Article
Oncology
Yoshihisa Tokumaru, Masanori Oshi, Ankit Patel, Eriko Katsuta, Li Yan, Fernando A. Angarita, Subhamoy Dasgupta, Masayuki Nagahashi, Nobuhisa Matsuhashi, Manabu Futamura, Kazuhiro Yoshida, Kazuaki Takabe
Summary: MiR-195 is a tumor suppressive microRNA that has been studied in breast cancer using data from two cohorts, showing that low expression of miR-195 is associated with aggressive cancer characteristics and poor prognosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Shipra Gandhi, Masanori Oshi, Vijayashree Murthy, Elizabeth A. Repasky, Kazuaki Takabe
Summary: High-thermogenesis triple-negative breast cancer (TNBC) is associated with a pro-tumor immune microenvironment and may serve as a biomarker for testing strategies to overcome this immunosuppression.
Article
Oncology
Dong Dong, Wei Wang, Heng Wang, Liang Chen, Tianyi Liu
Summary: This study comprehensively evaluated the expression pattern of immune-related genes in cutaneous melanoma and their correlation with the tumor immune microenvironment. The study identified three immune subtypes with different survival outcomes and found that IRGscore can serve as an independent predictor for immunotherapy and prognosis in melanoma patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tao Zhou, Kai Qian, Yun-Yun Li, Wen-Ke Cai, Sun-Jun Yin, Ping Wang, Gong-Hao He
Summary: This study systematically investigated the functions and clinical prognostic value of pyroptosis-related genes (PRGs) in acute myeloid leukemia (AML). The results showed that these genes were associated with AML prognosis and could serve as independent predictors. Furthermore, these genes were also associated with the tumor immune microenvironment and drug sensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Zijun Zhao, Zairan Wang, Zihan Song, Yue Wu, Qianxu Jin, Zongmao Zhao
Summary: This study systematically analyzed the role of the STEAP family in glioma and established risk models based on STEAP gene expression to independently predict the prognosis and treatment response of glioma patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Rongrong Wu, Joy Sarkar, Yoshihisa Tokumaru, Yamato Takabe, Masanori Oshi, Mariko Asaoka, Li Yan, Takashi Ishikawa, Kazuaki Takabe
Summary: Lymphangiogenesis plays a crucial role in the occurrence and development of breast cancer. High-iLEC breast cancer is associated with enriched lymphangiogenesis, angiogenesis, inflammatory response, and immune response-related gene sets, along with more stromal cells and fewer anti-cancer immune cells. However, the quantity of iLECs is not related to patient survival or lymph node metastasis. Low-iLEC breast cancer, on the other hand, is associated with cancer cell proliferation and an abundance of pro-cancer immune cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Wei Chen, Min-Yu Wen, Kai-Bin Yang, Li-Tao Zheng, Xuan Li
Summary: This study constructed a novel prognostic biomarker (PEPScore) based on pyroptosis-related genes to predict overall survival and guide therapy selection for lung squamous cell carcinoma (LUSC) patients. The low-PEPScore subgroup had better overall survival, higher mutation rate, and increased immune cell infiltration, indicating potential benefits from chemotherapy, immunotherapy, and radiotherapy.
FRONTIERS IN GENETICS
(2022)
Article
Clinical Neurology
Zhengye Jiang, Yanxi Shi, Wenpeng Zhao, Yaya Zhang, Yuanyuan Xie, Bingchang Zhang, Guowei Tan, Zhanxiang Wang
Summary: This study identified key genes in the TME that affect the prognosis of GBM by analyzing transcriptome profiles and conducting functional enrichment analysis. Higher immune and stromal scores were found to be correlated with tissue type and overall survival of GBM. A total of 48 hub genes were identified to be associated with GBM prognosis, and 14 antitumor drugs targeting these genes were evaluated for efficacy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Zuhui Pu, Qing Zhao, Jiaqun Chen, Yubin Xie, Lisha Mou, Xushan Zha
Summary: A 5-CSIRG signature that is closely related to the overall survival of melanoma patients was established using single-cell sequencing. A nomogram combining CSIRGs and clinical features was also constructed. Both the 5-CSIRG signature and nomograms can accurately predict the survival of melanoma patients and guide treatment decisions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zijun Zhao, Yue Wu, Zairan Wang, Jiayi Xu, Yizheng Wang, Zongmao Zhao
Summary: The study identified key autophagy-related genes in glioma and found a link between high-risk population and poor prognosis as well as an immune-inhibitory microenvironment. GSEA results showed that high-risk population was closely related to DNA repair and hypoxia pathways. 14 candidate drugs for the high-risk population were identified through CMap analysis.
Article
Oncology
Danlei Song, Yongjian Wei, Yuping Hu, Yueting Sun, Min Liu, Qian Ren, Zenan Hu, Qinghong Guo, Yuping Wang, Yongning Zhou
Summary: The identification of immunophenotypes in our study provides new therapeutic strategies for patients with ESCC.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Can Chen, Lin-Yuan Chen, Jie-Xin Zhang, Hua-Guo Xu
Summary: Recently, the prognostic value of m5C in ccRCC has been revealed, but its effect on immune infiltration and immunotherapeutic response remains unknown. By evaluating the m5C modification patterns in 530 ccRCC tumor samples, we identified three different patterns corresponding to different immune phenotypes. The m5Cscore calculated based on these patterns can predict patient prognosis and response to immune checkpoint inhibitors.
Article
Cell Biology
Xianxiong Ma, Hengyu Chen, Ming Yang, Zunxiang Ke, Mengyi Wang, Tao Huang, Lei Li
Summary: Through multidimensional genome-scale analyses, this study identified three immune subtypes of ER+ BC, with C2 showing up-regulated immune cell signatures and immune checkpoint genes, and being more sensitive to immunosuppressive agents.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Qi Tian, Huan Gao, Wen Zhao, Yan Zhou, Jin Yang
Summary: The study aimed to understand the SKCM microenvironment and develop an immune prognostic signature to predict patient outcomes. Through genetic analysis, patients were classified into three groups, with immune-related genes showing higher expression in the immune-high group. The prognostic model demonstrated strong predictive ability for SKCM patient outcomes.
Article
Oncology
Yao Wu, Qing Yin, Ya-Ling Zhou, Lei He, Zhi-Qing Zou, Xiao-Yue Dai, Wen Xia
Summary: This study aimed to investigate the potential risk of circulating HPV-DNA in NSCLC and analyze the abnormally expressed miRNAs in circulating HPV-DNA-positive NSCLC. Circulating HPV-DNA was found in 16 NSCLC patients, with higher levels of miR-183, miR-210, and miR-182, and lower levels of miR-144 compared to HPV-DNA-negative patients. Using miR-210 had the highest AUC for identifying circulating HPV-DNA-positive NSCLC patients, and the combination of miR-210 and miR-144 showed the best predictive performance. These findings suggest that circulating HPV-DNA could be a risk factor in NSCLC, and plasma miR-183, miR-210, miR-182, and miR-144 can be reliable biomarkers for identifying circulating HPV-DNA-positive NSCLC.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Nitai C. Hait, Aparna Maiti, Rongrong Wu, Valerie L. Andersen, Chang-Chieh Hsu, Yun Wu, Digantkumar G. Chapla, Kazuaki Takabe, Michael E. Rusiniak, Wiam Bshara, Jianmin Zhang, Kelley W. Moremen, Joseph T. Y. Lau
Summary: Our study found that extracellular ST6GAL1 can compensate for insufficient cellular ST6GAL1, promoting cancer cell proliferation and invasiveness. Moreover, we identified novel cofactors in the exosome-like particles that amplify the action of extrinsic ST6GAL1. Overall, this study reveals the importance of ST6GAL1 in tumor pathobiology.
CANCER GENE THERAPY
(2022)
Article
Oncology
Rongrong Wu, Arya Mariam Roy, Yoshihisa Tokumaru, Shipra Gandhi, Mariko Asaoka, Masanori Oshi, Li Yan, Takashi Ishikawa, Kazuaki Takabe
Summary: Tumor dormancy is an important mechanism for late breast cancer recurrence. This study investigates the clinical relevance of NR2F1 expression, a known biomarker for dormancy. The results show that high NR2F1 expression in breast cancer is associated with enriched metastasis and stem cell-related pathways, as well as suppressed cell proliferation. Furthermore, NR2F1 is predominantly expressed in cancer-associated fibroblasts, rather than in cancer cells.
Article
Biochemistry & Molecular Biology
Eriko Katsuta, Kazuaki Takabe, Marija Vujcic, Philip A. Gottlieb, Tao Dai, Arnaldo Mercado-Perez, Arthur Beyder, Qingfei Wang, Mateusz Opyrchal
Summary: High expression of PIEZO2 in breast cancer, particularly in triple-negative breast cancer (TNBC), is associated with worse clinical outcomes. Activation of PIEZO2 leads to increased cell motility and invasive phenotypes, as well as the upregulation of epithelial-mesenchymal transition (EMT)-related genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Fernando A. Angarita, Robert Brumer, Matthew Castelo, Nestor F. Esnaola, Stephen B. Edge, Kazuaki Takabe
Summary: De-escalation of breast cancer treatment can reduce morbidity and improve patients' quality of life. It is considered safe if the cancer outcomes are not affected compared to more aggressive treatments. This review provides an overview of de-escalation in the treatment of ductal carcinoma in situ (DCIS), local treatment of breast cancer, and surgery after neoadjuvant systemic therapy. Advancements in understanding the natural history and biology of breast cancer, imaging techniques, and adjuvant treatments have allowed for the reduction of treatment intensity. Identifying appropriate areas for de-escalation is crucial to minimize side effects while maintaining cancer outcomes. Less aggressive treatment modalities, or even no treatment, have been reconsidered if they achieve similar oncologic results as standard therapies. Careful consideration is needed to identify which patients benefit from de-escalation, as standard therapies still offer adequate cancer outcomes. This review highlights the importance of investigating de-escalation in breast cancer treatment, with future efforts aiming to clarify the role of different treatment modalities.
Editorial Material
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accumulated in cholestasis accelerate the growth of pancreatic cancer (PC) through S1PR2, indicating S1PR2 as a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Cell Biology
Irene Yu, Anthony Dakwar, Kazuaki Takabe
Summary: Immunotherapy has shown significant progress in the treatment of colorectal cancer (CRC) in the past decade. Immune checkpoint inhibitors have been particularly effective in improving patient outcomes in a specific subset of CRC. The efficacy and timing of immunotherapy for other subsets of CRC have gained attention, and this review discusses the latest advances and future directions for three main classes of immunotherapy for CRC: immune checkpoint inhibitors, adoptive cell transfer therapy, and tumor vaccines.
Article
Biochemistry & Molecular Biology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: Lysophosphatidic acid receptors (LPARs) play a role in promoting tumorigenesis and therapy resistance in various cancer subtypes. Our study found that increased expression of LPAR1, LPAR4, and LPAR6 correlated with a less aggressive phenotype, while high expression of LPAR2 was associated with increased tumor grade, mutational burden, and decreased survival. Different LPARs were also expressed in different cell types, suggesting potential compensatory signaling in LPAR inhibitor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Kohei Chida, Masanori Oshi, Arya Mariam Roy, Takafumi Yachi, Masaki Nara, Kyogo Yamada, Osamu Matsuura, Tadashi Hashizume, Itaru Endo, Kazuaki Takabe
Summary: This study found that the E2F target score, reflecting the activity of E2F target genes, is associated with the aggressiveness and prognosis of hepatocellular carcinoma. High E2F target score is associated with tumor grade, size, staging, proliferation score, MKI67 expression, as well as reduced abundance of hepatocytes and stromal cells. It is also associated with higher intratumoral genomic heterogeneity, homologous recombination deficiency, and progression of hepatocellular carcinoma.
Article
Oncology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: The lipid phosphate phosphatases (LPPs) are enzymes that regulate signaling in cells. Imbalance of LPP expression levels, with decreased LPP1/3 and increased LPP2, is associated with worse tumor biology, immune system evasion, and decreased survival in breast cancers. Most tumor LPP1/3 is produced by the stroma and LPP2 by cancer cells. Restoring the balance in LPP expression levels, particularly through LPP2 inhibition, could provide adjunct therapies for breast cancer patients.
Article
Oncology
Masanori Oshi, Danya Ziazadeh, Rongrong Wu, Kohei Chida, Akimitsu Yamada, Shinya Yamamoto, Kazutaka Narui, Li Yan, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
Summary: In this study, we identified a gene GALNT1 that is associated with poor prognosis in breast cancer patients specifically in the adolescent and young adult population. This finding provides new insights for the treatment of young patients.
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accelerate the growth of S1PR2 predominant pancreatic cancer, suggesting that S1PR2 may be a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Abhisha Sawant Dessai, Nadya Elhalawany, Eriko Katsuta, Christian Prechtl, Spencer Rosario, Bert W. O'Malley, Xiang H. Zhang, Subhamoy Dasgupta
Article
Oncology
Yasuaki Uemoto, Eriko Katsuta, Naoto Kondo, Yumi Wanifuchi-Endo, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Mitsuo Terada, Akiko Kato, Katsuhiro Okuda, Hiroshi Sugiura, Masayuki Komura, Hiroyuki Kato, Satoshi Osaga, Satoru Takahashi, Tatsuya Toyama
Summary: HECTD1 mRNA expression is significantly decreased in breast cancer tissues and is associated with aggressive tumor characteristics and poor prognosis in breast cancer patients. HECTD1 expression is inversely correlated with genes involved in mitochondrial cellular respiratory function in breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Eriko Katsuta, Abhisha Sawant Dessai, John M. L. Ebos, Li Yan, Toru Ouchi, Kazuaki Takabe
Summary: The phosphorylated histone variant, gamma-H2AX, plays a key role in breast cancer, and its high expression is associated with increased DNA repair, cell proliferation, metastasis, and worse survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)