Review
Medicine, General & Internal
Athanasios Kontogiannis, Alkis Matsas, Serena Valsami, Maria Effrosyni Livanou, Theodoros Panoskaltsis, Panagiotis Christopoulos
Summary: Heavy menstrual bleeding (HMB) is a common condition that affects the quality of life of adolescent and adult women. Primary hemostasis disorders, such as Von Willebrand disease (VWD), can be the underlying cause of HMB. Diagnosing these disorders can be challenging, but a thorough hematologic workup is important for the correct diagnosis. The goal of this study was to provide a comprehensive review of primary hemostasis disorders associated with HMB, serving as a reference guide for further study.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Bethany T. Samuelson Bannow, Vivia Chi, Paul Sochacki, Owen J. T. McCarty, Maureen K. Baldwin, Alison B. Edelman
Summary: The study investigated rates of heavy menstrual bleeding (HMB) in users of rivaroxaban and apixaban, finding an association between rivaroxaban use and the need for medical or surgical intervention for HMB. Most women did not have a documented menstrual history, indicating that many providers do not inquire about menstrual bleeding when initiating anticoagulant therapy. Menstruating women, especially those with a history of HMB, may be at increased risk for HMB requiring medical treatment depending on the type of OAC used.
THROMBOSIS RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Vanessa R. Byams, Connie H. Miller, Fiona M. Bethea, Karon Abe, Christopher J. Bean, Laura A. Schieve
Summary: This article provides an overview of bleeding disorders in women and girls, including their biology, clinical care, and state of the science. It also describes the activities of the CDC in surveillance, research, and education related to bleeding disorders. The importance of improving healthcare provider awareness and understanding of the unique needs of women and girls with bleeding disorders is emphasized.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Pharmacology & Pharmacy
Martina Orlandi, Silvia Vannuccini, Khadija El Aoufy, Maria Ramona Melis, Gemma Lepri, Gianluca Sambataro, Silvia Bellando-Randone, Serena Guiducci, Marco Matucci Cerinic, Felice Petraglia
Summary: This study evaluated gynecological symptoms and disorders in women of reproductive age with rheumatic diseases (RDs). The results showed that these patients commonly experienced menstrual irregularities, heavy menstrual bleeding, and dysmenorrhea, and their quality of life was significantly reduced. Therefore, it is important to inquire about gynecological symptoms in women with RDs and refer them to gynecologists for evaluation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Developmental
Misha Khalighi, Allison P. Wheeler, Oluyemisi A. Adeyemi-Fowode, Peter A. Kouides, Ramon A. Durazo-Arvizu, Kristina Haley, Candice M. Dersch, Angela C. Weyand, Maureen K. Baldwin, Claudia Borzutzky
Summary: This study compared patient outcomes in adolescents with and without inherited bleeding disorders (BD) who underwent treatment for heavy menstrual bleeding (HMB) using the 52-mg levonorgestrel-releasing intrauterine system (52-LNG-IUS) within 12 months of insertion. The findings showed that both groups experienced improvement in bleeding outcomes and had similar rates of spontaneous expulsion.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Hematology
Ming Y. Lim, Lenora Olson, Madhvi A. Rajpurkar, Angela C. Weyand
Summary: The study revealed that the use of combined hormonal contraceptives and antifibrinolytic agents for refractory heavy menstrual bleeding is commonly practiced, showing efficacy and relatively good safety profile. Further research is needed to investigate this treatment approach.
THROMBOSIS RESEARCH
(2021)
Article
Obstetrics & Gynecology
Gabriela P. Mena, Gregore Mielke, Wendy J. Brown
Summary: The study found that overweight and obese women are more likely to have irregular periods and heavy menstrual bleeding, but high levels of physical activity can reduce the odds of heavy menstrual bleeding.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Nicole E. Kendel, Ayesha Zia, Lucy E. Rosenbaum, Joseph R. Stanek, Fareeda W. Haamid, Myra Christian-Rancy, Sarah H. O'Brien
Summary: There is no association between the presence of inherited bleeding disorders (BDs) and higher intrauterine device (IUD) expulsion rates in adolescent females. IUD placement should be considered as a first-line option for adolescents with BDs experiencing heavy menstrual bleeding (HMB).
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2022)
Article
Hematology
Antoine Rauch, Leonard A. Valentino, Kevin Mills, Michelle L. Witkop, Maria E. Santaella, Donna DiMichele, Michael Recht, Sophie Susen
Summary: This study aims to create a national research blueprint agenda to improve the care for those with rare disorders and historically underserved populations, and to address the critical gaps faced by women with IBDs.
Review
Hematology
Nicola Curry, Louise Bowles, T. Justin Clark, Gillian Lowe, Jason Mainwaring, Sarah Mangles, Bethan Myers, Rezan Abdul Kadir
Summary: This guideline provides recommendations for the diagnosis and management of women with inherited bleeding disorders (IBDs), particularly focusing on heavy menstrual bleeding (HMB). It highlights the importance of multidisciplinary specialized care and cross-specialty communication between gynaecology and haematology teams.
Article
Public, Environmental & Occupational Health
Josep Perello-Capo, Joan Rius-Tarruella, Mercedes Andeyro-Garcia, Joaquim Calaf-Alsina
Summary: This study assessed the value of the SAMANTA questionnaire in monitoring hormonal treatment for heavy menstrual bleeding (HMB) in clinical practice. The findings suggest that the SAMANTA questionnaire is a valuable tool for monitoring HMB treatment.
JOURNAL OF WOMENS HEALTH
(2023)
Article
Hematology
Christine J. Guelcher, Jaime Chase, Debra Pollard
Summary: Over the last few decades, there has been an increasing focus on women with inherited bleeding disorders (WBD), leading to more patients being treated at Haemophilia Treatment Centres (HTC) worldwide. These women face unique challenges, including a significant risk of heavy menstrual bleeding (HMB). Nurses, who play a central role in patient and family education within the HTC, are well positioned to provide clinical care and education specifically for WBD. However, there is a lack of literature highlighting the role of HTC nurses and their potential impact on this growing but understudied patient population.
Article
Pharmacology & Pharmacy
Jianmin Shan, Hongjun Tian, Chunhua Zhou, Haibo Wang, Xiaoyan Ma, Ranli Li, Haiping Yu, Guangdong Chen, Jingjing Zhu, Ziyao Cai, Chongguang Lin, Langlang Cheng, Yong Xu, Sha Liu, Congpei Zhang, Qinghua Luo, Yunshu Zhang, Shili Jin, Chuanxin Liu, Qiuyu Zhang, Luxian Lv, Lei Yang, Jiayue Chen, Qianchen Li, Wei Liu, Weihua Yue, Xueqin Song, Chuanjun Zhuo
Summary: Limited studies have examined treatment-induced heavy menstrual bleeding (HMB) in women with severe mental illnesses. This study aimed to investigate the prevalence of HMB and associated factors in young women diagnosed with bipolar disorder (BP), major depressive disorder (MDD), or schizophrenia (SCZ). The results showed that high glycosylated hemoglobin (HbA1c) level, fasting blood sugar, 2-h postprandial blood glucose, and use of the medication valproate were significant risk factors for HMB, while lithium emerged as a protective factor. Pharmacotherapy-induced visual learning impairment was also associated with HMB.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Elizabeth A. Stewart, David F. Archer, Charlotte D. Owens, Kurt T. Barnhart, Linda D. Bradley, Eve C. Feinberg, Veronica Gillispie-Bell, Anthony N. Imudia, Ran Liu, Jin Hee Kim, Ayman Al-Hendy
Summary: In women with uterine fibroids and heavy menstrual bleeding who were not responders in previous clinical trials, treatment with elagolix plus add-back therapy showed a trend towards greater reduction in menstrual blood loss compared to placebo. Adverse events did not differ significantly between responders and nonresponders.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study explores the role of histone deacetylase 3 (HDAC3) in adenomyosis-associated heavy menstrual bleeding (HMB). The researchers found that reduced expression of HDAC3 is associated with HMB in women with adenomyosis. Higher stiffness and fibrosis in the adenomyotic lesions and neighboring endometrial-myometrial interface were observed in women with excessive bleeding compared to those with moderate/heavy bleeding. Inhibition of HDAC3 resulted in disrupted NF-KB signaling, inflammation, and increased bleeding in mice with induced adenomyosis. Overall, this study highlights the importance of HDAC3 in the pathogenesis of adenomyosis-associated HMB.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Hematology
Claudia Djambas Khayat, Sunil Lohade, Fulton D'Souza, Latha Gowda Shamanur, Omid Reza Zekavat, Irina Kruzhkova, Bruce Schwartz, Cristina Solomon, Sigurd Knaub, Flora Peyvandi
Summary: This study evaluated the efficacy, pharmacokinetics, and safety of human fibrinogen concentrate (HFC) in pediatric patients with congenital fibrinogen deficiency. The results showed a 100% success rate for on-demand bleeding treatment and surgical prophylaxis, with favorable PK parameters and safety profile.
Editorial Material
Medical Laboratory Technology
Sarra Fekih Salem, Wijdene El Borgi, Fatma BenLakhal, Salma Kefi, Mounira Meddeb, Balkis Meddeb, Emna Gouider
ANNALES DE BIOLOGIE CLINIQUE
(2021)
Letter
Hematology
Emna Hammami, Mariem Hadhri, Sarra Fekih Salem, Fatma Ben Lakhal, Wijden El Borgi, Emna Gouider
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2022)
Letter
Hematology
Emna Hammami, Wijden El Borgi, El Mahmoudi Hajer, Bouattour Houda, Mariem Achour, Kaouther Zahra, Balkis Meddeb, Emna Gouider
Review
Medical Laboratory Technology
Emna Hammami, Wijden El Borgi, Fatma Ben Lakhal, Sarra Fekih Salem, Hend Ben Neji, Emna Gouider
Summary: Factor VII deficiency is the most common rare inherited bleeding disorder, while acquired FVII deficiency is uncommon. This study presents a case of acquired FVII deficiency associated with AML and reviews the literature on this condition. The patient showed normalization of PT and FVII levels and achieved complete remission.
LABORATORY MEDICINE
(2022)
Article
Hematology
Manuel Carcao, Emna Gouider, Runhui Wu
Summary: The use of Lower dose/Lower frequency prophylaxis (LDP) along with increased use of antifibrinolytics offers a cost-effective option for managing patients with severe phenotype haemophilia. LDP results in significant reduction in bleeds, hospital admissions, and days lost from school compared to on demand therapy. Antifibrinolytics can serve as effective adjunctive agents for bleed management and hemostasis for surgeries, potentially reducing the need for expensive factor concentrates.
Article
Hematology
Cherifa Ouardani, Hejer Elmahmoudi, Wejden ELborgi, Maroua Gharbi, Achour Meriem, Emna Gouider
Summary: This study investigated the genetic alterations and their relationships with clinical and biological data in 40 Tunisian patients with FVII deficiency. Clinical heterogeneity was observed and 13 F7 gene mutations, including one novel mutation, were identified. There was no significant correlation between the severity of clinical manifestations and genotypes, but a relationship between nonpathogeneous mutations and clinical phenotypes was noticed.
BLOOD COAGULATION & FIBRINOLYSIS
(2022)
Article
Hematology
Claudia Djambas Khayat, Sunil Lohade, Omid Reza Zekavat, Irina Kruzhkova, Cristina Solomon, Flora Peyvandi
Summary: In patients with congenital fibrinogen deficiency, human fibrinogen concentrate (HFC) treatment was successful for perioperative bleeding management in adults, adolescents, and pediatric patients, with comparable efficacy across different age groups.
Article
Hematology
Jamie M. M. O'Sullivan, Ellia Tootoonchian, Baiba Ziemele, Michael Makris, Augusto B. B. Federici, Claudia Khayat Djambas, Magdy El Ekiaby, Dawn Rotellini, Robert F. F. Sidonio, Alfonso Iorio, Donna Coffin, Glenn F. F. Pierce, Jeffrey Stonebraker, Paula D. D. James, Michelle Lavin
Summary: Recent guidelines for von Willebrand Disease (VWD) highlighted the challenges in diagnosis and management. Identifying the number of persons with VWD (PwVWD) internationally will help target support to aid diagnosis of PwVWD. Registration rates of PwVWD vary internationally and are influenced by national income status.
Meeting Abstract
Hematology
Amine Sfaxi, Wijden Borgi, Fatma Ben Lakhal, Sarra Fekih Selem, Emna Gouider
Meeting Abstract
Hematology
Malek Terras, Rabeb Jaied, Wijden Borgi, Fatma Ben Lakhal, Sarra Fekih Salem, Emna Gouider
Meeting Abstract
Hematology
Ellia Tootoonchian, Magdy El Ekiaby, Emna Gouider, Alfonso Iorio, Mike Makris, Jamie O'Hara, Michael Recht, Glenn F. Pierce, Donna Coffin, Jeffrey Stonebraker
Meeting Abstract
Hematology
Eya Drissi, Wijden Borgi, Fatma Ben Lakhal, Sarra Fekih Salem, Emna Gouider
Meeting Abstract
Hematology
Rabeb Jaied, Malek Terras, Molka Bambia, Houda Bouattour, Kaouther Zahra, Mariem Achour, Balkis Meddeb, Emna Gouider
Article
Medical Laboratory Technology
Sarra Bahroun, Fatma Ben Lakhal, Wijdene ElBorgi, Sarra Fekih Salem, Meriem Achour, Emna Gouider
Summary: The study reports a rare case of isolated CD157 deficiency discovered during the search for a PNH clone, highlighting the challenges in result interpretation with potential false positives. The discussion provides insight into how biologists can address these difficulties and emphasizes the importance of following international guidelines before diagnosing a PNH clone with significant implications.
ANNALES DE BIOLOGIE CLINIQUE
(2021)