Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 151, Issue -, Pages 56-61Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.02.143
Keywords
Alopecia; Chitosan; Nanoparticle
Funding
- FAPDF (Fundacao de Apoio a Pesquisa do Distrito Federal)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
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In general, nanometer-sized drug delivery systems have a natural tendency for accommodation in the follicular cavities, which makes them advantageous in the treatment of conditions affecting these structures. Still, follicular targeting enhancement can improve therapy outcomes. Here, we compare two strategies to further promote dutasteride follicular-targeted delivery: the chemical modulation of nanosystem surface properties by coating with the natural polymer chitosan, and the application of a massage. For this, poly-(epsilon-caprolactone)-lipid-core nanocapsules (NC) containing dutasteride were developed and had their permeation profile compared to chitosan-coated nanocapsules (NC-CS). Nanocapsules showed high drug encapsulation efficiency (>94%), and stability for up to 90 days of storage. As expected, chitosan coating increased the size and zeta potential, from 199.0 +/- 0.5 nm (Pdl of 0.12) and - 13.6 +/- 0.6 mV to 224.9 +/- 3.4 nm (Pdl 023) and + 40.2 +/- 0.8 mV, respectively. Both coated and non-coated nanopartides targeted the hair follicles compared to a drug solution. Enhanced hair follicles targeting was observed after the massage procedure, with 5 and 2-fold increases relative to NC and NC-CS, respectively. In conclusion, this work demonstrates dutasteride nanocapsules can target the follicular casts, and a simple physical stimulation can enhance 5-times the drug amount accumulated. (C) 2018 Elsevier B.V. All rights reserved.
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