Journal
CEREBRAL CORTEX
Volume 26, Issue 11, Pages 4170-4179Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw249
Keywords
[C-11]ABP688; epilepsy; focal cortical dysplasia; metabotropic glutamate receptor type 5; positron-emission tomography
Categories
Funding
- Savoy Foundation for Epilepsy
- American Epilepsy Society
- Canadian Institutes of Health Research (CIHR) [MOP-115131, MOP-93614]
- Fonds de la recherche en sante du Quebec
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Metabotropic glutamate receptor type 5 (mGluR5) abnormalities have been described in tissue resected from epilepsy patients with focal cortical dysplasia (FCD). To determine if these abnormalities could be identified in vivo, we investigated mGluR5 availability in 10 patients with focal epilepsy and an MRI diagnosis of FCD using positron-emission tomography (PET) and the radioligand [C-11]ABP688. Partial volume corrected [C-11]ABP688 binding potentials (BPND) were computed using the cerebellum as a reference region. Each patient was compared to homotopic cortical regions in 33 healthy controls using region-of-interest (ROI) and vertex-wise analyses. Reduced [C-11]ABP688 BPND in the FCD was seen in 7/10 patients with combined ROI and vertex-wise analyses. Reduced FCD BPND was found in 4/5 operated patients (mean follow-up: 63 months; Engel I), of whom surgical specimens revealed FCD type IIb or IIa, with most balloon cells showing negative or weak mGluR5 immunoreactivity as compared to their respective neuropil and normal neurons at the border of resections. [C-11]ABP688 PET shows for the first time in vivo evidence of reduced mGluR5 availability in FCD, indicating focal glutamatergic alterations in malformations of cortical development, which cannot be otherwise clearly demonstrated through resected tissue analyses.
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