Journal
INFLAMMATORY BOWEL DISEASES
Volume 26, Issue 8, Pages 1131-1143Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izaa045
Keywords
inflammatory bowel disease; Crohn; ulcerative colitis; mucosal healing; inflammation
Categories
Funding
- Leona M. and Harry B. Helmsley Charitable Trust
- Jon Moulton Foundation
- Crohn's Colitis UK
- Guts Charity UK
- Chief Scientist Office (CSO) Scotland
- Medical Research Council (MRC)
- Wellcome Trust [108906/Z/15/Z]
- European Research Council [771443]
- Sir Henry Dale Fellowship - Wellcome Trust [206234/Z/17/Z]
- Sir Henry Dale Fellowship - Royal Society [206234/Z/17/Z]
- MRC Programme grant [MR/K013386/1]
- MRC SHIELD consortium [MRNO2995X/1]
- MRC [MR/K013386/1] Funding Source: UKRI
- European Research Council (ERC) [771443] Funding Source: European Research Council (ERC)
- Wellcome Trust [206234/Z/17/Z] Funding Source: Wellcome Trust
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Despite significant recent therapeutic advances, complete mucosal healing remains a difficult treatment target for many patients with inflammatory bowel diseases (IBD) to achieve. Our review focuses on the translational concept of promoting resolution of inflammation and repair as a necessary adjunctive step to reach this goal. We explore the roles of inflammatory cell apoptosis and efferocytosis to promote resolution, the new knowledge of gut monocyte-macrophage populations and their secreted prorepair mediators, and the processes of gut epithelial repair and regeneration to bridge this gap. We discuss the need and rationale for this vision and the tangible steps toward integrating proresolution therapies in IBD.
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