Journal
INORGANICA CHIMICA ACTA
Volume 504, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2020.119431
Keywords
Dithiocarbamate; Metal(II) complexes; Cytotoxicity; Anticancer; Cancer cells; Selectivity
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Funding
- Sasol, South Africa
- National Research Foundation (NRF), South Africa
- Tertiary Education Trust Fund (TETfund)
- Modibbo Adama University of Technology, Nigeria
- Faculty of Science, Liverpool John Moores University
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Mn(II), Cu(II), Zn(II) and Pt(II) complexes of 2-((p-tolylamino)methyl)phenolyldithiocarbamate were synthesized and characterized by elemental analyses and spectroscopic techniques. Spectroscopic studies indicate four coordinate geometry around the metal(II) ions and single crystal X-ray crystallography confirmed the molecular structures of Cu(II) and Pt(II) complexes as distorted square planar. In vitro cytotoxic effects of the complexes, indicative of potential anti-cancer properties, were evaluated using human cancer cell lines HeLa and MRC5-SV2, and a normal cell line, MRC5. The complexes exhibited significant toxicity against the cancer cell lines, with IC50 values of less than 50 mu M after 48 h of exposure. Cu(II) and Zn(II) were the most potent and were virtually equipotent in their cytotoxicity against each of the two cancer cells, but only Zn(II) exhibited higher selectivity for a cancer cell than for a normal cell. Mn(II) complex was the least potent, while Pt(II) was the least cancer cell-selective, exhibiting significantly higher toxicity against the parental (normal) MRC-5 cell than against its cancer variant, MRC5-SV2. These compounds could, therefore, inspire the development of inorganic drug leads to generate novel anti-cancer drugs to be delivered directly to the cancerous tissue or through special delivery systems.
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