Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons

Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity

(2019) Eduardo Leyva-Díaz et al.   DEVELOPMENT

The Post-GWAS Era: From Association to Function

(2018) Michael D. Gallagher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spinal Circuits for Touch, Pain, and Itch

(2018) Stephanie C. Koch et al.   Annual Review of Physiology

Identification of a candidate enhancer for DMRT3 involved in spastic cerebral palsy pathogenesis

(2018) Naoto Kubota et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Massively Parallel Single Nucleus Transcriptional Profiling Defines Spinal Cord Neurons and Their Activity during Behavior

(2018) Anupama Sathyamurthy et al.   Cell Reports

Neonatal Diabetes: Two Cases with Isolated Pancreas Agenesis due to Homozygous PTF1A Enhancer Mutations and One with Developmental Delay, Epilepsy, and Neonatal Diabetes Syndrome due to KCNJ11 Mutation

(2018) Olcay Evliyaoğlu et al.   Journal of Clinical Research in Pediatric Endocrinology

Enhancer redundancy provides phenotypic robustness in mammalian development

(2018) Marco Osterwalder et al.   NATURE

Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation

(2018) Patrick Torbey et al.   PLoS Genetics

Isolation of Adult Spinal Cord Nuclei for Massively Parallel Single-nucleus RNA Sequencing

(2018) Kaya J.E. Matson et al.   Jove-Journal of Visualized Experiments

Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog)

(2017) Anja J Will et al.   NATURE GENETICS

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord

(2017) Shuohao Sun et al.   NEURON

Repression by PRDM13 is critical for generating precision in neuronal identity

(2017) Bishakha Mona et al.   eLife

Pancreatic Agenesis due to Compound Heterozygosity for a Novel Enhancer and Truncating Mutation in the PTF1A Gene

(2017) Monica Gabbay et al.   Journal of Clinical Research in Pediatric Endocrinology

Hydraulic Extrusion of the Spinal Cord and Isolation of Dorsal Root Ganglia in Rodents

(2017) Mette Richner et al.   Jove-Journal of Visualized Experiments

Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks

(2016) Enrico Cannavò et al.   CURRENT BIOLOGY

Making sense out of spinal cord somatosensory development

(2016) Helen C. Lai et al.   DEVELOPMENT

Regulating the dorsal neural tube expression of Ptf1a through a distal 3′ enhancer

(2016) Bishakha Mona et al.   DEVELOPMENTAL BIOLOGY

Loss ofPtf1aLeads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei

(2016) Igor Y. Iskusnykh et al.   JOURNAL OF NEUROSCIENCE

Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A

(2016) Chinh Q. Hoang et al.   MOLECULAR AND CELLULAR BIOLOGY

Variable Phenotype of Diabetes Mellitus in Siblings with a Homozygous PTF1A Enhancer Mutation

(2015) E. Nazlı Gonc et al.   Hormone Research in Paediatrics

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

(2015) S. Bourane et al.   SCIENCE

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

(2014) Bo Duan et al.   CELL

A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord

(2014) Mark D. Borromeo et al.   DEVELOPMENT

Epigenetics, chromatin and genome organization: recent advances from the ENCODE project

(2014) L. Siggens et al.   JOURNAL OF INTERNAL MEDICINE

A Simplified Up-Down Method (SUDO) for Measuring Mechanical Nociception in Rodents Using von Frey Filaments

(2014) Robert P Bonin et al.   Molecular Pain

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function

(2014) K. J. Millen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prdm13 Mediates the Balance of Inhibitory and Excitatory Neurons in Somatosensory Circuits

(2013) Joshua C. Chang et al.   DEVELOPMENTAL CELL

Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities

(2013) Y. Xu et al.   JOURNAL OF NEUROSCIENCE

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis

(2013) Michael N Weedon et al.   NATURE GENETICS

A Brief Review on the Human Encyclopedia of DNA Elements (ENCODE) Project

(2013) Hongzhu Qu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

A Novel Behavioral Assay for Measuring Cold Sensation in Mice

(2012) Daniel S. Brenner et al.   PLoS One

In Vivo Neuronal Subtype-Specific Targets of Atoh1 (Math1) in Dorsal Spinal Cord

(2011) H. C. Lai et al.   JOURNAL OF NEUROSCIENCE

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

(2010) Sarah E. Ross et al.   NEURON

Multiple Transcriptional Mechanisms Control Ptf1a Levels during Neural Development Including Autoregulation by the PTF1-J Complex

(2009) D. M. Meredith et al.   JOURNAL OF NEUROSCIENCE

A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord

(2008) Dominique Bröhl et al.   DEVELOPMENTAL BIOLOGY

Ptf1a, Lbx1 and Pax2 coordinate glycinergic and peptidergic transmitter phenotypes in dorsal spinal inhibitory neurons

(2008) Menggui Huang et al.   DEVELOPMENTAL BIOLOGY

Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

(2008) A. Fukuda et al.   DIABETES

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

(2008) K. Hori et al.   GENES & DEVELOPMENT

Tlx1 and Tlx3 Coordinate Specification of Dorsal Horn Pain-Modulatory Peptidergic Neurons

(2008) Y. Xu et al.   JOURNAL OF NEUROSCIENCE

Transcriptional Autoregulation Controls Pancreatic Ptf1a Expression during Development and Adulthood

(2008) T. Masui et al.   MOLECULAR AND CELLULAR BIOLOGY