Article
Otorhinolaryngology
Wenjun Liao, Jinlan He, Qiheng Gou, Baofeng Duan, Ping Ai, Lei Liu, Yanchu Li, Kexing Ren, Min Yao, Nianyong Chen
Summary: The study found that local treatment of metastases in patients with metastatic nasopharyngeal carcinoma (NPC) significantly improved overall survival, suggesting that it should be considered in addition to chemotherapy in their treatment.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Shuo-Han Zheng, Yu-Tong Wang, Song-Ran Liu, Zi-Lu Huang, Guan-Nan Wang, Jin-Tao Lin, Shi-Rong Ding, Chen Chen, Yun-Fei Xia
Summary: The optimal treatment strategy for de novo metastatic nasopharyngeal carcinoma (mNPC) is a combination of palliative chemotherapy (PCT) followed by concurrent chemoradiotherapy. Specifically, concurrent chemoradiotherapy with single-agent platinum after 4-6 cycles of PCT is suggested to achieve better survival outcomes.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Zheran Liu, Ye Chen, Yonglin Su, Xiaolin Hu, Xingchen Peng
Summary: Nasopharyngeal carcinoma (NPC) is a severe malignancy that arises from the nasopharyngeal epithelium and is the third most common cancer in southern China. Treatment failures in NPC are often due to distant metastasis or locally advanced stages. This study aims to provide a comprehensive overview of recent advances in NPC treatment and explore various therapeutic possibilities for locally advanced, recurrent, and metastatic patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Lianlian Yang, Yinyin Xue, Zhigong Wei, Kexing Ren, Zheran Liu, Tangel Chang, Xingchen Peng, Yonglin Su, Yan Li
Summary: Local radiotherapy to metastatic lesions might be a protective factor for patients with metastatic nasopharyngeal carcinoma (mNPC) as shown in the study involving 109 patients with mNPC. The overall survival rates were significantly higher in patients who received local radiotherapy compared to those who did not receive radiotherapy to metastatic lesions.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Review
Oncology
Wing Lok Chan, James Chung Hang Chow, Zhi-yuan Xu, Jishi Li, Wing Tung Gobby Kwong, Wai Tong Ng, Anne W. M. Lee
Summary: Nasopharyngeal cancer is a difficult cancer to treat in the head and neck region, especially in elderly patients. The management of NPC in these patients requires a comprehensive evaluation to determine the most suitable treatment plan.
FRONTIERS IN ONCOLOGY
(2022)
Article
Otorhinolaryngology
Chih-Wen Twu, Po-Ju Lin, Hsiao-Hui Tsou, Yi-Chun Liu, Rong-San Jiang, Kai-Li Liang, Tian-Yun Lin, Wen-Yi Wang, Jin-Ching Lin
Summary: This study investigated the survival impact and toxicity of maintenance metronomic chemotherapy in patients with metastatic/recurrent nasopharyngeal carcinoma. The results showed that maintenance chemotherapy significantly improved overall and progression-free survivals while demonstrating low toxicity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Pharmacology & Pharmacy
Pei-Jing Li, Yu-Lin Lai, Fang He, Yuan-Yuan Chen, Zhuo-Sheng Gu, Wei Luo, Qun Zhang
Summary: This study compared the treatment outcomes of concurrent chemoradiotherapy (CCRT) versus radiotherapy (RT) alone in stage II nasopharyngeal carcinoma (NPC) patients. The findings showed no significant difference in survival rates and various survival indicators between the CCRT and RT groups. In the era of 2DRT, concurrent chemotherapy significantly improved some survival rates, but it had no significant effect in the era of intensity-modulated radiotherapy (IMRT).
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Otorhinolaryngology
Honggen Liu, Peiying Yang, Yingjie Jia
Summary: Oligometastatic nasopharyngeal carcinoma is a distinctive subset of metastatic NPC with survival advantages. Treatment strategies for de-novo oligometastatic NPC differ due to disease heterogeneity. More well-designed prospective clinical trials are needed to determine the best treatment paradigm.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Oncology
Ting Jin, Nan-Fang Liu, Qi-Feng Jin, Yong-Hong Hua, Xiao-Zhong Chen
Summary: This study evaluated the effectiveness and toxicity of radiation dose escalation for locally advanced nasopharyngeal carcinoma (LA-NPC) patients with local and/or regional residual lesions after standard treatment. The results showed high survival rates for local and regional control, as well as distant metastasis-free survival. There were no significant differences in survival rates based on age, virus status, tumor stage, or lymph node involvement. Further prospective studies are needed to validate these findings.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Pui-Lam Yip, Shing-Fung Lee, Cheuk-Wai Horace Choi, Po-Chung Sunny Chan, Ka-Wai Alice Cheung, Chung-Hang James Chow, Ka-Man Cheung, Wing-Yu Jessica Lai, Ho-Fun Victor Lee, Ka-On Lam, Chi-Leung Chiang, Chun-Yin Edwin Wong, Ming-Chun Darren Poon, Macy Tong, Kwok-Hung Au, Wai-Tong Ng, Kai-Cheong Roger Ngan, Wing-Mui Anne Lee, Yuk Stewart Tung
Summary: A study evaluated the external validity of a nomogram by Sun et al. to predict overall survival and the benefit of concurrent chemoradiation (CCRT) vs. radiotherapy (RT) alone in stage II nasopharyngeal carcinoma patients. The results showed that the nomogram lacked predictive accuracy when applied to these patients.
Article
Multidisciplinary Sciences
Susanna Hilda Hutajulu, Daniel Howdon, Kartika Widayati Taroeno-Hariadi, Mardiah Suci Hardianti, Ibnu Purwanto, Sagung Rai Indrasari, Camelia Herdini, Bambang Hariwiyanto, Ahmad Ghozali, Henry Kusumo, Wigati Dhamiyati, Sri Retna Dwidanarti, I. Bing Tan, Johan Kurnianda, Matthew John Allsop
Summary: The study aimed to determine the survival outcome and prognostic factors of nasopharyngeal cancer patients in Yogyakarta, Indonesia. Results showed that age, education status, ECOG index, stage, and treatment modality were independent predictors for patient survival in the region. The study highlighted the importance of combining chemotherapy and radiation for better outcomes in NPC patients.
Review
Oncology
Shan-Shan Yang, Jian-Gui Guo, Jia-Ni Liu, Zhi-Qiao Liu, En-Ni Chen, Chun-Yan Chen, Pu-Yun OuYang, Fei Han, Fang-Yun Xie
Summary: The meta-analysis showed that induction chemotherapy in patients with nasopharyngeal carcinoma significantly prolonged progression free survival and overall survival, while improving locoregional and distant control rates. The incidence of grade 3-4 adverse events during concurrent chemoradiotherapy was higher in the induction chemotherapy group, including leukopenia, thrombocytopenia, and fatigue.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jing Feng Zong, Po-Ju Lin, Hsiao-Hui Tsou, Qiaojuan Guo, Yi-Chun Liu, Hanchuan Xu, Chih-Wen Twu, Wei Zheng, Rong-San Jiang, Kai -Li Liang, Tian-Yun Lin, Jian Ji Pan, Shao Jun Lin, Jin-Ching Lin
Summary: The purpose of this study was to compare the acute toxicity of two different induction chemotherapy regimens in patients with advanced nasopharyngeal carcinoma. The results showed that the weekly chemotherapy regimen significantly reduced acute toxicities and had higher complete response rates and lower relapse rates, without compromising tumor response and survivals.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Yao-Can Xu, Kai-Hua Chen, Zhong-Guo Liang, Xiao-Dong Zhu
Summary: Concurrent chemoradiotherapy (CCRT) in stage II nasopharyngeal carcinoma (NPC) shows improved overall survival (OS), locoregional recurrence-free survival (LRFS), and progression-free survival (PFS) compared to 2DRT alone, but not in terms of metastasis-free survival (DMFS). However, adding concurrent chemotherapy to intensity-modulated RT (IMRT) did not significantly improve survival outcomes but increased acute toxicities. Subgroup analysis for stage N1 patients did not show significant survival benefits from CCRT, but increased incidence of acute toxicities.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Lin Su, Lei She, Liangfang Shen
Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xiao-Peng Tian, Wei-Juan Huang, Hui-Qiang Huang, Yan-Hui Liu, Liang Wang, Xi Zhang, Tong-Yu Lin, Hui-Lan Rao, Mei Li, Fang Liu, Fen Zhang, Li-Ye Zhong, Li Liang, Xiao-Liang Lan, Juan Li, Bing Liao, Zhi-Hua Li, Qiong-Lan Tang, Qiong Liang, Chun-Kui Shao, Qiong-Li Zhai, Run-Fen Cheng, Qi Sun, Kun Ru, Xia Gu, Xi-Na Lin, Kun Yi, Yue-Rong Shuang, Xiao-Dong Chen, Wei Dong, Wei Sang, Cai Sun, Hui Liu, Zhi-Gang Zhu, Jun Rao, Qiao-Nan Guo, Ying Zhou, Xiang-Ling Meng, Yong Zhu, Chang-Lu Hu, Yi-Rong Jiang, Ying Zhang, Hong-Yi Gao, Wen-Jun He, Zhong-Jun Xia, Cheng-Lei Wu, Mei-Yin Zhang, Hui-Yun Wang, Dan Xie, Qing-Qing Cai
Article
Oncology
Xiao-Peng Tian, Dan Xie, Wei-Juan Huang, Shu-Yun Ma, Liang Wang, Yan-Hui Liu, Xi Zhang, Hui-Qiang Huang, Tong-Yu Lin, Hui-Lan Rao, Mei Li, Fang Liu, Fen Zhang, Li-Ye Zhong, Li Liang, Xiao-Liang Lan, Juan Li, Bing Liao, Zhi-Hua Li, Qiong-Lan Tang, Qiong Liang, Chun-Kui Shao, Qiong-Li Zhai, Run-Fen Cheng, Qi Sun, Kun Ru, Xia Gu, Xi-Na Lin, Kun Yi, Yue-Rong Shuang, Xiao-Dong Chen, Wei Dong, Wei Sang, Cai Sun, Hui Liu, Zhi-Gang Zhu, Jun Rao, Qiao-Nan Guo, Ying Zhou, Xiang-Ling Meng, Yong Zhu, Chang-Lu Hu, Yi-Rong Jiang, Ying Zhang, Hong-Yi Gao, Wen-Jun He, Zhong-Jun Xia, Xue-Yi Pan, Hai Lan, Guo-Wei Li, Lu Liu, Hui-Zheng Bao, Li-Yan Song, Tie-Bang Kang, Qing-Qing Cai
Review
Hematology
Ma Shu-Yun, Tian Xiao-Peng, Jun Cai, Zhong Guang-Zheng, Chen Xu, Huang Hui-Qiang, Lin Tong-Yu, Li Zhi-Ming, Cai Qing-Qing
ANNALS OF HEMATOLOGY
(2020)
Article
Oncology
Xiao-Peng Tian, Ning Su, Liang Wang, Wei-Juan Huang, Yan-Hui Liu, Xi Zhang, Hui-Qiang Huang, Tong-Yu Lin, Shu-Yun Ma, Hui-Lan Rao, Mei Li, Fang Liu, Fen Zhang, Li-Ye Zhong, Li Liang, Xiao-Liang Lan, Juan Li, Bing Liao, Zhi-Hua Li, Qiong-Lan Tang, Qiong Liang, Chun-Kui Shao, Qiong-Li Zhai, Run-Fen Cheng, Qi Sun, Kun Ru, Xia Gu, Xi-Na Lin, Kun Yi, Yue-Rong Shuang, Xiao-Dong Chen, Wei Dong, Cai Sun, Wei Sang, Hui Liu, Zhi-Gang Zhu, Jun Rao, Qiao-Nan Guo, Ying Zhou, Xiang-Ling Meng, Yong Zhu, Chang-Lu Hu, Yi-Rong Jiang, Ying Zhang, Hong-Yi Gao, Wen-Jun He, Zhong-Jun Xia, Xue-Yi Pan, Lan Hai, Guo-Wei Li, Li-Yan Song, Tie-Bang Kang, Dan Xie, Qing-Qing Cai
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Xiao-Peng Tian, Jun Cai, Shu-Yun Ma, Yu Fang, Hui-Qiang Huang, Tong-Yu Lin, Hui-Lan Rao, Mei Li, Zhong-Jun Xia, Tie-Bang Kang, Dan Xie, Qing-Qing Cai
CANCER COMMUNICATIONS
(2020)
Article
Hematology
Xiao-Peng Tian, Shu-Yun Ma, Ken H. Young, Choon Kiat Ong, Yan-Hui Liu, Zhi-Hua Li, Qiong-Li Zhai, Hui-Qiang Huang, Tong-Yu Lin, Zhi-Ming Li, Zhong-Jun Xia, Li-Ye Zhong, Hui-Lan Rao, Mei Li, Jun Cai, Yu-Chen Zhang, Fen Zhang, Ning Su, Peng-Fei Li, Feng Zhu, Zijun Y. Xu-Monette, Esther Kam Yin Wong, Jeslin Chian Hung Ha, Lay Poh Khoo, Le Ai, Run-Fen Cheng, Jing Quan Lim, Sanjay De Mel, Siok-Bian Ng, Soon Thye Lim, Qing-Qing Cai
Summary: Constructing a classifier based on 7 SNPs is effective in predicting survival and treatment response for ENKTL patients. The classifier showed good prognostic efficacy in different cohorts and proved to be an independent prognostic factor with better accuracy than clinicopathological risk variables. Application of the classifier was not impacted by sample types and it can provide significant implications for clinical decision making.
Article
Oncology
Jun Cai, Xiaopeng Tian, Shuyun Ma, Liye Zhong, Wenyu Li, Liang Wang, Linlang Guo, Zhihua Li, Yudan Wu, Guangzheng Zhong, Huiqiang Huang, Zhongjun Xia, Yi Xia, Panpan Liu, Ning Su, Yu Fang, Yuchen Zhang, Qingqing Cai
Summary: An accurate predictive prognostic risk-stratification model for DLBCL patients was established and validated using data from 1406 patients and an independent cohort of 954 patients. The NPI model outperformed IPI and NCCN-IPI for prognostic stratification, and high-dose methotrexate treatment showed superior OS outcomes in CD5+ DLBCL patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Hematology
Shu-Yun Ma, Xiao-Peng Tian, Jun Cai, Ning Su, Yu Fang, Yu-Chen Zhang, Jin-Ni Wang, Robert Peter Gale, Qing-Qing Cai
Summary: A prognostic score for DLBCL patients based on infiltrating immune cells was constructed, showing that the immune risk score is an accurate and independent survival predictor in DLBCL patients.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Yu Fang, Ning Su, Shuyun Ma, Jun Cai, Liye Zhong, Wenyu Li, Huiqiang Huang, Zhiming Li, He Huang, Yi Xia, Panpan Liu, Linlang Guo, Zhihua Li, Yudan Wu, Xiaopeng Tian, Jinni Wang, Yuchen Zhang, Qingqing Cai
Summary: This multicenter analysis investigates the optimal timing and dose of prophylactic HD-MTX in DLBCL. The results suggest that concurrent HD-MTX may be associated with increased treatment-related toxicity and chemotherapy delays, while EOI HD-MTX has no significant difference in CNS relapse rate compared to concurrent administration. High-dose MTX may benefit CNS relapse control in the high-risk group, but may not be necessary for moderate-risk patients.
ANNALS OF HEMATOLOGY
(2022)
Meeting Abstract
Hematology
Qingqing Cai, Jinni Wang, Yu Fang, Ning Su, Shuyun Ma, Jun Cai, Yuchen Zhang, Xiaopeng Tian, Huiqiang Huang, Zhiming Li, He Huang, Yi Xia, Panpan Liu
Article
Oncology
Jinni Wang, Yu Fang, Shuyun Ma, Ning Su, Yuchen Zhang, Huiqiang Huang, Zhiming Li, He Huang, Xiaopeng Tian, Jun Cai, Yi Xia, Panpan Liu, Qingqing Cai
Summary: This study compared the efficacy of different treatment regimens in R/R PTCL patients. The combination of chidamide and ChT showed better progression-free survival in certain patient subgroups, suggesting it may be an effective treatment strategy for this condition.
Article
Oncology
Ning Su, Yu Fang, Jinni Wang, Xiaopeng Tian, Shuyun Ma, Jun Cai, Yuchen Zhang, Yi Xia, Panpan Liu, Qingqing Cai
Summary: Anlotinib demonstrated antitumor activity and manageable toxicity in the treatment of metastatic adenoid cystic carcinoma, leading to improved disease control rate and progression-free survival.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Hematology
Qihua Zou, Shuyun Ma, Xiaopeng Tian, Qingqing Cai
Summary: This review summarizes the genetic and molecular characteristics, treatment modalities, and prognostic factors of adult T-cell lymphoblastic lymphoma (T-LBL). Genetic mutations and abnormal activation of signaling pathways have been identified in this rare and aggressive subtype of non-Hodgkin's lymphoma. The recommended treatment includes intensive therapy, central nervous system prophylaxis, and mediastinal radiotherapy. Hematopoietic stem cell transplantation may be considered for high-risk or relapsed/refractory cases. Novel prognostic models based on miRNA, gene, and CpG have shown significant value in predicting outcomes for adult T-LBL.
Article
Biochemistry & Molecular Biology
Jun Cai, Panpan Liu, Huiqiang Huang, Yajun Li, Shuyun Ma, Hui Zhou, Xiaopeng Tian, Yuchen Zhang, Yan Gao, Yi Xia, Xuanye Zhang, Hang Yang, Lirong Li, Qingqing Cai
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
