Regulatory T‐cells in helminth infection: induction, function and therapeutic potential

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Helminth infections drive heterogeneity in human type 2 and regulatory cells

(2020) Karin de Ruiter et al.   Science Translational Medicine

Regulatory T cell adaptation in the intestine and skin

(2019) Natasha Whibley et al.   NATURE IMMUNOLOGY

Regulatory T cells and IgE expression in duodenal mucosa of Strongyloides stercoralis and human T lymphotropic virus type 1 co-infected patients

(2019) Luis Malpica et al.   PLoS Neglected Tropical Diseases

Ascaris lumbricoides Cystatin Prevents Development of Allergic Airway Inflammation in a Mouse Model

(2019) Sandra Coronado et al.   Frontiers in Immunology

Helminth-induced regulatory T cells and suppression of allergic responses

(2018) Jayden Logan et al.   CURRENT OPINION IN IMMUNOLOGY

TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus

(2018) Danielle J. Smyth et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Trichinella spiralis Excretory–Secretory Products Induce Tolerogenic Properties in Human Dendritic Cells via Toll-Like Receptors 2 and 4

(2018) Nataša Ilic et al.   Frontiers in Immunology

Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules

(2018) Rick M. Maizels et al.   IMMUNITY

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

(2017) Daniele C. Nascimento et al.   Nature Communications

A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells

(2017) Chris J. C. Johnston et al.   Nature Communications

Extracellular Vesicles from a Helminth Parasite Suppress Macrophage Activation and Constitute an Effective Vaccine for Protective Immunity

(2017) Gillian Coakley et al.   Cell Reports

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer

(2017) Eva Pastille et al.   PLoS Pathogens

Helminth Immunomodulation in Autoimmune Disease

(2017) Taylor B. Smallwood et al.   Frontiers in Immunology

Human Helminths and Allergic Disease: The Hygiene Hypothesis and Beyond

(2016) Helton C. Santiago et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Mycobacterium tuberculosis-specific CD4+T-cell response is increased, and Treg cells decreased, in anthelmintic-treated patients with latent TB

(2016) Frederic Toulza et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of the host immune system by helminth parasites

(2016) Rick M. Maizels et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Practices and outcomes of self-treatment with helminths based on physicians' observations

(2016) J. Liu et al.   JOURNAL OF HELMINTHOLOGY

Activation and Recruitment of Regulatory T Cells via Chemokine Receptor Activation in Trichinella spiralis-Infected Mice

(2016) Jeong-Bin Ahn et al.   KOREAN JOURNAL OF PARASITOLOGY

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

(2016) S. Navarro et al.   Science Translational Medicine

A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes

(2016) Azad A. Sulaiman et al.   PLoS Pathogens

Human helminth therapy to treat inflammatory disorders- where do we stand?

(2015) Helena Helmby   BMC IMMUNOLOGY

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

(2015) Ilaria Mosconi et al.   INFECTION AND IMMUNITY

Worms as therapeutic agents for allergy and asthma: Understanding why benefits in animal studies have not translated into clinical success

(2015) Holly Evans et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths

(2015) K A Smith et al.   Mucosal Immunology

Helminths and the microbiota: parts of the hygiene hypothesis

(2015) P. Loke et al.   PARASITE IMMUNOLOGY

Clinical trials of helminth therapy in autoimmune diseases: rationale and findings

(2015) J. O. Fleming et al.   PARASITE IMMUNOLOGY

The microbiota regulates type 2 immunity through ROR t+ T cells

(2015) C. Ohnmacht et al.   SCIENCE

Helminth therapy for organic diseases?

(2015) Irina Leonardi et al.   Translational Research

CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel

(2015) Yvonne Schmiedel et al.   PLoS Neglected Tropical Diseases

Hyperreactive Onchocerciasis is Characterized by a Combination of Th17-Th2 Immune Responses and Reduced Regulatory T Cells

(2015) Gnatoulma Katawa et al.   PLoS Neglected Tropical Diseases

Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance

(2015) Ashley Houlden et al.   PLoS One

Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli

(2015) Jacob Bak Holm et al.   PLoS One

Helminths in the hygiene hypothesis: sooner or later?

(2014) R. M. Maizels et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy

(2014) Corinne Cayrol et al.   CURRENT OPINION IN IMMUNOLOGY

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Cutting Edge: Foxp3+CD4+CD25+ Regulatory T Cells Induced by IL-2 and TGF-  Are Resistant to Th17 Conversion by IL-6

(2014) S. G. Zheng et al.   JOURNAL OF IMMUNOLOGY

Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia malayi

(2014) H. J. McSorley et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Limit Induction of Protective Immunity and Promote Immune Pathology following Intestinal Helminth Infection

(2014) D. V. Sawant et al.   JOURNAL OF IMMUNOLOGY

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

(2014) Linda J Wammes et al.   LANCET INFECTIOUS DISEASES

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

(2014) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foxp3+ Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

(2014) Birte Blankenhaus et al.   PLoS Pathogens

ICOS controls Foxp3+regulatory T-cell expansion, maintenance and IL-10 production during helminth infection

(2013) Stephen A. Redpath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4+CD25+ regulatory T cells in murine Schistosomiasis japonica

(2013) Chun-Lian Tang et al.   EXPERIMENTAL PARASITOLOGY

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Immunomodulation by helminth parasites: Defining mechanisms and mediators

(2013) Henry J. McSorley et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Regulatory T cells in nonlymphoid tissues

(2013) Dalia Burzyn et al.   NATURE IMMUNOLOGY

Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3+ Treg Cells

(2013) Laura E. Layland et al.   PLoS Neglected Tropical Diseases

Loss of the TGFβ-Activating Integrin αvβ8 on Dendritic Cells Protects Mice from Chronic Intestinal Parasitic Infection via Control of Type 2 Immunity

(2013) John J. Worthington et al.   PLoS Pathogens

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of Schistosoma haematobium Infection

(2012) Nadine Rujeni et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Human Neurocysticercosis: In Vivo Expansion of Peripheral Regulatory T Cells and Their Recruitment in the Central Nervous System

(2012) Laura Adalid-Peralta et al.   JOURNAL OF PARASITOLOGY

Regulatory T Cells in Human Lymphatic Filariasis: Stronger Functional Activity in Microfilaremics

(2012) Linda J. Wammes et al.   PLoS Neglected Tropical Diseases

Therapeutic Helminth Infection of Macaques with Idiopathic Chronic Diarrhea Alters the Inflammatory Signature and Mucosal Microbiota of the Colon

(2012) Mara Jana Broadhurst et al.   PLoS Pathogens

The S. mansoni glycoprotein ω-1 induces Foxp3 expression in NOD mouse CD4+ T cells

(2011) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced by, but Are Not Dependent upon, GITR-GITR Ligand Costimulation In Vivo

(2011) N. van der Werf et al.   JOURNAL OF IMMUNOLOGY

Strongyloides ratti Infection Induces Expansion of Foxp3 + Regulatory T Cells That Interfere with Immune Response and Parasite Clearance in BALB/c Mice

(2011) Birte Blankenhaus et al.   JOURNAL OF IMMUNOLOGY

The impact of parasite infections on the course of multiple sclerosis

(2011) Jorge Correale et al.   JOURNAL OF NEUROIMMUNOLOGY

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of Venom Allergen-Like (VAL) proteins

(2011) James P. Hewitson et al.   Journal of Proteomics

Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?

(2011) ALISON M. ELLIOTT et al.   PARASITOLOGY

Anthelminthic treatment during pregnancy is associated with increased risk of infantile eczema: randomised-controlled trial results

(2011) Harriet Mpairwe et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Schistosome Infection Intensity Is Inversely Related to Auto-Reactive Antibody Levels

(2011) Francisca Mutapi et al.   PLoS One

Suppression of Inflammatory Immune Responses in Celiac Disease by Experimental Hookworm Infection

(2011) Henry J. McSorley et al.   PLoS One

Role of dendritic cells in the induction of regulatory T cells

(2011) Rahul Kushwah et al.   Cell and Bioscience

CD4+CD25+ Regulatory Cells Contribute to the Regulation of Colonic Th2 Granulomatous Pathology Caused by Schistosome Infection

(2011) Joseph D. Turner et al.   PLoS Neglected Tropical Diseases

Induction of CD4+CD25+FOXP3+ Regulatory T Cells during Human Hookworm Infection Modulates Antigen-Mediated Lymphocyte Proliferation

(2011) Natasha Delaqua Ricci et al.   PLoS Neglected Tropical Diseases

Atopy and current intestinal parasite infection: a systematic review and meta-analysis

(2010) J. Feary et al.   ALLERGY

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation

(2010) Mark S. Wilson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells in human geohelminth infection suppress immune responses to BCG andPlasmodium falciparum

(2010) Linda J. Wammes et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-6: Regulator of Treg/Th17 balance

(2010) Akihiro Kimura et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

(2010) John R. Grainger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

At Homeostasis Filarial Infections Have Expanded Adaptive T Regulatory but Not Classical Th2 Cells

(2010) S. Metenou et al.   JOURNAL OF IMMUNOLOGY

Sensing the outside world: TSLP regulates barrier immunity

(2010) Steven F Ziegler et al.   NATURE IMMUNOLOGY

Effect of CD4+CD25+ regulatory T cells on the immune evasion of Schistosoma japonicum

(2010) Chun-lian Tang et al.   PARASITOLOGY RESEARCH

IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient

(2010) M. J. Broadhurst et al.   Science Translational Medicine

Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam

(2009) C. Flohr et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Gastrointestinal nematode infection interferes with experimental allergic airway inflammation but not atopic dermatitis

(2009) S. Hartmann et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+cells

(2009) Sebastian Rausch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Schistosoma mansoniegg antigens induce Treg that participate in diabetes prevention in NOD mice

(2009) Paola Zaccone et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells: A Role in the Control of Helminth-Driven Intestinal Pathology and Worm Survival

(2009) R. D'Elia et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cell Expansion in HTLV-1 and Strongyloidiasis Co-infection Is Associated with Reduced IL-5 Responses to Strongyloides stercoralis Antigen

(2009) Martin Montes et al.   PLoS Neglected Tropical Diseases

Filarial Lymphedema Is Characterized by Antigen-Specific Th1 and Th17 Proinflammatory Responses and a Lack of Regulatory T Cells

(2009) Subash Babu et al.   PLoS Neglected Tropical Diseases

Ascaris lumbricoides-induced suppression of total and specific IgE responses in atopic subjects is interleukin 10-independent and associated with an increase of CD25+ cells

(2008) Giovanni Matera et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Early recruitment of natural CD4+Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection

(2008) Matthew D. Taylor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-β

(2008) Judith S. Satoguina et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Functional Analysis of Effector and Regulatory T Cells in a Parasitic Nematode Infection

(2008) S. Rausch et al.   INFECTION AND IMMUNITY

Poor immunogenicity of BCG in helminth infected population is associated with increased in vitro TGF-β production

(2008) Daniel Elias et al.   VACCINE