Journal
CEREBRAL CORTEX
Volume 27, Issue 8, Pages 4083-4093Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhw220
Keywords
brain activity; fMRI; functional connectivity; hypnosis; resting state
Categories
Funding
- National Center for Complementary and Integrative Health [RCI AT0005733]
- National Institute of Biomedical imaging and Bioengineering [P41-EB015891]
- Randolph H. Chase, M.D. Fund II
- Jay and Rose Phillips Family Foundation
- Nissan Research Center
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Hypnosis has proven clinical utility, yet changes in brain activity underlying the hypnotic state have not yet been fully identified. Previous research suggests that hypnosis is associated with decreased default mode network (DMN) activity and that high hypnotizability is associated with greater functional connectivity between the executive control network (ECN) and the salience network (SN). We used functional magnetic resonance imaging to investigate activity and functional connectivity among these three networks in hypnosis. We selected 57 of 545 healthy subjects with very high or low hypnotizability using two hypnotizability scales. All subjects underwent four conditions in the scanner: rest, memory retrieval, and two different hypnosis experiences guided by standard pre-recorded instructions in counterbalanced order. Seeds for the ECN, SN, and DMN were left and right dorsolateral prefrontal cortex, dorsal anterior cingulate cortex (dACC), and posterior cingulate cortex (PCC), respectively. During hypnosis there was reduced activity in the dACC, increased functional connectivity between the dorsolateral prefrontal cortex (DLPFC; ECN) and the insula in the SN, and reduced connectivity between the ECN (DLPFC) and the DMN (PCC). These changes in neural activity underlie the focused attention, enhanced somatic and emotional control, and lack of self-consciousness that characterizes hypnosis.
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