Article
Engineering, Biomedical
Duo Fu, Mengjia Wang, Tao Yang, Min Li, Zhihui Liang, Chen Chen, Lei Zhang, Changying Xue, Bingbing Sun, Chuanbin Mao
Summary: This study investigated the interaction between nanofibers and the mucosal interface, as well as the impact of nanofiber length on immune responses. The results showed that shorter nanofibers had a stronger ability to activate immune responses and enhance mucosal and systematic antibody responses. Additionally, vaccines adjuvanted with shorter nanofibers were able to induce cytotoxic T lymphocyte responses, effectively inhibiting tumor growth.
Review
Oncology
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Bryan J. Neth, Ian E. Olson, Karishma Rajani, Masum Rahman, Samar Ikram, Moustafa A. Mansour, Bipasha Mukherjee, Arthur E. Warrington, Susan C. Short, Thomas von Zglinicki, Desmond A. Brown, Sandeep Burma, Tamar Tchkonia, Marissa J. Schafer, Darren J. Baker, Sani H. Kizilbash, James L. Kirkland, Terry C. Burns
Summary: This article discusses the challenges in treating high-grade gliomas and the role of senescent cells in tumor recurrence. It highlights the emerging evidence supporting the use of senolytic agents to eliminate latent, senescent-like cells to prevent tumor recurrence, and discusses how clearance of senescent cells can reduce tumor aggressiveness. Finally, it mentions that senolytics could improve the long-term effects of therapy on cognition and bone marrow function.
NPJ PRECISION ONCOLOGY
(2023)
Article
Virology
Karsten Eichholz, Tuan Hiep Tran, Coraline Cheneau, Thi Thu Phuong Tran, Oceane Paris, Martine Pugniere, Eric J. Kremer
Summary: This study examines the interactions between danger-associated molecular patterns and human adenoviruses and their impact on vaccines. The interaction between human adenoviruses and HNP-1 can modify the response of antigen-presenting cells, influencing vaccine efficacy. HNP-1 binds to the capsids of human adenoviruses and directs them to Toll-like receptor 4 (TLR4), leading to internalization, inflammasome response, and IL-1β release.
JOURNAL OF VIROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Bao Loc Nguyen, Cao Dai Phung, Duc-Vinh Pham, Ngoc Duy Le, Jee-Heon Jeong, Jeonghwan Kim, Ju-Hyun Kim, Jae-Hoon Chang, Sung Giu Jin, Han -Gon Choi, Sae Kwang Ku, Jong Oh Kim
Summary: The researchers designed a liposomal nanoparticle platform that delivers toll-like receptor 7 and toll-like receptor 3 agonists simultaneously to enhance the immunogenic condition of the tumor microenvironment in triple-negative breast cancer (TNBC). The treatment effectively inhibited tumor growth in mice and showed potential for combination therapy with immune checkpoint inhibitors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
David L. L. Goldblatt, Gabriella Valverde Ha, Shradha Wali, Vikram V. V. Kulkarni, Michael K. K. Longmire, Ana M. M. Jaramillo, Rosha P. P. Chittuluru, Adrienne Fouts, Margarita Martinez-Moczygemba, Jonathan T. T. Lei, David P. P. Huston, Michael J. J. Tuvim, Burton F. F. Dickey, Scott E. E. Evans
Summary: Allergic asthma is a chronic inflammatory respiratory disease characterized by eosinophilic infiltration and increased mucus production. Research has shown that a combination treatment of Pam2 and ODN can reduce allergic immune responses and lower sensitivity to allergens.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Allison M. Owen, Jessica B. Fults, Naeem K. Patil, Antonio Hernandez, Julia K. Bohannon
Summary: Despite improvements in critical care medicine, infection remains a significant challenge, especially for immunocompromised patients who are highly susceptible to severe infection leading to sepsis. Activation of the innate immune system, particularly through the phenomenon of trained immunity, shows promise in enhancing host immune defenses. Toll-like receptor (TLR) agonists have been identified as agents capable of inducing trained immunity through metabolic and epigenetic modifications, offering potential as immunotherapeutic agents in combatting infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Christopher J. Papayannakos, James A. DeVoti, Mohd Israr, Habeeb Alsudani, Vincent Bonagura, Bettie M. Steinberg
Summary: Cells can communicate through extracellular vesicles, and pathogens can alter the properties of EVs released from cells, potentially affecting intercellular communication and immune responses. Characterization of EVs under different stimuli showed variations in marker levels, indicating potential changes in cellular communication and immune responses.
CELLULAR SIGNALLING
(2021)
Article
Immunology
Sandra Vreman, Johanna M. J. Rebel, Joanne McCaffrey, Kristina Ledl, Ksenia Arkhipova, Damien Collins, Dennis McDaid, Huub F. J. Savelkoul, Kerstin Skovgaard, Anne C. Moore, Norbert Stockhofe-Zurwieden
Summary: This study investigated the immune-stimulatory potential of different Toll-like receptor agonists (TLRa) in neonatal and adult pigs vaccinated in the skin using dissolving microneedle patches. The results showed that TLR7/8a induced the most prominent early inflammatory and immune cell responses, particularly in the skin. There were age-dependent differences in the upregulation of immune response related genes between neonatal and adult pigs after vaccination.
Article
Oncology
Mia Aaboe Jorgensen, Stefano Ugel, Mie Linder Hubbe, Marco Carretta, Maria Perez-Penco, Stine Emilie Weis-Banke, Evelina Martinenaite, Katharina Kopp, Marion Chapellier, Annalisa Adamo, Francesco De Sanctis, Cristina Frusteri, Manuela Iezzi, Mai-Britt Zocca, Daniel Hargboll Madsen, Ayako Wakatsuki Pedersen, Vincenzo Bronte, Mads Hald Andersen
Summary: The expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) plays a central role in immunosuppression in tumors, and targeting ARG1 with therapeutic vaccines can activate antitumor immunity and modulate the tumor microenvironment effectively. Combined with anti-PD-1 checkpoint blockade, ARG1-targeting vaccines show increased T-cell infiltration, reduced Arg1 expression, and a shift towards a more proinflammatory microenvironment, leading to effective tumor control.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Maria Vono, Beatris Mastelic-Gavillet, Elodie Mohr, Malin Ostensson, Josefine Persson, Thorunn A. Olafsdottir, Sylvain Lemeille, David Pejoski, Oliver Hartley, Dennis Christensen, Peter Andersen, Arnaud M. Didierlaurent, Ali M. Harandi, Paul-Henri Lambert, Claire-Anne Siegrist
Summary: C-type lectin receptor (CLR) agonists have been found to be more effective than Toll-like receptor (TLR) agonists in inducing primary B cell responses in early life. This study investigates the mechanisms behind the difference in neonatal adjuvanticity between CLR-based (CAF(R)01) and TLR4-based (GLA-SE) adjuvants. The results demonstrate that CAF01 induces mixed Th1/Th17 neonatal responses and Tfh cells that are crucial for germinal center formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
James A. Carroll, Brent Race, Katie Williams, James F. Striebel, Bruce Chesebro
Summary: The study found that adult microglia exhibited higher reactivity to exposure to LPS or IMQ, but showed decreased expression of genes when exposed to CpG-ODN 1585. In vivo experiments indicated that microglial influences on neuroinflammation were specific to the agonist, with mice with reduced microglia showing more dysregulated responses to the TLR7 agonist IMQ.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Kewen He, Hampartsoum B. Barsoumian, Duygu Sezen, Nahum Puebla-Osorio, Ethan Y. Hsu, Vivek Verma, Chike O. Abana, Dawei Chen, Roshal R. Patel, Meidi Gu, Maria Angelica Cortez, James W. Welsh
Summary: Multiple rounds of radiation therapy may provide greater clinical benefit by enhancing the adaptive immune response through repeated exposure to tumor antigens released by pulsed radiation therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pataje G. Prasanna, Deborah E. Citrin, Jeffrey Hildesheim, Mansoor M. Ahmed, Sundar Venkatachalam, Gabriela Riscuta, Dan Xi, Guangrong Zheng, Jan van Deursen, Jorg Goronzy, Stephen J. Kron, Mitchell S. Anscher, Norman E. Sharpless, Judith Campisi, Stephen L. Brown, Laura J. Niedernhofer, Ana O'Loghlen, Alexandros G. Georgakilas, Francois Paris, David Gius, David A. Gewirtz, Clemens A. Schmitt, Mohamed E. Abazeed, James L. Kirkland, Ann Richmond, Paul B. Romesser, Scott W. Lowe, Jesus Gil, Marc S. Mendonca, Sandeep Burma, Daohong Zhou, C. Norman Coleman
Summary: Cellular senescence is crucial in suppressing tumor growth, but radiation and chemotherapy can lead to accumulation of senescent cells in both tumor and normal tissues, potentially promoting tumor relapse and resistance to treatment. Targeting cellular senescence could be important in the fight against cancer.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Review
Oncology
William Tyler Turchan, Sean P. Pitroda, Ralph R. Weichselbaum
Summary: This article reviews laboratory and clinical studies on the combination of radiotherapy and immunotherapy in the treatment of metastatic cancer, aiming to explore potential approaches to increase the therapeutic ratio of radioimmunotherapy.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yeeun Kim, Kyunghee Park, Yeon Jeong Kim, Sung-Won Shin, Yeon Joo Kim, Changhoon Choi, Jae Myoung Noh
Summary: This study investigated the role of entinostat, a histone deacetylase inhibitor, in improving the efficacy of radiotherapy and anti-PD-1 therapy in lung cancer treatment. The results showed that entinostat increased immune cell infiltration and potentiated the effects of CD8(+) T cells in tumor control. Transcriptomic profiling predicted that entinostat could increase the number of dendritic cells, B cells, and T cells in tumors treated with radiation and anti-PD-1. Overall, this study provides insights into the potential strategies for enhancing the efficacy of combined therapies in lung cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Christopher P. Fox, Matthew J. Ahearne, Ruth Pettengell, Claire Dearden, Dima El-Sharkawi, Shireen Kassam, Lucy Cook, Kate Cwynarski, Tim Illidge, Graham Collins
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Oncology
Chalid Assaf, Nathalie Waser, Martine Bagot, Mary He, Tina Li, Mehul Dalal, Francois Gavini, Fabrizio Trinchese, Athanasios Zomas, Meredith Little, Nicola Pimpinelli, Pablo L. Ortiz-Romero, Timothy M. Illidge
Summary: This study provides real-world data on the treatment patterns and outcomes of relapsed or refractory CTCL, highlighting the diverse treatment approaches and the lack of consensus in managing this condition.
Article
Oncology
S. Horwitz, O. A. O'Connor, B. Pro, L. Trumper, S. Iyer, R. Advani, N. L. Bartlett, J. H. Christensen, F. Morschhauser, E. Domingo-Domenech, G. Rossi, W. S. Kim, T. Feldman, T. Menne, D. Belada, A. Illes, K. Tobinai, K. Tsukasaki, S-P Yeh, A. Shustov, A. Huettmann, K. J. Savage, S. Yuen, P. L. Zinzani, H. Miao, V Bunn, K. Fenton, M. Fanale, M. Puhlmann, T. Illidge
Summary: In the 5-year update of ECHELON-2, frontline treatment of PTCL patients with A+CHP continues to show clinically meaningful improvements in PFS and OS compared to CHOP, with continued resolution or improvement of peripheral neuropathy.
ANNALS OF ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rebecca Benson, John Rodgers, Claire Nelder, Abigael Clough, Eleanor Pitt, Jacqui Parker, Lee Whiteside, Lucy Davies, Rachael Bailey, John Mcmahon, Hope Kolbe, Anthea Cree, Michael Dubec, Marcel Van Herk, Ananya Choudhury, Peter Hoskin, Cynthia Eccles
Summary: This study compares the impact of a dedicated educational tool versus experience gained in MR-guided radiotherapy on image registration in cervical cancer patients. The results show no significant differences between imaging modalities, while there was a significant reduction in interobserver variability in MR-MR imaging and an increase in observer confidence in all three modalities.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Oncology
T. Elumalai, C. Barker, T. Elliott, J. Malik, A. Tran, A. Hudson, Y. P. Song, K. Patel, J. Lyons, P. Hoskin, A. Choudhury, H. Mistry
Summary: This study conducted a pooled analysis of multiple clinical trials and non-trial datasets to investigate the changes in serum prostate-specific antigen (PSA) concentrations and their impact on survival in patients with metastatic castration-resistant prostate cancer treated with docetaxel. The results showed that both pre-treatment factors and time-dependent biomarkers had significant prognostic value in predicting overall survival in these patients.
Article
Oncology
T. Elumalai, W. Croxford, B. Buijtenhuijs, R. Conroy, B. Sanderson, D. Enting, C. Aversa, G. Doss, A. Das, N. S. Vasudev, E. Kitetere, S. Tolan, A. Law, P. Hoskin, H. Mistry, A. Choudhury
Summary: This study developed and validated a prognostic model for overall survival in locally advanced or metastatic bladder cancer patients treated with immune checkpoint inhibitors (ICIs). Five key prognostic factors were identified, and a nomogram was developed to calculate expected survival probabilities based on these factors. The model could assist in patient stratification and future trials incorporating PD-1/PD-L1 inhibitors.
Letter
Oncology
Jane Shortall, Giuseppe Palma, Hitesh Mistry, Eliana Vasquez Osorio, Alan McWilliam, Ananya Choudhury, Marianne Aznar, Marcel van Herk, Andrew Green
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Lotte Van der Weijst, Miguel E. Aguado-Barrera, David Azria, Patrick Berkovic, Pierre Boisselier, Erik Briers, Renee Bultijnck, Patricia Calvo-Crespo, Jenny Chang-Claude, Ananya Choudhury, Gilles Defraene, Sylvian Demontois, Alison M. Dunning, Rebecca M. Elliott, Dawn Ennis, Corinne Faivre-Finn, Marzia Franceschini, Sara Gutierrez-Enriquez, Carsten Herskind, Daniel S. Higginson, Sarah L. Kerns, Kerstie Johnson, Meritxell Molla, Maarten Lambrecht, Monica Ramos, Tiziana Rancati, Andreas Rimner, Barry S. Rosenstein, Dirk De Ruysscher, Ahmed Salem, Claudia Sangalli, Petra Seibold, Paloma Sosa-Fajardo, Elena Sperk, Hilary Stobart, Holly Summersgill, Veerle Surmont, Paul Symonds, Begona Taboada-Lorenzo, Christopher J. Talbot, Riccardo Valdagni, Ana Vega, Liv Veldeman, Marlon R. Veldwijk, Tim Ward, Adam Webb, Catharine M. L. West, Yolande Lievens
Summary: This study investigated the impact of radiotherapy on HRQoL and toxicity in non-small cell lung cancer patients. While overall HRQoL and toxicity did not change significantly over time, individual patients showed varied responses, emphasizing the importance of considering patient characteristics in treatment decisions regarding radiotherapy-induced toxicity and HRQoL outcomes.
Article
Oncology
Vicky Smith, Debayan Mukherjee, Anna Maria Tsakiroglou, Alexander Baker, Hitesh Mistry, Ananya Choudhury, Peter Hoskin, Timothy Illidge, Catharine M. L. West
Summary: Precision medicine is needed for muscle-invasive bladder cancer to improve survival rates. CD8 T cell counts show promise as a predictive biomarker for immune checkpoint inhibitors (ICIs). However, there is currently no biomarker to stratify patients for hypoxia-targeting or immune-targeting therapies.
Editorial Material
Urology & Nephrology
Priyamvada Maitre, Vijay Sangar, Ananya Choudhury
Article
Biochemistry & Molecular Biology
Vicky Smith, Dave Lee, Mark Reardon, Rekaya Shabbir, Sudhakar Sahoo, Peter Hoskin, Ananya Choudhury, Timothy Illidge, Catharine M. L. West
Summary: Hypoxia and suppressive TME are negative prognostic factors for MIBC. Transcriptomic analyses show that hypoxia increases immune signalling and infiltrates in bladder cancer. This study investigates the relationship between HIF-1 and -2, hypoxia, immune signalling, and infiltrates in MIBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Michael J. Dubec, David L. Buckley, Michael Berks, Abigael Clough, John Gaffney, Anubhav Datta, Damien J. McHugh, Nuria Porta, Ross A. Little, Susan Cheung, Christina Hague, Cynthia L. Eccles, Peter J. Hoskin, Robert G. Bristow, Julian C. Matthews, Marcel van Herk, Ananya Choudhury, Geoff J. M. Parker, Andrew McPartlin, James P. B. O'Connor
Summary: The study aimed to develop oxygen-enhanced MRI (OE-MRI) in head and neck cancer patients and translate the technique onto an MR Linac system. The results showed that OE-MRI was feasible and had good repeatability, and it has the potential to guide future clinical trials of biology guided adaptive radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Martin Swinton, Neethu Billy Graham Mariam, Jean Ling Tan, Katherine Murphy, Thiraviyam Elumalai, Manjusha Soni, Alexandra Ferrera, Charlotte Richardson, Richard Walshaw, Hitesh Mistry, Vijay Ramani, Yeepei Song, Alison Birtle, Ann Henry, Joachim Chan, Peter Hoskin, Ananya Choudhury
Summary: This study analyzed the survival outcomes of node-positive bladder cancer patients and found that there was no significant difference in survival rates between surgery and radiation therapy. Bladder-sparing treatment should be considered as an option for patients with poor survival rates.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Tanuj Puri, Michelle L. Frost, Amelia E. B. Moore, Ananya Choudhury, Sobhan Vinjamuri, Abhishek Mahajan, Claire Fynbo, Marie Vrist, Jorn Theil, Kalevi Kairemo, James Wong, Habib Zaidi, Mona-Elisabeth Revheim, Thomas J. Werner, Abass Alavi, Gary J. R. Cook, Glen M. Blake
Summary: This article reviews the rationale, methodology, and clinical utility of quantitative [F-18] sodium fluoride positron emission tomography-computed tomography (PET-CT) imaging in measuring bone metabolic flux. It explains the bone remodeling cycle and the aspects of bone remodeling addressed by [F-18]NaF PET-CT. The article discusses the technique, measurements involved, and the usefulness of [F-18]NaF PET-CT in studying bone remodeling. It also explores simplified measurement methods and highlights key clinical applications and potential future developments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Urszula M. Cytlak, Douglas P. Dyer, Jamie Honeychurch, Kaye J. Williams, Mark A. Travis, Timothy M. Illidge
Summary: Radiotherapy has both direct cytotoxic effects on tumors and potential immunomodulatory effects on surrounding tissues, leading to chronic inflammation and organ dysfunction. This can impact the quality of life for cancer survivors.
NATURE REVIEWS IMMUNOLOGY
(2022)