Article
Biochemistry & Molecular Biology
Andressa de Espindola Sobczyk, Claudia Leites Luchese, Debora Jung Luvizetto Faccin, Isabel Cristina Tessaro
Summary: Biopolymers like chitosan and alginate have been used in biomedical applications, especially in wound dressings as substitutes for synthetic polymers. The study compared the influence of antimicrobial agent incorporation form on the properties of chitosan/alginate-based films, finding that films containing oregano essential oil or ground oregano leaves showed promise for wound dressing applications with good physicochemical properties and antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Materials Science, Multidisciplinary
Biruk Fentahun Adamu, Jing Gao, Abdul Khalique Jhatial, Degu Melaku Kumelachew
Summary: Modern wound dressings are now incorporating functional materials like electrospun nanofibers to assist in wound healing and tissue regeneration. These dressings also provide breathability for cellular growth and have potential applications in drug delivery systems.
MATERIALS & DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Laura Colomina-Alfaro, Paola Sist, Silvia Marchesan, Ranieri Urbani, Artemis Stamboulis, Antonella Bandiera
Summary: This study focuses on the expression of antimicrobial peptides using the Human Elastin-like Polypeptide platform. The fusion construct allows for the release of the antimicrobial domain and maintains both the thermo-responsive behavior of the carrier and the antimicrobial activity of the added domain. The materials obtained from this approach have been evaluated for antimicrobial activity against bacterial-strain models.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Microbiology
Mohsen M. El-Sherbiny, Mohamed I. Orif, Mohamed E. El-Hefnawy, Sultan Alhayyani, Soha T. Al-Goul, Rawan S. Elekhtiar, Hoda Mahrous, Ahmed A. Tayel
Summary: Researchers have successfully developed novel bioactive nanocomposites using chitosan nanoparticles, cress seed mucilage, and selenium nanoparticles. These nanocomposites exhibit elevated bioactivities as bactericidal and anticancer agents. T1 is the strongest antibacterial formulation, while T3 is the superior anticancer amalgam.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joanna Jablonska, Magdalena Onyszko, Maciej Konopacki, Adrian Augustyniak, Rafal Rakoczy, Ewa Mijowska
Summary: The study demonstrated that paper sheets coated with chitosan, bacterial cellulose, and ZnO exhibit enhanced antibacterial and mechanical properties, making them suitable for food packaging applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Victor H. Pino-Ramos, Lorena Duarte-Pena, Emilio Bucio
Summary: Acrylic acid-agar hydrogels synthesized with gamma radiation as a crosslinking promoter exhibit excellent mechanical properties, high water absorption capacity, noticeable adhesion to skin, and antimicrobial activity when loaded with silver nanoparticles.
Article
Biochemistry & Molecular Biology
Isabela de Andrade Arruda Fernandes, Giselle Maria Maciel, Isabela Sampaio Ribeiro, Alessandra Cristina Pedro, Debora Goncalves Bortolini, Valeria Rampazzo Ribeiro, Lillian Barros, Charles Windson Isidoro Haminiuk
Summary: This research aimed to incorporate phenolic compounds (PC) into purified bacterial cellulose (BC) matrices through the biosorption process. The biosorbed membrane (BC-Bio) showed improved physical properties, including high water absorption capacity, thermal stability, and low water vapor permeability, as well as a high concentration of total phenolic compounds and antioxidant capacity. The release of PC in a buffered solution indicates that BC-Bio can be used as a polyphenol delivery system, making it a promising polymer for various industrial applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Infectious Diseases
Wanda Maczka, Martyna Twardawska, Malgorzata Grabarczyk, Katarzyna Winska
Summary: The main purpose of this article is to present the latest research on carvacrol's selected biological properties, including antimicrobial, anti-inflammatory, and antioxidant activity. Carvacrol, a monoterpenoid phenol, is found in many essential oils and is often accompanied by its isomer, thymol. It exhibits a strong antimicrobial effect against various bacteria and fungi that are harmful to humans or can cause significant economic losses, either alone or in combination with other compounds. Carvacrol also possesses powerful anti-inflammatory properties by preventing fatty acid peroxidation and reducing pro-inflammatory cytokine levels. It is considered a safe compound, although there is limited data on its metabolism in humans. Furthermore, this article discusses the biotransformations of carvacrol, as understanding the possible degradation pathways can help minimize environmental contamination with phenolic compounds.
Article
Engineering, Biomedical
Lei Zhou, Lei Fan, Feng-Miao Zhang, Yuhe Jiang, Min Cai, Cong Dai, Yi-An Luo, Ling-Jie Tu, Zheng-Nan Zhou, Xiao-Jun Li, Cheng-Yun Ning, Kai Zheng, Aldo R. Boccaccini, Guo-Xin Tan
Summary: In this study, hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating mesoporous bioactive glass nanoparticles were developed for bone regeneration. The addition of MBGNs enhanced the mechanical properties and accelerated gelation, while also promoting proliferation and osteogenic differentiation of stem cells in vitro and bone defect restoration in vivo. These hybrid hydrogels show promising potential as injectable biomaterials or scaffolds for bone regeneration applications.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Applied
Pu Wang, Ying Wu
Summary: Bioactive compounds face challenges in being applied in various industries, with colloidal delivery systems showing potential as a suitable approach to overcome solubility and stability issues.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Maria Teresa Fernandez Ponce, Cristina Cejudo Bastante, Lourdes Casas Cardoso, Casimiro Mantell, Enrique J. Martinez de la Ossa, Clara Pereyra
Summary: The study aimed to develop a bioactive transdermal patch functionalized with Annona leaf extracts using supercritical impregnation technique. It was found that the optimal impregnation conditions of ALE at 55 degrees C and 300 bar led to transdermal patches with antioxidant and antimicrobial capacity. The use of higher proportions of co-solvent in the system resulted in the best outcomes.
Review
Agriculture, Multidisciplinary
Sara Saez-Orviz, Ismael Marcet, Manuel Rendueles, Mario Diaz
Summary: Lactobionic acid (LBA) is a bioactive compound with promising applications in the food industry. It has unique properties due to its structure and composition, and has been traditionally known for its chelating, moisturizing, gelling, and antioxidant properties. Recent research has focused on its production, antimicrobial potential, and development of new functional food products. However, further comprehensive studies are needed to disseminate knowledge and influence its current regulation status.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Marina Alloisio, Andrea Dodero, Stefano Alberti, Silvia Vicini, Maila Castellano
Summary: Polysaccharide-based composites embedding silver nanoparticles show promising antimicrobial properties due to the combination of effective biocidal properties of the silver nanoparticles and the biocompatibility and environmental safety of the naturally occurring polymeric component. The silver nanoparticles stabilized with alginate chains were successfully synthesized in situ and electrospun into nanocomposite membranes for potential antimicrobial applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Clarisse Gosset-Erard, Minjie Zhao, Sonia Lordel-Madeleine, Said Ennahar
Summary: Extracts from pomegranate peels demonstrated significant antimicrobial activity, with punicalagin identified as the main antibacterial compound. Both α and β forms of punicalagin showed broad spectrum antibacterial activity, inhibiting a variety of Gram-positive and Gram-negative bacteria, as well as a yeast strain.
Article
Chemistry, Multidisciplinary
Monjurul Hoque, Ciara McDonagh, Brijesh K. Tiwari, Joseph P. Kerry, Shivani Pathania
Summary: Biopolymers, such as polysaccharides and proteins, are sustainable materials with film-forming potential, making them potential alternatives to plastics in food packaging. However, they have certain limitations that can be overcome through modification using cold plasma. Most studies have shown that cold plasma treatment improves the surface characteristics, mechanical properties, and thermal properties of biopolymer films, but its impact on barrier properties is limited. Cold plasma treatment also enhances the antimicrobial activity of films loaded with antimicrobial compounds.
APPLIED SCIENCES-BASEL
(2022)
Article
Polymer Science
Julia M. Frick Pavoni, Nicole Z. dos Santos, Izabelly C. May, Liliane D. Pollo, Isabel C. Tessaro
Summary: The properties of chitosan films are significantly affected by the type of acid and glutaraldehyde crosslinking, which reduces the swelling degree and increases fragility of the films. Crosslinking does not completely prevent the biodegradation of the films but requires a longer time. Ecotoxicity analysis suggests that the films can be composted.
Article
Polymer Science
Gabriela Leticia de Jesus, Camila Baldasso, Nilson Romeu Marcilio, Isabel Cristina Tessaro
JOURNAL OF APPLIED POLYMER SCIENCE
(2020)
Article
Engineering, Environmental
Juliana Both Engel, Marina Mac Ginity, Claudia Leites Luchese, Isabel Cristina Tessaro, Jordana Corralo Spada
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2020)
Article
Food Science & Technology
Alan Ambrosi, Mateus B. Motke, Erica A. Souza-Silva, Claudia A. Zini, Jeffrey R. McCutcheon, Nilo Sergio M. Cardozo, Isabel Cristina Tessaro
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2020)
Article
Materials Science, Ceramics
Melissa R. de la Rocha, Mirella Virginie, Andrei Khodakov, Liliane D. Pollo, Nilson R. Marcilio, Isabel C. Tessaro
Summary: The addition of coal fly ash to alumina-based membranes increases porosity and water permeability while reducing mechanical strength and linear shrinkage. These membranes have high cornstarch retention, making them cost-effective and suitable for applications such as wastewater treatment.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Chemical
Julia Menegotto Frick Pavoni, Nataly Leidens, Claudia Leites Luchese, Camila Baldasso, Isabel Cristina Tessaro
JOURNAL OF FOOD PROCESS ENGINEERING
(2020)
Article
Engineering, Biomedical
Patricia Hubner, Nilson Romeu Marcilio, Isabel Cristina Tessaro
Summary: Hydrogel films based on gelatin and PVA were developed and optimized using a central composite design method, showing characteristics suitable for biomedical applications such as wound dressings. The optimized film had good mechanical resistance, elasticity, and permeability to oxygen, making it a promising candidate for use in biomedical settings.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Ana Katiuce Fellenberg, Claudia Leites Luchese, Nilson Romeu Marcilio, Isabel Cristina Tessaro
Summary: This research focused on developing carbon membranes using poly(ether sulfone) as a polymeric precursor and DMSO as a solvent, formed through dip-coating technique on alumina ceramic tubes with pyrolysis conducted at 700 degrees C. The obtained carbon membranes showed high thermal stability and microporous characteristics, suitable for gas separation processes.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Engineering, Chemical
Vinicius da Costa Avila, Isabel Cristina Tessaro, Nilo Sergio Medeiros Cardozo
Summary: Accurate spatial discretization error estimates are crucial for certain CFD applications. This study evaluated the suitability of three error estimators in simulations of a benchmark bubble column and found that EH-LS was the only method suitable for both MixtM and hTFM. DTS resulted in inaccurate estimates for coarse meshes.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Chemistry, Applied
Juliana Both Engel, Claudia Leites Luchese, Isabel Cristina Tessaro
Summary: This study explored the use of cassava residues in producing foams, finding that pre-gelatinization can enhance the mechanical strength and elongation of biocomposites, while cassava inner bark can be used to create packaging materials with lower water absorption capacity. Additionally, skipping the pre-gelatinization step can increase production speed and reduce costs.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Andressa de Espindola Sobczyk, Claudia Leites Luchese, Debora Jung Luvizetto Faccin, Isabel Cristina Tessaro
Summary: Biopolymers like chitosan and alginate have been used in biomedical applications, especially in wound dressings as substitutes for synthetic polymers. The study compared the influence of antimicrobial agent incorporation form on the properties of chitosan/alginate-based films, finding that films containing oregano essential oil or ground oregano leaves showed promise for wound dressing applications with good physicochemical properties and antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Claudia Leites Luchese, Raul Barth Rodrigues, Isabel Cristina Tessaro
Summary: The development of starch-based films has shown the potential for creating transparent, non-toxic, biodegradable materials with good gas barrier properties. However, the use of starch in packaging should be avoided due to world hunger-related problems. Utilizing residual starches can reduce production costs and promote the development of innovative biomaterials. The addition of gelatinized starch from agro-industrial residues in bioplastic production has shown a decrease in tensile strength and elastic modulus values, but no significant impact on elongation percentage values.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Janice B. S. Hamm, Alan Ambrosi, Liliane D. Pollo, Nilson R. Marcilio, Isabel Cristina Tessaro
Summary: This paper presents a new approach for obtaining a thin polymeric film on porous supports using the dip-coating/phase inversion technique. The method, known as the wet-dry process, effectively minimizes intrusion into the support pores. Morphology was analyzed using scanning electron microscopy to confirm the efficacy of the new technique.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Engineering, Environmental
Jordana Corralo Spada, Sabrina Ferreira Seibert, Isabel Cristina Tessaro
Summary: Composites with high rice husk content and coated with PLA and PBAT were evaluated for their properties. The double coating of PLA resulted in a more uniform surface, decreased water absorption, and improved hydrophilicity.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
