Article
Oncology
Yoshihisa Tokumaru, Masanori Oshi, Ankit Patel, Eriko Katsuta, Li Yan, Fernando A. Angarita, Subhamoy Dasgupta, Masayuki Nagahashi, Nobuhisa Matsuhashi, Manabu Futamura, Kazuhiro Yoshida, Kazuaki Takabe
Summary: MiR-195 is a tumor suppressive microRNA that has been studied in breast cancer using data from two cohorts, showing that low expression of miR-195 is associated with aggressive cancer characteristics and poor prognosis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Sihan Chen
Summary: This study identified tumor microenvironment-related gene sets and core genes in glioma through data analysis. These genes have the potential to become targets for targeted therapies and disease detection in glioma.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Manabu Futamura, Yoshihisa Tokumaru, Kazuaki Takabe, Hirofumi Arakawa, Yoshimi Asano, Ryutaro Mori, Junichi Mase, Akira Nakakami, Kazuhiro Yoshida
Summary: The study demonstrates that MIEAP expression is downregulated in breast cancer patients, especially those with p53 mutations. Patients with high MIEAP expression have longer disease-free survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Clinical Neurology
Gang Zhu, Shirong Yang, Ronglin Wang, Jie Lei, Peigang Ji, Jiancai Wang, Kai Tao, Chen Yang, Shunnan Ge, Liang Wang
Summary: miR-154 acts as a biomarker in GBM by inhibiting migration, invasion, and EMT of GBM cells through targeting TCF12, suggesting the potential therapeutic target for GBM lies in the p53/miR-154/TCF12 pathway.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Genetics & Heredity
Lin Han, Yanjun Sun, Cansheng Lu, Chungeng Ma, Jian Shi, Dengqun Sun
Summary: MiR-3614-5p is associated with colorectal cancer, with low expression predicting poor survival rate and correlating with N, M, pathologic stage, neoplasm type, and lymphatic invasion. High expression enriches the P53 pathway and enhances NK T cell activation.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Weronika Tomaszewska, Joanna Kozlowska-Maslon, Dawid Baranowski, Anna Perkowska, Sandra Szalkowska, Urszula Kazimierczak, Patricia Severino, Katarzyna Lamperska, Tomasz Kolenda
Summary: The study found that miR-154-5p and miR-154-3p are downregulated in head and neck squamous cell carcinoma samples, associated with tumor growth, cancer staging, grading, HPV p16 status, and immune response. Additionally, elevated levels of miR-154 are linked to upregulated AKT-MTOR, CYCLIN D1, KRAS, EIF4E, RB, ATM, and EMT gene sets, indicating a potential role in pathogenesis, invasion, and immune response in HNSCC.
Article
Biochemistry & Molecular Biology
Sophie Mockly, Elisabeth Houbron, Herve Seitz
Summary: miR-34a does not meet the definition of tumor suppressor miRNAs, as it is not down-regulated in primary tumors and does not exhibit anti-tumorigenic activity. Therefore, synthetic administration of miR-34a is not efficient against solid tumors.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Babar Khan, Rosamaria Ruggieri, Eesha Jamil, Nhan L. Tran, Camila Gonzalez, Nancy Mugridge, Steven Gao, Jennifer MacDiarmid, Himanshu Brahmbhatt, Jann N. Sarkaria, John Boockvar, Marc Symons
Summary: The study suggests that microRNA-34a can effectively reduce the activation status of glioblastoma cells and enhance survival rates against multiple glioblastoma cell types. Combination therapy of temozolomide with microRNA-34a loaded nanocells targeted to epidermal growth factor receptor (EGFR) significantly enhances sensitivity of glioblastoma cells to treatment.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wei Feng Ma, Howard E. Boudreau, Thomas L. Leto
Summary: The study demonstrates that NOX4 is associated with cancer progression and patient survival, with TP53 mutations potentially switching the role of NOX4 in predicting prognosis.
Article
Biochemistry & Molecular Biology
Zekai Huang, Markus Kaller, Heiko Hermeking
Summary: miR-34a and miR-34b/c, as direct targets of p53, play a crucial role in the tumor suppressive effects of p53. Inactivating miR-34a and/or miR-34b/c in colorectal cancer cell line HCT116 had significant effects on proliferation, migration, invasion, chemosensitivity, autophagy, and apoptosis. The concomitant deletion of miR-34a and miR-34b/c resulted in EMT signature enrichment, impaired gene repression by the p53-DREAM pathway, and elevated autophagy. A gene signature upregulated in cells with combined inactivation of miR-34a and miR-34b/c was associated with invasive colon cancer subtype CMS4, poor overall survival in CRC patients, and 5-FU resistance in CRC cell lines.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Chunfeng Liu, Matjaz Rokavec, Zekai Huang, Heiko Hermeking
Summary: This study reveals that curcumin can activate the KEAP1/NRF2/ARE pathway and induce ROS to upregulate the expression of miR-34 in colorectal cancer cells. Curcumin can also inhibit migration and invasion of cancer cells and promote mesenchymal-epithelial transition by activating this pathway. Therefore, activation of the KEAP1/NRF2/miR-34 axis may contribute to the tumor suppressive effects of curcumin.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Environmental Sciences
Rili Hao, Xinyu Song, Dongxiao Sun-Waterhouse, Xintong Tan, Feng Li, Dapeng Li
Summary: The study found that cadmium can induce renal damage in mice through inflammation and apoptosis via the miR-34a/Sirt1/p53 axis. This is the first report on the role of miR-34a/Sirt1/p53 axis in regulating cadmium-induced apoptosis and nephrotoxicity in mice, providing new insights into miRNA-based regulation of heavy metal induced-nephrotoxicity.
ENVIRONMENTAL POLLUTION
(2021)
Article
Oncology
Narjes Jafari, Saeid Abediankenari, Hadi Hossein-Nataj
Summary: The study revealed that the effect of miR mimic in target gene repression may depend on its concentration and cell type, while pre-miRNAs may have a regulatory function in target repression. These findings will help to develop effective therapeutic strategies in cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Junhua Gong, Minghua Cong, Hao Wu, Menghao Wang, He Bai, Jingyuan Wang, Keting Que, Kaiwen Zheng, Wenfeng Zhang, Xiaoli Yang, Jianping Gong, Hanping Shi, Mingyong Miao, Fangchao Yuan
Summary: The study investigates the role of the p53/miR-34a/SIRT1 positive feedback loop in the termination of liver regeneration and its potential relationship with liver cancer. The overexpression of p53 or miR-34a terminates liver regeneration early and enhances the proapoptotic effect of the positive feedback loop. Additionally, the positive feedback loop is inhibited in hepatocellular carcinoma (HCC) patients with P53 mutations.
Article
Biochemistry & Molecular Biology
Matjaz Rokavec, Zekai Huang, Heiko Hermeking
Summary: This study conducted a comprehensive integrative meta-analysis of multiple computational and experimental miR-34 related datasets, and developed tools to identify and characterize novel miR-34 targets. The meta-analysis results were integrated into a user-friendly website, METAmiR34TARGET, which allows for the prediction of relevant miR-34 targets using expression data obtained from cell lines and tumors/tissues. The website also includes information on more than 200 experimentally validated miR-34 target mRNAs. This research is important for further understanding the role of the p53/miR-34 connection in tumor suppression and for identifying potential cancer drug targets.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Oncology
James D. Hampton, Erica J. Peterson, Samantha J. Katner, Tia H. Turner, Mohammad A. Alzubi, J. Chuck Harrell, Mikhail G. Dozmorov, Joseph B. McGee Turner, Pam J. Gigliotti, Vita Kraskauskiene, Mayuri Shende, Michael O. Idowu, Madhavi Puchalapalli, Bin Hu, Larisa Litovchick, Eriko Katsuta, Kazuaki Takabe, Nicholas P. Farrell, Jennifer E. Koblinski
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer without targetable biomarkers. This study found that sGAG levels can predict the sensitivity of TNBC to Triplatin, a platinum agent. Triplatin showed significant antitumor efficacy in TNBC models with high levels of sGAGs, even in carboplatin-resistant tumors. Improved neoadjuvant and adjuvant treatments may enhance the clinical outcome of TNBC.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Rongrong Wu, Ankit Patel, Yoshihisa Tokumaru, Mariko Asaoka, Masanori Oshi, Li Yan, Takashi Ishikawa, Kazuaki Takabe
Summary: RAD51 gene expression is associated with aggressive cancer biology, cancer cell proliferation, and poor survival in breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Masanori Oshi, Shipra Gandhi, Li Yan, Yoshihisa Tokumaru, Rongrong Wu, Akimitsu Yamada, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: The study aimed to investigate the clinical relevance of reactive oxygen species (ROS) in the breast cancer tumor microenvironment. The results showed that high ROS levels were significantly associated with cell proliferation-related genes, pro-cancer genes, immune-related genes, infiltrated immune cells, and increased cytolytic activity. High ROS was also associated with intratumor heterogeneity, mutation rates, immune response, and worse survival outcomes.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Review
Oncology
Ravi Kumar Gupta, Arya Mariam Roy, Ashish Gupta, Kazuaki Takabe, Ajay Dhakal, Mateusz Opyrchal, Pawel Kalinski, Shipra Gandhi
Summary: This article summarizes emerging opportunities to use less toxic therapies in early-stage triple-negative breast cancer (TNBC), providing a personalized approach for patients. It reviews completed and ongoing clinical trials and provides guidance on stratifying patients to maximize benefits without unnecessary toxicities.
Editorial Material
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accumulated in cholestasis accelerate the growth of pancreatic cancer (PC) through S1PR2, indicating S1PR2 as a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Cell Biology
Irene Yu, Anthony Dakwar, Kazuaki Takabe
Summary: Immunotherapy has shown significant progress in the treatment of colorectal cancer (CRC) in the past decade. Immune checkpoint inhibitors have been particularly effective in improving patient outcomes in a specific subset of CRC. The efficacy and timing of immunotherapy for other subsets of CRC have gained attention, and this review discusses the latest advances and future directions for three main classes of immunotherapy for CRC: immune checkpoint inhibitors, adoptive cell transfer therapy, and tumor vaccines.
Article
Biochemistry & Molecular Biology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: Lysophosphatidic acid receptors (LPARs) play a role in promoting tumorigenesis and therapy resistance in various cancer subtypes. Our study found that increased expression of LPAR1, LPAR4, and LPAR6 correlated with a less aggressive phenotype, while high expression of LPAR2 was associated with increased tumor grade, mutational burden, and decreased survival. Different LPARs were also expressed in different cell types, suggesting potential compensatory signaling in LPAR inhibitor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Kohei Chida, Masanori Oshi, Arya Mariam Roy, Takafumi Yachi, Masaki Nara, Kyogo Yamada, Osamu Matsuura, Tadashi Hashizume, Itaru Endo, Kazuaki Takabe
Summary: This study found that the E2F target score, reflecting the activity of E2F target genes, is associated with the aggressiveness and prognosis of hepatocellular carcinoma. High E2F target score is associated with tumor grade, size, staging, proliferation score, MKI67 expression, as well as reduced abundance of hepatocytes and stromal cells. It is also associated with higher intratumoral genomic heterogeneity, homologous recombination deficiency, and progression of hepatocellular carcinoma.
Article
Oncology
Matthew G. K. Benesch, Rongrong Wu, Xiaoyun Tang, David N. Brindley, Takashi Ishikawa, Kazuaki Takabe
Summary: The lipid phosphate phosphatases (LPPs) are enzymes that regulate signaling in cells. Imbalance of LPP expression levels, with decreased LPP1/3 and increased LPP2, is associated with worse tumor biology, immune system evasion, and decreased survival in breast cancers. Most tumor LPP1/3 is produced by the stroma and LPP2 by cancer cells. Restoring the balance in LPP expression levels, particularly through LPP2 inhibition, could provide adjunct therapies for breast cancer patients.
Article
Oncology
Masanori Oshi, Danya Ziazadeh, Rongrong Wu, Kohei Chida, Akimitsu Yamada, Shinya Yamamoto, Kazutaka Narui, Li Yan, Takashi Ishikawa, Itaru Endo, Kazuaki Takabe
Summary: In this study, we identified a gene GALNT1 that is associated with poor prognosis in breast cancer patients specifically in the adolescent and young adult population. This finding provides new insights for the treatment of young patients.
Article
Oncology
Joy Sarkar, Hiroaki Aoki, Rongrong Wu, Masayo Aoki, Phillip Hylemon, Huiping Zhou, Kazuaki Takabe
Summary: This study found that conjugated bile acids (CBAs) accelerate the growth of S1PR2 predominant pancreatic cancer, suggesting that S1PR2 may be a potential therapeutic target for metastatic pancreatic cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Abhisha Sawant Dessai, Nadya Elhalawany, Eriko Katsuta, Christian Prechtl, Spencer Rosario, Bert W. O'Malley, Xiang H. Zhang, Subhamoy Dasgupta
Article
Oncology
Yasuaki Uemoto, Eriko Katsuta, Naoto Kondo, Yumi Wanifuchi-Endo, Takashi Fujita, Tomoko Asano, Tomoka Hisada, Mitsuo Terada, Akiko Kato, Katsuhiro Okuda, Hiroshi Sugiura, Masayuki Komura, Hiroyuki Kato, Satoshi Osaga, Satoru Takahashi, Tatsuya Toyama
Summary: HECTD1 mRNA expression is significantly decreased in breast cancer tissues and is associated with aggressive tumor characteristics and poor prognosis in breast cancer patients. HECTD1 expression is inversely correlated with genes involved in mitochondrial cellular respiratory function in breast cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Eriko Katsuta, Abhisha Sawant Dessai, John M. L. Ebos, Li Yan, Toru Ouchi, Kazuaki Takabe
Summary: The phosphorylated histone variant, gamma-H2AX, plays a key role in breast cancer, and its high expression is associated with increased DNA repair, cell proliferation, metastasis, and worse survival.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
