Article
Clinical Neurology
Abdulaziz T. Bako, Alan Pan, Thomas Potter, Jonika Tannous, Carnayla Johnson, Eman Baig, Jennifer Meeks, Daniel Woo, Farhaan S. Vahidy
Summary: This study reports contemporary trends in nationwide incidence of intracerebral hemorrhage (ICH), finding an increase in ICH incidence among young and middle-aged Americans, highlighting the need for prevention strategies.
Article
Clinical Neurology
Yan Wan, Hongxiu Guo, Jing Shen, Shaoli Chen, Man Li, Yuanpeng Xia, Lei Zhang, Zhou Sun, Xiaolu Chen, Jiang Chang, David Wang, Quanwei He, Bo Hu
Summary: This study investigates the impact of preonset anti-hypertensive therapy on the outcomes of intracerebral hemorrhage (ICH) and finds that it is associated with lower mortality, which somewhat depends on the hematoma volume.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Kay-Cheong Teo, Sze-Man Fong, William C. Y. Leung, Ian Y. H. Leung, Yuen-Kwun Wong, Olivia M. Y. Choi, Ka-Keung Yam, Rachel C. N. Lo, Raymond T. F. Cheung, Shu-Leong Ho, Anderson C. O. Tsang, Gilberto K. K. Leung, Koon-Ho Chan, Kui-Kai Lau
Summary: This study aimed to determine the ideal hematoma volume cutoff for different intracerebral hemorrhage (ICH) locations in predicting ICH outcomes. The results showed that location-specific volume cutoff should be considered in patient selection for ICH trials, as the outcomes differed based on the size of the hematoma in different locations.
Article
Clinical Neurology
Jay B. Lusk, Quintin J. Quinones, Janet S. Staats, Kent J. Weinhold, Peter M. Grossi, Shahid M. Nimjee, Daniel T. Laskowitz, Michael L. James
Summary: This study explores and validates the feasibility of an integrated hematoma evacuation and sample preservation system in patients with intracerebral hemorrhage (ICH). By using flow cytometry analysis, it is found that the composition of white blood cells in hematoma samples differs from that in peripheral blood of healthy controls, providing important insights into neuroinflammation associated with ICH.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Lei Song, Xiao-Ming Qiu, Ting-Ting Guo, Hang Zhou, Dong-Fang Tang, Long-Sheng Wang, Yu-Fei Fu, Hui Chen, Hua-Qing Mao, Hai-Bao Wang, Yong-Qiang Yu
Summary: The involvement of the posterior limb of the internal capsule in deep intracerebral hemorrhage is associated with hematoma expansion and may serve as a promising predictor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Jawed Nawabi, Qi Li, Andreas Charidimou, Marco Pasi, Frieder Schlunk, Ashkan Shoamanesh, Aristeidis H. Katsanos, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Andrew D. Warren, Michele Laudisi, Anna Cavallini, Edip M. Gurol, Anand Viswanathan, Andrea Zini, Ilaria Casetta, Enrico Fainardi, Steven M. Greenberg, Alessandro Padovani, Jonathan Rosand, Joshua N. Goldstein
Summary: Noncontrast computed tomography hypodensities are a valuable alternative to the computed tomography angiography spot sign and provide significant added value in the prediction of hematoma expansion in intracerebral hemorrhage.
Article
Clinical Neurology
Luyuan Li, Vaelan A. Molian, Scott C. Seaman, Mario Zanaty, Matthew A. Howard, Jeremy D. Greenlee, David M. Hasan, Enrique C. Leira
Summary: In this retrospective study, the addition of hematoma evacuation during decompressive hemicraniectomy for spontaneous intracerebral hemorrhage did not significantly alter functional outcomes at 6 months, suggesting that the surgical approach may not affect patient outcomes.
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Clinical Neurology
Anne Mrochen, Maximilian Spruegel, Stefan T. Gerner, Jochen A. Sembill, Stefan Lang, Hannes Luecking, Joji B. Kuramatsu, Hagen B. Huttner
Summary: The study found that thrombocytopenia does not significantly affect hematoma enlargement and functional outcomes in ICH patients, but may increase mortality risk in patients receiving antiplatelet therapy.
Article
Clinical Neurology
Eman Baig, Jonika Tannous, Thomas Potter, Alan Pan, Taya Prince, Gavin Britz, Farhaan S. Vahidy, Abdulaziz T. Bako
Summary: This study reveals that compared to acute ischemic stroke, the incidence of intracerebral hemorrhage is consistently higher during colder quarters, suggesting the importance of evaluating and preventing factors driving seasonal variations in intracerebral hemorrhage incidence.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Yunjie Li, Xia Liu, Shiling Chen, Jingyi Wang, Chao Pan, Gaigai Li, Zhouping Tang
Summary: Antiplatelet medications are increasingly used for the prevention of ischemic stroke, but they may also increase the risk of intracerebral hemorrhage (ICH). Restarting antiplatelet therapy after ICH is a complex decision that depends on the individual patient's risks of both thrombotic events and bleeding. More research is needed to determine the optimal timing for restarting antiplatelet therapy and to provide evidence-based guidelines for clinical decision-making.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Clinical Neurology
Yujie Wu, Donghang Zhang, Hongyang Chen, Bin Liu, Cheng Zhou
Summary: This study found that prior use of antiplatelet therapy in patients with intracerebral hemorrhage is associated with a slightly increased mortality rate, but does not affect poor functional outcomes or hematoma expansion.
FRONTIERS IN NEUROLOGY
(2021)
Review
Endocrinology & Metabolism
Zexu Wang, Jie Wang, Jiayan Wang, Yinghua Liao, Xin Hu, Manni Wang
Summary: This study summarized the relationship between obesity and mortality after intracerebral hemorrhage (ICH). The findings suggest that obesity may be associated with lower mortality in ICH, reflecting the obesity paradox in this disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Clinical Neurology
Sunjoo Cho, Ashish K. Rehni, Kunjan R. Dave
Summary: Studies have shown that smokers have a higher risk of sICH, as smoking not only increases the risk of sICH but also leads to hematoma growth, worse outcomes, and higher risk of death from sICH.
Article
Clinical Neurology
Jiao Qin, Haihua Wei, Yuling Liu, Lixin Du, Jun Xia
Summary: The study showed an association between leukocyte subpopulations and hematoma expansion in Chinese individuals with spontaneous intracerebral hemorrhage. Elevated monocyte count was found to increase the risk of hematoma expansion, while increased neutrophil count was associated with a decreased risk. Adjusting for coagulation parameters revealed the importance of monocyte count in risk stratification for hematoma expansion.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Antonio Muscari, Giampaolo Bianchi, Paola Forti, Donatella Magalotti, Paolo Pandolfi, Marco Zoli
Summary: NT-proBNP is the best indicator of biological age, which can be estimated by simple formulas and might be used for prognostic purposes or as a surrogate end point in epidemiological and intervention studies.
Article
Geriatrics & Gerontology
Antonio Muscari, Giampaolo Bianchi, Paola Forti, Donatella Magalotti, Paolo Pandolfi, Marco Zoli
Summary: The study indicates that proBNPage is associated with manifestations of cardiovascular and noncardiovascular aging processes, and in some cases, the association is stronger than that of chronological age.
Article
Acoustics
Michele Domenico Spampinato, Andrea Sposato, Maria Teresa Migliano, Giovanni Gordini, Vincenzo Bua, Soccorsa Sofia
Summary: This study aimed to evaluate the diagnostic and prognostic characteristics of lung ultrasound in patients with suspected COVID-19. Results showed that COVID-19 patients had higher mortality rates and Lung Ultrasound Severity Index scores, with the index demonstrating the ability to distinguish between positive and negative cases and predict in-hospital mortality.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Microbiology
Matteo Guarino, Benedetta Perna, Francesca Remelli, Francesca Cuoghi, Alice Eleonora Cesaro, Michele Domenico Spampinato, Martina Maritati, Carlo Contini, Roberto De Giorgio
Summary: This study compared the MqSOFA score with the NEWS-2 score in predicting in-hospital mortality and 30-days mortality of COVID-19 patients. The results showed that both scores were equally effective in predicting mortality, but the MqSOFA score was easier to use and better suited for emergency settings. However, neither score was able to predict the recovery setting.
Article
Clinical Neurology
Michele Romoli, Elena Merli, Simone Galluzzo, Lorenzo Muccioli, Stefania Testoni, Anna Zaniboni, Sara Contardi, Luigi Simonetti, Paolo Tinuper, Andrea Zini
Summary: This pilot case-control study aims to investigate the diagnostic value of reverse Tmax (rTmax) in differentiating nonconvulsive status epilepticus (NCSE) from acute ischemic stroke in the hyperacute setting. The study found that rTmax mapping could accurately predict NCSE versus stroke in the hyperacute setting, indicating its potential as a reliable tool for detecting NCSE-induced hyperperfusion.
Article
Microbiology
Matteo Guarino, Benedetta Perna, Francesca Cuoghi, Michele Domenico Spampinato, Alice Eleonora Cesaro, Francesca Manza, Adriana Pretula, Anastasio Grilli, Martina Maritati, Giacomo Caio, Aldo Carnevale, Maria Elena Flacco, Roberto De Giorgio, Carlo Contini
Summary: This study aimed to explore the existence of bacterial co-infections in patients with COVID-19 and their impact on clinical manifestations. The results showed that patients with Chlamydia pneumoniae or Mycoplasma pneumoniae co-infections had worse respiratory/radiological features and higher rates of intensive care unit admissions compared to those infected with SARS-CoV-2 alone. However, the co-infection did not result in a higher mortality rate.
Article
Medicine, General & Internal
Michele Domenico Spampinato, Marcello Covino, Angelina Passaro, Matteo Guarino, Beatrice Marziani, Caterina Ghirardi, Adelina Ricciardelli, Irma Sofia Fabbri, Andrea Strada, Antonio Gasbarrini, Francesco Franceschi, Roberto De Giorgio
Summary: This study compares the accuracy of ABCD(2), ABCD(2)-I, and OTTAWA scores in predicting the risk of stroke after TIA. The results show that clinical scores have moderate prognostic accuracy for stroke after TIA, and suggest the need for further research and development of new predictive tools.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Antonio Muscari, Roberta Falcone, Guerino Recinella, Luca Faccioli, Paola Forti, Marco Pastore Trossello, Giovanni M. Puddu, Luca Spinardi, Marco Zoli
Summary: Hyperglycemic non-diabetic stroke patients have a worse prognosis, but this group is not associated with mortality or disability.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Soccorsa Sofia, Paolo Orlandi, Vincenzo Bua, Michele Imbriani, Laura Cecilioni, Alessandra Caruso, Cosima Schiavone, Andrea Boccatonda, Antonella Cianci, Michele Domenico Spampinato
Summary: This study analyzed the diagnostic accuracy of lung ultrasonography (LUS) and high-resolution computed tomography (HRCT) in detecting COVID-19. The results showed that both LUS and HRCT could detect signs of COVID-19, and LUS had a high sensitivity for COVID-19, which could effectively exclude COVID-19 infection.
JOURNAL OF DIAGNOSTIC MEDICAL SONOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Matteo Guarino, Benedetta Perna, Alice Eleonora Cesaro, Michele Domenico Spampinato, Rita Previati, Anna Costanzini, Martina Maritati, Carlo Contini, Roberto De Giorgio
Summary: This study found that capillary lactates can reliably predict 48-hour and 7-day mortality rates in sepsis patients, making them a valuable tool due to their affordability, speed, and reliability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Sossio Serra, Michele Domenico Spampinato, Alessandro Riccardi, Mario Guarino, Rita Pavasini, Andrea Fabbri, Fabio De Iaco
Summary: This systematic review examined the efficacy and safety of intranasal fentanyl (INF) for acute pain treatment in children, adults, and the elderly in prehospital emergency services (PHES) and emergency departments (ED). A total of 23 studies were included in the review, and the findings suggest that INF is effective and safe in both children and adults in PHES and ED settings. However, more high-quality studies are needed, particularly in the prehospital emergency services and older people.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Alessandro Riccardi, Mario Guarino, Sossio Serra, Michele Domenico Spampinato, Simone Vanni, Dana Shiffer, Antonio Voza, Andrea Fabbri, Fabio De Iaco
Summary: Pain is a common reason for medical consultations and emergency department visits. Ketamine, a drug initially used for sedation and anesthesia, has emerged as a versatile tool for pain management. However, its psychomimetic effects have limited its use in emergency departments. This narrative review discusses ketamine's role as an analgesic, its strengths and weaknesses, and the use of additional drugs for improving analgesia and treating side effects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sossio Serra, Michele Domenico Spampinato, Alessandro Riccardi, Mario Guarino, Andrea Fabbri, Luciano Orsi, Fabio De Iaco
Summary: This review aimed to identify literature on the management of severe end-of-life (EOL) pain in the emergency department (ED) and included 9 articles out of 532 identified. The included studies showed no evidence for a better approach for EOL patients with pain in the ED. The review provides recommendations for clinical practice, including the identification of EOL patients and unmet palliative care needs, multidimensional assessment of pain, multidisciplinary approach to management, and management of special situations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Matteo Guarino, Benedetta Perna, Alice Eleonora Cesaro, Martina Maritati, Michele Domenico Spampinato, Carlo Contini, Roberto De Giorgio
Summary: This review aims to update physicians on the main pillars of treatment for sepsis/septic shock, which include empirical antimicrobial treatment, fluid replacement, and the use of vasoactive agents. Other treatments such as mechanical ventilation, anticoagulation, and glycemic control are also recommended but their efficacy is debated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Matteo Guarino, Benedetta Perna, Martina Maritati, Francesca Remelli, Caterina Trevisan, Michele Domenico Spampinato, Anna Costanzini, Stefano Volpato, Carlo Contini, Roberto De Giorgio
Summary: This study aims to establish the correlation between PSP and COVID-19 severity. Analysis of a study population of 1373 COVID-19 patients showed that presepsin is a promising biomarker that can express COVID-19 severity.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)