Article
Neurosciences
Mor R. Alkaslasi, Noell E. Cho, Navpreet K. Dhillon, Oksana Shelest, Patricia S. Haro-Lopez, Nikhil T. Linaval, Josh Ghoulian, Audrey R. Yang, Jean-Philippe Vit, Pablo Avalos, Eric J. Ley, Gretchen M. Thomsen
Summary: Traumatic brain injury (TBI) has been linked to earlier disease onset and shortened survival in a genetically predisposed ALS population, with poor health of corticospinal motor neurons playing a key role in predicting disease outcome.
Article
Clinical Neurology
Robert Schulz, Marlene Boenstrup, Stephanie Guder, Jingchun Liu, Benedikt Frey, Fanny Quandt, Lutz A. Krawinkel, Bastian Cheng, Goetz Thomalla, Christian Gerloff
Summary: This study found an association between motor impairment in stroke patients and the microstructure of CST originating from M1 pyramidal neurons as well as beta oscillatory activity. The findings suggest a potential link between brain structure and function that may contribute to motor deficits in stroke patients.
Article
Biology
Catarina Catela, Yihan Chen, Yifei Weng, Kailong Wen, Paschalis Kratsios
Summary: This study identified the transcriptome of spinal motor neurons (MNs) in mice during embryonic and postnatal stages and discovered novel genes and transcription factors related to terminal differentiation. It was found that homeodomain transcription factors, including Hoxc8, played a crucial role in maintaining the expression of terminal differentiation markers in MNs. These findings provide insights into the evolutionary role of Hox in neuronal terminal differentiation.
Article
Multidisciplinary Sciences
Zhaoyi Xu, Shiying Liu, Xufeng Xue, Weiping Li, Jianping Fu, Cheri X. Deng
Summary: This study explored the effects of cyclic mechanical strains applied by acoustic tweezing cytometry (ATC) on human pluripotent stem cells (hPSCs). The results showed that even short-term ATC application could downregulate OCT4 and increase YAP nuclear localization in hPSCs. The displacement of integrin-bound microbubbles was closely correlated with OCT4 downregulation.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Michael A. Urbin, Jennifer L. Collinger, George F. Wittenberg
Summary: The asymmetry in corticospinal recruitment of spinal motor neurons post-stroke is directly correlated with hand impairments. Spike timing-dependent plasticity can transiently reverse recruitment failures, and this modulation is strongly associated with recruitment asymmetry and impairment severity.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Chemistry, Multidisciplinary
Min Hao, Zixian Zhang, Chao Liu, Yue Tian, Jiazhi Duan, Jianlong He, Zhaoyang Sun, He Xia, Shan Zhang, Shuhua Wang, Yuanhua Sang, Guogang Xing, Hong Liu
Summary: In this study, it is demonstrated that hydroxyapatite (HAp) nanorods can regulate the neural differentiation of NSCs and lead to the differentiation of NSCs into mature neurons exhibiting well-defined electrophysiological behavior within 5 days. RNA-sequencing data also reveal that the neuroactive ligand-receptor interaction pathway is dominant in the enriched differentiated neuronal population.
ADVANCED MATERIALS
(2021)
Review
Cell Biology
Aksu Gunay, Heather H. Shin, Oge Gozutok, Mukesh Gautam, P. Hande Ozdinler
Summary: Maintaining lipid homeostasis is crucial for the health and function of neurons, including upper motor neurons (UMNs). UMNs require a stable cell membrane to maintain their unique cytoarchitecture, and lipids play a key role in energy production and the building blocks of biomolecules.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhenmeiyu Li, Zicong Shang, Mengge Sun, Xin Jiang, Yu Tian, Lin Yang, Ziwu Wang, Zihao Su, Guoping Liu, Xiaosu li, Yan You, Zhengang Yang, Zhejun Xu, Zhuangzhi Zhang
Summary: In this study, it was demonstrated that the expression of the Sp9 gene in medium spiny neurons of the striatum can regulate the development of the striatum by promoting D2-MSN identity and repressing D1-MSN identity.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Nina M. Drager, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Summary: This study presents a screening platform to systematically elucidate the functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia. The researchers identified genes controlling microglia survival, activation, and phagocytosis, as well as disease-associated genes. They also determined regulators of disease-relevant microglial states using single-cell RNA sequencing. The platform has the potential for therapeutic targeting and functional characterization of microglia.
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Nikhilesh Natraj, Daniel B. Silversmith, Edward F. Chang, Karunesh Ganguly
Summary: This study evaluated the neural dynamics of the human grasp network during a repertoire of hand movements using electrocorticography and dimensionality reduction methods. The researchers found that the grasp network represented both finger and grasping movements. While the neural covariance at the distributed network level was preserved, the latent neural dynamics were specific to movement type, indicating compartmentalization into movement-specific submanifolds. This mesoscale organization allows for flexible switching between a repertoire of hand movements.
Article
Neurosciences
Guangmin Xu, Zigang Huang, Jiajing Sheng, Xiang Gao, Xin Wang, Jason Q. Garcia, Guanyun Wei, Dong Liu, Jie Gong
Summary: The study revealed the crucial role of fgfbp3 in axonal morphogenesis and regeneration of motor neurons in zebrafish, with loss of fgfbp3 leading to defects that can be partially rescued by fgfbp3 mRNA injection and overexpression. Transcriptome sequencing identified drd1b and neurod6a as potential rescuers for motor neuron malformation in fgfbp3 knockout embryos.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Patricia Perez-Garcia, Ricardo Pardillo-Diaz, Noelia Geribaldi-Doldan, Ricardo Gomez-Oliva, Samuel Dominguez-Garcia, Carmen Castro, Pedro Nunez-Abades, Livia Carrascal
Summary: Understanding the development of specialized neural circuits in adult mammals requires studying the changes in neuronal membrane properties and circuits during postnatal maturation. Research on layer V pyramidal neurons in the rat primary motor cortex showed that certain parameters are established at birth, while other properties continue to develop until adulthood. These modifications lead to a decrease in neuronal excitability and an increase in working range, providing more sensitive and accurate responses in young adult neurons.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Developmental Biology
Lindsey C. Mehl, Amritha Manjally, Ouzena Bouadi, Erin M. Gibson, Tuan Leng Tay
Summary: Microglia, the tissue-resident macrophages of the central nervous system, have been found to play significant roles in brain development and tissue repair. In addition to their function as immune cells, microglia also modulate the development and functions of neurons and glial cells through interactions.
Article
Cell Biology
Janise N. Kuehner, Junyu Chen, Emily C. Bruggeman, Feng Wang, Yangping Li, Chongchong Xu, Zachary T. McEachin, Ziyi Li, Li Chen, Chadwick M. Hales, Zhexing Wen, Jingjing Yang, Bing Yao
Summary: The study found that 5hmC undergoes dynamic changes during early human brain development and is associated with AD pathology. AD organoids display cellular and molecular phenotypes similar to those observed in human AD brains. These data suggest a highly coordinated molecular system that may be dysregulated in early developing AD organoids.
Article
Biochemistry & Molecular Biology
Ariane Mora, Jonathan Rakar, Ignacio Monedero Cobeta, Behzad Yaghmaeian Salmani, Annika Starkenberg, Stefan Thor, Mikael Boden
Summary: A prominent difference between the brain and spinal cord is their size, with the brain being larger than the spinal cord. The Polycomb Repressor Complex 2 (PRC2) plays a crucial role in promoting the expansion of the anterior central nervous system (CNS) and regulates genes involved in proliferation and immune response. By integrating transcriptomic and epigenetic data, this study reveals the distinct regulatory mechanisms of PRC2 on gene cohorts driving anterior CNS expansion.
NUCLEIC ACIDS RESEARCH
(2022)
Editorial Material
Neurosciences
Pushkar S. Joshi, Kunal K. Ghosh
Article
Multidisciplinary Sciences
Fikri Birey, Jimena Andersen, Christopher D. Makinson, Saiful Islam, Wu Wei, Nina Huber, H. Christina Fan, Kimberly R. Cordes Metzler, Georgia Panagiotakos, Nicholas Thom, Nancy A. O'Rourke, Lars M. Steinmetz, Jonathan A. Bernstein, Joachim Hallmayer, John R. Huguenard, Sergiu P. Pasca
Review
Neurosciences
Sergiu P. Pasca, Georgia Panagiotakos, Ricardo E. Dolmetsch
ANNUAL REVIEW OF NEUROSCIENCE, VOL 37
(2014)
Article
Computer Science, Software Engineering
Tobias Martin, Pushkar Joshi, Miklos Bergou, Nathan Carr
COMPUTER GRAPHICS FORUM
(2013)
Article
Neurosciences
Veronica T. Cheli, Diara A. Santiago Gonzalez, Norma N. Zamora, Tenzing N. Lama, Vilma Spreuer, Randall L. Rasmusson, Glenna C. Bett, Georgia Panagiotakos, Pablo M. Paez
Article
Cell Biology
Thomas Portmann, Mu Yang, Rong Mao, Georgia Panagiotakos, Jacob Ellegood, Gul Dolen, Patrick L. Bader, Brad A. Grueter, Carleton Goold, Elaine Fisher, Katherine Clifford, Pavitra Rengarajan, David Kalikhman, Darren Loureiro, Nay L. Saw, Zhou Zhengqui, Michael A. Miller, Jason P. Lerch, R. Mark Henkelman, Mehrdad Shamloo, Robert C. Malenka, Jacqueline N. Crawley, Ricardo E. Dolmetsch
Article
Neurosciences
Simone Mayer, Jiadong Chen, Dmitry Velmeshev, Andreas Mayer, Ugomma C. Eze, Aparna Bhaduri, Carlos E. Cunha, Diane Jung, Arpana Arjun, Emmy Li, Beatriz Alvarado, Shaohui Wang, Nils Lovegren, Michael L. Gonzales, Lukasz Szpankowski, Anne Leyrat, Jay A. A. West, Georgia Panagiotakos, Arturo Alvarez-Buylla, Mercedes F. Paredes, Tomasz J. Nowakowski, Alex A. Pollen, Arnold R. Kriegstein
Article
Biochemistry & Molecular Biology
David B. Kastner, Yusuf Ozuysal, Georgia Panagiotakos, Stephen A. Baccus
Article
Biology
Georgia Panagiotakos, Christos Haveles, Arpana Arjun, Ralitsa Petrova, Anshul Rana, Thomas Portmann, Sergiu P. Pasca, Theo D. Palmer, Ricardo E. Dolmetsch
Article
Cell Biology
Simon M. G. Braun, Ralitsa Petrova, Jiong Tang, Andrey Krokhotin, Erik L. Miller, Yitai Tang, Georgia Panagiotakos, Gerald R. Crabtree
Summary: Loss of the neural development-related BAF subunit BAF53a leads to cell cycle arrest and disruption of neurogenesis due to altered chromatin accessibility, which inhibits the binding of specific neural transcription factors and suppresses cell cycle gene expression, highlighting a novel mechanism regulating neural progenitor cell cycle exit in the presence of extrinsic proliferative cues.
GENES & DEVELOPMENT
(2021)
Review
Neurosciences
Georgia Panagiotakos, Sergiu P. Pasca
Summary: Recent genetic studies suggest that synaptic proteins and ion channels play a crucial role in the development of neurodevelopmental disorders. New evidence indicates that these proteins may have novel functions in immature cells during prenatal development. Advanced techniques, such as single-cell sequencing and human cellular models of disease, have provided insights into the expression and localization of these proteins in the developing brain compared to adults.
Review
Developmental Biology
Arpana Arjun McKinney, Ralitsa Petrova, Georgia Panagiotakos
Summary: The precise regulation of intracellular calcium plays a crucial role in neurodevelopment and neurological disorders. Understanding cell type-specific calcium signaling mechanisms is essential for deciphering normal development and disease progression in the nervous system.
Article
Orthopedics
K. D. Roy, P. Joshi, I. Ali, P. M. Shenoy, I. Malek, D. Barlow, A. Syed, Y. Joshi
Summary: This study compared the reliability and reproducibility of two classification systems (OBC and DJC) for diagnosing trochlear dysplasia. The results showed that OBC had a higher intraobserver reliability score compared to DJC, indicating that it is more reliable. There was no significant difference in the scores between consultants and registrars when evaluating the two classification systems.
