Journal
HYPERTENSION RESEARCH
Volume 43, Issue 10, Pages 1006-1014Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41440-020-0459-4
Keywords
BRD4; Cardiovascular disease; Atherosclerosis; Pulmonary arterial hypertension; Heart failure
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Funding
- Zhejiang Key Laboratory for Diagnosis and Therapy of Neonatal Diseases, the Key Laboratory of Reproductive Genetics (Zhejiang University), the Ministry of Education
- National Natural Science Foundation of China [81471480, 81630037, 81501293]
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Bromodomain-containing protein 4 (BRD4) is a member of the bromodomain and extra terminal (BET) protein family that has gained wide attention in the field of cancer due to its role in the formation of super enhancers (SEs) and the regulation of oncogene expression. However, there is increasing evidence that BRD4 also plays a pivotal role in a variety of cardiovascular diseases, suggesting that understanding the mechanisms of BRD4 in these diseases is important to advance studies and clinical treatment. In this article, we summarize the mechanisms of BRD4 in cardiovascular diseases, including pulmonary arterial hypertension, heart failure, atherosclerosis, and hypertension. In addition, we discuss small molecule inhibitors of BRD4 as novel therapeutic strategies for cardiovascular diseases.
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