Article
Biochemistry & Molecular Biology
Ioana A. Duceac, Liliana Verestiuc, Adina Coroaba, Dragos Arotaritei, Sergiu Coseri
Summary: The study presents a versatile approach to the production of chitosan beads with adjustable pore size and targeted properties through interaction with oxidized pullulan derivatives. Covalent or physical hybrid hydrogels were prepared based on the functional groups of the pullulan structure after oxidation. Drug loading and release assays showed high drug loading capacity and tunable release behavior in the drug loaded beads.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Food Science & Technology
Tianqi Cui, Yuxue Sun, Yue Wu, Jiarong Wang, Yangyue Ding, Jianjun Cheng, Mingruo Guo
Summary: Novel gelatin/dialdehyde starch (GDS) hydrogels were prepared using dialdehyde starch as a crosslinking agent. The hydrogels showed excellent mechanical properties, fatigue resistance, toughness, and self-recoverability. They behaved as elastic gels in rheological tests and had good stability and microstructure.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Review
Polymer Science
Ioana A. A. Duceac, Sergiu Coseri
Summary: Chitosan is a unique polysaccharide with amine groups naturally occurring in its structure, making it a polycation suitable for preparing polyelectrolyte complexes or imine bonds gels. Hydrogels have advantages such as quick gelation, no need for crosslinking agents, and self-healing and injectability properties, which are of great importance in various applications.
Article
Engineering, Biomedical
Jasper G. Steverink, Floris R. van Tol, Bas J. Oosterman, Tina Vermonden, Jorrit-Jan Verlaan, Jos Malda, Susanna Piluso
Summary: Adequate treatment of pain after spinal surgery is challenging, and current methods rely on opioids which have severe side effects. This study developed a ring-shaped hydrogel that can be implanted with spinal pedicle screws to provide sustained release of non-opioid analgesics.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Cigdem Bilici, Asena G. Tatar, Efsun Senturk, Caner Dikyol, Bahattin Koc
Summary: Recent studies have shown promising outcomes in 3D bioprinting of GelMA hydrogels with cell-laden structures for tissue engineering applications. However, the reliance on photo-induced gelation processes and the lack of alternative crosslinking methods have posed challenges. This study presents a novel approach using embedded bioprinting and bisulfite-initiated radical polymerization to form cell-laden GelMA hydrogel constructs, resulting in printed structures with high cell viability.
Article
Chemistry, Multidisciplinary
Swarnima Athavale, Stefano Micci-Barreca, Kailash Arole, Vrushali Kotasthane, Jackson Blivin, Huaixuan Cao, Jodie L. Lutkenhaus, Miladin Radovic, Micah J. Green
Summary: This passage introduces the personal backgrounds and research areas of several graduate students, focusing on the study of MXenes materials.
Article
Pharmacology & Pharmacy
Takahisa Suzuki, Shigeru Tsunoda, Kota Yamashita, Toshie Kuwahara, Mitsuru Ando, Yasuhiko Tabata, Kazutaka Obama
Summary: The objective of this study was to develop a new preparation method for cisplatin-incorporated gelatin hydrogels and evaluate its anticancer efficacy. The results showed that the gelatin hydrogels achieved sustained release of cisplatin and demonstrated superior anticancer effects with minimal toxicity compared to free cisplatin solution.
Article
Biochemistry & Molecular Biology
Asma Chetouani, Meriem Elkolli, Hichem Haffar, Henni Chader, Farid Riahi, Tony Varacavoudin, Didier Le Cerf
Summary: Gelatin cross-linked with oxidized pectin shows potential as a scaffold material for tissue engineering, with improved wound healing activity observed in animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Daniele Testore, Alice Zoso, Galder Kortaberria, Marco Sangermano, Valeria Chiono
Summary: This study developed electroconductive hydrogels with tunable electrical and mechanical properties for tissue engineering applications. The hydrogels were composed of a blend of polyethylene glycol diacrylate (PEGDA) and gelatin, and incorporated poly (3,4-ethylenedioxythiophene):poly (styrene sulfonate) (PEDOT:PSS) for electroactivity. The results showed that the physical properties of the hydrogels could be adjusted by the initial ratio of PEGDA to gelatin, and the addition of PEDOT:PSS improved the electrical properties. In vitro tests demonstrated the cytocompatibility of the hydrogels and suggested their potential for cardiac tissue engineering applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Xiuqiong Chen, Lili Sun, Hongcai Wang, Shanshan Cao, Ting Shang, Huiqiong Yan, Qiang Lin
Summary: This study integrated alginate hydrogels with nano-silica to produce nano-silica reinforced alginate-chitosan-gelatin nanocomposite hydrogels for biomedical purposes. The experimental findings show that the physicochemical properties and biological activities of the hydrogels were influenced by the content of nano-silica. This research provides a foundation for overcoming the limitations of alginate hydrogels and expanding their potential applications in tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Jia Liang, Zhule Wang, Andreas A. Poot, Dirk W. Grijpma, Piet J. Dijkstra, Rong Wang
Summary: It has been found that methacrylated gelatin (GelMA) can be used as a 3D printable scaffold material in tissue regeneration fields, but its long-term stability needs to be improved. A mixture of GelMA and tyramine-conjugated 8-arm PEG (8PEGTA) was used to create filaments with an interpenetrating network (IPN), increasing the shape stability of the printed scaffolds. This new material was demonstrated to be a good candidate for extrusion-based printing of constructs for tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Engineering, Biomedical
Xu Xue, Yan Hu, Sicheng Wang, Xiao Chen, Yingying Jiang, Jiacan Su
Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Spectroscopy
Gaurav Kulkarni, Preetam Guha Ray, Shreyasi Das, Souvik Biswas, Santanu Dhara, Soumen Das
Summary: The study utilized Raman spectroscopy guided approach for biochemical evaluation of cell-matrix interaction, revealing that EDC crosslinked gels exhibited superior cell proliferation compared to GTA counterparts.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Biochemistry & Molecular Biology
Farwa Mushtaq, Zulfiqar Ali Raza, Syeda Rubab Batool, Muhammad Zahid, Ozgun Can Onder, Ammara Rafique, Muhammad Anwaar Nazeer
Summary: Gelatin's versatile functionalization allows for easy crosslinking and combining with other materials, resulting in hybrid materials with improved properties. Gelatin-based hydrogels and composite hydrogels possess unique functional features suitable for various applications. The properties of hydrogels can be optimized by design. Gelatin hydrogels can be used for water retention, chemical absorption, and controlled release. Their soft mechanics make them useful in tissue engineering. Gelatin is a potential material for biosensors, drug delivery systems, antimicrobials, and packaging systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Characterization & Testing
Sayoni Maiti, Pritisha S. Khillar, Debasish Mishra, N. Arunai Nambiraj, Amit K. Jaiswal
Summary: The formation of hydrogels relies heavily on the intricate chemistry between the constituents and efficient crosslinking methods. In this study, a hydrogel composed of chitosan, gelatin, and oxidized guar gum was fabricated using both physical and self-crosslinking approaches. Different levels of periodate oxidation were conducted, and the resulting hydrogels were characterized to compare the level of oxidized guar gum and the essential characteristics of the hydrogels, with a focus on hydrogel chemistry.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)