Article
Biochemistry & Molecular Biology
Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Alessandro Oliva, Emanuele Pierpaolo Vodola, Giada Bianchetti, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Federica Iavarone, Andrea Urbani, Domenico Milardi, Alfredo Pontecorvi, Francesca Mancini
Summary: This study reveals the influence of specific interactors on the subcellular distribution of PTTG1 in seminoma. SPTBN1 acts as a cofactor to anchor PTTG1 in the cytoplasm and inhibit its nuclear translocation. Seminomas with higher nuclear PTTG1 levels show significantly lower levels of SPTBN1. These findings suggest that SPTBN1 may serve as a potential prognostic factor for seminoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Nicholas J. Webster, Rebecca L. Maywald, Susan M. Benton, Emily P. Dawson, Oscar D. Murillo, Emily L. LaPlante, Aleksandar Milosavljevic, Denise G. Lanza, Jason D. Heaney
Summary: NANOS2 plays a crucial role in coordinating the differentiation of germ cells, and its absence may increase susceptibility to tumors. Developmental phenotypes necessary for tumorigenesis typically occur in germ cells failing to express NANOS2.
Article
Oncology
Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Giada Bianchetti, Carmine Bruno, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Pierfrancesco Bassi, Alfredo Pontecorvi, Domenico Milardi, Francesca Mancini
Summary: This study investigated the role of PTTG1 in the EMT process in seminoma. The results showed that PTTG1 transcriptionally represses E-Cadherin through its cooperation with the transcriptional repressor ZEB1. It also demonstrated that PTTG1 and ZEB1 strongly localize together in the periphery of the tumors. These findings suggest that PTTG1 is a prognostic factor in seminoma clinical management.
Article
Medicine, Research & Experimental
Lionel Chia, Bowen Wang, Jung-Hyun Kim, Li Z. Luo, Shuai Shuai, Iliana Herrera, Sophia Y. Chen, Liping Li, Lingling Xian, Tait Huso, Mohammad Heydarian, Karen Reddy, Woo Jung Sung, Shun Ishiyama, Gongbo Guo, Elizabeth Jaffee, Lei Zheng, Leslie M. Cope, Kathy Gabrielson, Laura Wood, Linda Resar
Summary: High mobility group A1 (HMGA1) chromatin regulators are upregulated in various tumors, particularly pancreatic ductal adenocarcinomas (PDACs), where they upregulate FGF19 expression and drive tumor progression and stroma formation. HMGA1 deficiency disrupts oncogenic properties and impairs tumor growth and formation of a desmoplastic stroma in mouse models of PDAC. Similarly, disrupting FGF19 via gene silencing or FGFR4 inhibition recapitulates the phenotypes observed with HMGA1 deficiency, highlighting FGF19 as a potential therapeutic target for a molecularly defined PDAC subtype.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Editorial Material
Biochemistry & Molecular Biology
Amy H. Buck
Summary: In their recent Nature paper, Garcia-Martin et al. demonstrate that the sequences within a microRNA play a role in determining the amount of microRNA transferred to another cell via extracellular vesicles. This finding supports the growing evidence of cellular communication through RNA, but the mechanisms underlying how cells listen remain poorly understood.
Review
Biochemistry & Molecular Biology
Mireia Pujals, Linda Resar, Josep Villanueva
Summary: The gene encoding the HMGA1 chromatin remodeling protein is upregulated in various cancers, and recent research suggests that it may also act as a secreted factor promoting tumor progression. Studies in TNBC cell lines and tumors indicate that secreted HMGA1 through the RAGE receptor may contribute to tumor invasion and metastasis, suggesting potential therapeutic targets in cancers overexpressing HMGA1.
Article
Oncology
Marco De Martino, Pedro Nicolau-Neto, Luis Felipe Ribeiro Pinto, Alexandra Traverse-Glehen, Emmanuel Bachy, Vincenzo Gigantino, Rossella De Cecio, Francesco Bertoni, Paolo Chieffi, Alfredo Fusco, Francesco Esposito
Summary: The study found a significant correlation between HMGA1 and EZH2 expression in human lymphomas, where HMGA1 was able to bind the EZH2 promoter and induce its activity. Silencing HMGA1 expression resulted in decreased EZH2 levels, leading to reduced proliferation and migration rates of human lymphoma cell lines. These findings identify HMGA1 as an activator of EZH2, suggesting a novel molecular mechanism contributing to EZH2 overexpression in human malignancies and a synergism between the two proteins in cancer progression.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Marco De Martino, Simona Pellecchia, Francesco Esposito, Nadia Tosti, Cristina Quintavalle, Serenella Eppenberger-Castori, Vincenza Carafa, Alberto Righi, Paolo Chieffi, Alfredo Fusco, Luigi Maria Terracciano, Pierlorenzo Pallante
Summary: This study evaluated the expression of HMGA1 in neuroendocrine tumors and its role in tumor development. The results showed that HMGA1 is overexpressed in tumor samples and that its silencing interferes with the proliferation and migration abilities of tumor cells.
Article
Pathology
Ahmed S. Doghish, Hebatallah Ahmed Mohamed Moustafa, Mohammed S. Elballal, Al-Aliaa M. Sallam, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Ahmed E. Elesawy, Nourhan M. Abdelmaksoud, Reem K. Shahin, Heba M. Midan, Mahmoud A. Elrebehy, Ola Elazazy, Yara A. Nassar, Ibrahim M. Elazab, Ahmed S. Elballal, Mai S. Elballal, Ahmed I. Abulsoud
Summary: Testicular germ cell tumors (TGCTs) are the most common testicular neoplasms in adolescents and young males. Understanding the genetic basis and role of miRNAs in TGCTs is crucial for managing the increased incidence of these tumors.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Zhipeng Li, Huaxin Zhou, Zhijia Xia, Tong Xia, Gang Du, Strohmer Dorothee Franziska, Xiaoming Li, Xiangyu Zhai, Bin Jin
Summary: In this study, it was found that HMGA1 promotes the proliferation, EMT, metastasis, and stemness of iCCA. HMGA1 induces CCND1 expression by promoting CCND1 transcription and activating the PI3K signaling pathway. CDK4/6 inhibitor Palbociclib can suppress iCCA proliferation, migration, and invasion, especially during the first 3 days. Combination therapy of CDK4/6 inhibitor and PI3K/mTOR inhibitor shows more significant inhibition of CCND1, CDK4/6, and PI3K pathway compared to monotherapy.
BIOMARKER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lu Wang, Ji Zhang, Min Xia, Chang Liu, Xuyu Zu, Jing Zhong
Summary: HMGA1 is a regulatory protein that modifies the structure of DNA to regulate tumor-related genes in multiple systems. It acts through multiple signaling pathways and also affects the cell cycle, cell death, and chemotherapy resistance of tumor cells, which are closely related to tumorigenesis. Targeted intervention of HMGA1 may have significant implications for the diagnosis and treatment of cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Analytical
Hua Chai, Yuguo Tang, Peng Miao
Summary: Ultra-sensitive electrochemical analysis of miRNA is achieved through the construction of a three-dimensional DNA tetrahedral nanostructure, and successfully applied for the detection of miRNA in cell and serum samples.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Paromita Dey, Miles A. Soyer, Bijan K. Dey
Summary: The miR-24-3p/HMGA1/ID3 axis plays a critical role in skeletal muscle differentiation and regeneration by regulating the expression of high mobility group AT-hook 1 (HMGA1) and the inhibitor of differentiation 3 (ID3). Inhibition of miR-24-3p leads to increased muscle stem cells (MuSCs) and impairs skeletal muscle regeneration.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Andrology
David Dum, Stefan Steurer, Ronald Simon, Pia Victoria Zimmermann, Eike Burandt, Till Sebastian Clauditz, Margit Fisch, Michael Rink, Roland Dahlem, Wolfgang Hoeppner, Henrik Zecha, Ousman Doh, Cord Matthies, Waldemar Wilczak, Guido Sauter, Christoph Fraune
Summary: Among 574 cases of seminomas, only 1 case with MMR deficiency was identified, indicating a low frequency. However, MMR deficiency is not a significant determinant of lymphocyte infiltration in seminomas.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Cell Biology
Jianping Song, Donghai Cui, Jing Wang, Junchao Qin, Shourong Wang, Zixiang Wang, Xiangyu Zhai, Huan Ma, Delin Ma, Yanfeng Liu, Bin Jin, Zhaojian Liu
Summary: This study demonstrated that overexpression of high mobility group A1 (HMGA1) in cholangiocarcinomas is linked to poor prognosis and promotes cell proliferation and invasion. HMGA1 also enhances radioresistance by transcriptionally activating RAD51, a process that can be reversed by inhibiting RAD51.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Simona Pellecchia, Romina Sepe, Myriam Decaussin-Petrucci, Cristina Ivan, Masayoshi Shimizu, Carmela Coppola, Domenico Testa, George Adrian Calin, Alfredo Fusco, Pierlorenzo Pallante
Review
Oncology
Paolo Chieffi, Marco De Martino, Francesco Esposito
EXPERT REVIEW OF ANTICANCER THERAPY
(2020)
Article
Multidisciplinary Sciences
Marco De Martino, Davide De Biase, Floriana Forzati, Sara Carmela Credendino, Giuseppe Palma, Antonio Barbieri, Claudio Arra, Orlando Paciello, Eugenio Gaudio, Maurilio Ponzoni, Gabriella De Vita, Paolo Chieffi, Francesco Bertoni, Alfredo Fusco, Francesco Esposito
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Marco De Martino, Giuseppe Palma, Claudio Arra, Paolo Chieffi, Alfredo Fusco, Francesco Esposito
Article
Cell Biology
Marco De Martino, Francesco Esposito, Alfredo Fusco
Review
Biochemistry & Molecular Biology
Marco De Martino, Paolo Chieffi, Francesco Esposito
Summary: Testicular germ cell tumors are the leading form of solid cancer and death among males aged 20 to 40. The deregulation of miRNAs plays a key role in TGCTs, making them potential diagnostic and prognostic markers for testicular tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Simona Pellecchia, Marco De Martino, Francesco Esposito, Cristina Quintavalle, Alfredo Fusco, Pierlorenzo Pallante
Summary: GBM is classified into four subtypes based on molecular signature genes, with MPPED2 downregulation found in malignant neoplasias and being associated with poor prognosis. This study showed that restoring MPPED2 expression in GBM cell lines decreased cell growth, migration, and increased sensitivity to chemotherapy, suggesting a potential innovative therapy for GBM.
Correction
Multidisciplinary Sciences
Marco De Martino, Davide De Biase, Floriana Forzati, Sara Carmela Credendino, Giuseppe Palma, Antonio Barbieri, Claudio Arra, Orlando Paciello, Eugenio Gaudio, Maurilio Ponzoni, Gabriella De Vita, Paolo Chieffi, Francesco Bertoni, Alfredo Fusco, Francesco Esposito
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Marco De Martino, Francesco Esposito, Alfredo Fusco
Summary: The HMGA protein family consists of three non-histone chromatin remodeling proteins that lack transcriptional activity but can modify chromatin modeling and regulate gene expression by interacting with AT-rich DNA sequences and the transcription machinery, playing a key role in human cancer and embryogenesis.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Cell Biology
Marco De Martino, Simona Pellecchia, Francesco Esposito, Nadia Tosti, Cristina Quintavalle, Serenella Eppenberger-Castori, Vincenza Carafa, Alberto Righi, Paolo Chieffi, Alfredo Fusco, Luigi Maria Terracciano, Pierlorenzo Pallante
Summary: This study evaluated the expression of HMGA1 in neuroendocrine tumors and its role in tumor development. The results showed that HMGA1 is overexpressed in tumor samples and that its silencing interferes with the proliferation and migration abilities of tumor cells.
Review
Oncology
Marco De Martino, Francesco Esposito, Maria Capone, Pierlorenzo Pallante, Alfredo Fusco
Summary: Thyroid tumors are the most common neoplastic pathology of the endocrine system, with mutations in oncogenes and tumor suppressor genes playing a role in their development. Noncoding RNAs have been found to be crucial in regulating gene expression and tumor progression in thyroid cancer. Evaluating the noncoding RNA network could lead to a more personalized approach in the diagnosis, prognosis, and treatment of thyroid cancer.
Review
Oncology
Marco De Martino, Francesco Esposito, Pierlorenzo Pallante
Summary: Long non-coding RNAs (lncRNAs) are a diverse class of non-coding RNAs that modulate cellular pathways and are implicated in pathologies like cancer. They can act as oncogenes, tumor suppressors, or both in regulating cell proliferation. Interactions between lncRNAs and their molecular targets in controlling cell proliferation form a complex molecular network that may be helpful for treating molecular diseases like cancer in the future.
TRANSLATIONAL CANCER RESEARCH
(2021)