Article
Cell Biology
Bo Yu, Chenze Li, Yang Sun, Dao Wen Wang
Summary: Insulin treatment for patients with COVID-19 and T2D was found to be associated with a significant increase in mortality according to a retrospective study. Further analysis showed that insulin treatment was linked to enhanced systemic inflammation and aggravated injuries of vital organs, suggesting that caution should be exercised when using insulin treatment for these patients.
Review
Cell Biology
Hao Ying, Mohsen Ebrahimi, Mona Keivan, Seyed Esmaeil Khoshnam, Sarvenaz Salahi, Maryam Farzaneh
Summary: COVID-19, caused by the new coronavirus, can lead to respiratory symptoms and other complications in infected individuals. Current treatment options such as oxygen therapy and antiviral therapy may not be the most effective. miRNA-based therapies show promise in inhibiting virus replication and improving patient outcomes in the treatment of COVID-19.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Peter Horby, Wei Shen Lim, Jonathan R. Emberson, Marion Mafham, Jennifer L. Bell, Louise Linsell, Natalie Staplin, Christopher Brightling, Andrew Ustianowski, Einas Elmahi, Benjamin Prudon, Christopher Green, Timothy Felton, David Chadwick, Kanchan Rege, Christopher Fegan, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Alan Montgomery, Kathryn Rowan, Edmund Juszczak, J. Kenneth Baillie, Richard Haynes, Martin J. Landray
Summary: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Virology
Hamid Yaqoob, Daniel Greenberg, Frank Hwang, Curtis Lee, David Vernik, Ravi Manglani, Zhen Wang, M. Hassan Murad, Dipak Chandy, Oleg Epelbaum
Summary: In the management of COVID-19 pneumonia patients in the ICU, both high-dose corticosteroids (0.5-2 mg/kg/day of methylprednisolone equivalents) and pulse-dose corticosteroids (1 gm of methylprednisolone daily) have been used, with pulse-dose corticosteroid therapy associated with increased ICU-free days but no impact on hospital mortality, possibly due to severe renal failure. High-dose corticosteroids showed a favorable effect on reducing hospital mortality.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Dan Ma, Ximin Wang, Min Li, Chujiao Hu, Lei Tang
Summary: Periodic pandemics of coronavirus-related pneumonia have been a significant challenge since the outbreak of SARS and MERS. The ongoing COVID-19 pandemic poses a substantial threat to public health. Limited antiviral agents have been approved, and IFNs have shown promising outcomes in the treatment of SARS-CoV or MERS-CoV, but their efficacy and safety in COVID-19 treatment remain unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Anil Ucan, Pamir Cerci, Serdar Efe, Hakan Akgun, Ahmet Ozmen, Aysel Yagmuroglu, Muzaffer Bilgin, Deniz Avci
Summary: The study found that early initiation of Favipiravir (FPV) treatment has an impact on COVID-19 PCR negativity and disease progression, but does not significantly affect estimated survival time. Therefore, it is suggested to initiate FPV treatment promptly for better clinical outcomes in COVID-19 patients.
Review
Virology
Yajuan Ren, Guizuo Wang, Dong Han
Summary: This systematic review and meta-analysis aimed to determine the efficacy of statins in hospitalized patients with COVID-19. Seven RCTs met the inclusion criteria, but there was no significant difference in mortality, length of hospital stay, ICU admission, and mechanical ventilation between the statin group and the control group. Statins may not be effective in reducing adverse outcomes in hospitalized COVID-19 patients.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Plant Sciences
Zhenyu Zhao, Yanda Li, Liangyun Zhou, Xiuteng Zhou, Bowen Xie, Wenjin Zhang, Jiahui Sun
Summary: Traditional Chinese medicine (TCM) has shown significant effectiveness in preventing and treating COVID-19, with the ability to prevent iatrogenic infections and a high national participation rate in China. It is currently the best choice for the treatment and prevention of COVID-19 and is expected to be promoted globally.
Review
Infectious Diseases
Betsy Ann Joseph, Mahmoud Dibas, Kirk W. Evanson, Geeta Paranjape, Charan Thej Reddy Vegivinti, Pragadeesh Thamarai Selvan, Kavitha Saravu, Nitin Gupta, Yashwitha Sai Pulakurthi, Praneeth Reddy Keesari, Sriram Varsha, Spandana Chittajallu, Adam A. Dmytriw, Natalie L. Reierson, Nick Mikoff, Shelby Kamrowski, Megan Schmidt, Amber R. Davis, John M. Pederson, Hemant K. Mishra, Jillienne C. Touchette, Kevin Kallmes
Summary: Out of 858 total studies, 16 studies were included in the review, which consisted of 3 randomized control trials, 3 open-label trials, and 10 observational studies. Most of these studies did not report positive clinical outcomes with LPV/r treatment. The systematic review revealed insufficient evidence of effectiveness and clinical benefit of LPV/r in the treatment of COVID-19 patients.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Lalita Subedi, Stephanie Tchen, Bhakta Prasad Gaire, Bingren Hu, Kurt Hu
Summary: The novel coronavirus, SARS-CoV-2/COVID-19, has become a global pandemic, affecting people of all ages. Nutraceuticals and phytochemicals, such as vitamins C, D, E, zinc, melatonin, and other functional foods, may have potential therapeutic efficacies in fighting the threat of the COVID-19 pandemic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pierre Bost, Francesco De Sanctis, Stefania Cane, Stefano Ugel, Katia Donadello, Monica Castellucci, David Eyal, Alessandra Fiore, Cristina Anselmi, Roza Maria Barouni, Rosalinda Trovato, Simone Caligola, Alessia Lamolinara, Manuela Iezzi, Federica Facciotti, Annarita Mazzariol, Davide Gibellini, Pasquale De Nardo, Evelina Tacconelli, Leonardo Gottin, Enrico Polati, Benno Schwikowski, Ido Amit, Vincenzo Bronte
Summary: COVID-19 patients show unique immune features, including lung accumulation of naive lymphoid cells, systemic expansion and activation of myeloid cells, and immune suppression. Loss of monocyte-driven and neutrophil-driven immune suppression may lead to fatal outcomes in severe patients. On the other hand, a lung CXCR6(+) effector memory T cell subset may be associated with better prognosis in severe COVID-19 patients.
NATURE COMMUNICATIONS
(2021)
Article
Virology
Evgeny Golbets, Alon Kaplan, Tali Shafat, Yael Yagel, Alan Jotkowitz, Jenan Awesat, Leonid Barski
Summary: A 36-year-old male with diffuse large B-cell lymphoma developed secondary organizing pneumonia (OP) during treatment, which showed a rapid response to corticosteroids. This complication associated with viral respiratory infections may be underestimated worldwide.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell Biology
Ivan Cusacovich, Alvaro Aparisi, Miguel Marcos, Cristina Ybarra-Falcon, Carolina Iglesias-Echevarria, Maria Lopez-Veloso, Julio Barraza-Vengoechea, Carlos Duenas, Santiago Antonio Juarros Martinez, Beatriz Rodriguez-Alonso, Jose-Angel Martin-Oterino, Miguel Montero-Baladia, Leticia Moralejo, David Andaluz-Ojeda, Roberto Gonzalez-Fuentes
Summary: The study suggests that corticosteroid pulses treatment may significantly reduce mortality in severe COVID-19 patients, with significant differences remaining even after propensity score matching.
MEDIATORS OF INFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Maryam N. Naser, Rana Al-Ghatam, Abdulla H. Darwish, Manaf M. Alqahtani, Hajar A. Alahmadi, Khalifa A. Mohamed, Nahed K. Hasan, Nuria S. Perez, Giuseppe Remuzzi
Summary: Studies have shown that the occurrence of acute kidney injury (AKI) in hospitalized COVID-19 patients is high and associated with AKI staging. In addition to age, diabetes and hypertension are major risk factors for AKI development, while multiple comorbidities significantly increase the risk.
Article
Infectious Diseases
Ivan Ilic, Marina Zdravkovic, Stefan Timcic, Dragana Unic Stojanovic, Milovan Bojic, Goran Loncar
Summary: A study on infected healthcare workers at a cardiovascular hospital during the COVID-19 pandemic found that seasonal influenza immunization may be associated with less-severe pneumonia, supporting the implementation of preventive measures to reduce the global burden of COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)