Lipid–Protein and Protein–Protein Interactions in the Pulmonary Surfactant System and Their Role in Lung Homeostasis

Air Space Distension Precedes Spontaneous Fibrotic Remodeling and Impaired Cholesterol Metabolism in the Absence of Surfactant Protein C

(2020) Jannik Ruwisch et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex

(2020) Juho Liekkinen et al.   JOURNAL OF MOLECULAR BIOLOGY

Surfactant protein A expression and distribution in human lung samples from smokers with or without chronic obstructive pulmonary disease in China

(2020) Zhizhen Liu et al.   MEDICINE

CD44 Loss Disrupts Lung Lipid Surfactant Homeostasis and Exacerbates Oxidized Lipid-Induced Lung Inflammation

(2020) Yifei Dong et al.   Frontiers in Immunology

Surfactant Injury in the Early Phase of Severe Meconium Aspiration Syndrome

(2020) Chiara Autilio et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pulmonary surfactant protein SP-B nanorings induce the multilamellar organization of surfactant complexes

(2020) Marta Martinez-Calle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pulmonary alveolar proteinosis

(2019) Bruce C. Trapnell et al.   Nature Reviews Disease Primers

Phospholipid regulation of innate immunity and respiratory viral infection

(2019) Dennis R. Voelker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity

(2019) Ahmed A. Al-Qahtani et al.   IMMUNOBIOLOGY

Genetic causes of surfactant protein abnormalities

(2019) Lawrence M. Nogee   CURRENT OPINION IN PEDIATRICS

Quantitative Lipidomics in Pulmonary Alveolar Proteinosis

(2019) Matthias Griese et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alcohol-induced lipid dysregulation impairs glycolytic responses to LPS in alveolar macrophages

(2019) William S. Slovinsky et al.   ALCOHOL

Surfactant Protein B Deficiency Induced High Surface Tension: Relationship between Alveolar Micromechanics, Alveolar Fluid Properties and Alveolar Epithelial Cell Injury

(2019) Nina Rühl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine

(2019) Matthew C. Madison et al.   JOURNAL OF CLINICAL INVESTIGATION

Native supramolecular protein complexes in pulmonary surfactant: Evidences for SP-A/SP-B interactions

(2019) Marta Martínez-Calle et al.   Journal of Proteomics

Soluble defense collagens: Sweeping up immune threats

(2019) Cristina Casals et al.   MOLECULAR IMMUNOLOGY

Inhaled GM-CSF in neonatal mice provides durable protection against bacterial pneumonia

(2019) Elizabeth M. Todd et al.   Science Advances

Mechanism of IL‑8‑induced acute lung injury through pulmonary surfactant proteins A and B

(2019) Yinong Yang et al.   Experimental and Therapeutic Medicine

Reversal of Surfactant Protein B Deficiency in Patient Specific Human Induced Pluripotent Stem Cell Derived Lung Organoids by Gene Therapy

(2019) Sandra Lawrynowicz Leibel et al.   Scientific Reports

Pulmonary surfactant lipids inhibit infections with the pandemic H1N1 influenza virus in several animal models

(2019) Mari Numata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel therapeutic roles for surfactant-inositols and -phosphatidylglycerols in a neonatal piglet ARDS model: a translational study

(2018) Dietmar Spengler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair

(2018) Huiyan Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells

(2018) Marta Martínez-Calle et al.   FASEB JOURNAL

The Perturbation of Pulmonary Surfactant by Bacterial Lipopolysaccharide and Its Reversal by Polymyxin B: Function and Structure

(2018) Maros Kolomaznik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Homo- and hetero-oligomerization of hydrophobic pulmonary surfactant proteins SP-B and SP-C in surfactant phospholipid membranes

(2018) Elisa J. Cabré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The phospholipase A2activity of peroxiredoxin 6

(2018) Aron B. Fisher   JOURNAL OF LIPID RESEARCH

Paradoxical Bactericidal Effects of Hydrophobic Lung Surfactant Proteins and Their Peptide Mimics Using Liposome Molecular Trojan

(2018) Kunal Dutta et al.   Journal of Oleo Science

Inflammation in cystic fibrosis: An update

(2018) Erica A. Roesch et al.   PEDIATRIC PULMONOLOGY

Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS

(2018) Jamie R. Littlejohn et al.   PLoS One

The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus

(2018) I-Ni Hsieh et al.   Frontiers in Immunology

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis

(2018) Shin-Ichi Nureki et al.   JOURNAL OF CLINICAL INVESTIGATION

Programmed cell removal by calreticulin in tissue homeostasis and cancer

(2018) Mingye Feng et al.   Nature Communications

Surfactant protein D attenuates acute lung and kidney injuries in pneumonia-induced sepsis through modulating apoptosis, inflammation and NF-κB signaling

(2018) Juan Du et al.   Scientific Reports

The Role of Collectins and Galectins in Lung Innate Immune Defense

(2018) Cristina Casals et al.   Frontiers in Immunology

Phospholipid Remodeling in Physiology and Disease

(2018) Bo Wang et al.   Annual Review of Physiology

The micromechanics of lung alveoli: structure and function of surfactant and tissue components

(2018) Lars Knudsen et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins

(2018) Alastair Watson et al.   Journal of Innate Immunity

Involvement of Surfactant Protein D in Ebola Virus Infection Enhancement via Glycoprotein Interaction

(2018) Anne-Laure Favier et al.   Viruses-Basel

Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis

(2018) Bartosz Pilecki et al.   Frontiers in Immunology

Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD With Cystic Fibrosis

(2018) Zhenwu Lin et al.   Frontiers in Immunology

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

EMC3 coordinates surfactant protein and lipid homeostasis required for respiration

(2017) Xiaofang Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

ABCG1 regulates pulmonary surfactant metabolism in mice and men

(2017) Thomas Q. de Aguiar Vallim et al.   JOURNAL OF LIPID RESEARCH

Surfactant protein D regulates caspase-8-mediated cascade of the intrinsic pathway of apoptosis while promoting bleb formation

(2017) Pascal Djiadeu et al.   MOLECULAR IMMUNOLOGY

Pulmonary surfactant protein SP-D opsonises carbon nanotubes and augments their phagocytosis and subsequent pro-inflammatory immune response

(2017) Kirsten M. Pondman et al.   Nanoscale

Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver

(2017) Carlos M. Minutti et al.   SCIENCE

Evolutionary Convergence and Divergence in NLR Function and Structure

(2017) Etienne Meunier et al.   TRENDS IN IMMUNOLOGY

Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens

(2017) Soledad R. Ordonez et al.   Frontiers in Microbiology

Targeting cholesterol homeostasis in lung diseases

(2017) Anthony Sallese et al.   Scientific Reports

Surfactant Lipids at the Host–Environment Interface. Metabolic Sensors, Suppressors, and Effectors of Inflammatory Lung Disease

(2016) Michael B. Fessler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

(2016) Boon Chong Goh et al.   BIOCHEMISTRY

A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies

(2016) Nina Hobi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics

(2016) Nuria Roldan et al.   BIOPHYSICAL JOURNAL

Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films

(2016) Elena Lopez-Rodriguez et al.   BIOPHYSICAL JOURNAL

On the evolution of the pulmonary alveolar lipofibroblast

(2016) John S. Torday et al.   EXPERIMENTAL CELL RESEARCH

Crystal Structure of a Complex of Surfactant Protein D (SP-D) and Haemophilus influenzae Lipopolysaccharide Reveals Shielding of Core Structures in SP-D-Resistant Strains

(2016) Howard W. Clark et al.   INFECTION AND IMMUNITY

Surfactant protein A: A key player in lung homeostasis

(2016) Nadia Nathan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Surfactant Protein A Prevents IFN-γ/IFN-γ Receptor Interaction and Attenuates Classical Activation of Human Alveolar Macrophages

(2016) Carlos M. Minutti et al.   JOURNAL OF IMMUNOLOGY

A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6

(2016) Aron B. Fisher et al.   JOURNAL OF LIPID RESEARCH

Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling

(2016) Pitchaimani Kandasamy et al.   JOURNAL OF LIPID RESEARCH

Structure binding relationship of human surfactant protein D and various lipopolysaccharide inner core structures

(2016) Anika Reinhardt et al.   JOURNAL OF STRUCTURAL BIOLOGY

Surfactant Protein-D Is Essential for Immunity to Helminth Infection

(2016) Sumaiyya Thawer et al.   PLoS Pathogens

Serum Levels of Surfactant Proteins in Patients with Combined Pulmonary Fibrosis and Emphysema (CPFE)

(2016) Andriana I. Papaioannou et al.   PLoS One

Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease

(2015) Surafel Mulugeta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Palmitoylation as a key factor to modulate SP-C–lipid interactions in lung surfactant membrane multilayers

(2015) Nuria Roldan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol-mediated surfactant dysfunction is mitigated by surfactant protein A

(2015) Joshua Qua Hiansen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ABCA3 protects alveolar epithelial cells against free cholesterol induced cell death

(2015) Ralf Zarbock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hydrophobic Surfactant Proteins Strongly Induce Negative Curvature

(2015) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

(2015) Elisa Parra et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosisin vivo

(2015) Chiharu Ota et al.   EXPERIMENTAL LUNG RESEARCH

A model for the structure and mechanism of action of pulmonary surfactant protein B

(2015) Bárbara Olmeda et al.   FASEB JOURNAL

Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Specifically Interacts with Phospholipid Transfer Protein StarD10 to Facilitate Surfactant Phospholipid Trafficking in Alveolar Type II Cells

(2015) Sui Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS-induced clustering of CD14 triggers generation of PI(4,5)P2

(2015) A. P ociennikowska et al.   JOURNAL OF CELL SCIENCE

Natural Anti-Infective Pulmonary Proteins: In Vivo Cooperative Action of Surfactant Protein SP-A and the Lung Antimicrobial Peptide SP-BN

(2015) Juan Manuel Coya et al.   JOURNAL OF IMMUNOLOGY

Phosphatidylinositol inhibits respiratory syncytial virus infection

(2015) Mari Numata et al.   JOURNAL OF LIPID RESEARCH

Surfactant proteins in pediatric interstitial lung disease

(2015) Matthias Griese et al.   PEDIATRIC RESEARCH

SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation

(2015) Linlin Yang et al.   PLoS One

Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage

(2014) Sofie L. Johansson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Molecular biomarkers in idiopathic pulmonary fibrosis

(2014) Brett Ley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Identification and examination of a novel 9-bp insert/deletion polymorphism on porcineSFTPA1exon 2 associated with acute lung injury using an oleic acid-acute lung injury model

(2014) Yuebo Zhang et al.   ANIMAL SCIENCE JOURNAL

Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China

(2014) Hong-yi Yang et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Surfactant Protein A Binds to HIV and Inhibits Direct Infection of CD4+ Cells, but Enhances Dendritic Cell-Mediated Viral Transfer

(2014) G. D. Gaiha et al.   JOURNAL OF IMMUNOLOGY

Macrophage Dysfunction and Susceptibility to Pulmonary Pseudomonas aeruginosa Infection in Surfactant Protein C-Deficient Mice

(2014) S. W. Glasser et al.   JOURNAL OF IMMUNOLOGY

Orphan G Protein–Coupled Receptor GPR116 Regulates Pulmonary Surfactant Pool Size

(2013) James P. Bridges et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Persistence of LPS-Induced Lung Inflammation in Surfactant Protein-C–Deficient Mice

(2013) Stephan W. Glasser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Anionic Phospholipid Enables the Hydrophobic Surfactant Proteins to Alter Spontaneous Curvature

(2013) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

Hydrophobic Pulmonary Surfactant Proteins SP-B and SP-C Induce Pore Formation in Planar Lipid Membranes: Evidence for Proteolipid Pores

(2013) Elisa Parra et al.   BIOPHYSICAL JOURNAL

Efferocytosis and Lung Disease

(2013) Alexandra L. McCubbrey et al.   CHEST

Pulmonary surfactant protein A-induced changes in the molecular conformation of bacterial deep-rough LPS lead to reduced activity on human macrophages

(2013) Susanne P Keese et al.   Innate Immunity

Surfactant protein A binds TGF-β1 with high affinity and stimulates the TGF-β pathway

(2013) Coen HMP Willems et al.   Innate Immunity

Phosphatidylglycerol provides short-term prophylaxis against respiratory syncytial virus infection

(2013) Mari Numata et al.   JOURNAL OF LIPID RESEARCH

Surfactant Protein D Modulates HIV Infection of Both T-Cells and Dendritic Cells

(2013) Jens Madsen et al.   PLoS One

Lung Surfactant Levels are Regulated by Ig-Hepta/GPR116 by Monitoring Surfactant Protein D

(2013) Taku Fukuzawa et al.   PLoS One

18:1/18:1-Dioleoyl-phosphatidylglycerol prevents alveolar epithelial apoptosis and profibrotic stimulus in a neonatal piglet model of acute respiratory distress syndrome

(2013) Stefanie Preuß et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Poractant alfa (Curosurf.) increases phagocytosis of apoptotic neutrophils by alveolar macrophages in vivo

(2013) Coen HMP Willems et al.   RESPIRATORY RESEARCH

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

Protective Effect of Surfactant Protein D in Pulmonary Vaccinia Virus Infection: Implication of A27 Viral Protein

(2013) Julien Perino et al.   Viruses-Basel

Essential Regulation of Lung Surfactant Homeostasis by the Orphan G Protein-Coupled Receptor GPR116

(2013) Mi Young Yang et al.   Cell Reports

Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung

(2012) Blair R. Roszell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interfacial stress affects rat alveolar type II cell signaling and gene expression

(2012) Nina Hobi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Topology and lipid selectivity of pulmonary surfactant protein SP-B in membranes: Answers from fluorescence

(2012) Elisa J. Cabré et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surfactant phospholipid metabolism

(2012) Marianna Agassandian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Segregated ordered lipid phases and protein-promoted membrane cohesivity are required for pulmonary surfactant films to stabilize and protect the respiratory surface

(2012) Jorge Bernardino de la Serna et al.   FARADAY DISCUSSIONS

Pulmonary Surfactant Protein A Protects Lung Epithelium from Cytotoxicity of Human β-Defensin 3

(2012) Atsushi Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse Functions of Pulmonary Collectins in Host Defense of the Lung

(2012) Shigeru Ariki et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Differential Effects of the Hydrophobic Surfactant Proteins on the Formation of Inverse Bicontinuous Cubic Phases

(2012) Mariya Chavarha et al.   LANGMUIR

Anionic pulmonary surfactant lipid regulation of innate immunity

(2012) Mari Numata et al.   Expert Review of Respiratory Medicine

An Insight into the Diverse Roles of Surfactant Proteins, SP-A and SP-D in Innate and Adaptive Immunity

(2012) Annapurna Nayak et al.   Frontiers in Immunology

Interfacial sensing by alveolar type II cells: a new concept in lung physiology?

(2011) Andrea Ravasio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A combined action of pulmonary surfactant proteins SP-B and SP-C modulates permeability and dynamics of phospholipid membranes

(2011) Elisa Parra et al.   BIOCHEMICAL JOURNAL

A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant

(2011) Eleonora Keating et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lung Surfactant Protein SP-B Promotes Formation of Bilayer Reservoirs from Monolayer and Lipid Transfer between the Interface and Subphase

(2011) Svetlana Baoukina et al.   BIOPHYSICAL JOURNAL

Bacterial Lipopolysaccharide Promotes Destabilization of Lung Surfactant-Like Films

(2011) Olga Cañadas et al.   BIOPHYSICAL JOURNAL

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins

(2011) Taro Kawai et al.   EMBO Molecular Medicine

Innate Immune Collectin Surfactant Protein D Simultaneously Binds Both Neutrophil Extracellular Traps and Carbohydrate Ligands and Promotes Bacterial Trapping

(2011) D. N. Douda et al.   JOURNAL OF IMMUNOLOGY

Functional CD47/signal regulatory protein alpha (SIRPα) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo

(2011) Nicolas Legrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction

(2011) Helen Ilumets et al.   BMC Pulmonary Medicine

Hydrophobic Surfactant Proteins Induce a Phosphatidylethanolamine to Form Cubic Phases

(2010) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

Palmitoylation of Pulmonary Surfactant Protein SP-C Is Critical for Its Functional Cooperation with SP-B to Sustain Compression/Expansion Dynamics in Cholesterol-Containing Surfactant Films

(2010) Florian Baumgart et al.   BIOPHYSICAL JOURNAL

Combined and Independent Action of Proteins SP-B and SP-C in the Surface Behavior and Mechanical Stability of Pulmonary Surfactant Films

(2010) David Schürch et al.   BIOPHYSICAL JOURNAL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The molecular basis of pulmonary alveolar proteinosis

(2010) Brenna Carey et al.   CLINICAL IMMUNOLOGY

Surfactant Protein A2 Mutations Associated with Pulmonary Fibrosis Lead to Protein Instability and Endoplasmic Reticulum Stress

(2010) Meenakshi Maitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surfactant Protein A (SP-A)-mediated Clearance ofStaphylococcus aureusInvolves Binding of SP-A to the Staphylococcal Adhesin Eap and the Macrophage Receptors SP-A Receptor 210 and Scavenger Receptor Class A

(2010) Zvjezdana Sever-Chroneos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HumanizedSFTPA1andSFTPA2Transgenic Mice Reveal Functional Divergence of SP-A1 and SP-A2

(2010) Guirong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice

(2010) James P. Bridges et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

(2010) Anna D. Baker et al.   JOURNAL OF LIPID RESEARCH

Targeting Proteins to Liquid-Ordered Domains in Lipid Membranes†

(2010) Jeanne C. Stachowiak et al.   LANGMUIR

Collectins and fungal pathogens: roles of surfactant proteins and mannose binding lectin in host resistance

(2010) Elmer Brummer et al.   MEDICAL MYCOLOGY

Synthetic Surfactant Based on Analogues of SP-B and SP-C Is Superior to Single-Peptide Surfactants in Ventilated Premature Rabbits

(2010) Andreas Almlén et al.   Neonatology

The role of apoptosis in the pathophysiology of Acute Respiratory Distress Syndrome (ARDS): An up-to-date cell-specific review

(2010) Vasiliki Galani et al.   PATHOLOGY RESEARCH AND PRACTICE

Pulmonary Surfactant Pathophysiology: Current Models and Open Questions

(2010) Jesús Perez-Gil et al.   PHYSIOLOGY

Recent advances in alveolar biology: Evolution and function of alveolar proteins

(2010) Sandra Orgeig et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells

(2010) Anne Jäkel et al.   Protein & Cell

Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection

(2009) Stephan W. Glasser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of cholesterol in the biophysical dysfunction of surfactant in ventilator-induced lung injury

(2009) Dan Vockeroth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Surfactant Protein-B 121ins2 Heterozygosity, Reduced Pulmonary Function, and Chronic Obstructive Pulmonary Disease in Smokers

(2009) Marie Bækvad-Hansen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cholesterol modulates the exposure and orientation of pulmonary surfactant protein SP-C in model surfactant membranes

(2009) L. Gómez-Gil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surfactant Protein SP-B Strongly Modifies Surface Collapse of Phospholipid Vesicles: Insights from a Quartz Crystal Microbalance with Dissipation

(2009) Elisa J. Cabré et al.   BIOPHYSICAL JOURNAL

Pulmonary Surfactant Protein SP-C Counteracts the Deleterious Effects of Cholesterol on the Activity of Surfactant Films under Physiologically Relevant Compression-Expansion Dynamics

(2009) Leticia Gómez-Gil et al.   BIOPHYSICAL JOURNAL

The Closer we Look the more we See? Quantitative Microscopic Analysis of the Pulmonary Surfactant System

(2009) Matthias Ochs   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

P63 (CKAP4) as an SP-A Receptor: Implications for Surfactant Turnover

(2009) Sandra Bates   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes

(2009) Machiko Ikegami et al.   JOURNAL OF APPLIED PHYSIOLOGY

Cross-talk between Remodeling andde NovoPathways Maintains Phospholipid Balance through Ubiquitination

(2009) Phillip L. Butler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2

(2009) Koji Kuronuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Surfactant Protein B Propeptide Contains a Saposin-Like Protein Domain with Antimicrobial Activity at Low pH

(2009) L. Yang et al.   JOURNAL OF IMMUNOLOGY

Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains

(2009) Wondwossen Abate et al.   JOURNAL OF LIPID RESEARCH

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection

(2009) M. Numata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

(2008) Yongyu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

(2008) William J. Janssen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Surfactant Protein D Binds MD-2 through the Carbohydrate Recognition Domain†

(2008) Xiaomeng Nie et al.   BIOCHEMISTRY

Structure of pulmonary surfactant membranes and films: The role of proteins and lipid–protein interactions

(2008) Jesús Pérez-Gil   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influence of Lipid Saturation Grade and Headgroup Charge: A Refined Lung Surfactant Adsorption Model

(2008) U. Klenz et al.   BIOPHYSICAL JOURNAL

SP-A Permeabilizes Lipopolysaccharide Membranes by Forming Protein Aggregates that Extract Lipids from the Membrane

(2008) Olga Cañadas et al.   BIOPHYSICAL JOURNAL

Apoptosis in lung injury and fibrosis

(2008) F. Drakopanagiotakis et al.   EUROPEAN RESPIRATORY JOURNAL

Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome

(2008) Andreas Almlén et al.   JOURNAL OF APPLIED PHYSIOLOGY

Pulmonary Surfactant Protein D Inhibits Lipopolysaccharide (LPS)-induced Inflammatory Cell Responses by Altering LPS Binding to Its Receptors

(2008) Masami Yamazoe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse

(2007) Sandra R. Bates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants

(2007) Anatoly N. Mikerov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY