Article
Psychology, Clinical
Hannah Lemke, Lina Romankiewicz, Katharina Foerster, Susanne Meinert, Lena Waltemate, Stella M. Fingas, Dominik Grotegerd, Ronny Redlich, Katharina Dohm, Elisabeth J. Leehr, Katharina Thiel, Verena Enneking, Katharina Brosch, Tina Meller, Kai Ringwald, Simon Schmitt, Frederike Stein, Olaf Steinstraeter, Jochen Bauer, Walter Heindel, Andreas Jansen, Axel Krug, Igor Nenadic, Tilo Kircher, Udo Dannlowski
Summary: This study investigates the association between disease course in Major Depressive Disorder (MDD) and brain structural alterations. The results suggest that a more severe and chronic disease course in MDD is associated with reduced volume in brain regions relevant for executive and cognitive functions and emotion regulation.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Lingling Cao, Ruohan Feng, Yingxue Gao, Weijie Bao, Zilin Zhou, Kaili Liang, Xinyue Hu, Hailong Li, Lianqing Zhang, Yang Li, Lihua Zhuo, Guoping Huang, Xiaoqi Huang
Summary: This study aimed to explore the relationship between suprachiasmatic nucleus (SCN) functional connectivity (FC) and insomnia symptoms in adolescents with major depressive disorder (MDD). The results showed that adolescents with high insomnia symptoms had significantly decreased FC between the right SCN and bilateral precuneus compared to those with low insomnia symptoms and healthy controls. The altered FC between the SCN and precuneus may contribute to the neural mechanisms underlying sleep-related symptoms in depressive adolescents and could be potential targets for personalized treatment strategies.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Rubai Zhou, Jun Chen, Guoqing Zhao, Zuowei Wang, Daihui Peng, Weiping Xia, Ruizhi Mao, Jingjing Xu, Fan Wang, Chen Zhang, Yong Wang, Chengmei Yuan, Yousong Su, Jia Huang, Tao Yang, Chenglei Wang, Lvchun Cui, Jijun Wang, Lena Palaniyappan, Yiru Fang
Summary: The study identified a link between greater GM volume in the right parahippocampal gyrus and higher social function in patients with MDD. Even with improved overall social function over 12 weeks, there were continued differences in social function between high and low-functioning subgroups.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Review
Psychiatry
Adina S. Fischer, Kelsey E. Hagan, Ian H. Gotlib
Summary: Resilience in major depressive disorder (MDD) is characterized by distinct profiles of brain activation and functional connectivity in networks related to cognitive control, emotion regulation, and reward processing. Increased activation in the frontal cortical regions associated with cognitive appraisal and emotion regulation is common in resilient individuals at high risk for MDD and those with a favorable illness course. Functional connectivity between fronto-striato-limbic regions is also linked to positively interpreted stressful life events in high-risk individuals and a positive response to treatments in depressed individuals, indicating that neuro-compensatory changes and experience-dependent plasticity contribute to resilience in MDD. Ongoing research on functional neuroimaging biomarkers of resilience, in the context of environmental and developmental influences, will enhance our understanding and improve prevention and treatment strategies for MDD.
CURRENT OPINION IN PSYCHIATRY
(2021)
Article
Neurosciences
Tiffany C. Ho, Boris Gutman, Elena Pozzi, Hans J. Grabe, Norbert Hosten, Katharina Wittfeld, Henry Voelzke, Bernhard Baune, Udo Dannlowski, Katharina Foerster, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Tilo Kircher, Axel Krug, Susanne Meinert, Igor Nenadic, Nils Opel, Richard Dinga, Dick J. Veltman, Knut Schnell, Ilya Veer, Henrik Walter, Ian H. Gotlib, Matthew D. Sacchet, Andre Aleman, Nynke A. Groenewold, Dan J. Stein, Meng Li, Martin Walter, Christopher R. K. Ching, Neda Jahanshad, Anjanibhargavi Ragothaman, Dmitry Isaev, Artemis Zavaliangos-Petropulu, Paul M. Thompson, Philipp G. Saemann, Lianne Schmaal
Summary: This study investigated the differences in subcortical shape between patients with major depressive disorder (MDD) and healthy controls. The results showed that both adolescent-onset MDD and recurrent MDD patients had lower thickness and surface area in certain subcortical regions compared to healthy controls.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Victor M. Tang, Dengdeng Yu, Cory R. Weissman, Brett D. M. Jones, Guan Wang, Matthew E. Sloan, Daniel M. Blumberger, Zafiris J. Daskalakis, Bernard Le Foll, Daphne Voineskos
Summary: This study examined the treatment outcomes of patients with major depressive disorder (MDD) and comorbid alcohol use disorder (AUD). The results showed that patients with comorbid AUD had poorer response to antidepressant treatment. Addressing this comorbidity requires unique assessment and treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Yan Li, Zhonghao Wu, Zhi Chen, Heming Yu, Yong He, Yu Tian, Tianlan Lan, Mengge Bai, Xiangyu Chen, Ke Cheng, Peng Xie
Summary: This study aimed to explore the relationship between ferritin and major depressive disorder (MDD). Findings revealed decreased FTL levels in MDD patients and significantly reduced FTH expression in the hippocampus of depressed mice. These results provide new insight into the pathogenesis of MDD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jianbo Xiu, Jiayu Li, Zeyue Liu, Hui Wei, Caiyun Zhu, Rongrong Han, Zijing Liu, Wanwan Zhu, Yan Shen, Qi Xu
Summary: Major depressive disorder (MDD) is a prevalent and devastating mental illness. The diagnosis of MDD currently lacks reliable biomarkers. This study identified and validated a potential DNA methylation biomarker for MDD in the Chinese Han population, and investigated its functional implications, which could improve the diagnosis and treatment of MDD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Guohong Xu, Xiaoling Li, Caixia Xu, Guojun Xie, Jiaquan Liang
Summary: This study aimed to assess the impact of insomnia on the prognosis of patients with major depressive disorder (MDD), finding that insomnia may lead to poor treatment outcomes for patients with MDD and should be taken seriously.
Article
Clinical Neurology
C. Sophia Albott, Kelvin O. Lim, Christopher Erbes, Paul Thuras, Joseph Wels, Susanna J. Tye, Paulo R. Shiroma
Summary: This study examined the neurocognitive effects of repeated ketamine in participants with comorbid PTSD and MDD, finding that repeated ketamine infusions did not worsen cognition, but instead showed significant improvement in working memory. Additionally, certain neurocognitive performances at baseline can predict the response to ketamine for symptoms of PTSD and MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Sondos Ayyash, Andrew D. Davis, Gesine L. Alders, Glenda MacQueen, Stephen C. Strother, Stefanie Hassel, Mojdeh Zamyadi, Stephen R. Arnott, Jacqueline K. Harris, Raymond W. Lam, Roumen Milev, Daniel J. Mueller, Sidney H. Kennedy, Susan Rotzinger, Benicio N. Frey, Luciano Minuzzi, Geoffrey B. Hall
Summary: There is a growing interest in exploring the data fusion analysis of functional and structural imaging sources. A novel processing pipeline, FATCAT-awFC, was developed to identify connectivity changes in MDD patients compared to healthy individuals, revealing significant differences in specific brain networks. By combining structural and functional data, this method enhances our understanding of the intricate relationship between structural and functional connectivity in depression.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Xiaoqin Wang, Yi Xia, Rui Yan, Hao Sun, Yinghong Huang, Haowen Zou, Yishan Du, Lingling Hua, Hao Tang, Hongliang Zhou, Zhijian Yao, Qing Lu
Summary: This study aimed to explore the sex differences in the regional brain neuroimaging features of anhedonia in the context of major depressive disorder (MDD). The results showed significant differences in brain activity between males and females in relation to anhedonia, which may have clinical implications for treating anhedonia symptoms in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Jie Zhao, Hongmei Liu, Zhiguo Wu, Yun Wang, Tongdan Cao, Dongbin Lyu, Qinte Huang, Zhenling Wu, Yuncheng Zhu, Xiaohui Wu, Jun Chen, Yong Wang, Yousong Su, Chen Zhang, Daihui Peng, Zezhi Li, Han Rong, Tiebang Liu, Yong Xia, Wu Hong, Yiru Fang
Summary: The co-occurrence of insomnia and hypersomnia symptoms in patients with major depressive disorder is associated with more depressive symptoms, higher rate of suicidal ideation, and more severe impairment in physical, economic, work, and family relationships. Patients with both sleep disturbances are more likely to experience excessive worry about sleep, suicidal ideation, distress of social disharmony, somatic symptoms, lack of energy, hyperphagia, loss of mood reactivity, and diurnal change, while less likely to have anxious mood.
Article
Clinical Neurology
Qian Fang, Huanhuan Cai, Ping Jiang, Han Zhao, Yu Song, Wenming Zhao, Yongqiang Yu, Jiajia Zhu
Summary: Through comprehensive multi-modal neuroimaging meta-analyses, changes in brain structure and function were identified in drug-naive first-episode patients with major depressive disorder (DF-MDD). These changes were spatially associated with the expression of 1194 and 1733 genes, revealing common and distinct genetic modulations of brain structural and functional impairments in this disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neuroimaging
Siyi Yu, Fen Feng, Qi Zhang, Zhifu Shen, Zhengyan Wang, Youping Hu, Liang Gong
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Longfei Du, Ying Bai, Bing Han, Cancan He, Liang Gong, Rongrong Huang, Ling Shen, Jie Chao, Pei Liu, Hongxing Zhang, Haisan Zhang, Ling Gu, Junxu Li, Gang Hug, Chunming Xie, Zhijun Zhang, Honghong Yao
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Liang Gong, Huaisu Li, Dan Yang, Yinwei Peng, Duan Liu, Ming Zhong, Bei Zhang, Ronghua Xu, Jian Kang
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neuroimaging
Xi-Jian Dai, Na Wang, Si-Zhi Ai, Liang Gong, Weiqun Tao, Jingyi Fan, Jiubao Liu, Yongjun Wang
Summary: This study investigated the relationship between sleep-related networks in patients with chronic insomnia and good sleepers, finding that frequency-frequency couplings could serve as a useful biomarker for addressing insomnia-related brain networks. Functional deficits and network segregation may underlie the etiology of patients with chronic insomnia.
BRAIN IMAGING AND BEHAVIOR
(2021)
Editorial Material
Biochemistry & Molecular Biology
Yuan Zhang, Longfei Du, Ying Bai, Bing Han, Cancan He, Liang Gong, Rongrong Huang, Ling Shen, Jie Chao, Pei Liu, Hongxing Zhang, Haisan Zhang, Ling Gu, Junxu Li, Gang Hu, Chunming Xie, Zhijun Zhang, Honghong Yao
MOLECULAR PSYCHIATRY
(2020)
Article
Neuroimaging
Liang Gong, Siyi Yu, Ronghua Xu, Duan Liu, Xijian Dai, Zhengyan Wang, Youping Hu, Bohua Yan, Yu Kui, Bei Zhang, Fen Feng
Summary: Chronic insomnia disorder (CID) patients showed altered reward network connectivity in the salience and limbic networks, as well as decreased connectivity in the default mode network and within the reward circuit. Additionally, changes in reward network connectivity were associated with depression symptoms in CID patients, emphasizing the need to consider both insomnia and depression symptoms in future studies of CID.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Medicine, General & Internal
You-Cai Bi, Liang Gong
WORLD JOURNAL OF CLINICAL CASES
(2020)
Article
Medicine, Research & Experimental
Wei Peng, Xiaojuan Hong, Yaru Huangfu, Zhao Sun, Wei Shen, Fen Feng, Liang Gong, Zhifu Shen, Baojun Guo, Leixiao Zhang, Yanan Wang, Ying Zhao, Tianmin Zhu, Youping Hu, Siyi Yu
Summary: This study aims to provide scientific evidence for the mechanism of acupuncture in treating CID with GI disorder using multimodal MRI imaging data on brain structure, function, and metabolism.
Article
Neurosciences
Liang Gong, Min Shi, Jian Wang, Ronghua Xu, Siyi Yu, Duan Liu, Xin Ding, Bei Zhang, Xingping Zhang, Chunhua Xi
Summary: The study found abnormal LC-NE functional network in patients with CID, and the altered LC-NE function in dACC was associated with anxiety symptoms in CID. This extends the understanding of the neuropathological basis of CID and provides a potential treatment target for CID patients with anxiety.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
Liang Gong, Ronghua Xu, Dan Yang, Jian Wang, Xin Ding, Bei Zhang, Xingping Zhang, Zhengjun Hu, Chunhua Xi
Summary: This study used a machine learning approach to differentiate chronic insomnia disorder (CID) patients with depressive symptoms from those without depressive symptoms based on orbital frontal cortex (OFC) functional connectivity. The classification model based on OFC functional connectivity showed a total accuracy of 76.92%.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Liang Gong, Kewu He, Fang Cheng, Zhenping Deng, Kang Cheng, Xi'e Zhang, Wenjun Zhou, Jing Ou, Jian Wang, Bei Zhang, Xin Ding, Ronghua Xu, Chunhua Xi
Summary: This study investigates alterations in the ascending arousal network (AAN) and its connections with cortical networks in chronic insomnia disorder (CID). The findings suggest that patients with CID exhibit increased functional connectivity within the AAN and between the AAN and several cortical networks. These AAN-related connectivity patterns can be used to differentiate CID patients from good sleeper controls (GSCs) with a high level of accuracy. Additionally, machine learning techniques were employed to predict insomnia and anxiety symptoms in CID patients, indicating the potential of fMRI-based markers and machine learning in evaluating insomnia and comorbid mental symptoms.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Yang Yang, Wei Liang, Yongjun Wang, Dechang Peng, Liang Gong, Na Wang, Zhongjie Huang, Weikang Yang
Summary: The study aimed to investigate the pattern of volume changes in neurofunctional hippocampal subfields in patients with insomnia and their associations with risk of development of insomnia. Results showed that hippocampal volume atrophy in specific neurofunctional subfields was not only associated with insomnia but also a significant risk factor predicting the development of insomnia. The study also developed a practical and visual competing risk-nomogram tool for individual prediction of insomnia risk with high accuracy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Liang Gong, Ronghua Xu, Minhuang Qin, Duan Liu, Bei Zhang, Youcai Bi, Chunhua Xi
Article
Geriatrics & Gerontology
Liang Gong, Ronghua Xu, Duan Liu, Lin Lan, Bei Zhang, Chuantao Zhang
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)