Article
Multidisciplinary Sciences
Jennifer L. Ames, Assiamira Ferrara, Lyndsay A. Avalos, Sylvia E. Badon, Mara B. Greenberg, Monique M. Hedderson, Michael W. Kuzniewicz, Yinge Qian, Kelly C. Young-Wolff, Ousseny Zerbo, Yeyi Zhu, Lisa A. Croen
Summary: Research indicates that the prevalence of COVID-19 among reproductive-aged women is influenced by social and health disparities, with Hispanic women and those affected by pandemic-related job loss being more susceptible to the virus, while underlying comorbidities do not show a significant impact.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Andreas Zollner, Robert Koch, Almina Jukic, Alexandra Pfister, Moritz Meyer, Annika Roessler, Janine Kimpel, Timon E. Adolph, Herbert Tilg
Summary: The study investigates whether the persistence of SARS-CoV-2 antigen in infected tissues is responsible for postacute COVID-19 syndrome. The results suggest that viral antigen persistence may be the underlying cause of postacute COVID-19 and this concept should be validated in controlled clinical trials.
Review
Medicine, Research & Experimental
Chunxiu Yang, Shu-Yuan Xiao
Summary: COVID-19, caused by SARS-CoV-2, can lead to severe complications such as multiple organ failure, with most patients also experiencing gastrointestinal symptoms. Managing these symptoms presents challenges for patients with inflammatory bowel disease (IBD) due to potential interactions between the immune response to COVID-19 and dysregulated immunity associated with IBD.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Gastroenterology & Hepatology
Fabrizio Bossa, Sonia Carparelli, Anna Latiano, Orazio Palmieri, Francesca Tavano, Anna Panza, Maria Pastore, Antonio Marseglia, Mario D'Altilia, Tiziana Latiano, Giuseppe Corritore, Giuseppina Martino, Marianna Nardella, Maria Guerra, Fulvia Terracciano, Michele Sacco, Francesco Perri, Angelo Andriulli
Summary: The study found that treatment with biologic drugs does not increase the risk of SARS-CoV-2 infection in patients with inflammatory bowel disease. The majority of patients did not get infected with the virus, and only a small number experienced mild symptoms, with very few requiring hospitalization.
DIGESTIVE AND LIVER DISEASE
(2021)
Editorial Material
Multidisciplinary Sciences
Kara J. Mould, William J. Janssen
Summary: Severe COVID-19 pneumonia is characterized by lung inflammation, but many details remain unknown. Analysis of immune cells from the lungs provides insights into this mystery.
Review
Virology
Sha-Sha Tao, Xin-Yi Wang, Xiao-Ke Yang, Yu-Chen Liu, Zi-Yue Fu, Li-Zhi Zhang, Zhi-Xin Wang, Jing Ni, Zong-Wen Shuai, Hai-Feng Pan
Summary: This article discusses the effects of SARS-CoV-2 infection on the progression of IBD, the risk of COVID-19 infection and poor prognosis in IBD patients, the common mechanisms and genetic cross-linking between the two diseases, new treatment and care strategies for IBD patients, and the feasibility and risk of vaccination in the context of the COVID-19 epidemic.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Gastroenterology & Hepatology
Raffi Lev-Tzion, Gili Focht, Rona Lujan, Adi Mendelovici, Chagit Friss, Shira Greenfeld, Revital Kariv, Amir Ben-Tov, Eran Matz, Daniel Nevo, Yuval Barak-Corren, Iris Dotan, Dan Turner
Summary: COVID-19 vaccine effectiveness in IBD patients is comparable to non-IBD controls and is not affected by treatment with TNF inhibitors or corticosteroids. The risk of IBD exacerbation did not differ between vaccinated and unvaccinated patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Alessandra Giuliano, Walter Fries, Anna Viola, Alfredo Abbruzzese, Maria Cappello, Enrica Giuffrida, Lucio Carrozza, Antonino Carlo Privitera, Antonio Magnano, Concetta Ferracane, Giuseppe Scalisi, Maria Giovanna Minissale, Emiliano Giangreco, Serena Garufi, Carmelo Bertolami, Ugo Cucinotta, Francesco Graziano, Angelo Casa, Sara Renna, Giulia Teresi, Giulia Rizzuto, Mariella Mannino, Marcello Maida, Ambrogio Orlando
Summary: This retrospective study found that severe inflammatory bowel disease was an independent risk factor for severe COVID-19. Patients with inflammatory bowel disease did not have a higher risk of SARS-CoV-2 infection compared to the general population, and a worse prognosis was not typically associated with immunomodulatory drugs.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
David N. Fisman, Amy L. Greer, Gabrielle Brankston, Michael Hillmer, Sheila F. O'Brien, Steven J. Drews, Ashleigh R. Tuite
Summary: The study found that disease incidence and testing rates were highest in the oldest age group and lowest in those younger than 20 years, with no differences in incidence by sex. After adjusting for testing frequency, SIRs were lowest in children and adults aged 70 or older, but significantly higher in adolescents and males aged 20 to 49 compared to the overall population.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Paulina Krawiec, Violetta Opoka-Winiarska, Elzbieta Pac-Kozuchowska
Summary: This study presented four children with overlapping IBD flare and PIMS-TS/MIS-C, where IBD recognition often preceded the onset of PIMS-TS/MIS-C. These patients presented with gastrointestinal symptoms at PIMS-TS/MIS-C onset and required IVIG, ASA, and in some cases, steroids for treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Hamzah Z. Farooq, Emma Davies, Benjamin Brown, Thomas Whitfield, Peter Tilston, Ashley McEwan, Andrew Birtles, Robert O'Hara, Hannah Spencer, Louise Hesketh, Shazaad Ahmad, Malcolm Guiver, Nicholas Machin
Summary: The study presented the results of SARS-CoV-2 surveillance conducted by PHE Manchester during the first wave of the Covid-19 pandemic in the UK, highlighting the highest positivity rate in nasal swabs. This suggests that nasal swabs may be the optimal sample type for detecting SARS-CoV-2 within this dataset. Further research is needed to assess the utility of testing faecal, fluid, and CSF samples.
JOURNAL OF INFECTION
(2021)
Article
Medicine, General & Internal
Yamile Zabana, Ignacio Marin-Jimenez, Iago Rodriguez-Lago, Isabel Vera, Maria Dolores Martin-Arranz, Ivan Guerra, Javier P. Gisbert, Francisco Mesonero, Olga Benitez, Carlos Taxonera, Angel Ponferrada-Diaz, Marta Piqueras, Alfredo J. Lucendo, Berta Caballol, Miriam Manosa, Pilar Martinez-Montiel, Maia Bosca-Watts, Jordi Gordillo, Luis Bujanda, Noemi Mancenido, Teresa Martinez-Perez, Alicia Lopez, Cristina Rodriguez-Gutierrez, Santiago Garcia-Lopez, Pablo Vega, Montserrat Rivero, Luigi Melcarne, Maria Calvo, Marisa Iborra, Manuel Barreiro de Acosta, Beatriz Sicilia, Jesus Barrio, Jose Lazaro Perez Calle, David Busquets, Isabel Perez-Martinez, Merce Navarro-Llavat, Vicent Hernandez, Federico Arguelles-Arias, Fernando Ramirez Esteso, Susana Meijide, Laura Ramos, Fernando Gomollon, Fernando Munoz, Gerard Suris, Jone Ortiz de Zarate, Jose Maria Huguet, Jordina Llao, Mariana Fe Garcia-Sepulcre, Monica Sierra, Miguel Dura, Sandra Estrecha, Ana Fuentes Coronel, Esther Hinojosa, Lorenzo Olivan, Eva Iglesias, Ana Gutierrez, Pilar Varela, Nuria Rull, Pau Gilabert, Alejandro Hernandez-Camba, Alicia Brotons, Daniel Ginard, Eva Sese, Daniel Carpio, Montserrat Aceituno, Jose Luis Cabriada, Yago Gonzalez-Lama, Laura Jimenez, Maria Chaparro, Antonio Lopez-San Roman, Cristina Alba, Rocio Plaza-Santos, Raquel Mena, Sonsoles Tamarit-Sebastian, Elena Ricart, Margalida Calafat, Sonsoles Olivares, Pablo Navarro, Federico Bertoletti, Horacio Alonso-Galan, Ramon Pajares, Pablo Olcina, Pamela Manzano, Eugeni Domenech, Maria Esteve
Summary: Comorbidities and occupational exposure are the most relevant factors for COVID-19 in patients with IBD. The risk of COVID-19 does not seem to be increased by immunosuppressants or biologics, but there may be a potential effect of 5-aminosalicylates that requires further investigation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Maheeba Abdulla, Nafeesa Mohammed, Jehad AlQamish, Mahmoud Mosli
Summary: There is conflicting evidence regarding the impact of inflammatory bowel disease (IBD) on COVID-19. This study evaluated published evidence through a systematic review and meta-analysis, finding that ulcerative colitis is associated with increased risk of COVID-19, COVID-19 hospitalization, and severe COVID-19 infection, while Crohn's disease is associated with a lower risk of severe COVID-19.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Amit G. Singal, Andrew Masica, Kate Esselink, Caitlin C. Murphy, Jill A. Dever, Annika Reczek, Matthew Bensen, Nicole Mack, Ellen Stutts, Jamie L. Ridenhour, Evan Galt, Jordan Brainerd, Noa Kopplin, Sruthi Yekkaluri, Chris Rubio, Shelby Anderson, Kathryn Jan, Natalie Whitworth, Jacqueline Wagner, Stephen Allen, Alagar R. Muthukumar, Jasmin Tiro
Summary: The study aimed to estimate the prevalence of COVID-19, risk factors of infection, and related attitudes and behaviors in an urban population. The results showed that over 10% of the population in the city had been infected with COVID-19, and there were differences in attitudes and behaviors among different races and ethnicities.
Review
Gastroenterology & Hepatology
Ole Haagen Nielsen, John Mark Gubatan, Carsten Bogh Juhl, Sarah Elizabeth Streett, Cynthia Maxwell
Summary: Adverse pregnancy outcomes among pregnant IBD women using biologics are comparable with that of the general population.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Pediatrics
Leah K. Middelberg, Julie C. Leonard, Junxin Shi, Arturo Aranda, Julie C. Brown, Christina L. Cochran, Kasi Eastep, Raquel Gonzalez, Maya Haasz, Scott Herskovitz, Jennifer A. Hoffmann, Alexander Koral, Abdulraouf Lamoshi, Steven Levitte, Yu Hsiang J. Lo, Taylor Montminy, Inna Novak, Kenneth Ng, Nathan M. Novotny, Raphael H. Parrado, Wenly Ruan, Joseph Shapiro, Elizabeth M. Sinclair, Amanda M. Stewart, Saurabh Talathi, Melissa M. Tavarez, Peter Townsend, Julia Zaytsev, Bryan Rudolph
Summary: Despite intended for use by individuals over 14 years old, high-powered magnets commonly cause illnesses and lead to the need for invasive interventions and hospitalizations in children of all ages.
Review
Gastroenterology & Hepatology
John Gubatan, Grant E. Barber, Ole Haagen Nielsen, Carsten Bogh Juhl, Cynthia Maxwell, Michael L. Eisenberg, Sarah E. Streett
Summary: This study examined the association between the use of IBD medications (biologics, thiopurine, methotrexate) and semen parameters as well as adverse pregnancy outcomes among male patients with inflammatory bowel disease (IBD). The results showed that there was no significant difference in sperm count, motility, or abnormal morphology between patients exposed to IBD medications and nonexposed patients. The prevalence of adverse pregnancy outcomes was also similar between the two groups. Therefore, the use of IBD medications does not impair male fertility or increase the risk of adverse pregnancy outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
John Gubatan, Spencer Frost, Steven Levitte, Kian Keyashian
Summary: This study examined the 5-year outcomes of patients with perianal Crohn's disease (pCD) on biologic therapies and identified factors associated with long-term outcomes. The results showed that the use of anti-tumor necrosis factor (TNF) at the time of diagnosis was associated with decreased rates of perianal abscess recurrence, while ustekinumab was associated with increased rates of perianal fistula closure and decreased rates of perianal abscess recurrence. For patients who failed their first anti-TNF treatment, switching to another anti-TNF was associated with decreased rates of colectomy and permanent diversion.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Review
Nutrition & Dietetics
John Gubatan, Chiraag V. V. Kulkarni, Sarah Melissa Talamantes, Michelle Temby, Touran Fardeen, Sidhartha R. R. Sinha
Summary: Diet has a significant impact on intestinal immune homeostasis and the occurrence of inflammatory bowel disease (IBD). Studies have shown that ultra-processed foods, food additives, and emulsifiers are associated with a higher risk of IBD. While exclusion and elimination diets can improve symptoms, they do not affect objective markers of inflammation.
Editorial Material
Gastroenterology & Hepatology
Grant E. Barber, John Gubatan
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Pharmacology & Pharmacy
Ole Haagen Nielsen, Theresa Louise Boye, John Gubatan, Deepavali Chakravarti, James B. Jaquith, Eric C. LaCasse
Summary: JAK inhibitors are a new class of oral small molecules that provide therapeutic options for chronic inflammatory diseases, including inflammatory bowel disease (IBD). However, current JAK inhibitors may have serious adverse effects, and next-generation selective JAK inhibitors are expected to reduce these complications. Despite these concerns, JAK inhibitors have shown promise in modulating cytokine-driven inflammation and offer potential benefits in the treatment of IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Steven Levitte, Reza Yarani, Abantika Ganguly, Lynne Martin, John Gubatan, Helen R. R. Nadel, Benjamin Franc, Roberto Gugig, Ali Syed, Alka Goyal, K. T. Park, Avnesh S. S. Thakor
Summary: Intraarterial corticosteroid treatment can provide symptom relief for pediatric patients with inflammatory bowel disease (IBD) with minimal side effects. Vascular morphologic changes in the mesenteric circulation correlate with disease activity in patients with Crohn's disease. This approach shows promise as a locoregional therapy for IBD patients, but further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Shruthi Karthikeyan, Jeanne Shen, Kian Keyashian, John Gubatan
Summary: Small bowel adenocarcinomas (SBA) are rare malignancies with low survival rates, especially in Crohn's disease (CD) patients. Diagnosing CD-induced SBA is challenging due to overlapping symptoms and lack of early detection methods. This article discusses the future management of CD-induced SBA and the potential benefits of balloon enteroscopy and genetic testing for early detection.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Medicine, General & Internal
Mohamed Attauabi, Emilie Kristine Dahl, Johan Burisch, John Gubatan, Ole Haagen Nielsen, Jakob Benedict Seidelin
Summary: This study compared the onset of efficacy of biological therapies and small molecules in patients with moderate-to-severe ulcerative colitis (UC). The results showed that upadacitinib had significantly better clinical response and clinical remission at two weeks compared to other agents, while ustekinumab and ozanimod had the lowest efficacy.
Review
Pharmacology & Pharmacy
Amalie Rehde, Sebastian Kjaergaard Hendel, Carsten Bogh Juhl, John Gubatan, Ole Haagen Nielsen
Summary: This article systematically reviewed and meta-analyzed the effectiveness of non-budesonide therapies for microscopic colitis (MC) and compared them with other treatment options recommended by international guidelines. The results showed that bismuth subsalicylate (BSS) had the best treatment effect, followed by tumor necrosis factor inhibitors and bile acid sequestrants. These findings may help guide clinicians in selecting the most appropriate non-budesonide therapies for patients with MC.
Review
Biochemistry & Molecular Biology
Michelle Temby, Theresa L. Boye, Jacqueline Hoang, Ole H. Nielsen, John Gubatan
Summary: This article reviews the role of kinase signaling pathways in colitis-associated colon cancer, including MAPK, CDK, autophagy-activated kinases, JAK-STAT, and other kinases. It also discusses the involvement of JAK-STAT signaling in the pathogenesis of inflammatory bowel disease (IBD) and the potential use of JAK inhibitors for treating IBD.
Article
Gastroenterology & Hepatology
Kelly A. A. Hu, Jeanne Shen, Kerri Rieger, Mike T. T. Wei, John Gubatan
Summary: This study presents the first case of subcutaneous Sweet syndrome with sterile osteomyelitis in a patient with ulcerative colitis successfully treated with ustekinumab.
ACG CASE REPORTS JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Preston Lee, Mike T. Wei, John Gubatan, Erna Forgo, Gerald J. Berry, Rahul Verma, Shai Friedland
Summary: This study presents a unique case of lymphocytic colitis that occurred in a healthy middle-aged man after Moderna SARS-CoV-2 mRNA vaccination, revealing an unexpected dose-dependent worsening diarrhea complication of the vaccine.
ACG CASE REPORTS JOURNAL
(2022)
