Article
Chemistry, Multidisciplinary
Hyeon Ji Kim, Yong Geun Lim, Yeong Jun Song, Kyeongsoon Park
Summary: In this study, well-dispersible, tumor targetable, TME-responsive, and hypoxia alleviating MnO2 nano-photosensitizers were developed for photodynamic cancer therapy. The nanoparticles exhibited good dispersity and stability under biological conditions and effectively alleviated hypoxia inside tumor cells, leading to enhanced phototherapeutic effects. Therefore, these nanoparticles have promising potential for enhancing hypoxia alleviation-triggered phototherapeutic effects.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hoon Hyun, Min Ho Park, Gayoung Jo, Bo Young Lee, Jae Won Choi, Heung Jae Chun, Hyeon Soo Kim, Dae Hyeok Yang
Summary: The study developed a novel drug carrier for breast cancer therapy, with MGC/CDPF-ic-PTX showing promising anti-cancer effects, enhanced cellular uptake, sustained release, and potential therapeutic efficacy against breast cancer.
Review
Engineering, Biomedical
Muyue Yang, Jipeng Li, Ping Gu, Xianqun Fan
Summary: The development and metastasis of tumors are closely linked to the tumor microenvironment (TME). Nanoparticles, with their unique physical properties and design, show potential in efficiently penetrating TME and delivering therapeutic agents to specific components. However, the heterogeneity of tumors and individuals may limit the effectiveness of nanoparticle delivery systems in all types of tumors, calling for further understanding of TME changes at different stages of tumor development for the design of more personalized nanoplatforms.
BIOACTIVE MATERIALS
(2021)
Review
Immunology
Hassan Dianat-Moghadam, Reza Nedaeinia, Mohsen Keshavarz, Mehdi Azizi, Mohammad Kazemi, Rasoul Salehi
Summary: Angiogenesis is a characteristic of cancer biology, and current therapies targeting tumor vasculature have limitations. By combining immunotherapy and nanocarriers, the efficacy of antiangiogenic agents could be improved while reducing the dosage of chemotherapy drugs. Furthermore, the combination of immunotherapies and nano-based delivery systems can extend the window of vascular normalization and overcome the challenges of antiangiogenic agents in treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Manuela Curcio, Alessandro Paoli, Giuseppe Cirillo, Sebastiano Di Pietro, Martina Forestiero, Francesca Giordano, Loredana Mauro, Diana Amantea, Valeria Di Bussolo, Fiore Pasquale Nicoletta, Francesca Iemma
Summary: This study successfully prepared new dual pH/redox-responsive nanoparticles with affinity for folate receptors, demonstrating potential applicability as a new drug vector in cancer therapy.
Article
Biochemistry & Molecular Biology
Samira Kariminia, Mojtaba Shamsipur, Ali Barati
Summary: Cancer is one of the leading causes of death worldwide, and the development of nano-technology has led to advanced methods for cancer treatment. In this study, fluorescent carbon dots (CDs) were prepared from chitosan and modified with activated folic acid for controlled delivery of the anticancer drug doxorubicin. The results showed high loading efficiency and pH sensitivity of the CDs/CS-FA nanocarrier, making it a potential candidate for controlled drug delivery and cellular imaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Multidisciplinary
Huan Wang, Shiqi Lin, Songli Wang, Zhuxuan Jiang, Tianhao Ding, Xiaoli Wei, Ying Lu, Feng Yang, Changyou Zhan
Summary: In this study, folic acid-functionalized lipodiscs (FA-Disc) were successfully constructed to avoid opsonization by IgM and achieve folate targeting. FA-Disc retained folate binding activity and could effectively target folate receptor positive tumors in vivo. This study provides a solution to avoid negative regulation by IgM and achieve folate-enabled targeting by exploring disc-shaped nanocarriers.
Article
Biochemistry & Molecular Biology
Razvan Ghiarasim, Natalia Simionescu, Adina Coroaba, Cristina M. Uritu, Narcisa Laura Marangoci, Sorin-Alexandru Ibanescu, Mariana Pinteala
Summary: Researchers have developed a magnetic nanocarrier with high specificity by decorating the surface of magnetic nanoparticles with poly(2-hydroxyethyl methacrylate) and covalently binding folic acid to the polymer. The biocompatibility and folate-dependent internalization capacity of the nanocarriers were tested on different cell lines, and the magnetic properties of the functionalized nanoparticles were highlighted using magnetic resonance imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Mahdieh Nemati, Farhad Bani, Tina Sepasi, Reza Eghdam Zamiri, Yousef Rasmi, Houman Kahroba, Reza Rahbarghazi, Mohammed Reza Sadeghi, Yazhen Wang, Amir Zarebkohan, Huile Gao
Summary: The study revealed that the formation of protein corona around folic acid-modified chitosan nanoparticles in breast cancer patients can affect delivery efficiency. The corona changed the physicochemical properties of the nanoparticles, and the impact varied among different cell lines.
MOLECULAR PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Liquan Hong, Wen Li, Yang Li, Shouchun Yin
Summary: Traditional cancer chemotherapy often causes serious toxic and side effects because it cannot selectively target tumor cells. Targeted delivery systems using biocompatible and surface-modifiable nanocarriers provide a solution to this problem by specifically delivering drugs to tumor sites and minimizing damage to normal tissues and cells. This review focuses on the progress in research on various receptors overexpressed on cancer cell surfaces and different nano-delivery systems for targeted anticancer drug delivery. With continued research and development, targeted cancer nano-drugs are expected to become a breakthrough and an indispensable platform for precise cancer treatment.
Article
Biophysics
Su-Hyun Kwon, Hasan Al Faruque, Hyeonwoo Kee, Eunjoo Kim, Sukho Park
Summary: The study introduces an exosome-based hybrid nanostructure with improved targeting ability and therapeutic efficacy against colorectal cancer. By utilizing exosomes as a carrier and adding a tumor-targeting ligand, the structure exhibits enhanced targeting performance. Through in vitro and in vivo experiments, it was found that the structure could induce increased apoptosis and effectively inhibit tumor growth.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yeoul Kang, Junha Lim, Gurusamy Saravanakumar, Jinseong Kim, Mihyeon Park, Sooseok Im, Won Jong Kim
Summary: A polymer-based hypoxia-responsive nanocomplex was developed to enhance cancer immunotherapy by reprogramming tumor-associated macrophages (TAMs) into tumoricidal M1 macrophages. The study demonstrated that the nanocomplex successfully reduced the immunosuppressive components in hypoxic tumors and promoted infiltration of CD8(+) T cells, leading to favorable immunotherapy outcomes.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Mohadese Alirezaei, Maryam Ghobeh, Ali Es-haghi
Summary: In this study, AVEO-PCF-NPs were prepared by encapsulating AVEO in PLGA-NPs and coating the nanoparticles with CS and FA, showing significant anticancer effects by suppressing cancer cell growth, inducing apoptosis, and inhibiting angiogenesis.
PROCESS BIOCHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Meng Zhao, Xupeng Yang, Hao Fu, Chuanrong Chen, Yanhua Zhang, Zhihua Wu, Yourong Duan, Ying Sun
Summary: A novel tumor-targeted nanosized ultrasound contrast nanobubble was developed for more efficient molecular targeted therapy against triple-negative breast cancer (TNBC), showing potential in enhancing treatment efficacy and immunotherapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemical Research Methods
Zhongzhong Lu, Jincong Yan, Guangyue Zu, Mingsheng Xu, Jihuan Liu, Ye Zhang, Lei Shi, Xifeng Fei, Yi Cao, Renjun Pei
Summary: To achieve accurate diagnosis of tumors using MRI, switchable magnetic resonance contrast agents (CAs) that can enhance T-1 and T-2 contrast have been developed based on extremely small iron oxide nanoparticles (ESIONPs). In this study, a hypoxia-responsive ESIONP-based nanocluster, named EAmP, was developed for the first time. EAmP exhibited a T-2-to-T-1 switchable contrast enhancement function, effectively differentiating between normal tissue and tumor tissue. This switchable contrast agent offers high sensitivity and signal-to-noise ratio for the accurate diagnosis of tumors, making it a potential MRI nanoprobe for improving diagnostic accuracy of solid tumors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
