Article
Cell Biology
Chang Liu, Yaxing Chen, Wenyao Cui, Yi Cao, Long Zhao, Haoxiang Wang, Xiaoyin Liu, Shuangmin Fan, Keru Huang, Aiping Tong, Liangxue Zhou
Summary: In a hydrocephalus mouse model, the necroptosis pathway inhibitor Nec-1 and GSK872 showed neuroprotective effects by reducing necrotic cell death, attenuating levels of p-RIP3 and p-MLKL, slightly improving neurobehaviors, and inhibiting microglial and astrocyte activation and inflammation. RIP1/RIP3/MLKL pathway mediates necroptosis in the cortex and hippocampus.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Jiebo Zhu, Min Joung Lee, Hee Jin Chang, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Dahyun Go, Woosuk Chung, Eungseok Oh, Jun Young Heo
Summary: The kaolin-induced hydrocephalus model in mice revealed the association of ventricular dilation, behavioral defects, activation of microglia, and UPRmt in the pathogenesis of hydrocephalus. Additionally, the involvement of PARP-1/NF-κB signaling and apoptotic cell death in hydrocephalus was observed.
Article
Pediatrics
Emilie Groulx-Boivin, Mariane Paquette, May Khairy, Marc Beltempo, Roy Dudley, Amaryllis Ferrand, Mireille Guillot, Victoria Bizgu, Jarred Garfinkle
Summary: This study investigated the temporal evolution of post-hemorrhagic ventricular dilatation (PHVD) and compared neurodevelopmental impairments in newborns with different outcomes. The results showed that newborns with persistent PHVD without resolution are at higher risk for neurodevelopmental impairments, which may be due to larger ventricular dilatation.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Li-Jin Chen, Jeng-Rung Chen, Guo-Fang Tseng
Summary: Hydrocephalus alters neurotransmission pathways in the striatum, disrupting the balance between the basal ganglia circuits, which may contribute to motor impairments in hydrocephalus.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Medicine, Research & Experimental
Soudabeh Balarastaghi, Samira Barangi, Hossein Hosseinzadeh, Mohsen Imenshahidi, Zahra Moosavi, Bibi Marjan Razavi, Gholamreza Karimi
Summary: Arsenic is a heavy metal that can cause vascular toxicity. Melatonin, a hormone, has been shown to have protective effects against oxidative stress and apoptosis, as well as modulating autophagy. This study found that melatonin can protect against arsenic-induced vascular toxicity by inhibiting apoptosis and regulating the Sirt1/autophagy pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Microscopy
Reem Ibrahim Abd El-Hay, Shireen A. Mazroa, E. El-Mohandes, Moustafa Am
Summary: This study aimed to assess the microscopic changes in the cerebellar cortex of rats after MSG administration and the protective effects of melatonin and garlic. The rat groups were divided into control, MSG, MSG+melatonin, and MSG+garlic. The results showed that MSG caused vascular congestion, vacuolations, and irregular Purkinje and granule cells. Melatonin group displayed similar cerebellar cortex to the control group, while garlic group showed partial improvement. In conclusion, both melatonin and garlic provided partial protection against MSG-induced changes, with melatonin being more effective.
ULTRASTRUCTURAL PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Robert Puls, Clarissa von Haefen, Christoph Buehrer, Stefanie Endesfelder
Summary: The risk of oxidative stress is unavoidable in preterm infants and increases the risk of neonatal morbidities. Premature infants often require sedation and analgesia, and the commonly used opioids and benzodiazepines are associated with adverse effects. Impairment of cerebellar functions during cognitive development could be a crucial factor in neurodevelopmental disorders of prematurity. Recent studies have focused on dexmedetomidine (DEX), which has been associated with potential neuroprotective properties and is used as an off-label application in neonatal units. Exposure to high oxygen concentrations caused oxidative stress in the immature rat cerebellum, but pretreatment with DEX significantly reduced the damage and facilitated a faster recovery, confirming its neuroprotective effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Lamiaa A. Khatab, Ihab T. Abdel-Raheem, Asser I. Ghoneim
Summary: The study demonstrated that melatonin and L-carnitine can effectively protect isolated rat hepatocytes against methotrexate-induced toxicity by exerting antioxidative, antiinflammatory, and antiapoptotic effects. Further research on the clinical pharmacological and toxicological effects of these two drugs in patients receiving methotrexate is recommended.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Hindole Ghosh, Seema Rai, Md Dilshad R. Manzar, Seithikurippu R. M. Pandi-Perumal, Gregory M. J. Brown, Russel J. P. Reiter, Daniel P. Cardinali
Summary: The present study aimed to investigate the effects of melatonin and L-thyroxine on the expression of receptors, as well as metabolic, reproductive, and gonadotropic hormones in letrozole-induced polycystic ovary syndrome in rats.
Article
Biophysics
Katherine M. Satrom, Raghavendra B. Rao, Ivan Tkac
Summary: Neonatal hyperbilirubinemia can cause brain injury in specific regions such as the cerebellum and hippocampus in newborn infants. Extremely preterm infants are more susceptible to bilirubin neurotoxicity, but the exact mechanism and extent of the injury are not well understood. A study using a preterm rat model found that the cerebellum is more severely affected by hyperbilirubinemia than the hippocampus, with significant morphological changes and alterations in neurochemical profiles.
NMR IN BIOMEDICINE
(2023)
Article
Environmental Sciences
Wenxuan Dong, Lianqi Yan, Yun Tan, Shufang Chen, Kanglei Zhang, Zhonggui Gong, Wenjing Liu, Hui Zou, Ruilong Song, Jiaqiao Zhu, Gang Liu, Zongping Liu
Summary: This study explores the protective effects of melatonin against cadmium-induced nephrotoxicity and the underlying mechanism. The findings suggest that melatonin inhibits mitochondrial fission mediated by dynamin-related protein 1 and mitochondrial fission protein 1, leading to the attenuation of cytotoxicity and oxidative stress induced by cadmium.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Maria Grazia Morgese, Maria Bove, Lorenzo Di Cesare Mannelli, Stefania Schiavone, Anna Laura Colia, Stefania Dimonte, Emanuela Mhillaj, Vladyslav Sikora, Paolo Tucci, Carla Ghelardini, Luigia Trabace
Summary: Alzheimer's disease is a common neurodegenerative disorder with ongoing efforts to find a cure. Research has shown that an animal model mimicking comorbid conditions typical of early phase AD has been established.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Romain Gerbier, Delphine Ndiaye-Lobry, Pablo B. Martinez de Morentin, Erika Cecon, Lora K. Heisler, Philippe Delagrange, Florence Gbahou, Ralf Jockers
Summary: Functional fingerprint of heteromers composed of G(i)-coupled melatonin MT2 receptors and G(q)-coupled serotonin 5-HT2C receptors was identified in mouse brain, with melatonin activating G(q) proteins and PLC in a concentration-dependent manner in the hypothalamus and cerebellum. These effects were absent in cortex, inhibited by the 5-HT2C receptor-specific inverse agonist SB-243213, and were fully recapitulated in MT2 and 5-HT2C knockout mice. Furthermore, antidepressant agomelatine had similar effects to melatonin but blocked melatonin-promoted G(q) activation due to its 5-HT2C antagonistic component, providing strong functional evidence for the existence of MT2/5-HT2C heteromeric complexes.
Article
Immunology
Swaimanti Sarkar, Ankur Das, Ankan Mitra, Songita Ghosh, Sreya Chattopadhyay, Debasish Bandyopadhyay
Summary: This study found that adrenaline-copper complex can cause damage to cardiomyocytes, while melatonin can protect them. The results indicate that melatonin exerts cardioprotective effects through multiple mechanisms, including reducing oxidative stress, regulating inflammation, and inhibiting cell apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biology
Serhat Aras, Mustafa Efendioglu, Aini Wulamujiang, Sidika Seyma Ozkanli, Mevlut Sait Keles, Ihsan Oguz Tanzer
Summary: The study shows that melatonin has a radioprotective effect against early brain damage caused by different dose rate beams, improving histopathological and biochemical parameters. However, there is no significant difference between low and high dose rate beams in terms of their effects on the brain. Further studies are needed to clarify the radiobiological uncertainties of different dose rates on various tissues.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Oncology
Emel Oyku Cetin, Derya Selcen Salmanoglu, Ilknur Ozden, Gizem Ors-Kumoglu, Sibel Akar, Melis Demirozer, Fatih Karabey, Kubilay Dogan Kilic, Levent Kirilmaz, Yigit Uyanikgil, Canan Sevimli-Gur
Summary: The study found that niosome formulations containing propolis showed higher activity than ethanol extract of propolis in cancer cells, with faster decrease in cancer cell viability, indicating a potential anti-cancer activity.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Rezan Karaali, Ejder Saylav Bora, Huseyin Acar, Yigit Uyanikgil, Ibrahim Halil Sever, Mumin Alper Erdogan, Oytun Erbas
Summary: This study investigated the role of beta blockers in reducing inflammation in a sepsis model and their influence on acute lung injury (ALI). The results showed that beta-blocker administration significantly decreased inflammatory biomarkers in septic rats and could potentially prevent ALI.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Erman Bagcioglu, Volkan Solmaz, Oytun Erbas, Bahattin Ozkul, Burak Cakar, Yigit Uyanikgil, Ibrahim Sogut
Summary: Modafinil has been found to alleviate neuroinflammation, behavioral, and histopathological alterations induced by propionic acid (PPA) in rats. The study showed that Modafinil significantly reduced autism-like behaviors, decreased inflammatory factor levels, and improved histopathological changes caused by PPA. These results demonstrate the potential role of Modafinil in ameliorating PPA-induced neuroinflammation.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Meliha Ekinci, Emine Esin Caliskan, Burak Cakar, Derya Ilem-Ozdemir, Yigit Uyanikgil, Emel Oyku Cetin Uyanikgil
Summary: The aim of this research was to develop and evaluate the cancer cell incorporation capacity of technetium-99m ([99mTc]Tc)-radiolabeled niosomes. Niosome formulations were developed and characterized, and then radiolabeled with [99mTc]Tc. The cell incorporation of radiolabeled niosomes in cancer cells was assessed and showed higher percentages compared to the control.
Article
Chemistry, Multidisciplinary
Aytekin Kose, Meltem Kaya, Canberk Tomruk, Yigit Uyanikgil, Nurhan Kishali, Yunus Kara, Gulsah Sanli-Mohamed
Summary: The anticancer activity of N-benzylisoindole-1,3-dione derivatives was evaluated against A549 Luc adenocarcinoma. In vitro studies showed that both compounds exhibited inhibitory effects on the viability of A549 cells. In vivo studies in nude mice confirmed the potential of these compounds as active ingredients, as they effectively inhibited tumor growth and showed no significant toxicity.
Article
Surgery
Burak Ergun Tatar, Caner Gelbal, Can Uslu, Bengi Yilmaz, Canberk Tomruk, Yigit Uyanikgil, Tunc Akkoc, Mehmet Bozkurt
Summary: In this study, stem cells derived from compact bone showed positive results in repairing zygomatic arch defects in rats, indicating that they can be used as an alternative in stem cell applications.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Neurosciences
Mumin Alper Erdogan, Miray Turk, Gizem Dinler Doganay, Ibrahim Halil Sever, Bahattin Ozkul, Ibrahim Sogut, Ebru Eroglu, Yigit Uyanikgil, Oytun Erbas
Summary: Recent research suggests that the COVID-19 virus could potentially affect embryonic organs, including the brain. This study investigates the effects of exposure to the spike protein of the virus during pregnancy. The findings indicate that exposure to the spike protein may lead to neurodevelopmental problems, such as autistic symptoms, and harmful effects on specific brain regions.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2023)
Article
Neurosciences
Asuman Kaplan Algin, Canberk Tomruk, Cigdem Gozde Aslan, Sinan Saban Akkurt, Gulcihan Mehtap Cinar, Sezgin Ulukaya, Yigit Uyanikgil, Yasemin Akcay
Summary: The study investigated the effects of ozone treatment on neurodegeneration in a Parkinson's disease model induced by rotenone. Ozone treatment significantly improved biomarkers related to Parkinson's disease in the model. Further studies should explore the dosage, duration, and administration methods of ozone treatment in humans for potential Parkinson's disease treatment.
NEUROSCIENCE LETTERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
N. Cini, O. Atasoy, M. A. Erdogan, G. Yaprak, E. Eroglu, C. Sirin, Y. Uyanikgil, O. Erbas
Summary: The study found that granisetron has neuroprotective properties in a rat model of radiation-induced brain damage.
INTERNATIONAL JOURNAL OF RADIATION RESEARCH
(2023)
Article
Biology
C. Dibekoglu, Y. Uyanikgil, O. Erbas
Summary: This study investigated the effectiveness of sulfasalazine in preventing and treating acute respiratory distress syndrome (ARDS) induced by intra-abdominal sepsis in a rat model. The results showed significant reductions in inflammation markers and oxidative stress levels in the sulfasalazine group compared to the control group, as well as improved lung tissue scores and oxygenation levels. These findings suggest that sulfasalazine is effective in preventing and treating ARDS.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Ferit Durankus, Korkut Budak, Yakup Albayrak, Ibrahim H. Sever, Bahattin Ozkul, Yigit Uyanikgil, Neslihan Albayrak, Oytun Erbas
Summary: The purpose of this study was to investigate the benefits of atorvastatin on the propionic acid-induced autism model. The results showed that atorvastatin can increase sphingosine-1-phosphate levels and reduce inflammatory actions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Biology
O. Sorgun, A. Cakir, E. S. Bora, M. A. Erdogan, Y. Uyanikgil, O. Erbas
Summary: This study demonstrated that betaine suppressed inflammation and ameliorated acute lung injury in a rat model of sepsis-induced acute respiratory distress syndrome (ARDS) through histopathological examination, radiologic imaging, and biochemical analysis.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Clinical Neurology
Goekhan Gurkan, Ozum Atasoy, Nilsu Cini, Ibrahim Halil Sever, Bahattin Ozkul, Gokhan Yaprak, Cansin Sirin, Yigit Uyanikgil, Ceren Kizmazoglu, Mumin Alper Erdogan, Oytun Erbas
Summary: This study compared the effects of brain irradiation on rats with and without G-CSF treatment. The results showed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects, as well as increased neurotrophic factor expression and neuronal counts. Additionally, G-CSF was effective in lowering lactate levels.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2023)
Article
Medicine, General & Internal
Canbolat Nur, Ozkul Bahattin, Sever Ibrahim Halil, Sogut Ibrahim, Eroglu Ebru, Uyanikgil Yigit, Erbas Oytun
Summary: Vitamin C and E treatment can improve outcomes in septic rats and can be used as adjunctive therapy for septic patients.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
(2022)
Article
Medicine, General & Internal
Ezgi Turunc, Yigit Uyanikgil, Tijen Kaya Temiz, Ayfer Yalcin
Summary: This study examined the effects of prenatal stress induced by dexamethasone exposure on gene expression levels of epigenetic enzymes in the hippocampus and cerebral cortex of male rats. The results showed that prenatal dexamethasone exposure led to changes in the expression levels of epigenetic enzymes, suggesting potential epigenetic dysregulation caused by prenatal stress.
EUROPEAN JOURNAL OF THERAPEUTICS
(2022)