Article
Polymer Science
Chavee Laomeephol, Apichai Vasuratna, Juthamas Ratanavaraporn, Sorada Kanokpanont, Jittima Amie Luckanagul, Martin Humenik, Thomas Scheibel, Siriporn Damrongsakkul
Summary: Binary-blended hydrogels fabricated from Bombyx mori silk fibroin and recombinant spider silk protein showed improved gelation time and cellular interactions compared to individual materials, suggesting potential for biomedical applications. Mixing the two materials enhanced cellular activities, making the hydrogels suitable for various biomedical uses.
Article
Biochemistry & Molecular Biology
Xiaosheng Tao, Fujian Jiang, Kang Cheng, Zhenzhen Qi, Vamsi K. Yadavalli, Shenzhou Lu
Summary: The study introduces a new conjugated material, cationic silk fibroin (CSF), created through chemical modification of silk fibroin with epsilon-Poly-(L-lysine) (epsilon-PLL), that demonstrates excellent pH responsiveness and swelling behavior. Additionally, the CSF hydrogel shows glucose-responsive properties when glucose oxidase (GOx) is added, providing potential for rapid drug release applications. The versatility and biological properties of fibroin make stimuli-responsive silk hydrogels promising for intelligent drug delivery and other biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Chen-Man Zong, Fei-Fan Shuang, Jie Chen, Ping-Yue Wang, Jing-Rou Li, Dong- Yang Zhang, Peng Song, Tao Chen, Wei-Guo Zhao, Xiao-Hui Yao
Summary: Hydrogels with improved mechanical properties are prepared using a multidimensional material design method involving in situ gelation of silk fabric and nacre-inspired layer-by-layer assembly. This method significantly enhances the strength of the silk fibroin hydrogels and allows for longitudinal extension. The application of biomineralization and hot pressing helps reduce interface defects and improve the interaction between organic and inorganic interfaces.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Ines A. Barroso, Kenny Man, Thomas J. Hall, Thomas E. Robinson, Sophie E. T. Louth, Sophie C. Cox, Anita K. Ghag
Summary: Corneal transplantation is the current gold standard treatment for severe corneal diseases and injuries. However, the shortage of donor tissue remains a challenge. Additionally, the difficult instillation and drainage of antibiotic eye drops in ocular surgery is an issue of concern. In this study, antimicrobial silk-based hydrogels were developed, which can be photoactivated in situ and fully adapt to the shape of corneal injuries. These hydrogels have the potential to facilitate corneal regeneration and could be applied in various soft tissue engineering fields.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Zhibin Peng, Ming Li, Yuan Wang, Hongbo Yang, Wei Wei, Min Liang, Jianhui Shi, Ruixuan Liu, Rui Li, Yubo Zhang, Jingsong Liu, Xu Shi, Ran Wan, Yao Fu, Rui Xie, Yansong Wang
Summary: A self-assembling imageable silk hydrogel has been developed for the treatment of osteosarcoma. Iodine has been shown to induce apoptosis in osteosarcoma cells, and the silk hydrogel has demonstrated good therapeutic efficacy and biosafety in the treatment of the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Shaorong Yan, Junyao Li, Yunli Gao, Jun You, Shuo Xu, Chunru Wang, Yongqiang Yang, Xiaochen Wu
Summary: Excessive oxidative stress, bacterial infections, and inflammation are the primary obstacles to skin wound healing. In this study, bioactive hydrogels were developed by incorporating curcumin and silver nanoparticles into a silk fibroin matrix, improving their dispersibility and stability. These hydrogels demonstrated biological safety, antioxidative and anti-inflammatory efficacy, as well as antibacterial effects, effectively promoting wound repair.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Mahdi Yonesi, Milagros Ramos, Carmen Ramirez-Castillejo, Rocio Fernandez-Serra, Fivos Panetsos, Adrian Belarra, Margarita Chevalier, Francisco J. Rojo, Jose Perez-Rigueiro, Gustavo Guinea, Daniel Gonzalez-Nieto
Summary: Central nervous system diseases impose a significant social and economic burden, with inflammation being a common factor that affects the stability of biomaterials and therapies. This study explored the stability of silk fibroin hydrogels in different neuroinflammatory contexts using in vitro and in vivo models. The results showed that silk hydrogels remained relatively stable and did not degrade extensively in the presence of inflammation, contrasting with the rapid degradation of collagen under the same conditions. These findings support the potential use of silk fibroin hydrogels for intracerebral applications in cerebral pathologies.
Article
Materials Science, Multidisciplinary
Xueping Liu, Hui Wu, Peng Pan, Mengmeng Wang, Wenjing Zhang, Cheng Hu, Shenzhou Lu, Mingzhong Li, Yu Liu
Summary: In this study, thermosensitive hydroxybutyl chitosan (HBC)/silk fibroin (SF) hybrid hydrogels were prepared by physical interaction. The HBC/SF hybrids showed rapid sol-gel transition at physiological temperature and had the potential to be used as injectable tissue engineering scaffolds and soft tissue fillers. The introduction of SF component effectively reduced the cytotoxicity of HBC hydrogel.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
Pramod Dorishetty, Rajkamal Balu, Amy Gelmi, Jitendra P. Mata, Anita Quigley, Naba K. Dutta, Namita Roy Choudhury
Summary: In this study, a regenerated silk fibroin/reduced graphene oxide hybrid ink system was developed and used to fabricate hydrogels with tunable properties and cell-gel interactions through extrusion printing and photocrosslinking. The incorporation of isopropyl alcohol (IPA) and increase in rGO content affected the viscosity, contact angle, printing accuracy, and physical properties of the hybrid ink and hydrogels. The increase in rGO content also improved the crosslink density, mechanical properties, and decreased the micropore size of the hybrid hydrogels. Furthermore, the hybrid and bioprinted hydrogels showed good biocompatibility with marginal difference in cell viability. These findings suggest the potential application of the developed hydrogel systems in tissue engineering and other functional applications.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Firoz Babu Kadumudi, Masoud Hasany, Malgorzata Karolina Pierchala, Mohammadjavad Jahanshahi, Nayere Taebnia, Mehdi Mehrali, Cristian Florian Mitu, Mohammad-Ali Shahbazi, Tiberiu-Gabriel Zsurzsan, Arnold Knott, Thomas L. Andresen, Alireza Dolatshahi-Pirouz
Summary: The novel biomaterial CareGum exhibits unique properties such as high mechanical toughness, record-breaking elongation capacity, good conformability, increased electrical conductivity and Young's modulus, as well as self-healing capabilities. By leveraging these characteristics, a durable and self-healing bionic glove is developed for hand gesture sensing and sign translation. CareGum shows promise for applications in fields like cyborganics, bionics, soft robotics, human-machine interfaces, 3D-printed electronics, and flexible bioelectronics.
ADVANCED MATERIALS
(2021)
Article
Engineering, Biomedical
Li Zhao, Jizhong Zhao, Fan Zhang, Zijie Xu, Fan Chen, Yating Shi, Chen Hou, Yicheng Huang, Changjian Lin, Rui Yu, Wenxi Guo
Summary: The one-pot method of thermal polymerization is introduced to fabricate silk fibroin-doped hydrogels, which exhibit excellent mechanical properties, adhesion, and self-healing capabilities, making them suitable for applications in pressure sensors and electronic skin fields.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Pramod Dorishetty, Rajkamal Balu, Amy Gelmi, Jitendra P. Mata, Naba K. Dutta, Namita Roy Choudhury
Summary: The development of protein-based 3D printable hydrogel systems with tunable structure and properties is crucial in biomedical applications. Hybrid hydrogels co-cross-linked between globular soy protein isolate (SPI) and fibrous silk fibroin (SF) were successfully 3D printed for the first time, showing tunable mechanical properties and increased printing accuracy with higher SF content. The fabricated hybrid hydrogels exhibited larger micropores and good cell attachment and proliferation, demonstrating their potential for tissue engineering applications.
Article
Engineering, Biomedical
Yuet Cheng, Gu Cheng, Congyong Xie, Chengcheng Yin, Xiangyang Dong, Zhi Li, Xue Zhou, Qun Wang, Hongbing Deng, Zubing Li
Summary: A silk fibroin hydrogel reinforced by short silica nanoparticles-distributed-silk fibroin nanofibers with superior osteoinductive properties was fabricated for treating bone defects. The composite scaffold mimics the extracellular matrix of native bone and enhances mechanical properties. In vivo studies confirmed successful bone repair using this composite hydrogel.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Yule Xu, Qiaolin Chen, Zhengzhong Shao, Jiahong Wei, Xuyou Zhu, Ao Rong, Xin Chen, Yusu Ni, Yi Jiang
Summary: In this study, robust regenerated silk fibroin (RSF) hydrogels were investigated as potential grafts for posterior scleral reinforcement (PSR) to prevent the progression of high myopia. The experiments on animals showed that RSF hydrogels exhibited good biocompatibility and improved the biomechanical properties of the reinforced sclera.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fan Zhang, Chuanjin Yin, Xueju Qi, Chuanlong Guo, Xiaochen Wu
Summary: Antibacterial hydrogels, such as the SF/Ag/GA hydrogel, combine the biocompatible and biodegradable properties of silk fibroin with the antibacterial activity of silver and anti-inflammatory properties of glycyrrhizic acid. This hydrogel shows high water content, acceptable mechanical properties, and great potential for promoting tissue regeneration during wound healing.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shanchen Yang, YaXin Zhang, Ying Zhang, Jie Deng, Ningxin Chen, Sida Xie, Yue Ma, Zhaohui Wang
Summary: This study investigates the issue of pore structure variation caused by separator swelling in aqueous zinc-ion batteries (AZBs) using a nanocellulose separator as an example. A multifunctional separator composed of Zr4+-hydrolysate-coated nanocellulose (Zr-CNF) is developed, which demonstrates excellent swelling resistance, pore-structure stability, and percolating porosity. The Zr-CNF separator enables dendrite-free Zn anode with high Coulombic efficiency and exceptional cyclability. It also shows feasibility in other aqueous battery systems. This study provides a facile approach to address separator swelling issue and offers insights into future efficient and sustainable aqueous battery technologies.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dan Luo, Tianhui Shi, Qiao-Hong Li, Qinqin Xu, Maria Stromme, Qian-Feng Zhang, Chao Xu
Summary: A method for synthesizing porous organic polymers (POPs) with amine and aminal linkages using inexpensive monomers and green solvents is reported. The method demonstrates good generality and enables large-scale synthesis of various POPs at room temperature. The resulting POPs show potential applications in CO2 separation and efficient heterogeneous catalysis, providing an environmentally friendly and cost-effective approach for large-scale synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Xiangni Zhang, Shanchen Yang, Zhaohui Wang
Summary: A bio-based, electrostatic shielding, ion-sieving separator has been developed for stabilizing Zn metal anode. By surface amine functionalization, the cationic nanocellulose separator with immobilized cationic groups exhibits uniformly distributed nanopores, inhibits SO42- migration, and enhances Zn2+ transference number. The combination of ion-sieving nanofibrous network and immobilized electrostatic shielding functional groups leads to smoother and more compact Zn deposition/stripping behavior. With this separator, highly reversible Zn metal anodes and durable supercapacitors have been achieved.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Kefan Zhou, Min Zhang, Xiangni Zhang, Tianyu Wang, Helin Wang, Zhiqiao Wang, Xiaoyu Tang, Miao Bai, Shaowen Li, Zhaohui Wang, Yue Ma
Summary: In this study, an ultra-lightweight, thin, high strength, and thermally robust composite solid electrolyte (CSE) has been designed to address the technological barriers in the construction of energy-dense all-solid-state batteries (ASSBs). The ASSB prototype, consisting of the PEO/MPEG@LLZTO-Nanocellulose (PLCN) CSE film, high-mass-loading LiFePO4 cathode, and thin-layer lithium anode, exhibits high gravimetric energy density, cycling stability, and operation reliability within a wider temperature range.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Hangning Liu, Runmeng Liu, Yingjun Ma, Lin Wang, Changhui Sun, Tong Xu, Haidong Liu, Jie Wang
Summary: This study proposes a simple in-situ strategy for the construction of high-dispersive cobalt oxide nanoneedle arrays on a copper foam substrate. The resulting CoO arrays serve as binder-free anodes in lithium-ion batteries, leading to outstanding rate capability and superior long-term cycling stability. This approach streamlines the electrode fabrication steps and holds significant promise for the future development of the battery industry.
Article
Engineering, Chemical
Shijie Shi, Haiqin Tang, Li Zhen, Menglin Fan, Lizhong Sun, Siying Tao, Jiaojiao Yang, Jianshu Li, Jiyao Li
Summary: Matrix vesicles (MVs), as a type of extracellular vesicles, play a crucial role in the initial stage of hard tissue mineralization. Bioinspired nanovesicles derived from platelet membranes are able to penetrate deep into dentinal tubules, providing nucleation sites and templates for mineral crystal formation. The acidic phospholipids on the nanovesicle surface can recruit mineral ions from the environment, promoting in situ biomineralization. Moreover, proteins on the nanovesicle surface can inhibit collagen hydrolysis and protect the mineralization template.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Jieyu Zhu, Haiqin Tang, Shunhua Wang, Yuan Zong, Qinyue Dai, Hongkun Wu, Kunneng Liang, Jiaojiao Yang
Summary: Current implant systems lack the ability to prevent infections and promote osseointegration, which is crucial for reducing implant failure. This study developed a mussel-inspired layer-by-layer self-assembly platform for implant modification using tannic acid, osteoanabolic drug, and antibacterial agents. The modified implant showed excellent antibacterial properties and significant osteogenic induction ability, offering potential clinical prospects for improving osseointegration after implantation.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Physical
Ying Zhang, Zhi Zeng, Shanchen Yang, Yaxin Zhang, Yue Ma, Zhaohui Wang
Summary: A heterostructure engineered, multiscale ion-sieving separator with desired macro-meso-molecular pores is designed, which can achieve durable aqueous Zn-ion batteries. The combination of mesoporous nanocellulose and cation-permeable PEDOT:PSS used in the separator yields a high ionic transference number and fast Zn2+ desolvation kinetics. The unique separator enables highly compact and dendrite-free Zn deposition, as well as remarkable reversibility to full AZBs with high I2 mass loading cathodes.
ENERGY STORAGE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ying Zhang, Yaxin Zhang, Jie Deng, Rongrong Xue, Shanchen Yang, Yue Ma, Zhaohui Wang
Summary: A self-adapting soft polymeric composite interface (SAP) is designed to overcome the challenges in aqueous zinc ion batteries (AZBs). The SAP interface leverages dynamic in situ electrochemical bonding, ensuring intimate contact with the zinc electrode and possessing self-healing and volume accommodation capabilities. Experimental results demonstrate high reversibility and long lifespan of the zinc electrode.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shaowen Li, Zhigang Chai, Zhaohui Wang, Cheuk-Wai Tai, Jiefang Zhu, Kristina Edstroem, Yue Ma
Summary: This study comprehensively investigates the factors influencing lithium solubility in lithium-zinc alloy and analyzes the spatial distribution of intermediate alloy/lithium metallic species under different conditions. The driving force of lithium diffusion into the solid solution and the correlation between interfacial charge transfer thermodynamics and rate-limiting kinetics are explored. The study also explores lithiophilic alloy sites that promote homogeneous metal plating.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ying Zhang, Shanchen Yang, Jie Deng, Ningxin Chen, Sida Xie, Jiajun Zhou, Zhaohui Wang
Summary: A zincophilic heterogeneous interface consisting of metallic Ag layer and PEDOT:PSS was designed via a chemical displacement and drop casting process. The interface inhibits dendrite growth/side reactions, reduces the nucleation barrier, and shields SO42- migration. The modified Zn anode exhibits a cyclic lifespan of 200 h and reduced voltage hysteresis, and enables high-performance full cells based on LiMn2O4.
Review
Polymer Science
Tianhui Shi, Zheng Wu, Zhongqi Wu, Qian-Feng Zhang, Maria Stromme, Chao Xu
Summary: This review summarizes recent studies on the synthesis and CO2 capture performance of amine-functionalized POPs, and discusses the structure-performance relationships and challenges in practical applications.
JOURNAL OF POLYMER SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Christos S. Katsiotis, Maria Stromme, Ken Welch
Summary: This study investigated the effect of different processing parameters of the hot melt extrusion process on the mechanical properties and printability of drug-loaded mesoporous materials in fused deposition modeling (FDM) dosage forms. The results showed a correlation between the printability of the filaments and their mechanical properties. The mesoporous materials displayed a thermal protective feature, shifting the drug's decomposition temperature to higher temperatures.
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
(2023)
Article
Materials Science, Biomaterials
Wenlin Chu, Haiqin Tang, Zhiyun Dong, Ailin Hou, Rongmin Qiu, Xinyuan Xu, Jiaojiao Yang, Libang He, Jun Luo, Jianshu Li
Summary: The study synthesized diblock copolymer PEG-PAsp-ALN and modified them as bioactive bifunctional coatings on teeth to treat dental caries. The coatings can inhibit proteins and bacterial adhesion while promoting rapid and thorough remineralization on the tooth surface. This approach demonstrates the potential of the copolymer as a multifunctional protecting layer for high-efficiency prevention and treatment of dental caries.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Physical
Michelle Ahlen, Yi Zhou, Daniel Hedbom, Hae Sung Cho, Maria Stromme, Osamu Terasaki, Ocean Cheung
Summary: Sulfur hexafluoride (SF6) is a highly potent greenhouse gas emitted from high-voltage electrical applications. Solid adsorbents, such as metal-organic frameworks (MOFs), offer a cost-effective and energy-efficient solution for capturing and recovering SF6. This study presents gallium- and vanadium-based MOFs with exceptional SF6 uptake and selectivity, demonstrating their potential in mitigating SF6 emissions and reducing global warming contributions.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
