Journal
FUTURE ONCOLOGY
Volume 16, Issue 10, Pages 559-571Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2020-0010
Keywords
head and neck squamous cell carcinoma; prognosis; survival; systemic inflammatory marker
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Funding
- Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant [20172017]
- National Natural Science Foundation of China [81802563]
- Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine [JYZZ008G]
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Aim: To explore the prognostic value of the systemic inflammatory marker (SIM) based on neutrophil, lymphocyte and monocyte counts in head and neck squamous cell carcinoma (HNSCC) patients. Patients & methods: We retrospectively collected the data of 367 patients with HNSCC who underwent surgery. The Kaplan-Meier survival analysis and Cox regression analysis were conducted on disease-free survival and overall survival. Results: A high SIM (>1.34) was associated with larger tumor size, advanced clinical stage and shorter survival time. The survival analysis showed that only clinical stage and SIM were independent prognostic indicators of disease-free survival and overall survival. Conclusion: The SIM positively correlated with tumor progression and might be a powerful prognostic indicator of poor outcome in patients with HNSCC.
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