary: Network meta-analysis has been widely used in evidence-based medicine to evaluate the effectiveness of multiple treatments. The prediction interval, which incorporates uncertainties and heterogeneity, is an important output of network meta-analysis. However, current standard methods based on t-distribution have been found to underestimate uncertainty in realistic situations. In this study, we propose two new methods based on bootstrap and Kenward-Roger adjustment to construct more accurate prediction intervals.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Psychology, Clinical
Toshi A. Furukawa, Susumu Iwata, Masaru Horikoshi, Masatsugu Sakata, Rie Toyomoto, Yan Luo, Aran Tajika, Noriko Kudo, Eiji Aramaki
Summary: This study investigated the potential use of artificial intelligence and natural language processing to facilitate cognitive restructuring in internet cognitive-behavior therapy. The language model T5 was used to predict thoughts and feelings, and the accuracy of the predictions was validated. The results showed that correctly predicted thought-feeling pairs led to more effective reduction of negative emotions in cognitive restructuring.
COGNITIVE THERAPY AND RESEARCH
(2023)
Article
Psychology, Clinical
Ryuhei So, Naoki Emura, Kozue Okazaki, Sakiko Takeda, Takashi Sunami, Kohei Kitagawa, Yoshitake Takebayashi, Toshi A. Furukawa
Summary: This study compared the effects of therapist-guided internet interventions with unguided ones on gambling behavior, cognition, and stage of change. The results showed that there were no significant differences between the guided and unguided groups in terms of improvement in gambling symptoms, behavior, and stage of change.
ADDICTIVE BEHAVIORS
(2024)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)