Article
Chemistry, Inorganic & Nuclear
E. S. Cakmakci, E. Subasi, E. Ozturk, A. Sahiner, B. Sen Yuksel
Summary: Metal(II) complexes including Co(II), Ni(II), Pd(II) and Zn(II) were synthesized and characterized. These complexes were obtained by reacting metal(II) chlorides with the ligand. The structures and properties of these complexes were determined by various characterization techniques including elemental analysis, FT-IR, 1H NMR, and single crystal X-ray diffraction.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Carolina Rivera, Hector A. Bacilio-Beltran, Ana M. Puebla-Perez, Irma I. Rangel-Salas, Jose G. Alvarado-Rodriguez, Roberto Flores-Moreno, Gilberto Velazquez-Juarez, A. Aaron Peregrina-Lucano, Elvia Becerra-Martinez, Jaime Valdez-Ruvalcaba, Jose E. Rubio, Sara A. Cortes-Llamas
Summary: The synthesis of cis and trans isomers of platinum complexes with a symmetric N-heterocyclic carbene ligand has been reported. These complexes were obtained from a masked N-heterocyclic carbene precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated, and the cis-[Pt((NHC)-N-Me)(2)Cl-2] complex exhibited the highest cytotoxic effect in the HeLa cervical cancer cell line.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Bishoy El-Aarag, Fathy El-Saied, Tarek Salem, Nesrin Khedr, Shaden A. M. Khalifa, Hesham R. El-Seedi
Summary: This study synthesized new metal complexes and evaluated their antitumor activity, showing that the tested complexes possessed proliferative inhibition and could reduce tumor volume, affect protein levels, and enzyme activity.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Mayada S. Ali, Fathy A. El-Saied, Mohamad ME. Shakdofa, Sadashiva Karnik, Laila A. Jaragh-Alhadad
Summary: Thiosemicarbazone compound exhibits significant anticancer activity, which is enhanced by the presence of metal ions. New Ni(II), Cu(II), Pd(II), and Pt(II) complexes synthesized from the ligand H3L showed potent antiproliferation activity at the micromolar level.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Riccardo Pettinari, Fabio Marchetti, Alessia Tombesi, Fenghe Duan, Liming Zhou, Luigi Messori, Chiara Giacomelli, Laura Marchetti, Maria Letizia Trincavelli, Tiziano Marzo, Diego La Mendola, Gabriele Balducci, Enzo Alessio
Summary: This study investigated the interactions between two cationic ruthenium(II) [9]aneS3 complexes and a model protein, revealing a limited reactivity and modest cytotoxicity against cancer cell lines. The moderate pharmacological activity is likely attributed to the relatively high stability of these complexes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kritika Bajaj, Robert M. Buchanan, Craig A. Grapperhaus
Summary: Fungi are common in nature and typically do not harm their hosts, but a small number of pathogenic fungi are rapidly spreading worldwide, posing a threat to global ecosystem health. Emerging drug-resistant fungi highlight the need for new antifungal agents, with metal complexes showing higher activity compared to non-coordinated ligands.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Pallavi Jain, Vijay K. K. Vishvakarma, Prashant Singh, Sandeep Yadav, Rajesh Kumar, Sulekh Chandra, Dinesh Kumar, Namita Misra
Summary: Mn(II) and Cu(II) complexes with the ligand 2-acetyl-5-methylfuranthiosemicarbazone were synthesized and their structures were determined using analytical and spectroscopic techniques. Molar conductance confirmed the electrolytic nature of the complexes. Theoretical study explained the structural property and reactivity of the complexes. Global reactivity descriptors were used to study the chemical reactivity and stability of the ligand and metal complexes. Biological potency evaluation showed that the complexes had higher inhibitory action than the ligand, with Cu(II) complex having the most inhibitory effect. Molecular docking and ADME analysis further supported the experimental results.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jin Wang, Zhi-Meng Zhang, Ming-Xue Li
Summary: The synthesis of four metal complexes and their antimicrobial and cytotoxic activities were investigated in this study. The results showed that the antibacterial activity of cadmium (II) and antimony (III) complexes was enhanced compared to their ligands, with Cd2 and Sb2 demonstrating effective antibacterial activity and Cd2 showing the most effective antiproliferative activity against HepG2 cells.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Physical
Fekadu Muleta, Tegene Desalegn, Rajalakshmanan Eswaramoorthy, Ankita Garg
Summary: The newly synthesized Cu(II) and Zn(II) complexes showed better antibacterial and antioxidant potential compared to the ligands, indicating a potential new approach for treating multidrug resistance pathogens.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Ali A. A. Al-Riyahee, Peter N. Horton, Simon J. Coles, Angelo J. Amoroso, Simon J. A. Pope
Summary: The synthesis of two thiosemicarbazone derivatised ligands (L1 and L2) was achieved by reacting 1-(2-pyridinyl)ethanone hydrazone with benzoyl or pivaloyl isothiocyanate. Mononuclear complexes of nickel (II), copper (II), and zinc (II) with these ligands were synthesized and characterized using various techniques. The solid-state molecular structures of eight examples were successfully determined by single crystal X-ray diffraction.
Article
Chemistry, Physical
C. T. Gracelin Retnam, S. Viola Rose, B. Sindhu Kumari
Summary: Bivalent metal chelates of manganese, cobalt, nickel, copper, and zinc were synthesized from 3-acetylcoumarin derivative. The compounds were characterized using various techniques and showed moderate activity in DNA cleavage, antifungal, antibacterial, antioxidant, and anticancer studies.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Ahmed Gaber, Moamen S. Refat, Arafa A. M. Belal, Ibrahim M. El-Deen, Nader Hassan, Rozan Zakaria, Majid Alhomrani, Abdulhakeem S. Alamri, Walaa F. Alsanie, Essa M. Saied
Summary: The synthesis of eight new mononuclear and binuclear metal methoxy thiosemicarbazone complexes was reported, with characterization using various analytical techniques. The metal complexes showed improved antibacterial activity compared to the ligand alone, with Cu2+ complexes displaying significant antibacterial activity. The in silico molecular docking study indicated that the MTSC ligand could potentially inhibit the oxidoreductase protein.
Article
Chemistry, Applied
Ilknur Babahan-Bircan, Safiye Emirdag, Ali Ozmen, Muruvvet Abbak, Oguejiofo T. Ujam, Ilke Demirkaya, M. Emin Gunay
Summary: A novel hybrid ligand and its metal complexes were synthesized and evaluated for their antiproliferative and apoptotic properties in human breast and prostate cancer cell lines. The compounds showed higher efficacy, especially in the PC-3 breast cancer cell line, by triggering apoptosis in the cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Dunya Yousif Fnfoon, Khalid J. Al-Adilee
Summary: In this study, the complexation of Cu(II), Ag(I), and Au(III) ions with a newly synthesized azo imidazole ligand was investigated. The compounds were characterized by various techniques, and their anticancer properties were evaluated. The results demonstrated that the synthesized compounds exhibited promising anticancer properties and could be potential candidates for future anti-tumor drug applications.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Ibrahim I. Ozturk, Kadriye Turk, Anita M. Grzeskiewicz, Maciej Kubicki, Christina N. Banti, Sotiris K. Hadjikakou
Summary: The study synthesized and characterized bismuth(III) thiosemicarbazone complexes and evaluated their antiproliferative and antibacterial activities. The complexes showed promising antiproliferative activity against human adenocarcinoma cervical cancer cells and moderate activity against Gram-negative bacteria.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Christine A. Phipps, Dillon T. Hofsommer, Calian D. Zirilli, Bailee G. Duff, Mark S. Mashuta, Robert M. Buchanan, Craig A. Grapperhaus
Summary: A series of thiosemicarbazonato-hydrazinatopyridine metal complexes were evaluated as CO2 capture agents, and the Zn(II) complexes showed effective CO2 capture from dilute sources with high efficiency. Ligand substitution and metal ion variation were found to affect the CO2 capture affinity, mainly associated with ligand basicity and metal ion Lewis acidity. The complexes demonstrated reversible CO2 capture and the equilibrium constants varied with different metals and ligands.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Blake Martin, Sashil Chapagain, Peter Armstrong, Craig A. Grapperhaus, Matthew O. Reese, Thad Druffel
Summary: In this study, a mixed-cation perovskite ink with a robust coating window was developed using a classical roll-to-roll manufacturing method and intense pulsed light annealing. The method resulted in blade-coated, flexible, mixed-cation perovskite solar cells with a champion power conversion efficiency of 16.7%, and it is one of the fastest processing methods for the perovskite layer. The overall reduction in processing time with a stable ink represents an advance toward the scaled production of perovskite solar cells on flexible substrates.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Dillon T. Hofsommer, Manu Gautam, Sandesh S. Uttarwar, Craig A. Grapperhaus, Joshua M. Spurgeon
Summary: Electrochemical CO2 reduction in methanol shows promise for reducing greenhouse gas emissions and producing value-added products. Critical factors for achieving high selectivity for methyl formate production on a Pb cathode in methanol include high pH near the electrode, low bulk pH, low water content, and regeneration of Pb2+ sites. The use of co-electrolysis with dilute molecular oxygen (4% O-2) can repair the Pb catalyst through in situ surface oxidation. Sustained high selectivity for methyl formate can be achieved with the use of CO2, dilute O2, and single-pass catholyte flow for over 72 hours.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Physical
Sashil Chapagain, Blake Martin, Peter Armstrong, Craig L. Perkins, Matthew O. Reese, Thad Druffel, Craig A. Grapperhaus
Summary: Solution processing of flexible perovskite solar cells enables scalable, high-throughput printing of lightweight and cost-effective solar cells. However, the deposition of metal oxide charge transport layers has been limited by solvent incompatibilities and high processing temperatures. In this study, we achieve high-performance, inverted flexible perovskite solar cells by directly depositing yttrium-doped SnO2 nanoparticles functionalized with acetate on top of perovskite using blade coating. Yttrium doping improves charge extraction and reduces series resistance, leading to increased efficiency.
ACS APPLIED ENERGY MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Manu Gautam, Francois Nkurunziza, Matthew C. Mulvehill, Sandesh S. Uttarwar, Dillon T. Hofsommer, Craig A. Grapperhaus, Joshua M. Spurgeon
Summary: This paper presents the recent progress in coupling CO2 reduction with secondary reactions in a non-aqueous solvent through tandem cathodic reactions. A two-membrane flow electrolyzer with both anion and cation exchange membranes is used to prevent methanol flooding the cathode. However, low-water-content catholyte compositions lead to increased cell resistance and lower operating current densities, highlighting the need for new ionomer materials tailored for non-aqueous solvents.
Article
Chemistry, Inorganic & Nuclear
Kritika Bajaj, Sarah A. Andres, Dillon T. Hofsommer, Okolocha Chekwube Michael, Mark S. Mashuta, Paula J. Bates, Robert M. Buchanan, Craig A. Grapperhaus
Summary: A series of isomeric bis(alkylthiocarbamate) copper complexes were synthesized and evaluated for their antiproliferation activity. One of the complexes, CuL2a, showed potent activity and selectivity against lung adenocarcinoma cells.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kritika Bajaj, Sarah A. Andres, Dillon T. Hofsommer, Aidan F. Greene, Oleksandr Hietsoi, Mark S. Mashuta, Theresa Weis, Levi J. Beverly, Paula J. Bates, Robert M. Buchanan, Craig A. Grapperhaus
Summary: A series of hybrid copper complexes with similar electronic environments but distinct physical structures have been prepared, characterized, and evaluated for their antiproliferation activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Peter J. Armstrong, Sashil Chapagain, Rojita Panta, Craig Grapperhaus, Thad Druffel
Summary: Perovskite solar cells have commercial potential due to their low-cost materials and manufacturing processes while maintaining high efficiency. Nanomaterials offer attractive properties for perovskite devices, such as low-cost inks, low temperature processing, and good charge transport. This feature article reviews the use of nanomaterials in the hole and electron transport layers, highlighting the leading materials and providing insights for their deployment in large scale applications.
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Multidisciplinary
Peter J. Armstrong, Sashil Chapagain, Rojita Panta, Craig Grapperhaus, Thad Druffel
Summary: Perovskite solar cells have commercial potential due to their low-cost materials and manufacturing processes. Nanomaterials, including low-cost inks and stable material properties, have attractive properties for perovskite devices. This article reviews the use of nanomaterials in the hole transport and electron transport layers, focusing on leading materials SnO2 and NiOx.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Christine A. Phipps, Dillon T. Hofsommer, Calian D. Zirilli, Bailee G. Duff, Mark S. Mashuta, Robert M. Buchanan, Craig A. Grapperhaus
Summary: In this study, a series of thiosemicarbazonato-hydrazinatopyridine metal complexes were evaluated as CO2 capture agents. The Zn(II) complexes were found to effectively capture CO2 from dilute sources.
INORGANIC CHEMISTRY
(2023)