Article
Engineering, Biomedical
Qiong Yuan, Benkai Bao, Meiqi Li, Ling Li, Xinyi Zhang, Yanli Tang
Summary: This study synthesized a novel conjugated polymer, PT-C3-NH2, and combined it with a biodegradable porous scaffold to construct a 3D composite porous scaffold, PLGA@GC-PT. The bioactive PT-C3-NH2 with excellent biocompatibility promoted endothelial cell migration and induced osteoblast differentiation. The PLGA@GC-PT scaffold showed great biomimetic properties and biodegradability, and exhibited excellent new bone generation in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lili Hao, Jiaxiang Li, Peng Wang, Zongliang Wang, Zhenxu Wu, Yu Wang, Zixue Jiao, Min Guo, Tongfei Shi, Qigang Wang, Yoshihiro Ito, Yen Wei, Peibiao Zhang
Summary: This study experimentally demonstrates the feasibility of magneto-controlled degradation for implants, and provides an optimizing strategy for better heating efficiency of nanomaterials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Muhammad Umar Aslam Khan, Saiful Izwan Abd Razak, Mohamed Nainar Mohamed Ansari, Razauden Mohamed Zulkifli, Nurliyana Ahmad Zawawi, Muhammad Arshad
Summary: This study synthesized a polymeric composite material for bone tissue engineering, using arabinoxylan, beta-glucan, nano-hydroxyapatite, graphene oxide, and acrylic acid. The fabricated porous scaffolds were coated with chitosan to enhance their biological activities. Results showed that the BGH3 scaffold had desirable morphological, structural, swelling, degradation, and mechanical properties, as well as cytocompatibility with MC3T3-E1 cell lines. The findings suggest that these polymeric scaffolds could be a potential bone substitute for regenerating defective bone tissue.
Review
Polymer Science
Shuo Chen, Yihan Wang, Lei Yang, Chengzhen Chu, Shichun Cao, Zhao Wang, Jiajia Xue, Zhengwei You
Summary: In this review, the recent progress in synthesis, process technologies, and biomedical applications of biodegradable elastomers is summarized. The emphasis is on the molecular design and processing strategies of biodegradable polyesters and polyurethanes, as well as the newly developed functionalities in biomedical applications. Future research directions, challenges, and potential solutions are discussed.
PROGRESS IN POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Sohail Sarwar, Abdul Ghaffar, Qingrong Huang, Meraj Khalid, Aneela Anwar, Abdulfatah M. Alayoubi, Muhammad Latif
Summary: Blending natural polysaccharides with synthetic polymers to create composite films for drug delivery systems has received much attention due to their biodegradability and biocompatibility. This study focuses on the easy preparation of Starch/Poly(allylamine hydrochloride) (ST/PAH) blend films and their potential as a sustained-release DDS for various biomedical applications. The films exhibited intermolecular H-bonding and hydrophobic characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Daniela Filip, Doina Macocinschi, Mirela-Fernanda Zaltariov, Bianca-Iulia Ciubotaru, Alexandra Bargan, Cristian-Dragos Varganici, Ana-Lavinia Vasiliu, Dragos Peptanariu, Mihaela Balan-Porcarasu, Mihaela-Madalina Timofte-Zorila
Summary: This research focused on hydrogel-based polymeric blends for tissue scaffolds, showing that the HPC component had a significant influence on scaffold behavior while the Pluronic F68 component improved thermal stability. All blends demonstrated good mechanical strength and enhanced biocompatibility on the NHDF cell line.
Review
Polymer Science
Sybele Saska, Livia Pilatti, Alberto Blay, Jamil Awad Shibli
Summary: 3D printing is valuable in tissue engineering, but the structures produced are static. 4D printing is a new technology that uses smart materials to enable dynamic changes in printed structures, allowing engineered tissues to undergo planned morphological changes.
Review
Chemistry, Multidisciplinary
Ting Liu, Yuan Wang, Min Hong, Jeffrey Venezuela, Wei Shi, Matthew Dargusch
Summary: This article comprehensively reviews the applications and prospects of biodegradable piezoelectric materials in biomedical field, including biological force sensing, self-powering biomedical devices, tissue regeneration and medical diagnosis. It summarizes the material synthesis methods and device fabrication techniques, discusses the strategies to achieve high-performance biodegradable piezoelectric materials and devices, and explores their biomedical applications. Finally, future research directions are proposed.
Article
Engineering, Biomedical
Louis Chaigneau, Aurelien Perrot, Damien Brezulier, Jean-Francois Coulon, Francois Chevire, Ronan Lebullenger
Summary: Due to population ageing, the synthesis and optimization of biomaterials with desired physico-chemical characteristics are important in regenerative medicine. The use of 3D printing techniques has led to the manufacture of PLA-BG composite scaffolds, but the composite has lower mechanical strength possibly due to the ionic salting-out caused by BG. This study aims to counteract this by coating BG particles with a thin layer of gold, and evaluating the mechanical and biological characteristics of the 3D composite objects to preserve their bioactive nature.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Manufacturing
Ji-Ho Ahn, Jinyoung Kim, Ginam Han, DongEung Kim, Kwang-Hee Cheon, Hyun Lee, Hyoun-Ee Kim, Young-Jig Kim, Tae-Sik Jang, Hyun-Do Jung
Summary: Biodegradable composite scaffolds with high ceramic loadings were fabricated using binder jetting technique, which demonstrated superior mechanical properties and biocompatibility in tissue engineering applications.
ADDITIVE MANUFACTURING
(2021)
Review
Polymer Science
Saleh O. Alaswad, Amira S. Mahmoud, Prabhakarn Arunachalam
Summary: The rising significance and rapid progress of biopolymers, a distinctive class of polymeric materials, have been driven by their tunable electrical conductivity and biodegradability characteristics. This article discusses the recent advancements and applications of biodegradable polymers, with a focus on their use in drug delivery, tissue engineering, and wound healing.
Article
Engineering, Industrial
Dayue Jiang, Fuda Ning, Ying Wang
Summary: The study showed that PLA-based composite scaffolds with optimized printing parameters have accurate pore dimensions and evenly distributed iron-based powders, with lower thermal expansion coefficients, enhanced mechanical properties, reduced surface roughness, and superior degradation resistance, wetting behavior, and cytocompatibility. These results demonstrate the potential of PLA/iron scaffolds in bone tissue engineering applications.
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ji-Bong Choi, Yu-Kyoung Kim, Seon-Mi Byeon, Jung-Eun Park, Tae-Sung Bae, Yong-Seok Jang, Min-Ho Lee
Summary: The study involved fabricating a composite hydrogel by incorporating BCP into GelMA, resulting in a material with excellent mechanical properties, high cell viability, and strong bone differentiation ability for bone regeneration. The hydrogel also offers advantages for clinical use due to its customizable structure.
Article
Biotechnology & Applied Microbiology
Matthew D. Kerr, Wade T. Johnson, David A. McBride, Arun K. Chumber, Nisarg J. Shah
Summary: Sustained release of vaccine components using a biodegradable hyaluronic acid cryogel was shown to enhance immune response and provide long-lasting protection. A formulation called CpG-OVA-HAC2 was identified to minimize inflammation and improve immune response. These findings suggest the potential of CpG-OVA-HAC2 in enhancing vaccine delivery.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Yiting Ze, Yanxi Li, Linyang Huang, Yixin Shi, Peiran Li, Ping Gong, Jie Lin, Yang Yao
Summary: Mature vasculature is crucial for the survival of bioengineered tissue constructs. However, creating fully vascularized tissue constructs remains a great challenge in tissue engineering. Indirect 3D bioprinting has gained attention for its ability to create complex vascular network-like channels in thick tissue constructs while maintaining endothelial cell activity. Biodegradable materials play an important role in tissue engineering, especially in the selection of scaffolds and sacrificial materials in indirect 3D bioprinting.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Negin Jalilinejad, Mohammad Rabiee, Nafiseh Baheiraei, Ramin Ghahremanzadeh, Reza Salarian, Navid Rabiee, Omid Akhavan, Payam Zarrintaj, Aleksander Hejna, Mohammad Reza Saeb, Ali Zarrabi, Esmaeel Sharifi, Satar Yousefiasl, Ehsan Nazarzadeh Zare
Summary: Human cardiac tissue lacks proper self-regenerating capability, making tissue engineering critical for addressing the growing rate of deaths associated with cardiovascular disorders. Carbon-based nanomaterials, specifically their conductivity, have revolutionized tissue engineering by providing an appropriate microenvironment for cell protection against attacking mechanisms. The use of conductive biomaterials in cardiac tissue engineering, including graphene, graphene oxide, carbon nanotubes, and carbon nanofibers, has been studied extensively.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Applied
Mojtaba Bagherzadeh, Abdullah Aldhaher, Nafiseh Baheiraei, Sepideh Ahmadi, Navid Rabiee
Summary: In this paper, a novel form of nanocomposite based on bioactive glass and CuAl LDH was developed and examined for its ability to regulate gene expressions and promote cell growth.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Psychiatry
Masoumeh Beheshti, Nikta Rabiei, Mohammad Taghizadieh, Pariya Eskandari, Samaneh Mollazadeh, Ehsan Dadgostar, Michael R. Hamblin, Arash Salmaninejad, Raziye Emadi, Amir Hossein Mohammadi, Hamed Mirazei
Summary: Obsessive-compulsive disorder (OCD) is a debilitating neuropsychiatric disorder characterized by intrusive thoughts and repetitive or ritualized actions. It is believed to have a genetic component, but the specific genetic factors involved are still unknown. This review summarizes the single nucleotide polymorphisms associated with OCD symptoms, early onset disease, neuroimaging results, and response to therapy. This information can help to understand the genetic basis of OCD, characterize individual patients, predict prognosis, and develop personalized treatment approaches.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Correction
Nanoscience & Nanotechnology
Marzieh Ramezani Farani, Maryam Azarian, Hamid Heydari Sheikh Hossein, Zohreh Abdolvahabi, Zahra Mohammadi Abgarmi, Arash Moradi, Seyyedeh Maedeh Mousavi, Milad Ashrafizadeh, Pooyan Makvandi, Mohammad Reza Saeb, Navid Rabiee
ACS APPLIED BIO MATERIALS
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biotechnology & Applied Microbiology
Ali Arash Anoushirvani, Arezoo Jafarian Yazdi, Sanaz Amirabadi, Sahar Ahmadi Asouri, Rana Shafabakhsh, Amirhossein Sheida, Maryam Sadat Hosseini Khabr, Ameneh Jafari, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Leila Kalantari, Sayyed Alireza Talaei Zavareh, Hamed Mirzaei
Summary: Neuroblastoma is the most common extracranial malignancy in childhood and is derived from neural crest. Non-coding RNAs (ncRNAs) have been found to play important roles in various cancers, including glioma and gastrointestinal cancers, by regulating cancer gene networks. Recent studies have shown that ncRNA genes are deregulated in human cancers through various mechanisms, and disturbances in their expression can act as either oncogenes or tumor suppressor genes, leading to the development of cancer. Moreover, ncRNAs can be secreted from tumor cells in exosomes and transferred to other cells, exerting their functions. However, further research is needed to fully understand the roles of ncRNAs in neuroblastoma.
CANCER GENE THERAPY
(2023)
Review
Biochemistry & Molecular Biology
Nasim Ebrahimi, Elmira Fardi, Hajarossadat Ghaderi, Sahar Palizdar, Roya Khorram, Reza Vafadar, Masoud Ghanaatian, Fatemeh Rezaei-Tazangi, Payam Baziyar, Amirhossein Ahmadi, Michael R. Hamblin, Amir Reza Aref
Summary: Targeted therapy is a new approach in cancer treatment, using drugs that specifically target proteins in cancer cells. Inhibiting these proteins can impede cancer progression. Understanding the structures, activation mechanisms, and functions of receptor tyrosine kinases (RTKs) has led to the development of targeted drug therapies, including RTK inhibitors (RTKIs), some of which have been used in clinical settings. This article discusses RTKs and their role in cancer treatment, as well as the potential effects of combination drug therapy for drug resistant cancers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Environmental Sciences
Bahareh Farasati Far, Mohammad Reza Naimi-Jamal, Hossein Daneshgar, Navid Rabiee
Summary: In this study, natural biomaterials and DNA were successfully decorated on ZIF-67 to develop a promising co-delivery platform for the drug DOX-SOR. The modified MOFs showed stable structure and efficient drug loading and release. Cell experiments demonstrated that the decorated nanoparticles not only improved cell viability but also showed anticancer properties.
ENVIRONMENTAL RESEARCH
(2023)
Review
Chemistry, Physical
Houra Nekounam, Javad Malakootikhah, Donya Shaterabadi, Babak Negahdari, Mohammad Reza Kandi, Michael R. Hamblin
Summary: This article summarizes the advances in the preparation, optimization, and applications of silica nanoparticles in biomedical nanotechnology, as well as the inevitable human, environmental, and industrial contacts with these particles. Understanding the physicochemical properties of silica nanoparticles and their interactions with biological systems at the cellular level is crucial for the rational design of these particles. Control of toxicity risk can guide the design of silica nanoparticles for drug delivery and bioimaging systems.
Review
Microbiology
Weitao Zhu, Michael R. Hamblin, Xiang Wen
Summary: Rosacea is a chronic inflammatory skin disorder affecting the centrofacial region. Its etiology and treatment methods are still unclear. This review examines common bacterial species found in the skin and gut microbiota of rosacea patients and their role in pathogenesis. Additionally, it summarizes the impact of factors such as temperature and age on rosacea and reviews commonly used clinical treatment methods, including antibiotics and probiotics, along with their mechanisms and precautions.
FRONTIERS IN MICROBIOLOGY
(2023)
Correction
Nanoscience & Nanotechnology
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Abdullah Aldhaher, Pooyan Makvandi, Rassoul Dinarvand, Maryam Jouyandeh, Mohammad Reza Saeb, Masoud Mozafari, Mohammadreza Shokouhimehr, Michael R. Hamblin, Rajender S. Varma
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Physical
A. Shiny Golda, Ajith P. Varghese, Navid Rabiee, Bernaurdshaw Neppolian, Sandeep Kumar Lakhera
Summary: In this study, a new 2D-2D nanosheet photocatalyst was developed with NiCuInS2: In2S3/g-C3N4. The heterojunction exhibited significantly improved hydrogen production due to the synergistic effects of Ni-Cu-In trimetallic active sites and the dual S-scheme heterojunction, enabling efficient charge separation and transfer.
Article
Environmental Sciences
Azin Rostami, Mohammad Rabiee
Summary: This study presents a green and inexpensive method for extracting natural anthocyanin fluorophore from Red Cabbage and demonstrates its application for fluorescent bioimaging of HER2 positive breast cancer cells. The extracted anthocyanins exhibit proper fluorescence intensity, negligible photobleaching and no cytotoxicity, making them a potential fluorescent probe for biological diagnosis and bio-imaging techniques.
ENVIRONMENTAL RESEARCH
(2023)
Article
Engineering, Biomedical
Fahimeh Ghasemi Moravej, Abdollah Amini, Reza Masteri Farahani, Samira Mohammadi-Yeganeh, Atarodalsadat Mostafavinia, Houssein Ahmadi, Hamidreza Omidi, Fatemehalsadat Rezaei, Latif Gachkar, Michael R. Hamblin, Sufan Chien, Mohammad Bayat
Summary: Diabetic wounds lead to chronic inflammation and the development of diabetic foot ulcers, which can cause amputation and death. This study examined the effect of photobiomodulation (PBM) plus allogeneic diabetic adipose tissue-derived stem cells (ad-ADS) on wound healing in type I diabetic rats. The results showed that the ad-ADS plus PBM treatment group had significantly better histological results compared to the other experimental groups.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Materials Science, Biomaterials
Christopher Igwe Idumah, I. C. Nwuzor, S. R. Odera, U. J. Timothy, U. Ngenegbo, F. A. Tanjung
Summary: This paper presents recent advancements in drug delivery applications of polymeric hydrogel nanoarchitectures and hydrogel derivatives, including the incorporation of nanoparticulates and the enhancement of the chemical, biological, electrical, and mechanical properties of hydrogels. The application of magnetically responsive and smart hydrogels as drug delivery systems is also discussed.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Remya K. Rajan, Sunitha Chandran, Annie John, Ramesh Parameswaran
Summary: This study outlines the fabrication and characterization of pamidronate (PDS) embedded nanofibrous scaffolds based on polycaprolactone/polycaprolactone-polyethyleneglycol-polycaprolactone (PCL/CEC) blends for osteoporotic bone defect management. The electrospinning technique was utilized to fabricate PDS-loaded scaffolds, and the effect of PDS on the blends was evaluated in terms of surface morphology, wettability, biodegradability, and in vitro cytocompatibility. The results showed that the PCL/CEC-PDS scaffolds had a fibroporous architecture, appropriate mechanical properties, and the ability to support cell growth, indicating their potential for managing osteoporotic bone defects.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Kubra Aydin, Handan Sevim, Hatice Kaplan Can
Summary: This study aims to develop a new dental material by designing, synthesizing, and characterizing nanocomposites, and evaluate their cytotoxic effects on human gingival fibroblasts. The results of this research will contribute to a better understanding of the properties and safety of this material, providing reference for clinical applications in dentistry.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Review
Materials Science, Biomaterials
Angelica Jimenez-Rosales, Stefani Cortes-Camargo, Pedro Estanislao Acuna-Avila
Summary: The immune response to drug-delivering systems and implanted medical devices based on biomaterials is complex, and the goal is to design biomaterials that can respond to stimuli, preserve tissue function, and optimize cellular structures. Understanding the material's structure and location, as well as the severity of damage and other factors, is crucial in developing biocompatible biomaterials.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
Article
Materials Science, Biomaterials
Fatemeh Daliri Shadmehri, Ehsan Karimi, Ehsan Saburi
Summary: Bone tissue engineering utilizes polymeric scaffolds and stem cells to create a supportive matrix resembling the in vivo environment for bone repair. The study found that a composite matrix of polycaprolactone and fibrin enhanced the differentiation of adipose-derived stem cells into osteo-like cells.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2024)
