Article
Environmental Sciences
Min Joo Kim, Sunmi Kim, Sohyeon Choi, Inae Lee, Min Kyong Moon, Kyungho Choi, Young Joo Park, Yoon Hee Cho, Young Min Kwon, Jiyoung Yoo, Gi Jeong Cheon, Jeongim Park
Summary: Exposure to mercury and cadmium may disrupt thyroid hormones, possibly through alteration of deiodinase activity. The association of exposure to PAHs with thyroid hormones appears to be insignificant.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Debasish Giri, Karuppusamy Raja, Govindasamy Mugesh
Summary: This study investigates the regioselective deiodinations of L-thyroxine and finds that the electronic properties of the iodine atoms can be modulated, leading to changes in the deiodination selectivity. This discovery is important for understanding the relationship between abnormal thyroid hormone levels and clinical conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Environmental Sciences
Min Joo Kim, Sohyeon Choi, Sunmi Kim, Inae Lee, Min Kyong Moon, Kyungho Choi, Jeongim Park, Yoon Hee Cho, Young Min Kwon, Jiyoung Yoo, Gi Jeong Cheon, Young Joo Park
Summary: This study examined the associations between persistent organic pollutants (POPs) and thyroid hormone levels in humans, and found that these associations are influenced by sex, menopausal status, and age. Different POPs had different effects on different hormones, and the associations varied in different population groups. Furthermore, the study also suggested that thyroxine-binding globulin (TBG) and peripheral deiodinase activity (G(D)) may play important roles in explaining the changes in total T4 and total T3.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mikiko Okazaki-Hada, Azusa Maruoka, Masatoshi Yamamoto, Mitsuru Ito, Mitsuyoshi Hirokawa, Mitsushige Nishikawa, Takashi Akamizu, Akira Miyauchi, Nagaoki Toyoda
Summary: This case report describes a rare case of poorly differentiated thyroid carcinoma with triiodothyronine (T3) thyrotoxicosis, characterized by elevated type 1 and type 2 iodothyronine deiodinases (D1 and D2) activities in the tumor.
Article
Environmental Sciences
Xiao Liang, Yin Wang, Lu Liu, Xi Zhang, Li Li, Rong Tang, Dapeng Li
Summary: This study investigated the effects of nitrite exposure on thyroid hormone levels and intestinal iodothyronine deiodinases activity in grass carp. The results showed that nitrite exposure altered thyroid hormone levels, morphology of thyroid follicles, and gene expressions related to thyroid hormone metabolism.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ichiro Yamauchi, Yoriko Sakane, Takafumi Yamashita, Takuro Hakata, Taku Sugawa, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Keisho Hirota, Yohei Ueda, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki
Summary: This study aimed to investigate the effects of peripheral iodothyronine deiodinases (DIOs) on thyroid hormone economy. The results showed that D2 could enhance local thyroid hormone action and promote its circulation, while D3 could decrease circulating T3 and T4 levels with elevated reverse T3, leading to consumptive hypothyroidism. Additionally, the D3 mice are expected to be a novel hypothyroidism model.
Article
Cell Biology
Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Emery Di Cicco, Caterina Miro, Melania Murolo, Mariano Stornaiuolo, Monica Dentice
Summary: Thyroid hormones regulate glutamine metabolism and anaplerotic fluxes in skeletal muscle, playing a role in muscle weight regulation and protection against muscle loss during atrophy.
Article
Pharmacology & Pharmacy
Min Liu, Zhenlong Yu, Zikuang Zhao, Fangyu Yang, Meirong Zhou, Chao Wang, Xiangge Tian, Baojing Zhang, Guobiao Liang, Xiaohui Liu, Jing Shao
Summary: This study investigated the underlying mechanism of BDE47 neurotoxicity in human SK-N-AS neuronal cells. The results showed that BDE47 induced thyroid hormone metabolism disorder in neuronal cells by inhibiting the expression of the main enzyme, Dio3. Further research revealed that BDE47 up-regulated miR-24-3p, which binds to the 3'-UTR of Dio3 and inhibits its expression. BDE47 also inhibited the deiodinase activity of Dio3. Overall, this study provides new insights into the role of miRNAs in neurodevelopmental toxicity mediated by environmental pollutants.
Article
Multidisciplinary Sciences
Patricia Gerhardt, Sabine Begall, Caroline Fraedrich, Kostja Renko, Thomas B. Hildebrandt, Susanne Holtze, Alexandra Heinrich, Arne Sahm, Xheni Meci, Josef Koehrle, Eddy Rijntjes, Yoshiyuki Henning
Summary: African mole-rats have adapted to the challenges of living underground by evolving low basal metabolism and body temperature. Their unique thyroid hormone phenotype and adaptations to the subterranean habitat were studied by comparing two mole-rat species with the house mouse as a laboratory model. Surprisingly, despite species-specific differences, both mole-rat species showed similar serum thyroid hormone concentrations. This study provides important insights into understanding adaptations to the subterranean habitat.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Qiuhong Liu, Han Li, Weiwei He, Qing Zhao, Caoxin Huang, Qingxuan Wang, Zeyu Zheng, Xiaofang Zhang, Xiulin Shi, Xuejun Li
Summary: The study found that aerobic exercise significantly improved hepatic steatosis, inflammation, and fibrosis in NASH mice. The activation of hepatic thyroid hormone signaling and circulating thyroid hormones may be involved in the amelioration effect of aerobic exercise on NASH progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agronomy
Olga V. Kostyunina, Olga S. Mityashova, Nikolay V. Bardukov, Olga V. Aleynikova, Irina Y. Lebedeva
Summary: This study aimed to investigate the associations between cow genotypes and thyroid profiles and reproductive traits. Blood samples were collected from Russian black-and-white cows and hormonal levels were measured by ELISA. RT-PCR analysis revealed a polymorphism at position 13,149 in the DIO1 gene. The results showed that cows with the CC genotype had higher reproductive ability.
Article
Pharmacology & Pharmacy
Serena Sagliocchi, Melania Murolo, Annunziata Gaetana Cicatiello, Caterina Miro, Annarita Nappi, Emery Di Cicco, Sepehr Torabinejad, Evelina La Civita, Veronica Romano, Daniela Terracciano, Mariano Stornaiuolo, Monica Dentice
Summary: The iodothyronine deiodinases are a group of enzymes that regulate thyroid hormone metabolism and affect various physiological processes. Deregulation of these enzymes is associated with several human pathologies. This study identifies Cefuroxime as a novel inhibitor of D2 activity, potentially offering a new treatment option for hyperthyroid pathologies.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Ichiro Yamauchi, Takafumi Yamashita, Taku Sugawa, Tetsuya Tagami, Ikuko Hanaoka, Takeshi Usui, Keisho Hirota, Takuro Hakata, Yohei Ueda, Toshihito Fujii, Yoriko Sakane, Akihiro Yasoda, Nobuya Inagaki
Summary: A patient with RTH beta developed hypothyroidism due to a specific gene variant, which resolved after discontinuation of bezafibrate treatment. Experimental findings suggest that the upregulation of liver DIO3 may be involved in this hypothyroidism phenomenon.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Toxicology
Jonathan T. Haselman, Jennifer H. Olker, Patricia A. Kosian, Joseph J. Korte, Jeffrey S. Denny, Joseph E. Tietge, Michael W. Hornung, Sigmund J. Degitz
Summary: This study investigated the effects of a model DIO inhibitor on a laboratory model species, Xenopus laevis, to understand the linkages between in vitro potency, in vivo biochemical responses, and adverse organismal outcomes. The results showed that the inhibitor could inhibit DIO in vitro and cause delayed metamorphosis and reduced growth in the exposed amphibians.
TOXICOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Zhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao, Peipei Jiang, Dan Liu, Zhiyin Wang, Haining Lv, Ruotian Li, Ying Hong, Jianwu Dai, Yali Hu, Guangfeng Zhao
Summary: Defective autophagy plays an important role in endometrial fibrosis by regulating EEC-EMT through the DIO2-MAPK/ERK-MTOR pathway.
Article
Medicine, Research & Experimental
N. V. Naryzhnaya, E. S. Prokudina, E. A. Nesterov, S. Yu. Tsibulnikov, L. N. Maslov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Article
Medicine, Research & Experimental
E. S. Prokudina, N. Naryzhnaya, E. A. Nesterov, S. Yu Tsibulnikov, L. N. Maslov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2020)
Review
Cardiac & Cardiovascular Systems
Andrey V. Krylatov, Sergey Y. Tsibulnikov, Alexander V. Mukhomedzyanov, Alla A. Boshchenko, Victor E. Goldberg, Amteshwar S. Jaggi, Reinhold G. Erben, Leonid N. Maslov
Summary: Natriuretic peptides have various cardioprotective effects such as preventing reperfusion injury, limiting infarction, anti-apoptotic and anti-inflammatory effects. They regulate multiple signaling pathways, reduce mortality in heart disease patients, but have limited effectiveness in diabetic rats.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)
Article
Physiology
Boris K. Kurbatov, Ekaterina S. Prokudina, Leonid N. Maslov, Natalia Naryzhnaya, Sergey Logvinov, Alexander S. Gorbunov, Alexandr Mukhomedzyanov, Andrey Krylatov, Nikita S. Voronkov, Andrey S. Sementsov, Konstantin Zavadovsky, Viktor V. Saushkin, Rajendra P. Nagarajan, Peter R. Oeltgen
Summary: Takotsubo syndrome (TS) is a rare and dangerous disease with unclear pathogenesis related to stress exposure, characterized by heart damage and elevated serum creatine kinase MB levels. Research has found that activation of beta(1)-adrenergic receptor (AR) plays a significant role in stress-induced cardiac injury (SICI).
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Andrey Krylatov, Leonid Maslov, Sergey Y. Tsibulnikov, Nikita Voronkov, Alla Boshchenko, James Downey, Robert Mentzer
Summary: This text provides evidence that autophagy in cardiomyocytes can be activated by hypoxia/reoxygenation or ischemia/reperfusion, and discusses how increases in autophagy may have both beneficial and detrimental effects on the heart. It also highlights the regulation of autophagy by various molecules in this setting.
CURRENT CARDIOLOGY REVIEWS
(2021)
Article
Medicine, General & Internal
E. S. Prokudina, L. N. Maslov, N. Naryzhnaya, B. K. Kurbatov, A. Mukhomedzyanov, V. V. Shipulin, A. Krylatov, S. Yu Tsibulnikov, N. S. Voronkov
Summary: The development of stress cardiomyopathy (SCM) is related to the adrenergic system and beta(1)-adrenergic receptor, while the parasympathetic nervous system plays an important role in resisting stress.
BYULLETEN SIBIRSKOY MEDITSINY
(2021)
Review
Cardiac & Cardiovascular Systems
Leonid N. Maslov, Sergey V. Popov, Alexandr V. Mukhomedzyanov, Natalia V. Naryzhnaya, Nikita S. Voronkov, Vyacheslav V. Ryabov, Alla A. Boshchenko, Igor Khaliulin, N. Rajendra Prasad, Feng Fu, Jian-Ming Pei, Sergey V. Logvinov, Peter R. Oeltgen
Summary: Ca2+ overload and increased reactive oxygen species production play a significant role in reperfusion injury of cardiomyocytes. The NLRP3 inflammasome and increased adrenergic system activity during coronary perfusion restoration worsen the damage to the heart.
CURRENT CARDIOLOGY REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Sergey Popov, Alexander Mukhomedzyanov, Nikita S. Voronkov, Ivan A. Derkachev, Alla A. Boshchenko, Feng Fu, Galina Z. Sufianova, Maria S. Khlestkina, Leonid N. Maslov
Summary: Ischemia/reperfusion leads to increased autophagic flux in the heart. Preconditioning stimulates autophagic flux by activating AMPK and PI3-kinase and inhibiting mTOR. The cardioprotective effect of postconditioning is associated with autophagy activation and increased activity of NO-synthase and AMPK. Oxidative stress stimulates autophagy, possibly through AMPK activation.
Article
Medicine, Research & Experimental
G. Z. Sufianova, A. G. Shapkin, M. S. Khlestkina, L. N. Maslov, A. V. Mukhomedzyanov, N. S. Voronkov, A. A. Sufianov
Summary: This study observed the effect of pre-administration of citicoline on spontaneous bioelectrical activity and gasping duration in mice during global strangulation ischemia of the brain. The results showed that citicoline exhibited the maximum neuroprotective effect when administered 60 min before ischemia simulation and this effect was completely prevented by pre-administration of a selective P2Y6 receptor antagonist, MRS2578. The experimental data suggest the leading role of receptor mechanisms in the neuroprotective activity of citicoline.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
N. Naryzhnaya, A. Mukhomedzyanov, S. Yu Tsibulnikov, L. N. Maslov
BYULLETEN SIBIRSKOY MEDITSINY
(2020)
Article
Biochemistry & Molecular Biology
Sergey Y. Tsibulnikov, Leonid N. Maslov, Natalya Naryzhnaya, Vladimir V. Ivanov, Yury Bushov, Nikita S. Voronkov, Amteshwar S. Jaggi, Yi Zhang, Peter R. Oeltgen
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2019)