Article
Cell Biology
Qoyama Noel Baito, Halmat M. Jaafar, Talar Ahmad Merza Mohammad
Summary: In this study, piperine was found to induce apoptosis and reduce proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) through inhibition of the NF-kappa B pathway. It also decreased the expression of genes related to RA-FLS proliferation, apoptosis inhibition, and inflammation, while increasing the expression of apoptosis-related genes. Moreover, piperine reduced the secretion of cytokines and chemokines by FLSs as a result of NF-kappa B inhibition.
CELLULAR IMMUNOLOGY
(2023)
Review
Immunology
Zewen Wu, Dan Ma, Helin Yang, Jinfang Gao, Gailian Zhang, Ke Xu, Liyun Zhang
Summary: Fibroblast-like synoviocytes (FLS) play a crucial role in the pathophysiology of rheumatoid arthritis (RA) and have become the main focus of research. Advances in technology, such as high-throughput sequencing, have made it possible to identify different FLS subsets, allowing for a detailed study of RA pathogenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaolu Yu, Junnan Zhou, Fuli Zhao, Xuan Liu, Yuhang Mao, Li Diao, Chuanjun Wen, Mei Liu
Summary: Tomatidine (Td) shows inhibitory effects on inflammatory responses in arthritis and therapeutic effects on synovial inflammation and joint destruction in rats. Td can significantly suppress the production of pro-inflammatory cytokines and may act by reducing the activation of MAPKs and NF-κB.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Mehrnoosh Adib, Mahdi Taghadosi, Mohammad Naghi Tahmasebi, Arash Sharafat Vaziri, Ahmadreza Jamshidi, Mahdi Mahmoudi, Elham Farhadi
Summary: This study investigates the effects of PRIMA-1(MET) on apoptosis induction and inhibition of pro-inflammatory cytokines in fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA). The results show that PRIMA-1(MET) induces apoptosis in RA-FLSs, upregulates Noxa expression, and downregulates IL-6, IL-1β, p53, and phospho-IKBa expression. Furthermore, PRIMA-1(MET) treatment suppresses pro-inflammatory cytokine production and inhibits NF-kappa B activity. Therefore, PRIMA-1(MET) could be considered as a new therapeutic strategy for rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Immunology
Ji Hyeon Ryu, Jisu Park, Bo-Young Kim, Yeonye Kim, Nam Gyun Kim, Yong-Il Shin
Summary: This study investigates the effects and mechanisms of photobiomodulation (PBM) on fibroblast-like synoviocytes (FLSs) from rheumatoid arthritis (RA) patients and a mouse model of collagen-induced arthritis (CIA). PBM significantly reduced proliferation, migration, and invasion of RA-FLSs, and inhibited synovial inflammation and cartilage degradation in the CIA model. PBM therapy also showed a synergistic effect when combined with methotrexate (MTX), a disease-modifying anti-rheumatic drug (DMARD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Wei Lin, Yingli Liu, Shuoyang Zhang, Siqi Xu, Qian Qiu, Cuicui Wang, Di Liu, Chuyu Shen, Meilin Xu, Maohua Shi, Youjun Xiao, Guoqiang Chen, Hanshi Xu, Liuqin Liang
Summary: In this study, it was found that Schisandrin (SCH), a natural compound, can inhibit the proliferation, migration, and inflammatory cytokine expression of rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs) by targeting SREBF1-mediated activation of the PI3K/AKT and NF-kappa B signaling pathways. Moreover, SCH can alleviate joint inflammation and cartilage and bone destruction in collagen-induced arthritis (CIA) model mice, suggesting its therapeutic potential for rheumatoid arthritis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuan Liu, Peishi Rao, Hongyan Qian, Yesi Shi, Shiju Chen, Jingying Lan, Dan Mu, Rongjuan Chen, Xinwei Zhang, Chaoqiong Deng, Gang Liu, Guixiu Shi
Summary: Fibroblast-like synoviocytes (FLS) are the main cell component in inflamed joints of patients with rheumatoid arthritis (RA) and interact with infiltrating T cells. Under normal conditions, FLS have inhibitory effects on T cells, but in RA, FLS exhibit a proinflammatory phenotype. The signals that control FLS heterogeneity are still unclear.
Article
Biochemistry & Molecular Biology
Min Wang, Tianming Dai, Siming Li, Wen Wang
Summary: This study found that eugenol can inhibit the proliferation, migration, invasion, angiogenesis, and inflammatory response of fibroblast-like synovial cells from rheumatoid arthritis (RA), and promote apoptosis. The molecular mechanisms of eugenol may be associated with vascular endothelial growth factor (VEGF) and NF-kappaB (NF-kB) signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Xiao-Feng Li, Sha Wu, Qi Yan, Yuan-Yuan Wu, He Chen, Su-Qin Yin, Xin Chen, Hua Wang, Jun Li
Summary: The study reveals that PTEN methylation promotes inflammation and activation in fibroblast-like synoviocytes (FLS) in the pathogenesis of rheumatoid arthritis (RA). Inhibiting methylation can reduce inflammation and alleviate joint swelling, potentially serving as an effective treatment strategy for RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shihui Zhang, Zhizhong Shen, Gao Chao, Xiaolong Du, Wentao Zhang, Dan Jin, Yafei Liu
Summary: This study found that circular RNA_0004712 (circ_0004712) is up-regulated in rheumatoid arthritis (RA) and plays a role in RA progression by regulating the miR-633/TRAF6/NF-kappa B signaling pathway. Silencing circ_0004712 suppressed the viability, proliferation, migration, and inflammation of RA fibroblast-like synoviocytes (RA-FLSs) and promoted apoptosis. Circ_0004712 was shown to interact with miR-633 and TRAF6, providing new targets for the treatment of RA.
BIOCHEMICAL GENETICS
(2023)
Article
Biotechnology & Applied Microbiology
Weihong Xu, Lu Ye, Huaxiang Wu
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with increasing incidence globally. The study revealed that miR-4423-3p is downregulated in RA patients and targets MMP13 to inhibit cell proliferation, migration, and invasion while promoting apoptosis in HFLS-RA cells.
Article
Oncology
Jian Chen, Xian Lin, Juan He, Dandan Liu, Lianhua He, Miaomiao Zhang, Huijie Luan, Yiping Hu, Cheng Tao, Qingwen Wang
Summary: The study found that ATT has potential therapeutic effects on RA by suppressing proliferation, migration, and invasion of RA-FLSs, as well as inducing apoptosis. ATT achieves therapeutic potential for RA by modulating the METTL3/ICAM2/PI3K/AKT/p300 feedback loop.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Richard Ainsworth, Deepa Hammaker, Gyrid Nygaard, Cecilia Ansalone, Camilla Machado, Kai Zhang, Lina Zheng, Lucy Carrillo, Andre Wildberg, Amanda Kuhs, Mattias N. D. Svensson, David L. Boyle, Gary S. Firestein, Wei Wang
Summary: This study characterizes clusters of RA cell lines with distinctive TF biology by integrating transcriptomic and epigenomic data and validates the predicted differences.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Yanhua Zuo, Huaheng Xu, Yanxia Li, Zongfang Zhang, Ran Tao, Manxiang Wang
Summary: Synovial samples from RA patients and normal controls were used to isolate FLSs. Increased expression of circ_0007707 was observed in synovial samples from RA patients and FLS-RA cells. Circ_0007707 silencing inhibited cell proliferation, induced cell apoptosis, and decreased cell inflammatory response in FLS-RA cells. Mechanistically, circ_0007707 mediated cell apoptosis and inflammatory response in FLS-RA cells through the miR-27b-3p/PDE3B axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Rheumatology
S. Wu, Y. Jiang, Y. Teng, X. Liu, L. Zhou, W. Li
Summary: IL-33 inhibits apoptosis and promotes proliferation of RA FLSs, increases the expression levels of Bcl-2 protein and decreases the expression levels of Bax protein. Additionally, IL-33 enhances the expression levels of inflammatory cytokines TNF-alpha and IL-6 through the NF-kappa B pathway.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)