Article
Endocrinology & Metabolism
Esphie Grace Fodra Fojas, Adam John Buckley, Nader Lessan
Summary: The neck circumference is closely associated with dysglycemia, components of the MetS, and factors predictive of NAFLD, indicating its potential as a surrogate marker for body composition and health risks.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Yujian Li, Huiqing Zhou, Xiang Yang, Jun Zheng, Fan Zhang, Mangmang Xu, Hao Li
Summary: This study found that neck circumference is an independent predictor of 180-day functional outcome in ICH patients, and can predict poor functional outcome at 6 months.
FRONTIERS IN NEUROLOGY
(2021)
Article
Pediatrics
Zbigniew Kulaga, Anna Swiader-Lesniak, Aneta Kotowska, Mieczyslaw Litwin
Summary: This paper provides normative values for waist circumference, hip circumference, waist-to-height ratio, and waist-to-hip ratio for Polish children and adolescents aged 3-18 years, aiming for more precise monitoring of abdominal fat accumulation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
R. Kiran, Harshitha, Madhavi Bhargava
Summary: This study determined the cut-offs of mid-upper arm circumference (MUAC) and neck circumference (NC) for screening overweight, abdominal obesity, and high body fat percentage. The study found that both MUAC and NC had good sensitivity and specificity for screening overweight and abdominal obesity, with neck circumference being the most preferred anthropometric method.
Article
Nutrition & Dietetics
Maria del Carmen Inarritu-Perez, Martha Kaufer-Horwitz, Liria Yamamoto-Kimura, Cristina Moran-Alvarez, Guadalupe Alvear-Galindo, Alejandra Moreno-Altamirano, Veronica Cruz-Licea
Summary: Neck circumference can be utilized as an initial screening tool for identifying overweight/obesity in 12-14-year-old Mexican adolescents, with significant correlations found between neck circumference and weight, BMI, waist circumference, and mid-upper arm circumference.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Pediatrics
Evelyn Valencia-Sosa, Guillermo Julian Gonzalez-Perez, Erika Martinez-Lopez, Roberto Rodriguez-Echevarria
Summary: Neck circumference and wrist circumference are proposed as indicators of metabolic changes in children, with blood pressure showing the most significant correlation. However, total cholesterol and LDL-cholesterol do not show significant associations with these indicators, and results are conflicting.
Article
Anthropology
Magdalena Zeglen, Lukasz Kryst, Malgorzata Kowal, Agnieszka Woronkowicz
Summary: This study analyzed the correlation between anthropometric cardiometabolic risk factors and calf adiposity in 4-16-year-olds from Poland. The results suggest that individuals with higher calf adiposity may have a lower cardiometabolic risk.
AMERICAN JOURNAL OF HUMAN BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Derya Tepe, Songul Yilmaz
Summary: The prevalence of masked hypertension in obese adolescents has been found to be quite high, especially in those with severe obesity and high waist circumference/height ratio. Regular ABPM monitoring is recommended in adolescents with these conditions, even if their office blood pressure measurements are normal.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: Neck fat is associated with obesity and neck circumference in adolescents, with females having more neck fat than males. However, it does not appear to correlate with the presence and severity of obstructive sleep apnea syndrome (OSAS).
Article
Clinical Neurology
Sherri L. Katz, Henrietta Blinder, Tanvi Naik, Nicholas Barrowman, Indra Narang
Summary: Neck circumference and neck-to-height ratio predict obstructive sleep apnea (OSA) in children with obesity; male sex and NHR independently predict OSA severity; Children with NHR above identified thresholds are more likely to have moderate-severe OSA.
Article
Clinical Neurology
Christopher M. Cielo, Brendan T. Keenan, Andrew Wiemken, Ignacio E. Tapia, Andrea Kelly, Richard J. Schwab
Summary: The study found that neck fat is associated with obesity and neck circumference in adolescents, with females having significantly greater neck fat than males. However, neck fat does not appear to correlate with the presence and severity of OSAS.
Article
Environmental Sciences
Linling Yu, Hong Mei, Da Shi, Xing Wang, Man Cheng, Lieyang Fan, Yang Xiao, Ruyi Liang, Bin Wang, Meng Yang, Weihong Chen
Summary: This study aimed to investigate the effects of caffeine exposure on children's health. The findings suggest that higher caffeine consumption is associated with increased risks of obesity and overweight, as well as higher BMI z-scores and waist circumference. The relationship between caffeine exposure and adverse adiposity outcomes is more significant in children aged 6-11 years compared to those aged 12-19 years.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jina Yeo, In Cheol Hwang, Hong Yup Ahn
Summary: This study found an association between oxidative imbalance and central obesity, with higher oxidative imbalance scores being related to smaller neck circumference.
OBESITY RESEARCH & CLINICAL PRACTICE
(2022)
Article
Orthopedics
Jun Chen, Liming Zhu, Xiaocong Yao, Zhongxin Zhu
Summary: This study evaluated the association between waist circumference (WC) and femoral neck bone mineral density (BMD) among older adults using the NHANES database. The results showed a positive correlation between WC and femoral neck BMD in non-adjusted models, but a negative correlation after adjusting for body mass index (BMI). Subgroup analysis revealed that this negative correlation was only present in men. Furthermore, an inverted U-shaped curve relationship between WC and femoral neck BMD was identified.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Medicine, General & Internal
Felix Teufel, Jacqueline A. Seiglie, Pascal Geldsetzer, Michaela Theilmann, Maja E. Marcus, Cara Ebert, William Andres Lopez Arboleda, Kokou Agoudavi, Glennis Andall-Brereton, Krishna K. Aryal, Brice Wilfried Bicaba, Garry Brian, Pascal Bovet, Maria Dorobantu, Mongal Singh Gurung, David Guwatudde, Corine Houehanou, Dismand Houinato, Jutta M. Adelin Jorgensen, Gibson B. Kagaruki, Khem B. Karki, Demetre Labadarios, Joao S. Martins, Mary T. Mayige, Roy Wong McClure, Joseph Kibachio Mwangi, Omar Mwalim, Bolormaa Norov, Sarah Crooks, Farshad Farzadfar, Sahar Saeedi Moghaddam, Bahendeka K. Silver, Lela Sturua, Chea Stanford Wesseh, Andrew C. Stokes, Utibe R. Essien, Jan-Walter De Neve, Rifat Atun, Justine I. Davies, Sebastian Vollmer, Till W. Barnighausen, Mohammed K. Ali, James B. Meigs, Deborah J. Wexler, Jennifer Manne-Goehler
Summary: The prevalence of overweight, obesity, and diabetes is increasing rapidly in low-income and middle-income countries, with BMI affecting the risk of diabetes, but there are significant regional variations in this association.
Article
Developmental Biology
Leticia R. de Oliveira, Carlos A. Longui, Guilherme Guaragna-Filho, Jose L. da Costa, Rafael Lanaro, Maria I. Chiamolera, Maricilda P. de Mello, Andre M. Morcillo, Andrea T. Maciel-Guerra, Gil Guerra-Junior
Summary: This study aimed to determine a testosterone (T) cutoff level using LC-MS/MS after stimulation with recombinant human chorionic gonadotropin (rhCG) in the evaluation of gonadal steroidogenesis in patients with 46,XY disorders of sex development (DSD).
SEXUAL DEVELOPMENT
(2023)
Article
Developmental Biology
Julia P. Vicentin, Mayra de Souza El Beck, Carlos W. Germano, Juliana G. R. Andrade, Beatriz A. Barros, Roberto B. Silva, Marcio L. Miranda, Nilma L. Viguetti-Campos, Tarsis A. P. Vieira, Tais N. Mazzola, Mara S. Guaragna, Helena Fabbri-Scallet, Maricilda P. Mello, Antonia P. Marques-de-Faria, Andrea T. Maciel-Guerra, Gil Guerra-Junior
Summary: This retrospective study aimed to verify the association between the time of diagnosis and initial and final sex assignment in a disorder of sex development (DSD) group. The results showed that while there were no changes in sex assignment proportions, there was an increased awareness of the need for early referral and changes in clinical, cytogenetic, and diagnostic aspects.
SEXUAL DEVELOPMENT
(2023)
Article
Developmental Biology
Helena Fabbri-Scallet, Ralf Werner, Mara S. Guaragna, Juliana G. R. de Andrade, Andrea T. Maciel-Guerra, Nadine C. Hornig, Olaf Hiort, Gil Guerra-Junior, Maricilda P. de Mello
Summary: NR5A1 is a crucial transcription factor involved in reproduction and endocrine function. Pathogenic variants in this gene are responsible for diverse sex development disorders. Through molecular studies, we discovered four variants in the NR5A1 non-coding region in three patients with 46,XY sex development disorder. In vitro analyses demonstrated the impact of these variants on promoter activity. Whole exome sequencing also identified variants in SRA1, WWOX, and WDR11 genes. This study highlights the importance of careful molecular analysis of the neglected NR5A1 non-coding region, which may explain some cases of idiopathic sex development disorders.
SEXUAL DEVELOPMENT
(2023)
Review
Immunology
Alice Abend Bardagi, Clarissa dos Santos Paschoal, Giovanna Ganem Favero, Luisa Riccetto, Maria Luisa Alexandrino Dias, Gil Guerra Junior, Giovanna Degasperi
Summary: Adipose tissue is an endocrine organ that secretes important hormones like leptin. Leptin not only controls satiety, but also regulates immune responses. Leptin receptors have been found in the bone marrow, playing a crucial role in hematopoiesis.
IMMUNOLOGICAL INVESTIGATIONS
(2023)
Article
Education, Special
F. Bertapelli, K. Pitetti, G. Guerra-Junior
Summary: This study found that muscular strength is associated with total and central adiposity in adolescents with intellectual disability. Higher muscular strength is correlated with lower levels of fat.
JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
(2023)
Article
Genetics & Heredity
Flavia Marcorin de Oliveira, Beatriz Amstalden Barros, Ana Paula dos Santos, Nilma Lucia Viguetti Campos, Tais Nitsch Mazzola, Paulo Latuf Filho, Liliana Aparecida Lucci De Angelo Andrade, Mara Sanches Guaragna, Maricilda Palandi de Mello, Gil Guerra-Junior, Tarsis Antonio Paiva Vieira, Andrea Trevas Maciel-Guerra
Summary: This article reports on two siblings with atypical genitalia, with the boy being confirmed to have ovotesticular disorders of sex development (OT-DSD) and the girl having bilateral ovaries. The study found a 737-kb duplication at Xq27.1, including the entire SOX3 gene, in both siblings. These findings support the pathogenic role of SOX3 overexpression in 46,XX individuals leading to variable DSD phenotypes.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Biochemistry & Molecular Biology
Ana Paula Francese-Santos, Jakob A. Meinel, Cristiane S. C. Piveta, Juliana G. R. Andrade, Beatriz A. Barros, Helena Fabbri-Scallet, Vera Lucia Gil-da-Silva-Lopes, Gil Guerra-Junior, Axel Kuenstner, Hauke Busch, Olaf Hiort, Maricilda P. de Mello, Ralf Werner, Andrea T. Maciel-Guerra
Summary: We report a girl with 46,XY partial gonadal dysgenesis who carries a 297 kb duplication at Xp21.2 upstream of the NR0B1 gene. This is the first description of an Xp21.2 duplication upstream of NR0B1 associated with 46,XY partial gonadal dysgenesis. The fine mapping of the breakpoints revealed a tandem duplication of TASL (CXorf21), GK, and partially TAB3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Raiany Rosa Bergamo, Mauro Alexandre Pascoa, Jefferson Eduardo Hespanhol, Anderson Marques de Moraes, Gil Guerra-Junior
Summary: This study evaluated the association between food consumption and body composition with bone parameters in adolescent soccer players. The results showed that lean mass was a predictor of bone parameters, and high protein intake was negatively associated with bone mass and geometry.
Article
Endocrinology & Metabolism
Carolina Trombeta Reis, Marina Cruvinel Macedo, Andre Moreno Morcillo, Gil Guerra-Junior, Sofia Helena Valente de Lemos-Marini
Summary: This study aimed to analyze the association between anthropometric factors, physical appearance, and quality of life in Turner syndrome (TS) women. The results showed that dissatisfaction with height and physical appearance was related to lower scores in mental health and role emotional domains. Participants who desired to change their physical appearance had higher scores in the mental component, social function, and mental health domains. Therefore, there is a need to develop and validate an official questionnaire to assess how specific characteristics of TS interfere with the quality of life in more detail.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Biology
Felipe Rodrigues de Oliveira, Tais Nitsch Mazzola, Maricilda Palandi de Mello, Ana Paula Francese-Santos, Sofia Helena V. de Lemos-Marini, Andrea Trevas Maciel-Guerra, Olaf Hiort, Ralf Werner, Gil Guerra-Junior, Helena Fabbri-Scallet
Summary: The group of disorders known as 46,XY gonadal dysgenesis (GD) includes complete and partial GD (PGD) and testicular regression syndrome (TRS). DHX37 gene variants were identified as a cause of PGD and TRS, indicating its importance in sex development disorders. Variants in DHX37 were found in 4 out of 25 individuals with 46,XY DSD, suggesting a potential role of DHX37 in testis development.
Article
Nutrition & Dietetics
Analiza M. Silva, Francesco Campa, Silvia Stagi, Luis A. Gobbo, Roberto Buffa, Stefania Toselli, Diego Augusto Santos Silva, Ezequiel M. Goncalves, Raquel D. Langer, Gil Guerra-Junior, Dalmo R. L. Machado, Emi Kondo, Hiroyuki Sagayama, Naomi Omi, Yosuke Yamada, Tsukasa Yoshida, Wataru Fukuda, Maria Cristina Gonzalez, Silvana P. Orlandi, Josely C. Koury, Tatiana Moro, Antonio Paoli, Salome Kruger, Aletta E. Schutte, Angela Andreolli, Carrie P. Earthman, Vanessa Fuchs-Tarlovsky, Alfredo Irurtia, Jorge Castizo-Olier, Gabriele Mascherini, Cristian Petri, Laura K. Busert, Mario Cortina-Borja, Jeanette Bailey, Zachary Tausanovitch, Natasha Lelijveld, Hadeel Ali Ghazzawi, Adam Tawfiq Amawi, Grant Tinsley, Suvi T. Kangas, Cecile Salpeteur, Adriana Vazquez-Vazquez, Mary Fewtrell, Chiara Ceolin, Giuseppe Sergi, Leigh C. Ward, Berit L. Heitmann, Roberto Fernandes da Costa, German Vicente-Rodriguez, Margherita Micheletti Cremasco, Alessia Moroni, John Shepherd, Jordan Moon, Tzachi Knaan, Manfred J. Mueller, Wiebke Braun, Jose M. Garcia-Almeida, Antonio L. Palmeira, Ines Santos, Sofus C. Larsen, Xueying Zhang, John R. Speakman, Lindsay D. Plank, Boyd A. Swinburn, Jude Thaddeus Ssensamba, Keisuke Shiose, Edilson S. Cyrino, Anja Bosy-Westphal, Steven B. Heymsfield, Henry Lukaski, Luis B. Sardinha, Jonathan C. Wells, Elisabetta Marini
Summary: Background Bioelectrical impedance analysis (BIA) is a widely used technique for estimating body composition and health-related parameters. The BIA International Database is a key resource for research on body composition, containing a large and diverse dataset of BIA measurements and derived body components. This project aims to advance understanding of the variability of body composition and encourage researchers to join the consortium.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Developmental Biology
Guilherme Guaragna-Filho, Gil Guerra-Junior, Rieko Tadokoro-Cuccaro, Ieuan A. Hughes, Beatriz A. Barros, Olaf Hiort, Antonio Balsamo, Tulay Guran, Paul M. Holterhus, Sabine Hannema, Sukran Poyrazoglu, Feyza Darendeliler, Jillian Bryce, S. Faisal Ahmed, Charmian A. Quigley
Summary: This study evaluated the practice of assigning female gender to 46, XY infants with limited virilization, particularly in the case of partial androgen insensitivity syndrome (PAIS). The results showed that female assignment is becoming less common in PAIS and there is no evidence to support prophylactic prepubertal gonadectomy in reducing the risk of germ cell tumor.
SEXUAL DEVELOPMENT
(2023)
Article
Endocrinology & Metabolism
Juliano Henrique Borges, Daniela Albiero Camargo, Leticia Esposito Sewaybricker, Renata Isa Santoro, Daniel Minutti de Oliveira, Sofia Helena Valente de Lemos-Marini, Bruno Geloneze, Gil Guerra-Junior, Ezequiel Moreira Goncalves
Summary: This study compared ambulatory blood pressure (ABP) between young adults with congenital adrenal hyperplasia (CAH) and a control group. The results showed no differences in systolic BP, diastolic BP, and pulse pressure between the two groups. Additionally, there were no associations between glucocorticoid dose, androgen levels, and ABP parameters.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Review
Developmental Biology
Beatriz Amstalden Barros, Mara Sanches Guaragna, Helena Fabbri-Scallet, Maricilda Palandi de Mello, Gil Guerra-Junior, Andrea Trevas Maciel-Guerra
Summary: This study aimed to search for NR5A1 variants in SRY-negative 46,XX OT-DSD patients and perform a systematic review on the contribution of NR5A1 variations to 46,XX OT-DSD. Pathogenic variants of NR5A1 were not found in our patients. Further molecular investigations are important as the etiology of most 46,XX OT-DSD cases remains elusive.
SEXUAL DEVELOPMENT
(2023)
Article
Biophysics
Nubia Maria Oliveira, Aryanne Hydeko Fukuoka, Catarina Nunes Matias, Gil Guerra-Junior, Ezequiel Moreira Goncalves
Summary: This study aimed to investigate the use of bioelectrical muscle localized phase angle (ML-PhA) and whole body phase angle (WB-PhA) as indicators of muscle power and strength in active young women. The results showed that both ML-PhA and WB-PhA may serve as markers of muscle power in this population.
PHYSIOLOGICAL MEASUREMENT
(2023)
