Article
Pharmacology & Pharmacy
Xingxing Hu, Menglin Zou, Lan Ni, Mingyang Zhang, Weishuai Zheng, Bing Liu, Zhenshun Cheng
Summary: DEC1 plays a significant role in pulmonary fibrosis by promoting epithelial-mesenchymal transition (EMT) through the PI3K/AKT/GSK-3 beta/beta-catenin integrated signaling pathway, leading to the accumulation of fibroblasts and myofibroblasts and excessive collagen deposition. Targeting DEC1 may be a potential novel therapeutic approach for idiopathic pulmonary fibrosis (IPF).
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Zhi-Qing Chen, You Zhou, Feng Chen, Jun-Wen Huang, Jing Zheng, Hao-Liang Li, Tao Li, Lang Li
Summary: The study demonstrated that pretreatment with breviscapine could significantly alleviate myocardial injury caused by CME, reduce myocardial inflammation and apoptosis, and improve cardiac function. However, when breviscapine was combined with LY294002, these protective effects were eliminated.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
F. Wang, F. Shu, X-Q Wang, L-L Zheng, H-L Wang, L. Li, H-G Lv
Summary: The study demonstrates that SEV pretreatment significantly ameliorates ADR-induced myocardial injury by regulating the phosphorylation level of the PI3K/Akt/GSK-3 beta signaling pathway.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yang
Summary: This study found that TREM2 can inhibit tau hyperphosphorylation and neuronal apoptosis through the activation of the PI3K/Akt/GSK-3β signaling pathway, thereby improving Alzheimer's disease. This finding helps us better understand the protective role of TREM2 in tau pathology and provides new ideas and targets for the treatment of Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Plant Sciences
Xiang-wen Meng, Can-xia He, Xiao Chen, Xiao-song Yang, Chao Liu
Summary: This study found that the extract of Gnaphalium affine D. Don significantly improved cardiomyocyte viability and exhibited antioxidant effects by regulating various proteins and genes to alleviate oxidative stress and reduce cell apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Chung-Yuh Tzeng, Wei-Shan Lee, Keng-Fan Liu, Hsi-Kai Tsou, Chun-Jung Chen, Wen-Huang Peng, Jen-Chieh Tsai
Summary: This study investigated the effect and mechanism of action of allantoin on AD-related memory impairment. The results showed that allantoin could improve cognitive impairment in A beta(1-42)-induced rats by activating the PI3K/Akt/GSK-3 beta signaling pathway to reduce abnormal hyperphosphorylation of Tau. These findings suggest that allantoin may be a potential therapeutic agent for neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Yan-Cui Liang, Qian Zhong, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Mohammad Rizwan Khan, Rosa Busquets, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Apigenin (API) inhibits proliferation, induces apoptosis, and prevents migration and invasion of Ishikawa cells. The study suggests that API could be a promising dietary supplement and adjuvant chemotherapeutic agent.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Hui Shao, Jingyan Chen, Ali Li, Lili Ma, Yongzhi Tang, Huazhong Chen, Yongping Chen, Junyan Liu
Summary: Salvigenin inhibits the proliferation, migration, and invasion of hepatocellular carcinoma cells by reducing glucose uptake and lactate production, suppressing glycolysis, and enhancing sensitivity to 5-fluorouracil.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Tao Li, Zhiqing Chen, You Zhou, Haoliang Li, Jian Xie, Lang Li
Summary: Resveratrol pretreatment alleviates myocardial damage induced by CME by improving cardiac dysfunction, reducing serum levels of myocardial injury biomarkers, and decreasing cardiomyocyte apoptosis. Resveratrol also regulates the levels of proteins and mRNAs associated with apoptosis in myocardial tissues.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Jin-Long Pang, Lian-Song Xu, Qian Zhao, Wen-Wen Niu, Xiang-Yu Rong, Shan-Shan Li, Xian Li
Summary: This study found that sodium cantharidate (SCA) promotes apoptosis of breast cancer cells by inhibiting the PI3K-Akt-mTOR pathway and inducing autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Shijie Wei, Yubao Zhang, Xiaoran Ma, Yan Yao, Qinqin Zhou, Wenfeng Zhang, Chao Zhou, Jing Zhuang
Summary: This study reveals that matrine, an alkaloid from the medicinal plant Sophora flavescens, has strong anticancer effects and can be explored as a new therapeutic agent for triple-negative breast cancer (TNBC). Through bioinformatics analysis and network pharmacology, researchers found that matrine inhibits the PI3K/AKT pathway, suppresses cell proliferation and invasion, induces apoptosis and autophagy, effectively inhibiting the growth and spread of TNBC.
SCIENTIFIC REPORTS
(2023)
Article
Toxicology
Tianyang Wang, Xuejiao Wen, Ziwen Zhang, Minjuan Xie, Jie Zhou
Summary: The study found that phillyrin has significant effects on diabetic nephropathy, reducing blood glucose levels, improving renal injury, enhancing antioxidant capacity, and suppressing renal cell apoptosis through modulating related signaling pathways.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Review
Oncology
Huayi Li, Lorenzo Prever, Emilio Hirsch, Federico Gulluni
Summary: The PI3K signaling pathway is crucial in breast cancer and inhibitors targeting this pathway show promising activity, but resistance and adverse reactions limit their efficacy. Combination therapies and identifying suitable patient subpopulations are needed to enhance therapeutic benefit.
Article
Orthopedics
Yubin Qi, Lin Yao, Jianke Liu, Wen Wang
Summary: This study demonstrates that piperine (PIP) enhances the sensitivity and cytotoxicity of Doxorubicin (DOX) in osteosarcoma therapy, possibly through inhibiting the PI3K/AKT/GSK-3 beta signaling pathway.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Yang Zhang, Fei Teng, Suhang Li, Ling Wan, Tingting Lin
Review
Chemistry, Analytical
Tingting Lin, Xin Lv, Shuang Li, Qingji Wang
Article
Chemistry, Analytical
Tingting Lin, Kun Zhou, Sijia Yu, Pengfei Wang, Ling Wan, Jing Zhao
Review
Chemistry, Analytical
Tingting Lin, Xin Lv, Zhineng Hu, Aoshu Xu, Caihui Feng
Article
Computer Science, Information Systems
Tingting Lin, Xiaokang Yao, Sijia Yu, Yang Zhang
Article
Chemistry, Analytical
Dapeng Yang, Xiaohuan Wang, Junze Sun, Heng Chen, Chenhao Ju, Tingting Lin, Baofeng Tian, Fan Zheng
Summary: A novel liquid jet gyroscope based on electrochemical transducers has been proposed, which uses electrolyte as the jet medium and achieves high sensitivity velocity measurements. The feasibility of the method was demonstrated in theory and confirmed through simulation results, showing higher sensitivity in the near DC frequency band.