Article
Neuroimaging
Peter Kochunov, Meghann C. Ryan, Qifan Yang, Kathryn S. Hatch, Alyssa Zhu, Sophia Thomopoulos, Neda Jahanshad, Lianne Schmaal, Paul M. Thompson, Shuo Chen, Xiaoming Du, Bhim M. Adhikari, Heather Bruce, Stephanie Hare, Eric L. Goldwaser, Mark D. Kvarta, Thomas E. Nichols, L. Elliot Hong
Summary: Researchers found that the RVI index showed significant elevation in patients with major depressive disorder and Alzheimer's disease, relatively specific to the respective diagnoses. These neuroanatomic deviation patterns offer a useful biomarker for population-wide assessments of similarity to neuropsychiatric illnesses.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Kangfuxi Zhang, Zhao Fu, Qingjuan Lai, Yilu Zhao, Jing Liu, Qingjiu Cao
Summary: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have common brain abnormalities, which contribute to their high co-occurrence and comorbidity. However, these neuroanatomic anomalies may change over development and the developmental variation of ADHD and ASD is unclear. Our study conducted a systematic literature search and meta-analysis to identify shared white matter abnormalities in ADHD and ASD from childhood to adulthood. The findings show variable white matter developmental trajectories in ADHD and ASD, and overlapping corpus callosum tract abnormalities in their development. The overlapping abnormalities of the corpus callosum tract increase with age, possibly related to the increasing shared symptoms and comorbidity in these disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Ali Baran Tanrikulu, Ikbal Inanli, Serdar Arslan, Ali Metehan Caliskan, Ismet Esra Cicek, Ibrahim Eren
Summary: This study aimed to investigate the white matter (WM) integrity within different stages of bipolar disorder (BD) and its potential as a biomarker for clinical staging. The results suggest that WM integrity in the corpus callosum genu and right sagittal stratum may serve as biomarkers for clinical staging of BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Peter Kochunov, Yizhou Ma, Kathryn S. Hatch, Neda Jahanshad, Paul M. Thompson, Bhim M. Adhikari, Heather Bruce, Andrew Van der Vaart, Eric L. Goldwaser, Aris Sotiras, Mark D. Kvarta, Tianzhou Ma, Shuo Chen, Thomas E. Nichols, L. Elliot Hong
Summary: Severe mental illnesses (SMI), including major depressive (MDD), bipolar (BD), and schizophrenia spectrum (SSD) disorders have multifactorial risk factors. The regional vulnerability index (RVI) is a novel brain index that measures individual's brain-wide similarity to expected SMI patterns. The study found significant associations between RVI and MDD and SSD, as well as associations with childhood adversity and lower cognitive performance in nonpsychiatric controls. RVI shows similar or better specificity for SMI than polygenic risk scores (PRS).
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Emily L. Dennis, Karen Caeyenberghs, Kristen R. Hoskinson, Tricia L. Merkley, Stacy J. Suskauer, Robert F. Asarnow, Talin Babikian, Brenda Bartnik-Olson, Kevin Bickart, Erin D. Bigler, Linda Ewing-Cobbs, Anthony Figaji, Christopher C. Giza, Naomi J. Goodrich-Hunsaker, Cooper B. Hodges, Elizabeth S. Hovenden, Andrei Irimia, Marsh Konigs, Harvey S. Levin, Hannah M. Lindsey, Jeffrey E. Max, Mary R. Newsome, Alexander Olsen, Nicholas P. Ryan, Adam T. Schmidt, Matthew S. Spruiell, Benjamin S. C. Wade, Ashley L. Ware, Christopher G. Watson, Anne L. Wheeler, Keith Owen Yeates, Brandon A. Zielinski, Peter Kochunov, Neda Jahanshad, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: The study explored the association between moderate-severe traumatic brain injury (TBI) in pediatric patients and widespread white matter disruption, as well as the impact of demographic and clinical variables on this disruption. Results revealed altered white matter diffusion metrics and indicated that injury severity and time post-injury significantly influenced these changes. A sex-by-group interaction was also observed with female TBI patients showing lower fractional anisotropy in specific WM tracts and experiencing more reported behavioral problems. Future work will focus on harmonizing neurocognitive data to identify clinically meaningful patient subtypes.
Article
Neurosciences
Clara F. Weber, Evelyn M. R. Lake, Stefan P. Haider, Ali Mozayan, Pratheek S. Bobba, Pratik Mukherjee, Dustin Scheinost, Robert T. Constable, Laura Ment, Seyedmehdi Payabvash
Summary: The study utilized functionally guided tractography to identify ASD-related microstructural connectome changes, showing that early ASD-related WM disruptions can be detected using functional nodes, and supporting the benefit of functionally informed nodes in diffusion imaging-based tractography.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neuroimaging
Masoumeh Rostampour, Zeinab Gharaylou, Nima Rostampour, Donya Kaveh, Khadijeh Noori, Reza Fadaei, Masoud Tahmasian, Habibolah Khazaie, Mojtaba Zarei
Summary: This study aimed to understand the alterations of white matter tracts in patients with insomnia using diffusion tensor imaging. It found significantly increased fractional anisotropy in certain white matter tracts and correlations between diffusion measures and sleep variables. The study highlights the importance of examining whole-tract and waypoint white matter integrity in insomnia disorder.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Psychiatry
Fabrizio Piras, Federica Piras, Yoshinari Abe, Sri Mahavir Agarwal, Alan Anticevic, Stephanie Ameis, Paul Arnold, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan-Carl Beucke, Premika S. W. Boedhoe, Irene Bollettini, Silvia Brem, Anna Calvo, Kang Ik Kevin Cho, Valentina Ciullo, Sara Dallaspezia, Erin Dickie, Benjamin Adam Ely, Siyan Fan, Jean-Paul Fouche, Patricia Gruner, Deniz A. Guersel, Tobias Hauser, Yoshiyuki Hirano, Marcelo Q. Hoexter, Mariangela Iorio, Anthony James, Y. C. Janardhan Reddy, Christian Kaufmann, Kathrin Koch, Peter Kochunov, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Rachel Marsh, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Yuki Sakai, Eiji Shimizu, Daniela Simon, Helen Blair Simpson, Noam Soreni, Philipp Staempfli, Emily R. Stern, Philip Szeszko, Jumpei Takahashi, Ganesan Venkatasubramanian, Zhen Wang, Je-Yeon Yun, Dan J. Stein, Neda Jahanshad, Paul M. Thompson, Odile A. van den Heuvel, Gianfranco Spalletta, Francesca Assogna, Rosa Calvo, Stella J. de Wit, Morgan Hough, Masaru Kuno, Euripedes C. Miguel, Astrid Morer, Christopher Pittenger, Sara Poletti, Enrico Smeraldi, Joao R. Sato, Aki Tsuchiyagaito, Susanne Walitza, Ysbrand D. van der Werf, Daniela Vecchio, Mojtaba Zarei
Summary: The study investigated microstructural alterations in cortico-subcortical connections in OCD patients, finding significant FA reduction in certain brain regions in adults but not in children. Lower FA was associated with younger age of onset, longer duration of illness, and higher percentage of medicated patients.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Aleksi J. Sihvonen, Paula Virtala, Anja Thiede, Marja Laasonen, Teija Kujala
Summary: This study utilized a hodological approach to investigate the relationships between structural white matter connectivity and reading skills and phonological processing. The findings revealed specific brain regions associated with reading skills and phonological processing, as well as structural connectivity anomalies in dyslexics.
Article
Substance Abuse
Jonatan Ottino-Gonzalez, Anne Uhlmann, Sage Hahn, Zhipeng Cao, Renata B. Cupertino, Nathan Schwab, Nicholas Allgaier, Nelly Alia-Klein, Hamed Ekhtiari, Jean-Paul Fouche, Rita Z. Goldstein, Chiang-Shan R. Li, Christine Lochner, Edythe D. London, Maartje Luijten, Sadegh Masjoodi, Reza Momenan, Mohammad Ali Oghabian, Annerine Roos, Dan J. Stein, Elliot A. Stein, Dick J. Veltman, Antonio Verdejo-Garcia, Sheng Zhang, Min Zhao, Na Zhong, Neda Jahanshad, Paul M. Thompson, Patricia Conrod, Scott Mackey, Hugh Garavan
Summary: This study identified white matter differences in individuals dependent on cocaine, methamphetamine, and nicotine. The support vector machine was the most effective algorithm in accurately classifying individuals with stimulant dependence.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Neuroimaging
Ivana Kancheva, Floor Buma, Gert Kwakkel, Angelina Kancheva, Nick Ramsey, Mathijs Raemaekers
Summary: This study aimed to assess secondary white matter degeneration after ischemic stroke and found that it spreads along the entire damaged tract and worsens over time.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Steven L. Meisler, John D. E. Gabrieli
Summary: Reading involves a widely distributed brain network and white matter tracts play an important role in transmitting information between constituent network nodes. A study with a large dataset of 686 children found that while white matter FA increased with age, there were no significant correlations between overall reading abilities and tract FAs. However, higher FA in specific tracts was associated with better nonword reading skills in older children.
Article
Clinical Neurology
Jiye Lee, Minjeong Kim, Nambeom Kim, Yunjee Hwang, Kyung Hwa Lee, Jooyoung Lee, Yu Jin Lee, Seog Ju Kim
Summary: This study investigated the white matter integrity in shift and non-shift workers and found that the white matter integrity of the anterior cingulum was associated with sleep quality and activity in shift workers.
NATURE AND SCIENCE OF SLEEP
(2022)
Article
Clinical Neurology
Heather M. Clark, Nirubol Tosakulwong, Stephen D. Weigand, Farwa Ali, Hugo Botha, Nha Trang Thu Pham, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, J. Eric Ahlskog, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study found that impairments in swallowing function were associated with specific brain regions' reduced gray matter volumes and abnormal white matter integrity. The impairments in the oral and pharyngeal phases of swallowing corresponded to different regions of neuroanatomical impairment.
MOVEMENT DISORDERS
(2021)
Article
Psychology, Clinical
Eamonn Kennedy, Emily L. Dennis, Hannah M. Lindsey, Terri deRoon-Cassini, Stefan Du Plessis, Negar Fani, Milissa L. Kaufman, Nastassja Koen, Christine L. Larson, Sarah Laskowitz, Lauren A. M. Lebois, Rajendra A. Morey, Mary R. Newsome, Cori Palermo, Nicholas J. Pastorek, Abigail Powers, Randall Scheibel, Soraya Seedat, Antonia Seligowski, Dan J. Stein, Jennifer Stevens, Delin Sun, Paul Thompson, Maya Troyanskaya, Sanne J. H. van Rooij, Amanda A. Watts, Carissa W. Tomas, Wright Williams, Frank G. Hillary, Mary Jo Pugh, Elisabeth A. Wilde, David F. Tate
Summary: This study uses a multisite mega analysis to derive quantitative recommendations for equating scores across measures of PTSD severity. The results suggest that harmonization and covariate adjustments can significantly improve inference of scores across different instruments.
Article
Psychology, Clinical
Marcelo C. Batistuzzo, Karthik Sheshachala, Daniel M. Alschuler, Dianne M. Hezel, Roberto Lewis-Fernandez, Niels T. de Joode, Chris Vriend, Karolina M. Lempert, Madhuri Narayan, Clara Marincowitz, Christine Lochner, Dan J. Stein, Janardhanan C. Narayanaswamy, Odile A. van den Heuvel, Helen Blair Simpson, Melanie Wall
Summary: To improve the consistency of neurocognitive testing across countries, a prospective harmonization approach was used in a global collaborative study. Five tasks were administered to participants from Brazil, India, the Netherlands, South Africa, and the USA. Despite procedural similarity, the Netherlands and India sites showed differences in cognitive performance, indicating potential selection sampling bias. Future studies should follow similar harmonization procedures and consider measuring additional confounding variables.
Article
Psychology, Clinical
Emma C. Lathan, Abigail Powers, Anna Kottakis, Alfonsina Guelfo, Greg J. Siegle, Jessica A. Turner, Matthew D. Turner, Vijwala Yakkanti, Jahnvi Jain, Yara Mekawi, Andrew P. Teer, Joseph M. Currier, Negar Fani
Summary: This study found a unique association between moral injury and sexual violence as well as lower hfHRV in civilians.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Borwin Bandelow, Christer Allgulander, David S. Baldwin, Daniel Lucas da Conceicao Costa, Damiaan Denys, Nesrin Dilbaz, Katharina Domschke, Eric Hollander, Siegfried Kasper, Hans-Juergen Moeller, Elias Eriksson, Naomi A. Fineberg, Josef Haettenschwiler, Hisanobu Kaiya, Tatiana Karavaeva, Martin A. Katzman, Yong-Ku Kim, Takeshi Inoue, Leslie Lim, Vasilios Masdrakis, Jose M. Menchon, Euripedes C. Miguel, Antonio E. Nardi, Stefano Pallanti, Giampaolo Perna, Dan Rujescu, Vladan Starcevic, Dan J. Stein, Shih-Jen Tsai, Michael Van Ameringen, Anna Vasileva, Zhen Wang, Joseph Zohar
Summary: According to the guideline by the World Federation of Societies of Biological Psychiatry, OCD and PTSD can be effectively treated with medications and CBT. SSRIs and CBT are first-line treatments for OCD, while SSRIs and venlafaxine are first-line treatments for PTSD.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Emily L. Dennis, Mary R. Newsome, Hannah M. Lindsey, Maheen Adamson, Tara A. Austin, Seth G. Disner, Blessen C. Eapen, Carrie Esopenko, Carol E. Franz, Elbert Geuze, Courtney Haswell, Sidney R. Hinds II, Cooper B. Hodges, Andrei Irimia, Kimbra Kenney, Inga K. Koerte, William S. Kremen, Harvey S. Levin, Rajendra A. Morey, John Ollinger, Jared A. Rowland, Randall S. Scheibel, Martha E. Shenton, Danielle R. Sullivan, Leah D. Talbert, Sophia I. Thomopoulos, Maya Troyanskaya, William C. Walker, Xin Wang, Ashley L. Ware, John Kent Werner, Wright Williams, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) in military populations can lead to disruptions in brain structure and function, causing cognitive and psychological dysfunction. A study conducted a mega-analysis of neuroimaging and clinical data from military personnel and veterans, finding that deployment-related TBI is associated with increased left lateralization in the cingulum, a white matter tract. This effect was primarily observed in individuals whose worst injury occurred before age 40.
HUMAN BRAIN MAPPING
(2023)
Article
Psychology, Clinical
Roseli G. Shavitt, Karthik Sheshachala, Dianne M. Hezel, Melanie M. Wall, Srinivas Balachander, Christine Lochner, Janardhanan C. Narayanaswamy, Daniel L. C. Costa, Maria Alice de Mathis, Anton J. L. M. van Balkom, Niels T. de Joode, Madhuri Narayan, Odile A. van den Heuvel, Dan J. Stein, Euripedes C. Miguel, Helen Blair Simpson, Y. C. Janardhan Reddy
Summary: This study describes the steps taken to ensure measurement fidelity of core clinical measures in a five-country study on brain signatures of obsessive-compulsive disorder (OCD). The researchers used standardized instruments and implemented techniques such as translating instruments, developing a clinical decision manual, and providing reliability training to evaluators. The results showed high interrater reliability for most scales and consistent factor structures across sites.
Review
Psychiatry
Olivia Wootton, Shareefa Dalvie, Ezra Susser, Ruben C. Gur, Dan J. Stein
Summary: Schizophrenia, a neurodevelopmental disorder, is a leading cause of disability globally. Cognitive deficits are a characteristic of schizophrenia and can predict functional outcomes. Within-individual variability (WIV) in cognitive performance is higher in schizophrenia, and it provides additional insight into cognitive function beyond mean performance measures. Despite limited research, this narrative review summarizes the clinical, neural, and genetic correlates of WIV in schizophrenia and identifies knowledge gaps and future research directions.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Psychiatry
Amy S. Adams, Goodman Sibeko, Dan J. Stein
Summary: Despite being a new discipline, global mental health has made significant advances in optimizing mental health services in low- and middle-income countries. This review focuses on middle-income countries such as Brazil, China, India, and South Africa, examining key issues including mental health legislation, burden of disease, task-sharing, and capacity-building.
CURRENT OPINION IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Junyu Chen, Evan Gatev, Todd Everson, Karen N. Conneely, Nastassja Koen, Michael P. Epstein, Michael S. Kobor, Heather J. Zar, Dan J. Stein, Anke Huels
Summary: Recent studies have focused on developing methylation risk scores (MRS), which use weighted sums of DNA methylation (DNAm) values at pre-selected CpG sites. Most current MRS approaches only include genome-wide significant CpG sites and do not consider co-methylation. New methods that relax the p-value threshold and account for DNAm inter-correlation show promise in improving predictive performance of MRS.
Article
Multidisciplinary Sciences
Andre Zugman, Luz Maria Alliende, Vicente Medel, Richard A. I. Bethlehem, Jakob Seidlitz, Grace Ringlein, Celso Arango, Aurina Arnatkeviciute, Laila Asmal, Mark Bellgrove, Vivek Benegal, Miquel Bernardo, Pablo Billeke, Jorge Bosch-Bayard, Rodrigo Bressan, Geraldo F. Busatto, Mariana N. Castro, Tiffany Chaim-Avancini, Albert Compte, Monise Costanzi, Leticia Czepielewski, Paola Dazzan, Camilo de la Fuente-Sandoval, Marta Di Forti, Covadonga M. Diaz-Caneja, Ana Maria Diaz-Zuluaga, Stefan Du Plessis, Fabio L. S. Duran, Sol Fittipaldi, Alex Fornito, Nelson B. Freimer, Ary Gadelha, Clarissa S. Gama, Ranjini Garani, Clemente Garcia-Rizo, Cecilia Gonzalez Campo, Alfonso Gonzalez-Valderrama, Salvador Guinjoan, Bharath Holla, Agustin Ibanez, Daniza Ivanovic, Andrea Jackowski, Pablo Leon-Ortiz, Christine Lochner, Carlos Lopez-Jaramillo, Hilmar Luckhoff, Raffael Massuda, Philip McGuire, Jun Miyataaaa, Romina Mizrahi, Robin Murray, Aysegul Ozerdem, Pedro M. Pan, Mara Parellada, Lebogan Phahladira, Juan P. Ramirez-Mahalu, Ramiro Reckziegel, Tiago Reis Marques, Francisco Reyes-Madrigal, Annerine Roos, Pedro Rosa, Giovanni Salum, Freda Scheffler, Gunter Schumann, Mauricio Serpa, Dan J. Stein, Angeles Tepper, Jeggan Tiego, Tsukasa Ueno, Juan Undurraga, Eduardo A. Undurrag, Pedro Valdes-Sosaooo, Isabel Valliy, Mirta Villarrealu, Toby T. Winton-Brownrrr, Nefize Yalin, Francisco Zamorano, Marcus V. Zanetti, Anderson M. Winkler, Daniel S. Pine, Sara Evans-Lacko, Nicolas A. Crossley
Summary: Gender inequality has been linked to higher mental health risks and lower academic achievement for women globally. Differences in brain structure between men and women may be partially explained by unequal exposure to harsher conditions in gender-unequal countries, leading to worse outcomes for women. A meta-analysis of MRI scans from 139 samples across 29 countries revealed that women in gender-equal countries had no differences or even thicker cortical regions, while those in countries with greater gender inequality had thinner cortices. These findings highlight the potential negative impact of gender inequality on women's brains and the need for policies based on neuroscience for gender equality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Sheri-Michelle Koopowitz, Heather J. Zar, Dan J. Stein, Jonathan C. Ipser
Summary: There is growing evidence of abnormalities in intrinsic functional connectivity (FC) in both PTSD and MDD. However, there has been limited research on their co-occurrence. Characterizing these abnormalities in this clinical population is crucial for understanding the impairments associated with different networks.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Psychology, Clinical
Sean R. McWhinney, Christoph Abe, Martin Alda, Francesco Benedetti, Erlend Boen, Caterina del Mar Bonnin, Tiana Borgers, Katharina Brosch, Erick J. Canales-Rodriguez, Dara M. Cannon, Udo Dannlowski, Ana M. Diaz-Zuluaga, Lorielle M. F. Dietze, Torbjorn Elvsashagen, Lisa T. Eyler, Janice M. Fullerton, Jose M. Goikolea, Janik Goltermann, Dominik Grotegerd, Bartholomeus C. M. Haarman, Tim Hahn, Fleur M. Howells, Martin Ingvar, Neda Jahanshad, Tilo T. J. Kircher, Axel Krug, Rayus T. Kuplicki, Mikael Landen, Hannah Lemke, Benny Liberg, Carlos Lopez-Jaramillo, Ulrik F. Malt, Fiona M. Martyn, Elena Mazza, Colm McDonald, Genevieve McPhilemy, Sandra Meier, Susanne Meinert, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Roel A. Ophoff, Bronwyn J. Overs, Julia-Katharina Pfarr, Julian A. Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Maike Richter, Kai G. Ringwald, Gloria Roberts, Alex Ross, Raymond Salvador, Jonathan Savitz, Simon Schmitt, Peter R. Schofield, Kang Sim, Dan J. Stein, Frederike Stein, Henk S. Temmingh, Katharina Thiel, Sophia I. Thomopoulos, Neeltje E. M. van Haren, Cristian Vargas, Eduard Vieta, Annabel Vreeker, Lena Waltemate, Lakshmi N. Yatham, Christopher R. K. Ching, Ole A. Andreassen, Paul M. Thompson, Tomas Hajek
Summary: This study found that body mass index (BMI) and bipolar disorder (BD) have an impact on brain structure, particularly in cortical thickness. Both BMI and BD negatively affect the same brain regions, and BMI has a greater effect on brain alterations in individuals with BD. It is important to assess the neuroanatomical changes in BD caused by BMI and the effects of psychiatric medications on the brain.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Sheri-Michelle Koopowitz, Karen Thea Mare, Marilyn Lake, Christopher du Plooy, Nadia Hoffman, Kirsten A. Donald, Susan Malcolm-Smith, Lynne Murray, Heather J. Zar, Peter Cooper, Dan J. Stein
Summary: This study investigated the effects of dialogic book-sharing on language development, neurocognitive function, and socio-emotional domains in 3.5-year-old children from low-income South African communities. The results showed no significant differences between the intervention and control groups after 4 months post-intervention.
COMPREHENSIVE PSYCHIATRY
(2024)
Article
Clinical Neurology
Jared Keeley, Geoffrey M. Reed, Tahilia Rebello, Julia Brechbiel, Jose Angel Garcia-Pacheco, Kazeem Adebayo, Oluyomi Esan, Oluyinka Majekodunmi, Akin Ojagbemi, Lucky Onofa, Rebeca Robles, Chihiro Matsumoto, Maria Elena Medina-Mora, Cary S. Koganl, Maya Kulygina, Wolfgang Gaebel, Min Zhao, Michael C. Roberts, Pratap Sharanr, Jose Luis Ayuso-Mateos, Brigitte Khoury, Dan J. Steinu, Anne M. Lovell, Kathleen Pike, Francis Creedxd, Oye Gureje
Summary: The ICD-11 diagnostic guidelines for Bodily Distress Disorder (BDD) show improvement in clinicians' diagnostic accuracy and perceived clinical utility compared to the guidelines for Somatoform Disorders in ICD-10.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Simone R. Williams, Frances C. Robertson, Catherine J. Wedderburn, Jessica E. Ringshaw, Layla Bradford, Charmaine N. Nyakonda, Nadia Hoffman, Shantanu H. Joshi, Heather J. Zar, Dan J. Stein, Kirsten A. Donald
Summary: This study found that decreased levels of glutamate in the parietal gray matter and lower choline ratios in the parietal white matter were observed in children who are HIV-exposed uninfected (CHEU), suggesting regional alterations and myelin loss. Additionally, the study revealed associations between neurometabolite profiles and motor developmental outcomes in CHEU.
FRONTIERS IN NEUROSCIENCE
(2023)