Journal
IEEE SENSORS JOURNAL
Volume 20, Issue 11, Pages 5720-5724Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2020.2973949
Keywords
Attomolar detection; graphene biosensor; reusable biosensor
Funding
- Gates Foundation
- National Science Foundation (NSF) [EFRI 2-DARE 1542879]
- SUNFEST Program NSF Research Experience for Undergraduates (REU) [EEC1659190]
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Graphene-based biosensors can be produced in a scalable manner at reasonable cost, and they show significant promise for sensitive detection of small molecules and biomarkers such as proteins, single strand nucleic acids, and drug targets. Here, we describe an approach that enables a limit of detection of 1 aM for a ssDNA target without amplification. We also show that a sensor based on a short (20mer) probe complementary to a portion of a longer (100mer) target provides enhanced sensitivity and saturation signal level. Finally, we show that graphene-based DNA biosensors can be repeatedly recycled with consistent sensor responses by melting off bound target strands. These results show the potential utility of this technology in nucleic acid detection for disease diagnostics.
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