A sensitive and accurate quantification method for the detection of hepatitis B virus covalently closed circular DNA by the application of a droplet digital polymerase chain reaction amplification system

Title
A sensitive and accurate quantification method for the detection of hepatitis B virus covalently closed circular DNA by the application of a droplet digital polymerase chain reaction amplification system
Authors
Keywords
Covalently closed circular DNA (cccDNA), cccDNA-specific primer, Droplet digital PCR, Hepatitis B virus, HepG2.215 cell line, Plasmid-safe ATP-dependent deoxynuclease
Journal
BIOTECHNOLOGY LETTERS
Volume 37, Issue 10, Pages 2063-2073
Publisher
Springer Nature
Online
2015-07-17
DOI
10.1007/s10529-015-1890-5

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