Review
Biochemistry & Molecular Biology
Ratna Shree Sharma, Johannes Pallua, Michael Schirmer
Summary: This meta-analysis examines the occurrence of adverse events in the placebo arms of double-blind, randomized, placebo-controlled studies in rheumatoid arthritis. The results show that patients in the placebo arms reported adverse events such as nausea and hepatobiliary disorders at similar rates to those in the verum arms. It is important for patients to be aware that adverse events can still occur even with placebo medication.
Article
Pharmacology & Pharmacy
Fabrizio Benedetti, Martina Amanzio, Fabio Giovannelli, Karen Craigs-Brackhahn, Aziz Shaibani
Summary: This study revealed that participants who read a list of possible adverse events before receiving a placebo treatment reported more adverse events compared to those who did not read the list. Moreover, increased activity in the hypothalamic-pituitary-adrenal axis and higher state anxiety scores were observed in those who reported multiple adverse events, indicating a potential neuroendocrine mechanism following placebo administration.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Tariku Sisay, Roza Wami
Summary: This study aimed to estimate the prevalence rate of adverse drug reactions (ADRs) among major depressive disorder (MDD) patients by age and gender at the outpatient department of Amanuel Mental Specialized Hospital (AMSH) in Addis Ababa, Ethiopia. The overall prevalence of antidepressant-related adverse reactions was 69%, with females showing a higher prevalence rate. Young study subjects had significantly higher ADR rates compared to the elderly, and ADRs were more common in patients taking polypharmacy than monopharmacy.
Article
Clinical Neurology
Christian P. Cheung, Mathura T. Thiyagarajah, Haben Y. Abraha, Celina S. Liu, Krista L. Lanctot, Alex J. Kiss, Mahwesh Saleem, Ari Juda, Anthony J. Levitt, Ayal Schaffer, Amy H. Cheung, Mark Sinyor
Summary: This study found that among patients receiving active treatment in antidepressant trials, drug-drug trials had lower rates of adverse events compared to other designs. However, there were no significant differences in adverse event rates across different designs for patients receiving placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Elan A. Cohen, Howard H. Hassman, Larry Ereshefsky, David P. Walling, Vera M. Grindell, Richard S. E. Keefe, Katarzyna Wyka, William P. Horan
Summary: The high and growing placebo response rates in clinical trials for CNS indications present a major challenge for drug development. This study found that educating participants about placebo response factors through the Placebo-Control Reminder Script (PCRS) can help mitigate placebo response rates and reduce the number of adverse events.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Caroline Kamp Jorgensen, Sophie Juul, Faiza Siddiqui, Mark Abie Horowitz, Joanna Moncrieff, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen
Summary: This study aims to assess the risks of adverse events with venlafaxine or mirtazapine in adults with major depressive disorder through systematic reviews. The effects of venlafaxine and mirtazapine will be evaluated separately in two reviews. The assessment of bias risk will be conducted using the Cochrane risk-of-bias tool version 2, and clinical significance will be assessed using an eight-step procedure. The results of this study will provide important information for the treatment of major depressive disorder.
SYSTEMATIC REVIEWS
(2023)
Article
Psychology, Developmental
Robert L. Findling, Melissa P. DelBello, Alessandro Zuddas, Graham J. Emslie, Anders Ettrup, Maria L. Petersen, Simon N. Schmidt, Monika Rosen
Summary: The study evaluated the efficacy and safety of vortioxetine in adolescents with MDD, and found no significant difference between vortioxetine at two doses and placebo.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Caroline Kamp Jorgensen, Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen
Summary: Major depressive disorder is a common psychiatric disorder with a significant burden on patients and societies. Tricyclic antidepressants are frequently used in the treatment of major depressive disorder, but their effects are small and uncertain. This systematic review aims to assess the effects and safety of tricyclic antidepressants, providing necessary background information for the treatment of major depressive disorder.
SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Victor M. Tang, Dengdeng Yu, Cory R. Weissman, Brett D. M. Jones, Guan Wang, Matthew E. Sloan, Daniel M. Blumberger, Zafiris J. Daskalakis, Bernard Le Foll, Daphne Voineskos
Summary: This study examined the treatment outcomes of patients with major depressive disorder (MDD) and comorbid alcohol use disorder (AUD). The results showed that patients with comorbid AUD had poorer response to antidepressant treatment. Addressing this comorbidity requires unique assessment and treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Marsal Sanches, Joao Quevedo, Jair C. Soares
Summary: Despite significant advances in understanding the pathophysiology of MDD, many depressed patients do not respond well to traditional pharmacological agents. Researchers are exploring new targets and directions in pharmacological treatment for MDD. In addition to traditional antidepressants, many novel compounds are currently under investigation, with promising preliminary results.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Microbiology
Yaping Wang, Jingjing Zhou, Junbin Ye, Zuoli Sun, Yi He, Yingxin Zhao, Siyu Ren, Guofu Zhang, Min Liu, Peng Zheng, Gang Wang, Jian Yang
Summary: This study reveals that antidepressants can improve abnormal blood metabolism and have a weak inhibitory effect on the gut microbiota. The gut microbiota is associated with changes in plasma metabolites and clinical remission in patients with major depressive disorder (MDD). Furthermore, the presence of sporulation genes can predict the efficacy of antidepressant treatment.
Review
Medicine, General & Internal
Julia W. Haas, Friederike L. Bender, Sarah Ballou, John M. Kelley, Marcel Wilhelm, Franklin G. Miller, Winfried Rief, Ted J. Kaptchuk
Summary: This systematic review and meta-analysis found that significantly more adverse events (AEs) were reported in the vaccine groups compared with the placebo groups, but the rates of reported AEs in the placebo arms were still substantial. Public vaccination programs should take into account the high rates of AEs in placebo arms.
Review
Oncology
Sandy Simon, Katherine E. Francis, Janene E. Dalrymple, Val Gebski, Sarah J. Lord, Michael Friedlander, Chee Khoon Lee
Summary: Non-drug-related adverse events are common in ovarian cancer patients in maintenance therapy RCTs. Potential explanations include the nocebo effect, residual toxicities from previous treatment, or underlying disease.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Clinical Neurology
Frederikke Hordam Gronemann, Janne Petersen, Sarah Alulis, Kristoffer Jarlov Jensen, Jesper Riise, Mikkel Zollner Ankarfeldt, Espen Jimenez Solem, Nikolaj Bodker, Merete Osler
Summary: This study found that the majority of MDD patients in Denmark initially received treatment with antidepressants or ECT, and often changed medications during the course of treatment. TRD patients were more likely to use SNRIs, and a significant proportion initiated new treatments in the following year.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Stefanie Kremer, Teresa Wiesinger, Tom Bschor, Christopher Baethge
Summary: This meta-analysis explores the effects of antidepressants on social functioning in patients with major depressive disorder (MDD). The results suggest that the impact of antidepressants on social functioning is modest and uncertain in comorbid depression. Strong correlations between social functioning efficacy and depressive symptom efficacy and quality of life effects indicate overlapping domains.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Clinical Neurology
Myuri Ruthirakuhan, Zahinoor Ismail, Nathan Herrmann, Damien Gallagher, Krista L. Lanctot
Summary: This study found that mild behavioral impairment (MBI) is a predictor of progression to Alzheimer's disease (AD). MBI and its domains, particularly psychosis, were associated with clinically-diagnosed AD and neuropathology-confirmed AD.
ALZHEIMERS & DEMENTIA
(2022)
Article
Geriatrics & Gerontology
Shankar Tumati, Krista L. Lanctot, RuoDing Wang, Abby Li, Andrew Davis, Nathan Herrmann
Summary: This retrospective study found that medical cannabis is more often used by older women, with pain relief being the primary indication and CBD-containing cannabis oils being the most common type used. Follow-up data showed improvements in pain, sleep, and mood symptoms among older adults after cannabis use. More research is needed to determine proper indications, doses of active ingredients, and outcomes in the older adult population.
Article
Sport Sciences
Alexandra M. Coates, Christian P. Cheung, Katharine D. Currie, Trevor J. King, Margo L. Mountjoy, Jamie F. Burr
Summary: The study compared the cardiac function of elite swimmers, water polo players, and artistic swimmers. Male swimmers showed volume-based functional adaptations distinct from the mixed volume-pressure adaptations of water polo players. Female swimmers and water polo players did not show sport-specific differences like males, but had greater volume-based adaptations compared to artistic swimmers.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Orthopedics
Alexandra M. Coates, Christian P. Cheung, Katharine D. Currie, Trevor J. King, Margo L. Mountjoy, Jamie F. Burr
Summary: This study compares the cardiac structure of elite swimmers, water polo players, and artistic swimmers, and finds that gender and sport-specific factors contribute to differences in cardiac remodeling.
CLINICAL JOURNAL OF SPORT MEDICINE
(2022)
Article
Neurosciences
Vivian Feng, Shankar Tumati, Ruoding Wang, Kritleen K. Bawa, Damien Gallagher, Nathan Herrmann, Susan Marzolini, Paul Oh, Ana Andreazza, Krista L. Lanctot
Summary: This study found that markers of late-stage lipid peroxidation are elevated in coronary artery disease patients with poor sleep and are associated with daily disturbances. However, this association is not related to other factors or with sleep quality and its factors after exercise intervention.
Letter
Cardiac & Cardiovascular Systems
Christian P. Cheung, Massimo Nardone, Jordan B. Lee, Ryleigh E. Baker, Philip J. Millar, Jamie F. Burr
Article
Geriatrics & Gerontology
Doyoung Kim, Alex Kiss, Susan E. Bronskill, Krista L. Lanctot, Nathan Herrmann, Damien Gallagher
Summary: Previous studies have reported conflicting findings regarding the relationship between depression and Alzheimer's neuropathology. This cross-sectional study found that late life depression is associated with the spread of amyloid pathology beyond the neocortex, including regions critical for regulation of mood and motivated behavior.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Geriatrics & Gerontology
Krista L. Lanctot, Zahinoor Ismail, Kritleen K. Bawa, Jeffrey L. Cummings, Masud Husain, Moyra E. Mortby, Philippe Robert
Summary: This narrative review discusses the clinical features of apathy and depression in individuals with neurocognitive disorders, aiming to differentiate the two syndromes based on clinical presentation, diagnostic criteria, neuropathological features, and response to treatments.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Myuri Ruthirakuhan, Hugo Cogo-Moreira, Walter Swardfager, Nathan Herrmann, Krista L. Lanctot, Sandra E. Black
Summary: This study identified three groups of cardiovascular risk factors in cognitively normal elderly individuals, and only the vascular-dominant group was significantly associated with incidence of Alzheimer's disease. Selective mortality may contribute to the attenuated association between the vascular-metabolic group and incident AD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Psychology, Clinical
Krista L. Lanctot, Clara Chen, Ethan Mah, Alex Kiss, Abby Li, Dave Shade, Roberta W. Scherer, Danielle Vieira, Hamadou Coulibaly, Paul B. Rosenberg, Alan J. Lerner, Prasad R. Padala, Olga Brawman-Mintzer, Christopher H. van Dyck, Anton P. Porsteinsson, Suzanne Craft, Allan Levey, William J. Burke, Jacobo Mintzer, Nathan Herrmann
Summary: This study conducted a cost consequence analysis using data from the Apathy in Dementia Methylphenidate Trial 2 to investigate the economic attractiveness of treating apathy with methylphenidate. The results showed that methylphenidate treatment improved health utility over the 6-month follow-up period, while there was no significant difference in resource utilization costs between the treatment and placebo groups. These findings can help decision-making to improve the quality of life for patients with Alzheimer's disease while considering the burden on the healthcare system.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Natasha Z. Anita, Felicia Kwan, Si Won Ryoo, Chelsi Major-Orfao, William Z. Lin, Shiropa Noor, Krista L. Lanctot, Nathan Herrmann, Paul I. Oh, Baiju R. Shah, Jeremy Gilbert, Angela Assal, Ilana J. Halperin, Ameer Y. Taha, Walter Swardfager
Summary: Type 2 diabetes mellitus (T2DM) increases the risk of cognitive decline and dementia. Disruptions in the cytochrome P450-soluble epoxide hydrolase (CYP450-sEH) pathway have been reported in T2DM, obesity, and cognitive impairment. This study analyzes linoleic acid (LA)-derived CYP450-sEH oxylipins and their relationship with cognition in T2DM, considering potential differences between obese and nonobese individuals.
JOURNAL OF LIPID RESEARCH
(2023)
Letter
Clinical Neurology
Massimo Nardone, Christian P. Cheung, Ryleigh E. Baker, Kathryn Pfundt, Jordan B. Lee, Jamie F. Burr, Philip J. Millar
CLINICAL AUTONOMIC RESEARCH
(2023)
Article
Orthopedics
Margo Mountjoy, Carla Edwards, Christian P. Cheung, Jamie Burr, Vincent Gouttebarge
Summary: The study aims to use the International Olympic Committee Sport Mental Health Assessment Tool 1 (SMHAT-1) to determine the prevalence of mental health symptoms in university student athletes over an academic year. The study also explores the internal consistency of the screening tools from the SMHAT-1. The results show that university-level athletes generally suffer from mental health symptoms, highlighting the necessity for team physicians to have the clinical competence to recognize and treat these symptoms.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
Article
Health Care Sciences & Services
Melissa B. Korman, Rosalie Steinberg, Lina Gagliardi, Brenda Stewart, Carmen Llanos Acero, Joanne Davies, Robert Maunder, Thomas Walker, Tracey DasGupta, Lisa DiProspero, Mark Sinyor, Janet Ellis
Summary: The COVID-19 pandemic has significantly affected the mental well-being of healthcare workers, and the STEADY staff wellness program, developed based on the Knowledge-to-Action Implementation Science Framework, has proven effective in promoting their well-being through more frequent and shorter in-person contact and peer support.
Article
Psychology, Clinical
Hugo Cogo-Moreira, Saffire H. Krance, Sandra E. Black, Nathan Herrmann, Krista L. Lanctot, Bradley J. MacIntosh, Michael Eid, Walter Swardfager
Summary: Longitudinal invariance, a fundamental scale property, is essential for tracking change over time using mean comparisons. A study evaluating the ADAS-Cog data found that the three correlated factors model and its subscales did not achieve longitudinal configural invariance under traditional modeling. However, in models considering item-specific effects, structural and metric invariance were achieved for the language and memory subscales.
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)